Name

SPINT2 Gene

serine peptidase inhibitor, Kunitz type, 2

This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

spint2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term spint2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SPINT2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SPINT2 from the Pathway Commons Protein-Protein Interactions dataset.