Name

TIGAR Gene

TP53 induced glycolysis regulatory phosphatase

This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]

tigar Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tigar in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

tigarmediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tigarmediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.