Name

TOP2A Gene

topoisomerase (DNA) II alpha 170kDa

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]

top2a Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term top2a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

TOP2A Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for TOP2A from the Pathway Commons Protein-Protein Interactions dataset.

top2alpha Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term top2alpha in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

top2alphadna Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term top2alphadna in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.