Name

TNFSF12 Gene

tumor necrosis factor (ligand) superfamily, member 12

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

TNFSF12-TNFSF13 Gene

TNFSF12-TNFSF13 readthrough

This gene encodes a member of the tumor necrosis factor superfamily. It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines. [provided by RefSeq, Jul 2008]

tnfsf12 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tnfsf12 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

TNFSF12 Gene Set

From Guide to Pharmacology Protein Ligands of Receptors

receptors of the TNFSF12 ligand (protein) from the curated Guide to Pharmacology Protein Ligands of Receptors dataset.

TNFSF12 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for TNFSF12 from the Pathway Commons Protein-Protein Interactions dataset.