Name

TNFRSF1B Gene

tumor necrosis factor receptor superfamily, member 1B

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]

tnfrsf1b Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tnfrsf1b in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

TNFRSF1B Gene Set

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein TNFRSF1B from the curated Hub Proteins Protein-Protein Interactions dataset.

TNFRSF1B Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for TNFRSF1B from the MSigDB Cancer Gene Co-expression Modules dataset.

TNFRSF1B Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for TNFRSF1B from the Pathway Commons Protein-Protein Interactions dataset.

A-Vietnam-1203-2004(H5N1)_2day-TNFRSF1BKO_None_GSE40792 Gene Set

From GEO Signatures of Differentially Expressed Genes for Viral Infections

genes differentially expressed following the A-Vietnam-1203-2004(H5N1)_2day-TNFRSF1BKO_None_GSE40792 virus perturbation from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.

SARS-CoV MA15_Day4-TNFRsf1b KO_None_GSE40824 Gene Set

From GEO Signatures of Differentially Expressed Genes for Viral Infections

genes differentially expressed following the SARS-CoV MA15_Day4-TNFRsf1b KO_None_GSE40824 virus perturbation from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.