Name

TSN Gene

translin

This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

TSNAX-DISC1 Gene

TSNAX-DISC1 readthrough (NMD candidate)

This gene represents naturally occurring read-through transcription between the neighboring TSNAX (translin-associated factor X) and DISC1 (disrupted in schizophrenia 1) genes on chromosome 1. Alternative splicing results in multiple transcript variants, all of which are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. These alterations in gene processing may be associated with risk for psychiatric illness, most notably, schizophrenia. [provided by RefSeq, Nov 2010]

TSNAXIP1 Gene

translin-associated factor X interacting protein 1

TSNAX Gene

translin-associated factor X

This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs. [provided by RefSeq, Jul 2008]

TSNARE1 Gene

t-SNARE domain containing 1

TSN Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for TSN from the Pathway Commons Protein-Protein Interactions dataset.

tsnps Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tsnps in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

tsnare Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tsnare in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

tsnax Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tsnax in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

tsnp Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tsnp in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

tsnares Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tsnares in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

TSNAXIP1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for TSNAXIP1 from the Pathway Commons Protein-Protein Interactions dataset.

TSNAX Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for TSNAX from the Pathway Commons Protein-Protein Interactions dataset.