Name

WDR7 Gene

WD repeat domain 7

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) that may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. The encoded protein forms the beta subunit of rabconnectin-3 and binds directly with Rab3A GDP/GTP exchange protein and indirectly with Rab3A GDP/GTP activating protein; these proteins are regulators of Rab3 small G protein family members involved in control of the calcium-dependant exocytosis of neurotransmitters. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

WDR7-OT1 Gene

WDR7 overlapping transcript 1

WDR78 Gene

WD repeat domain 78

WDR70 Gene

WD repeat domain 70

WDR73 Gene

WD repeat domain 73

The protein encoded by this gene is thought to contain multiple WD40 repeats. WD40 repeats are motifs that contain 40-60 amino acids, and usually end with Trp-Asp (WD). This protein is found in the cytoplasm during interphase, but accumulates at the spindle poles and astral microtubules during mitosis. Reduced expression of this gene results in abnormalities in the size and morphology of the nucleus. Mutations in this gene have been associated with Galloway-Mowat syndrome PMID: 25466283), which is a rare autosomal recessive disorder that affects both the central nervous system and kidneys. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

WDR72 Gene

WD repeat domain 72

This gene encodes a protein with eight WD-40 repeats. Mutations in this gene have been associated with amelogenesis imperfecta hypomaturation type 2A3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

WDR75 Gene

WD repeat domain 75

WDR74 Gene

WD repeat domain 74

WDR77 Gene

WD repeat domain 77

WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear ribonucleoprotein core particles (Friesen et al., 2002 [PubMed 11756452]).[supplied by OMIM, Mar 2008]

WDR76 Gene

WD repeat domain 76

WDR7 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for WDR7 from the Pathway Commons Protein-Protein Interactions dataset.

wdr72 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term wdr72 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

wdr77 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term wdr77 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

BL7352 (WDR70) Gene Set

From NURSA Protein Complexes

proteins in the BL7352 (WDR70) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

WDR77 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for WDR77 from the NURSA Protein-Protein Interactions dataset.

WDR78 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for WDR78 from the Pathway Commons Protein-Protein Interactions dataset.

WDR70 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for WDR70 from the Pathway Commons Protein-Protein Interactions dataset.

WDR73 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for WDR73 from the Pathway Commons Protein-Protein Interactions dataset.

WDR75 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for WDR75 from the Pathway Commons Protein-Protein Interactions dataset.

WDR74 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for WDR74 from the Pathway Commons Protein-Protein Interactions dataset.

WDR77 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for WDR77 from the Pathway Commons Protein-Protein Interactions dataset.

WDR76 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for WDR76 from the Pathway Commons Protein-Protein Interactions dataset.