Harmonizome

signal transducer and activator of transcription 2, 113kDa

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

From ENCODE Transcription Factor Targets

target genes of the STAT2 transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for STAT2 from the Pathway Commons Protein-Protein Interactions dataset.

From TRANSFAC Curated Transcription Factor Targets

target genes of the STAT2 transcription factor in low- or high-throughput transcription factor functional studies from the TRANSFAC Curated Transcription Factor Targets dataset.

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT2_K562_hg19_2 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT2_K562_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat2containing in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat2p48 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat2ifnar2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat2irf9 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Biological Process Annotations

genes participating in the tyrosine phosphorylation of stat2 protein biological process from the curated GO Biological Process Annotations dataset.