Name

SLC12A1 Gene

solute carrier family 12 (sodium/potassium/chloride transporter), member 1

This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010]

slc12a1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term slc12a1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SLC12A1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SLC12A1 from the Pathway Commons Protein-Protein Interactions dataset.