Name

SMAD2 Gene

SMAD family member 2

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

SMAD2 Gene Set

From CHEA Transcription Factor Targets

target genes of the SMAD2 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

smad2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term smad2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SMAD2 Gene Set

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein SMAD2 from the curated Hub Proteins Protein-Protein Interactions dataset.

SMAD2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SMAD2 from the Pathway Commons Protein-Protein Interactions dataset.

SMAD2-18955504-HaCaT-human Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the SMAD2-18955504-HaCaT-human transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

smad2-smad3 protein complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the smad2-smad3 protein complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

smad2-smad4 protein complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the smad2-smad4 protein complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

smad2-smad3 protein complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the smad2-smad3 protein complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

SKI-SMAD2-SMAD4 pentameric complex Gene Set

From CORUM Protein Complexes

proteins in the SKI-SMAD2-SMAD4 pentameric complex protein complex from the CORUM Protein Complexes dataset.

SKI-SMAD2 hexameric complex Gene Set

From CORUM Protein Complexes

proteins in the SKI-SMAD2 hexameric complex protein complex from the CORUM Protein Complexes dataset.

TIF1gamma-SMAD2-SMAD3 complex Gene Set

From CORUM Protein Complexes

proteins in the TIF1gamma-SMAD2-SMAD3 complex protein complex from the CORUM Protein Complexes dataset.

SMAD2-FAST1 complex Gene Set

From CORUM Protein Complexes

proteins in the SMAD2-FAST1 complex protein complex from the CORUM Protein Complexes dataset.

SMAD2-SMAD4-FAST1 complex Gene Set

From CORUM Protein Complexes

proteins in the SMAD2-SMAD4-FAST1 complex protein complex from the CORUM Protein Complexes dataset.

PML-SMAD2/3-SARA complex Gene Set

From CORUM Protein Complexes

proteins in the PML-SMAD2/3-SARA complex protein complex from the CORUM Protein Complexes dataset.

Smad2-Smad4 complex Gene Set

From CORUM Protein Complexes

proteins in the Smad2-Smad4 complex protein complex from the CORUM Protein Complexes dataset.

CREBBP-SMAD2 hexameric complex Gene Set

From CORUM Protein Complexes

proteins in the CREBBP-SMAD2 hexameric complex protein complex from the CORUM Protein Complexes dataset.

SMAD2-SKI complex Gene Set

From CORUM Protein Complexes

proteins in the SMAD2-SKI complex protein complex from the CORUM Protein Complexes dataset.

CREBBP-SMAD2-SMAD4 pentameric complex Gene Set

From CORUM Protein Complexes

proteins in the CREBBP-SMAD2-SMAD4 pentameric complex protein complex from the CORUM Protein Complexes dataset.

SMAD2-SKI-NCOR complex Gene Set

From CORUM Protein Complexes

proteins in the SMAD2-SKI-NCOR complex protein complex from the CORUM Protein Complexes dataset.

SMAD4-SMAD2-SMAD3 complex Gene Set

From CORUM Protein Complexes

proteins in the SMAD4-SMAD2-SMAD3 complex protein complex from the CORUM Protein Complexes dataset.

smad2smad4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term smad2smad4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

smad23dvl23dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term smad23dvl23dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

smad2smad3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term smad2smad3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

smad2receptor Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term smad2receptor in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

smad2mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term smad2mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

smad24 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term smad24 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

smad23 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term smad23 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

smad23smad4dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term smad23smad4dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

smad23dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term smad23dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

smad234 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term smad234 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

smad23l Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term smad23l in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

smad2dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term smad2dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

smad2independent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term smad2independent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

smad2-smad3 protein complex Gene Set

From GO Cellular Component Annotations

proteins localized to the smad2-smad3 protein complex cellular component from the curated GO Cellular Component Annotations dataset.

Regulation of cytoplasmic and nuclear SMAD2/3 signaling Gene Set

From PID Pathways

proteins participating in the Regulation of cytoplasmic and nuclear SMAD2/3 signaling pathway from the PID Pathways dataset.

Regulation of nuclear SMAD2/3 signaling Gene Set

From PID Pathways

proteins participating in the Regulation of nuclear SMAD2/3 signaling pathway from the PID Pathways dataset.

SMAD2/3 Phosphorylation Motif Mutants in Cancer Gene Set

From Reactome Pathways

proteins participating in the SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway from the Reactome Pathways dataset.

SMAD2/3 MH2 Domain Mutants in Cancer Gene Set

From Reactome Pathways

proteins participating in the SMAD2/3 MH2 Domain Mutants in Cancer pathway from the Reactome Pathways dataset.

SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Gene Set

From Reactome Pathways

proteins participating in the SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway from the Reactome Pathways dataset.

Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Gene Set

From Reactome Pathways

proteins participating in the Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway from the Reactome Pathways dataset.

Loss of Function of SMAD2/3 in Cancer Gene Set

From Reactome Pathways

proteins participating in the Loss of Function of SMAD2/3 in Cancer pathway from the Reactome Pathways dataset.

Downregulation of SMAD2/3:SMAD4 transcriptional activity Gene Set

From Reactome Pathways

proteins participating in the Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway from the Reactome Pathways dataset.