SETD2 Gene

SET domain containing 2

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]

setd2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term setd2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SETD2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SETD2 from the Pathway Commons Protein-Protein Interactions dataset.