Name

SSX2 Gene

synovial sarcoma, X breakpoint 2

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about 45 kb downstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013]

SSX2IP Gene

synovial sarcoma, X breakpoint 2 interacting protein

This gene encodes a protein that binds the cancer-testis antigen Synovial Sarcoma X breakpoint 2 protein. The encoded protein may regulate the activity of Synovial Sarcoma X breakpoint 2 protein in malignant cells. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Oct 2009]

SSX2B Gene

synovial sarcoma, X breakpoint 2B

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 6757, located about 45 kb upstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013]

ssx2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ssx2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SSX2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SSX2 from the Pathway Commons Protein-Protein Interactions dataset.

ssx2ip Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ssx2ip in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SSX2IP Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SSX2IP from the Pathway Commons Protein-Protein Interactions dataset.