Name

UBE2D2 Gene

ubiquitin-conjugating enzyme E2D 2

Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

ube2d2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ube2d2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

UBE2D2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for UBE2D2 from the Pathway Commons Protein-Protein Interactions dataset.