Name

SKP2 Gene

S-phase kinase-associated protein 2, E3 ubiquitin protein ligase

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]

skp2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term skp2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SKP2 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for SKP2 from the NURSA Protein-Protein Interactions dataset.

SKP2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SKP2 from the Pathway Commons Protein-Protein Interactions dataset.

p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex Gene Set

From CORUM Protein Complexes

proteins in the p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (SKP1A, SKP2, CUL1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (SKP1A, SKP2, CUL1) protein complex from the CORUM Protein Complexes dataset.

SCF subcomplex (WEE1, SKP2, BTRC) Gene Set

From CORUM Protein Complexes

proteins in the SCF subcomplex (WEE1, SKP2, BTRC) protein complex from the CORUM Protein Complexes dataset.

CDH1-SKP2 complex Gene Set

From CORUM Protein Complexes

proteins in the CDH1-SKP2 complex protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) protein complex from the CORUM Protein Complexes dataset.

P-TEFb-SKP2 complex Gene Set

From CORUM Protein Complexes

proteins in the P-TEFb-SKP2 complex protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (Skp1A, Skp2, Cul1, Rbx1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (Skp1A, Skp2, Cul1, Rbx1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (CSN1, CSN8, HRT1, SKP1, SKP2, CUL1, CUL2, CUL3) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (CSN1, CSN8, HRT1, SKP1, SKP2, CUL1, CUL2, CUL3) protein complex from the CORUM Protein Complexes dataset.

skp2independent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term skp2independent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

skp2b Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term skp2b in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

skp2mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term skp2mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

skp2dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term skp2dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

skp2cks1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term skp2cks1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

skp2p27kip1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term skp2p27kip1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

skp2cyclin Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term skp2cyclin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

BL8037 (SKP2) Gene Set

From NURSA Protein Complexes

proteins in the BL8037 (SKP2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

SCF(Skp2)-mediated degradation of p27/p21 Gene Set

From Reactome Pathways

proteins participating in the SCF(Skp2)-mediated degradation of p27/p21 pathway from the Reactome Pathways dataset.