Name

TBK1 Gene

TANK-binding kinase 1

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010]

tbk1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tbk1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

TBK1 Gene Set

From KEA Substrates of Kinases

substrates of the kinase TBK1 from the curated KEA Substrates of Kinases dataset.

TBK1 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for TBK1 from the NURSA Protein-Protein Interactions dataset.

TBK1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for TBK1 from the Pathway Commons Protein-Protein Interactions dataset.

TBK1 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase TBK1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

tbk1s Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tbk1s in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

tbk1dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tbk1dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

tbk1traf3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tbk1traf3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

tbk1mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tbk1mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

tbk1ikki Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tbk1ikki in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

tbk1irf3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tbk1irf3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

tbk1ikkepsilondependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tbk1ikkepsilondependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

TBK1_druginhibition_188_GSE53658 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the TBK1_druginhibition_188_GSE53658 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

TBK1_knockdown_53_GSE17643 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the TBK1_knockdown_53_GSE17643 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

Tbk1/Ikki binding domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tbk1/Ikki binding domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

TBK1.DF Gene Set

From MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations

genes differentially expressed following the TBK1.DF gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

TBK1.DN.48HRS Gene Set

From MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations

genes differentially expressed following the TBK1.DN.48HRS gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

BL703 (TBK1) Gene Set

From NURSA Protein Complexes

proteins in the BL703 (TBK1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

BL702 (TBK1) Gene Set

From NURSA Protein Complexes

proteins in the BL702 (TBK1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

BL701 (TBK1) Gene Set

From NURSA Protein Complexes

proteins in the BL701 (TBK1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Gene Set

From Reactome Pathways

proteins participating in the Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway from the Reactome Pathways dataset.