Name

VHL Gene

von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

VHLL Gene

von Hippel-Lindau tumor suppressor-like

Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha. [provided by RefSeq, Jan 2010]

vhl Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vhl in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

VHL Gene Set

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein VHL from the curated Hub Proteins Protein-Protein Interactions dataset.

VHL Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for VHL from the Pathway Commons Protein-Protein Interactions dataset.

VHL Gene Set

From PhosphoSitePlus Phosphosite-Disease Associations

proteins associated with the disease VHL from the curated PhosphoSitePlus Phosphosite-Disease Associations dataset.

VHL-TCEB1-TCEB2 complex Gene Set

From CORUM Protein Complexes

proteins in the VHL-TCEB1-TCEB2 complex protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2) protein complex from the CORUM Protein Complexes dataset.

VHL-VDU1-TCEB1-TCEB2 complex Gene Set

From CORUM Protein Complexes

proteins in the VHL-VDU1-TCEB1-TCEB2 complex protein complex from the CORUM Protein Complexes dataset.

VHL-TBP1-HIF1A complex Gene Set

From CORUM Protein Complexes

proteins in the VHL-TBP1-HIF1A complex protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2, RBX1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2, RBX1) protein complex from the CORUM Protein Complexes dataset.

von hippel-lindau syndrome (vhl). Gene Set

From GAD Gene-Disease Associations

genes associated with the disease von hippel-lindau syndrome (vhl). in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

vhlhifvegf Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vhlhifvegf in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

vhldeficient Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vhldeficient in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

vhl30 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vhl30 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

vhlmediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vhlmediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

vhlptp1bsrc Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vhlptp1bsrc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

vhlinduced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vhlinduced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

vhlvon Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vhlvon in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

vhlregulated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vhlregulated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

vhlhif1alpha Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vhlhif1alpha in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

vhlr200w Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vhlr200w in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

vhlak Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vhlak in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

vhl19 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vhl19 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

vhlhif Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vhlhif in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

vhldefective Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vhldefective in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

vhluxt Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vhluxt in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

vhlhifinduced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vhlhifinduced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

vhlnull Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vhlnull in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

VHL_Deficiency_GDS3769_513_mouse_Immortalized embryonic fibroblasts Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the VHL_Deficiency_GDS3769_513_mouse_Immortalized embryonic fibroblasts gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

VHLL Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for VHLL from the Pathway Commons Protein-Protein Interactions dataset.