Name

VRK1 Gene

vaccinia related kinase 1

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]

vrk1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vrk1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

VRK1 Gene Set

From KEA Substrates of Kinases

substrates of the kinase VRK1 from the curated KEA Substrates of Kinases dataset.

VRK1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for VRK1 from the Pathway Commons Protein-Protein Interactions dataset.

VRK1 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase VRK1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

vrk1vrk2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vrk1vrk2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

vrk1mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vrk1mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

vrk1p53 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vrk1p53 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

VRK1_knockout_64_GSE19329 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the VRK1_knockout_64_GSE19329 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.