Name

SOX2 Gene

SRY (sex determining region Y)-box 2

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]

SOX2-OT Gene

SOX2 overlapping transcript

SOX21-AS1 Gene

SOX21 antisense RNA 1 (head to head)

SOX21 Gene

SRY (sex determining region Y)-box 21

SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000). SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the HMG domain. For additional background information on SOX genes, see SOX1 (MIM 602148).[supplied by OMIM, Apr 2004]

SOX2 Gene Set

From CHEA Transcription Factor Targets

target genes of the SOX2 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

sox2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sox2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SOX2 Gene Set

From JASPAR Predicted Transcription Factor Targets

target genes of the SOX2 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.

SOX2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SOX2 from the Pathway Commons Protein-Protein Interactions dataset.

SOX2 Gene Set

From TRANSFAC Predicted Transcription Factor Targets

target genes of the SOX2 transcription factor predicted using known transcription factor binding site motifs from the TRANSFAC Predicted Transcription Factor Targets dataset.

SOX2-19030024-MESC-mouse Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the SOX2-19030024-MESC-mouse transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

SOX2-18555785-MESC-mouse Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the SOX2-18555785-MESC-mouse transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

SOX2-18358816-MESC-mouse Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the SOX2-18358816-MESC-mouse transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

SOX2-20726797-SW620-HUMAN Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the SOX2-20726797-SW620-HUMAN transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

SOX2-16153702-HESC-human Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the SOX2-16153702-HESC-human transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

SOX2-21211035-LN229_GBM-HUMAN Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the SOX2-21211035-LN229_GBM-HUMAN transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

SOX2-18692474-MESC-mouse Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the SOX2-18692474-MESC-mouse transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

OCT1-SOX2 DNA-protein complex Gene Set

From CORUM Protein Complexes

proteins in the OCT1-SOX2 DNA-protein complex protein complex from the CORUM Protein Complexes dataset.

PAX6-SOX2 DNA-protein complex Gene Set

From CORUM Protein Complexes

proteins in the PAX6-SOX2 DNA-protein complex protein complex from the CORUM Protein Complexes dataset.

OCT4-SOX2 DNA-protein complex Gene Set

From CORUM Protein Complexes

proteins in the OCT4-SOX2 DNA-protein complex protein complex from the CORUM Protein Complexes dataset.

sox2mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sox2mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

sox2induced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sox2induced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

sox21 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sox21 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

sox2expressing Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sox2expressing in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

sox2associated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sox2associated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

sox2fn1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sox2fn1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

sox2sox21 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sox2sox21 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

sox2oct1hoxb1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sox2oct1hoxb1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

sox2oct4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sox2oct4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

sox2ot Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sox2ot in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

sox2oct34 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sox2oct34 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SOX2_Deficiency_GDS4853_321_human_AZ-521 gastric cancer (GC) cell line - 18 Hours Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the SOX2_Deficiency_GDS4853_321_human_AZ-521 gastric cancer (GC) cell line - 18 Hours gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

SOX2_Deficiency_GDS4853_320_human_AZ-521 gastric cancer (GC) cell line - 12 Hours Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the SOX2_Deficiency_GDS4853_320_human_AZ-521 gastric cancer (GC) cell line - 12 Hours gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

SOX2_Deficiency_GDS4853_319_human_AZ-521 gastric cancer (GC) cell line - 8 Hours Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the SOX2_Deficiency_GDS4853_319_human_AZ-521 gastric cancer (GC) cell line - 8 Hours gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

SOX2_Deficiency_GDS4853_322_human_AZ-521 gastric cancer (GC) cell line - 24 Hours Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the SOX2_Deficiency_GDS4853_322_human_AZ-521 gastric cancer (GC) cell line - 24 Hours gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

BL6579 (SOX2) Gene Set

From NURSA Protein Complexes

proteins in the BL6579 (SOX2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

SOX21 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SOX21 from the Pathway Commons Protein-Protein Interactions dataset.

POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Gene Set

From Reactome Pathways

proteins participating in the POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation pathway from the Reactome Pathways dataset.

POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation Gene Set

From Reactome Pathways

proteins participating in the POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation pathway from the Reactome Pathways dataset.