Name

WRN Gene

Werner syndrome, RecQ helicase-like

This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008]

WRNIP1 Gene

Werner helicase interacting protein 1

Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]

wrn Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term wrn in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

WRN Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for WRN from the Pathway Commons Protein-Protein Interactions dataset.

WRN-TRF2 complex Gene Set

From CORUM Protein Complexes

proteins in the WRN-TRF2 complex protein complex from the CORUM Protein Complexes dataset.

WRN-Ku70-Ku80-PARP1 complex Gene Set

From CORUM Protein Complexes

proteins in the WRN-Ku70-Ku80-PARP1 complex protein complex from the CORUM Protein Complexes dataset.

WRNIP1_GM12878_hg19_1 Gene Set

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the WRNIP1_GM12878_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

WRNIP1 Gene Set

From ENCODE Transcription Factor Targets

target genes of the WRNIP1 transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

wrnip1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term wrnip1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

wrnmediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term wrnmediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

wrnparp1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term wrnparp1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

wrnp Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term wrnp in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

BL1308 (WRN) Gene Set

From NURSA Protein Complexes

proteins in the BL1308 (WRN) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

BL1309 (WRN) Gene Set

From NURSA Protein Complexes

proteins in the BL1309 (WRN) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

WRNIP1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for WRNIP1 from the Pathway Commons Protein-Protein Interactions dataset.