Name

ZAP70 Gene

zeta-chain (TCR) associated protein kinase 70kDa

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

zap70 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term zap70 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ZAP70 Gene Set

From KEA Substrates of Kinases

substrates of the kinase ZAP70 from the curated KEA Substrates of Kinases dataset.

ZAP70 Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for ZAP70 from the MSigDB Cancer Gene Co-expression Modules dataset.

ZAP70 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for ZAP70 from the Pathway Commons Protein-Protein Interactions dataset.

ZAP70 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase ZAP70 from the curated PhosphoSitePlus Substrates of Kinases dataset.

ZAP70-CRKL-WIPF1-WAS complex Gene Set

From CORUM Protein Complexes

proteins in the ZAP70-CRKL-WIPF1-WAS complex protein complex from the CORUM Protein Complexes dataset.

zap70vav1talin Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term zap70vav1talin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

zap70positive Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term zap70positive in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

zap70dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term zap70dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

zap70cd38 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term zap70cd38 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

BL7029 (ZAP70) Gene Set

From NURSA Protein Complexes

proteins in the BL7029 (ZAP70) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.