Name Description Size
Adjacency_matrix_LM_space_42809x42809.gctx Adjacency matrix of all significant CD signatures. Cosine similarity is used to compute the signature similarity. 13.7GB
CD_signatures_LM_42809x978.gctx CD signature matrix in the Landmark gene space. 330.6MB
CD_signatures_full_42809x22268.gctx CD signature matrix in the full space (22268 probes). 7.1GB
CD_signatures_binary_42809.gmt CD signatures (up/down gene sets) in the full space in gmt format. 115.0MB
CD_signatures_binary_42809.json CD signatures (up/down gene sets) in the full space in json format. 169.5MB
CD_signature_metadata.csv Metadata of the signatures indexed by the `sig_id`. 4.8MB
Drugs_metadata.csv Metadata of the drugs indexed by the `pert_id` 7.4MB
Probes_L1000_metadata.csv Metadata of the probes of the Landmark genes. 16.3KB
Probes_full_metadata.csv Metadata of the probes used in the full space. 364.2KB
Plot Cell line Signatures
All cell lines all 16848
BT20 (FWD) BT20 571
THP1 (tSNE) THP1 229
NPC (tSNE) NPC 973
HT29 (tSNE) HT29 2717
A549 (FWD) A549 4115
A375 (FWD) A375 3086
A375 (tSNE) A375 3086
HCC515 (tSNE) HCC515 2504
MDAMB231 (FWD) MDAMB231 545
HEPG2 (tSNE) HEPG2 1861
HCC515 (FWD) HCC515 2504
MDAMB231 (tSNE) MDAMB231 545
NEU (tSNE) NEU 378
SKB (tSNE) SKB 868
A549 (tSNE) A549 4115
SKBR3 (FWD) SKBR3 541
HA1E (FWD) HA1E 3005
MCF10A (tSNE) MCF10A 471
ASC (FWD) ASC 777
VCAP (FWD) VCAP 5856
HT29 (FWD) HT29 2717
BT20 (tSNE) BT20 571
VCAP (tSNE) VCAP 5856
MCF7 (FWD) MCF7 6965
THP1 (FWD) THP1 229
ASC (tSNE) ASC 777
MCF10A (FWD) MCF10A 471
NEU (FWD) NEU 378
PC3 (tSNE) PC3 5638
HA1E (tSNE) HA1E 3005
SKB (FWD) SKB 868
NPC (FWD) NPC 973
SKBR3 (tSNE) SKBR3 541
MCF7 (tSNE) MCF7 6965
HS578T (tSNE) HS578T 454
PHH (tSNE) PHH 505
PHH (FWD) PHH 505
PC3 (FWD) PC3 5638
HS578T (FWD) HS578T 454
HEPG2 (FWD) HEPG2 1861