TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]
TAF1C Gene Set
interacting proteins for TAF1C from the Pathway Commons Protein-Protein Interactions dataset.