Name

STAT5B Gene

signal transducer and activator of transcription 5B

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]

stat5b Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat5b in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

STAT5B Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for STAT5B from the Pathway Commons Protein-Protein Interactions dataset.

STAT5B Gene Set

From TRANSFAC Curated Transcription Factor Targets

target genes of the STAT5B transcription factor in low- or high-throughput transcription factor functional studies from the TRANSFAC Curated Transcription Factor Targets dataset.

STAT5B Gene Set

From TRANSFAC Predicted Transcription Factor Targets

target genes of the STAT5B transcription factor predicted using known transcription factor binding site motifs from the TRANSFAC Predicted Transcription Factor Targets dataset.

STAT5B homodimer complex Gene Set

From CORUM Protein Complexes

proteins in the STAT5B homodimer complex protein complex from the CORUM Protein Complexes dataset.

stat5braralpha Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat5braralpha in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat5bstat3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat5bstat3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat5b_18687707_colon_lof_mouse_gpl5759_gds3385 Gene Set

From GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations

genes differentially expressed following the stat5b_18687707_colon_lof_mouse_gpl5759_gds3385 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

leukemia, acute promyelocytic, stat5b/rara type Gene Set

From OMIM Gene-Disease Associations

genes associated with the leukemia, acute promyelocytic, stat5b/rara type phenotype from the curated OMIM Gene-Disease Associations dataset.