Name

VPS33B Gene

vacuolar protein sorting 33 homolog B (yeast)

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C vacuolar protein sorting proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Mutations in this gene are associated with arthrogryposis-renal dysfunction-cholestasis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

VIPAS39 Gene

VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog

This gene encodes a protein involved in the sorting of lysosomal proteins. Mutations in this gene are associated with ARCS2 (arthrogryposis, renal dysfunction, and cholestasis-2). Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]

vps33b Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vps33b in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

VPS33B Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for VPS33B from the Pathway Commons Protein-Protein Interactions dataset.