Name

TLR5 Gene

toll-like receptor 5

This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]

tlr5 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tlr5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

TLR5 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for TLR5 from the Pathway Commons Protein-Protein Interactions dataset.

tlr5dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tlr5dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

tlr5induced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tlr5induced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Toll Like Receptor 5 (TLR5) Cascade Gene Set

From Reactome Pathways

proteins participating in the Toll Like Receptor 5 (TLR5) Cascade pathway from the Reactome Pathways dataset.