Name

XIAP Gene

X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]

xiap Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term xiap in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

XIAP Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for XIAP from the Pathway Commons Protein-Protein Interactions dataset.

xiapxaf1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term xiapxaf1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

xiapinteracting Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term xiapinteracting in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

xiapinduced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term xiapinduced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

xiapbir3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term xiapbir3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

xiapdependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term xiapdependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

xiapmediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term xiapmediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

xiapring Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term xiapring in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.