TPM3 Gene

tropomyosin 3

This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

TPM3P8 Gene

tropomyosin 3 pseudogene 8

TPM3P9 Gene

tropomyosin 3 pseudogene 9

TPM3P7 Gene

tropomyosin 3 pseudogene 7

TPM3P4 Gene

tropomyosin 3 pseudogene 4

TPM3P5 Gene

tropomyosin 3 pseudogene 5

TPM3P2 Gene

tropomyosin 3 pseudogene 2

TPM3P1 Gene

tropomyosin 3 pseudogene 1

TPM3P6 Gene

tropomyosin 3 pseudogene 6

tpm3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tpm3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

TPM3 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for TPM3 from the NURSA Protein-Protein Interactions dataset.

TPM3 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for TPM3 from the Pathway Commons Protein-Protein Interactions dataset.