Name

SPHK1 Gene

sphingosine kinase 1

The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

sphk1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sphk1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SPHK1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SPHK1 from the Pathway Commons Protein-Protein Interactions dataset.

sphk1dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sphk1dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

sphk1s1ps1p1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sphk1s1ps1p1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

sphk1s1ps1prs Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sphk1s1ps1prs in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

sphk1mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sphk1mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SPHK1-interactor/A-kinase anchor 110kDa Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the SPHK1-interactor/A-kinase anchor 110kDa protein domain from the InterPro Predicted Protein Domain Annotations dataset.

BL2920 (SPHK1) Gene Set

From NURSA Protein Complexes

proteins in the BL2920 (SPHK1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.