Name

SOCS1 Gene

suppressor of cytokine signaling 1

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]

socs1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term socs1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SOCS1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SOCS1 from the Pathway Commons Protein-Protein Interactions dataset.

socs13 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term socs13 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

socs1regulation Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term socs1regulation in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

socs1expression Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term socs1expression in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.