Name

SHANK2 Gene

SH3 and multiple ankyrin repeat domains 2

This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

SHANK2-AS2 Gene

SHANK2 antisense RNA 2

SHANK2-AS3 Gene

SHANK2 antisense RNA 3

SHANK2-AS1 Gene

SHANK2 antisense RNA 1

shank2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term shank2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SHANK2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SHANK2 from the Pathway Commons Protein-Protein Interactions dataset.

GluR delta-2 complex, postsynaptic (GluR delta-2, Shank1, Shank2, mGluR1 alpha, Homer, PSD-95) Gene Set

From CORUM Protein Complexes

proteins in the GluR delta-2 complex, postsynaptic (GluR delta-2, Shank1, Shank2, mGluR1 alpha, Homer, PSD-95) protein complex from the CORUM Protein Complexes dataset.

shank2mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term shank2mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

shank2e Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term shank2e in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.