Name

SOCS2-AS1 Gene

SOCS2 antisense RNA 1

SOCS2 Gene

suppressor of cytokine signaling 2

This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

socs2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term socs2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SOCS2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SOCS2 from the Pathway Commons Protein-Protein Interactions dataset.