Name

XBP1 Gene

X-box binding protein 1

This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]

XBP1P1 Gene

X-box binding protein 1 pseudogene 1

xbp1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term xbp1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

XBP1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for XBP1 from the Pathway Commons Protein-Protein Interactions dataset.

XBP1 Gene Set

From TRANSFAC Curated Transcription Factor Targets

target genes of the XBP1 transcription factor in low- or high-throughput transcription factor functional studies from the TRANSFAC Curated Transcription Factor Targets dataset.

XBP1 Gene Set

From TRANSFAC Predicted Transcription Factor Targets

target genes of the XBP1 transcription factor predicted using known transcription factor binding site motifs from the TRANSFAC Predicted Transcription Factor Targets dataset.

xbp1independent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term xbp1independent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

xbp1responsive Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term xbp1responsive in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

xbp1mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term xbp1mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

xbp1u Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term xbp1u in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

xbp1s Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term xbp1s in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

XBP1_OE_GDS2861_60_human_MCF7 breast cancer cells Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the XBP1_OE_GDS2861_60_human_MCF7 breast cancer cells gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

XBP1_OE_GDS5065_273_mouse_F424a adipocytes Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the XBP1_OE_GDS5065_273_mouse_F424a adipocytes gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

SC-7160 (XBP1) Gene Set

From NURSA Protein Complexes

proteins in the SC-7160 (XBP1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

XBP1(S) activates chaperone genes Gene Set

From Reactome Pathways

proteins participating in the XBP1(S) activates chaperone genes pathway from the Reactome Pathways dataset.