Name

SH2B3 Gene

SH2B adaptor protein 3

This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

sh2b3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sh2b3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SH2B3 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SH2B3 from the Pathway Commons Protein-Protein Interactions dataset.

sh2b3atxn2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sh2b3atxn2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.