Name

STRADA Gene

STE20-related kinase adaptor alpha

The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]

STRADA Gene Set

From KEA Substrates of Kinases

substrates of the kinase STRADA from the curated KEA Substrates of Kinases dataset.

STRADA Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for STRADA from the Pathway Commons Protein-Protein Interactions dataset.

stradalpha Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stradalpha in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stradalpharac1pak1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stradalpharac1pak1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stradalphamo25alpha Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stradalphamo25alpha in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.