Name

THPO Gene

thrombopoietin

Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]

thpo Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term thpo in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

THPO Gene Set

From Guide to Pharmacology Protein Ligands of Receptors

receptors of the THPO ligand (protein) from the curated Guide to Pharmacology Protein Ligands of Receptors dataset.

THPO Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for THPO from the MSigDB Cancer Gene Co-expression Modules dataset.

THPO Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for THPO from the Pathway Commons Protein-Protein Interactions dataset.

thpositive Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term thpositive in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

thpok Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term thpok in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.