Name

SHC1 Gene

SHC (Src homology 2 domain containing) transforming protein 1

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

SHC1P2 Gene

SHC (Src homology 2 domain containing) transforming protein 1 pseudogene 2

SHC1P1 Gene

SHC (Src homology 2 domain containing) transforming protein 1 pseudogene 1

shc1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term shc1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SHC1 Gene Set

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein SHC1 from the curated Hub Proteins Protein-Protein Interactions dataset.

SHC1 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for SHC1 from the NURSA Protein-Protein Interactions dataset.

SHC1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SHC1 from the Pathway Commons Protein-Protein Interactions dataset.

ITGA6-ITGB4-SHC1-GRB2 complex Gene Set

From CORUM Protein Complexes

proteins in the ITGA6-ITGB4-SHC1-GRB2 complex protein complex from the CORUM Protein Complexes dataset.

BL8103 (SHC1) Gene Set

From NURSA Protein Complexes

proteins in the BL8103 (SHC1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

EPI-1629-1 (SHC1) Gene Set

From NURSA Protein Complexes

proteins in the EPI-1629-1 (SHC1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

SHC1 events in EGFR signaling Gene Set

From Reactome Pathways

proteins participating in the SHC1 events in EGFR signaling pathway from the Reactome Pathways dataset.

SHC1 events in ERBB4 signaling Gene Set

From Reactome Pathways

proteins participating in the SHC1 events in ERBB4 signaling pathway from the Reactome Pathways dataset.

SHC1 events in ERBB2 signaling Gene Set

From Reactome Pathways

proteins participating in the SHC1 events in ERBB2 signaling pathway from the Reactome Pathways dataset.