Name

TNNI2 Gene

troponin I type 2 (skeletal, fast)

This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

tnni2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tnni2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

TNNI2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for TNNI2 from the Pathway Commons Protein-Protein Interactions dataset.