Name

SLC22A1 Gene

solute carrier family 22 (organic cation transporter), member 1

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. [provided by RefSeq, Jul 2008]

SLC22A18AS Gene

solute carrier family 22 (organic cation transporter), member 18 antisense

SLC22A13 Gene

solute carrier family 22 (organic anion/urate transporter), member 13

This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine. [provided by RefSeq, Sep 2008]

SLC22A18 Gene

solute carrier family 22, member 18

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Two alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Oct 2010]

SLC22A16 Gene

solute carrier family 22 (organic cation/carnitine transporter), member 16

This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. [provided by RefSeq, Dec 2011]

SLC22A17 Gene

solute carrier family 22, member 17

SLC22A14 Gene

solute carrier family 22, member 14

This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 3. The encoded protein is a transmembrane protein which is thought to transport small molecules and since this protein is conserved among several species, it is suggested to have a fundamental role in mammalian systems. [provided by RefSeq, Jul 2008]

SLC22A15 Gene

solute carrier family 22, member 15

Organic ion transporters, such as SLC22A15, transport various medically and physiologically important compounds, including pharmaceuticals, toxins, hormones, neurotransmitters, and cellular metabolites. These transporters are also referred to as amphiphilic solute facilitators (ASFs).[supplied by OMIM, Apr 2004]

SLC22A12 Gene

solute carrier family 22 (organic anion/urate transporter), member 12

The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

SLC22A10 Gene

solute carrier family 22, member 10

SLC22A11 Gene

solute carrier family 22 (organic anion/urate transporter), member 11

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

slc22a1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term slc22a1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SLC22A1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SLC22A1 from the Pathway Commons Protein-Protein Interactions dataset.

slc22a1abcb1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term slc22a1abcb1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

slc22a16 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term slc22a16 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

slc22a17 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term slc22a17 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

slc22a12 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term slc22a12 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

slc22a11 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term slc22a11 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

slc22a18 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term slc22a18 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

slc22a11slc22a12 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term slc22a11slc22a12 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SLC22A15 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SLC22A15 from the Pathway Commons Protein-Protein Interactions dataset.

SLC22A18 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SLC22A18 from the Pathway Commons Protein-Protein Interactions dataset.

SLC22A16 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SLC22A16 from the Pathway Commons Protein-Protein Interactions dataset.

SLC22A17 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SLC22A17 from the Pathway Commons Protein-Protein Interactions dataset.

SLC22A12 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SLC22A12 from the Pathway Commons Protein-Protein Interactions dataset.

SLC22A11 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SLC22A11 from the Pathway Commons Protein-Protein Interactions dataset.

SLC22A18AS Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SLC22A18AS from the Pathway Commons Protein-Protein Interactions dataset.