A1CF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.51961309
2L-phenylalanine catabolic process (GO:0006559)7.51961309
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.16334196
4L-phenylalanine metabolic process (GO:0006558)7.16334196
5exogenous drug catabolic process (GO:0042738)7.12890544
6epoxygenase P450 pathway (GO:0019373)6.88656558
7aromatic amino acid family catabolic process (GO:0009074)6.77498724
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.16521344
9tryptophan catabolic process (GO:0006569)6.13354754
10indole-containing compound catabolic process (GO:0042436)6.13354754
11indolalkylamine catabolic process (GO:0046218)6.13354754
12kynurenine metabolic process (GO:0070189)6.00822239
13bile acid biosynthetic process (GO:0006699)5.90321671
14omega-hydroxylase P450 pathway (GO:0097267)5.85288127
15tryptophan metabolic process (GO:0006568)5.79106871
16alpha-linolenic acid metabolic process (GO:0036109)5.70205271
17glyoxylate metabolic process (GO:0046487)5.69561277
18urea metabolic process (GO:0019627)5.53863626
19urea cycle (GO:0000050)5.53863626
20cysteine metabolic process (GO:0006534)5.37496106
21negative regulation of fibrinolysis (GO:0051918)5.35346341
22high-density lipoprotein particle remodeling (GO:0034375)5.29089612
23complement activation, alternative pathway (GO:0006957)5.20376601
24protein carboxylation (GO:0018214)5.20337606
25peptidyl-glutamic acid carboxylation (GO:0017187)5.20337606
26regulation of protein activation cascade (GO:2000257)5.19010086
27sulfur amino acid catabolic process (GO:0000098)5.18104026
28regulation of fibrinolysis (GO:0051917)5.15779891
29nitrogen cycle metabolic process (GO:0071941)5.09587206
30bile acid metabolic process (GO:0008206)5.09499425
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.04618148
32serine family amino acid catabolic process (GO:0009071)5.01893661
33drug metabolic process (GO:0017144)5.00638648
34aromatic amino acid family metabolic process (GO:0009072)4.91671388
35regulation of complement activation (GO:0030449)4.85547088
36homocysteine metabolic process (GO:0050667)4.80958081
37lysine metabolic process (GO:0006553)4.72097242
38lysine catabolic process (GO:0006554)4.72097242
39regulation of triglyceride catabolic process (GO:0010896)4.68282808
40regulation of cholesterol esterification (GO:0010872)4.68060453
41tyrosine metabolic process (GO:0006570)4.67567201
42reverse cholesterol transport (GO:0043691)4.66698661
43amino-acid betaine metabolic process (GO:0006577)4.64004208
44protein-lipid complex remodeling (GO:0034368)4.60439057
45macromolecular complex remodeling (GO:0034367)4.60439057
46plasma lipoprotein particle remodeling (GO:0034369)4.60439057
47alpha-amino acid catabolic process (GO:1901606)4.58824818
48triglyceride homeostasis (GO:0070328)4.54745580
49acylglycerol homeostasis (GO:0055090)4.54745580
50cellular ketone body metabolic process (GO:0046950)4.49237232
51negative regulation of sterol transport (GO:0032372)4.49194666
52negative regulation of cholesterol transport (GO:0032375)4.49194666
53bile acid and bile salt transport (GO:0015721)4.47730156
54regulation of plasminogen activation (GO:0010755)4.46559020
55phospholipid efflux (GO:0033700)4.46435940
56negative regulation of protein activation cascade (GO:2000258)4.44105981
57phenylpropanoid metabolic process (GO:0009698)4.40819857
58indolalkylamine metabolic process (GO:0006586)4.36783926
59oxidative demethylation (GO:0070989)4.34977405
60glycine metabolic process (GO:0006544)4.32210664
61negative regulation of hemostasis (GO:1900047)4.31560782
62negative regulation of blood coagulation (GO:0030195)4.31560782
63coenzyme catabolic process (GO:0009109)4.31005933
64ethanol metabolic process (GO:0006067)4.27002954
65cellular glucuronidation (GO:0052695)4.26480242
66amine catabolic process (GO:0009310)4.23937760
67cellular biogenic amine catabolic process (GO:0042402)4.23937760
68cellular amino acid catabolic process (GO:0009063)4.23789755
69imidazole-containing compound metabolic process (GO:0052803)4.23577988
70glutamate metabolic process (GO:0006536)4.22095058
71plasma lipoprotein particle clearance (GO:0034381)4.21801338
72drug catabolic process (GO:0042737)4.16798394
73serine family amino acid metabolic process (GO:0009069)4.15604971
74cholesterol efflux (GO:0033344)4.14876172
75benzene-containing compound metabolic process (GO:0042537)4.11628402
76plasma lipoprotein particle organization (GO:0071827)4.08963969
77ethanol oxidation (GO:0006069)4.06140698
78cellular modified amino acid catabolic process (GO:0042219)4.05980942
79flavonoid metabolic process (GO:0009812)4.01101683
80intestinal absorption (GO:0050892)4.00883470
81positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.00428303
82dicarboxylic acid biosynthetic process (GO:0043650)3.99135024
83negative regulation of coagulation (GO:0050819)3.98405330
84polyketide metabolic process (GO:0030638)3.95663994
85doxorubicin metabolic process (GO:0044598)3.95663994
86daunorubicin metabolic process (GO:0044597)3.95663994
87serine family amino acid biosynthetic process (GO:0009070)3.95035700
88plasma lipoprotein particle assembly (GO:0034377)3.94837186
89acute-phase response (GO:0006953)3.94396297
90low-density lipoprotein particle remodeling (GO:0034374)3.91308469
91ketone body metabolic process (GO:1902224)3.88642550
92regulation of bile acid biosynthetic process (GO:0070857)3.87866033
93regulation of humoral immune response (GO:0002920)3.86587918
94negative regulation of wound healing (GO:0061045)3.86485127
95arginine metabolic process (GO:0006525)3.82769958
96aldehyde catabolic process (GO:0046185)3.82633198
97fibrinolysis (GO:0042730)3.81641003
98protein-lipid complex subunit organization (GO:0071825)3.81622907
99regulation of cholesterol homeostasis (GO:2000188)3.81447587
100uronic acid metabolic process (GO:0006063)3.80146780
101glucuronate metabolic process (GO:0019585)3.80146780
102phospholipid homeostasis (GO:0055091)3.78589580
103short-chain fatty acid metabolic process (GO:0046459)3.76473893
104very-low-density lipoprotein particle assembly (GO:0034379)3.76183029
105fat-soluble vitamin biosynthetic process (GO:0042362)3.75871431
106organic acid catabolic process (GO:0016054)3.74702254
107carboxylic acid catabolic process (GO:0046395)3.74702254
108cholesterol homeostasis (GO:0042632)3.74476099
109intestinal cholesterol absorption (GO:0030299)3.73521884
110positive regulation of triglyceride lipase activity (GO:0061365)3.71994462
111positive regulation of lipoprotein lipase activity (GO:0051006)3.71994462
112heme transport (GO:0015886)3.70750866
113positive regulation of lipid catabolic process (GO:0050996)3.70250634
114acetyl-CoA metabolic process (GO:0006084)3.69723376
115sterol homeostasis (GO:0055092)3.68856174
116cofactor catabolic process (GO:0051187)3.66057373
117complement activation, classical pathway (GO:0006958)3.64957145
118blood coagulation, intrinsic pathway (GO:0007597)3.64856720
119S-adenosylmethionine metabolic process (GO:0046500)3.64116420
120drug transmembrane transport (GO:0006855)3.63320362
121positive regulation of blood coagulation (GO:0030194)3.62227540
122positive regulation of hemostasis (GO:1900048)3.62227540
123cytolysis (GO:0019835)3.60021842
124complement activation (GO:0006956)3.59883228
125negative regulation of complement activation (GO:0045916)3.59743515
126urate metabolic process (GO:0046415)3.58500925
127protein activation cascade (GO:0072376)3.56627975
128aminoglycoside antibiotic metabolic process (GO:0030647)3.55894572
129protein-lipid complex assembly (GO:0065005)3.54069752
130negative regulation of lipase activity (GO:0060192)3.53805707
131lipoprotein metabolic process (GO:0042157)3.50884480
132hormone catabolic process (GO:0042447)3.49984968
133alkaloid metabolic process (GO:0009820)3.45467312
134positive regulation of coagulation (GO:0050820)3.38266319

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.30934233
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.15318424
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.92403549
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.50178203
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.21417016
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.00208465
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.57594921
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.06074777
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.95095241
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.06886080
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06015730
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7272445
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94804863
14CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76081459
15* FOXA2_19822575_ChIP-Seq_HepG2_Human1.66170282
16GATA1_22025678_ChIP-Seq_K562_Human1.63633371
17CLOCK_20551151_ChIP-Seq_293T_Human1.54815931
18HTT_18923047_ChIP-ChIP_STHdh_Human1.54704591
19* HNF4A_19822575_ChIP-Seq_HepG2_Human1.45472586
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40605160
21TCF4_18268006_ChIP-ChIP_LS174T_Human1.37269901
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26639113
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.22086980
24NFE2_27457419_Chip-Seq_LIVER_Mouse1.18960422
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17838326
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15845436
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15814103
28* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15399059
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14574732
30IGF1R_20145208_ChIP-Seq_DFB_Human1.12588282
31SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11927759
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10808338
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09735979
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.08396927
35ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06646622
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05775454
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02293527
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00317866
39GATA4_25053715_ChIP-Seq_YYC3_Human0.97396153
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94633149
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94256407
42PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93894957
43IRF8_22096565_ChIP-ChIP_GC-B_Human0.93883113
44FLI1_27457419_Chip-Seq_LIVER_Mouse0.93496992
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92298518
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92120952
47SMAD1_18555785_Chip-Seq_ESCs_Mouse0.90992111
48TRIM28_21343339_ChIP-Seq_HEK293_Human0.90976187
49EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89187521
50ER_23166858_ChIP-Seq_MCF-7_Human0.88737798
51OCT4_18555785_Chip-Seq_ESCs_Mouse0.88736486
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.88670482
53ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87947318
54GBX2_23144817_ChIP-Seq_PC3_Human0.87811514
55STAT3_18555785_Chip-Seq_ESCs_Mouse0.86209485
56ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83817862
57RUNX1_27457419_Chip-Seq_LIVER_Mouse0.83672703
58EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.82863321
59ESRRB_18555785_Chip-Seq_ESCs_Mouse0.82707393
60SOX2_18555785_Chip-Seq_ESCs_Mouse0.82212479
61CTCF_18555785_Chip-Seq_ESCs_Mouse0.81723945
62ZFX_18555785_Chip-Seq_ESCs_Mouse0.81496376
63TCF4_22108803_ChIP-Seq_LS180_Human0.81322288
64KLF5_20875108_ChIP-Seq_MESCs_Mouse0.81143035
65CRX_20693478_ChIP-Seq_RETINA_Mouse0.81070980
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80955277
67STAT3_23295773_ChIP-Seq_U87_Human0.79902914
68SUZ12_18555785_Chip-Seq_ESCs_Mouse0.79209385
69KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79205148
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.79162796
71AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78970258
72KLF4_18555785_Chip-Seq_ESCs_Mouse0.78422922
73RARG_19884340_ChIP-ChIP_MEFs_Mouse0.78313663
74CMYC_18555785_Chip-Seq_ESCs_Mouse0.77952516
75P53_22387025_ChIP-Seq_ESCs_Mouse0.77857245
76* HNFA_21074721_ChIP-Seq_CACO-2_Human0.77109092
77* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.76996534
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76806185
79SOX2_19829295_ChIP-Seq_ESCs_Human0.76570339
80NANOG_19829295_ChIP-Seq_ESCs_Human0.76570339
81AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76505738
82TP53_18474530_ChIP-ChIP_U2OS_Human0.76407124
83OCT4_21477851_ChIP-Seq_ESCs_Mouse0.76294304
84P300_18555785_Chip-Seq_ESCs_Mouse0.76122835
85SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75758571
86NANOG_18555785_Chip-Seq_ESCs_Mouse0.75241371
87PU1_27457419_Chip-Seq_LIVER_Mouse0.74859080
88RARA_24833708_ChIP-Seq_LIVER_Mouse0.74673612
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.74650256
90FOXA1_25329375_ChIP-Seq_VCAP_Human0.74632180
91FOXA1_27270436_Chip-Seq_PROSTATE_Human0.74632180
92NMYC_18555785_Chip-Seq_ESCs_Mouse0.73952430
93ESR2_21235772_ChIP-Seq_MCF-7_Human0.73104219
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72845650
95SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72681481
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72581704
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68677058
98NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65823365
99NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65823365
100RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.64079645
101FOXA1_25552417_ChIP-Seq_VCAP_Human0.63249878
102FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.62849946
103CDX2_20551321_ChIP-Seq_CACO-2_Human0.61844549
104* RARB_24833708_ChIP-Seq_LIVER_Mouse0.60795691
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.59964030
106ZNF263_19887448_ChIP-Seq_K562_Human0.59368873
107RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59112639
108BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58476167
109CEBPB_22108803_ChIP-Seq_LS180_Human0.57325864
110ESR1_21235772_ChIP-Seq_MCF-7_Human0.56697837
111AR_20517297_ChIP-Seq_VCAP_Human0.55556677
112FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.55279567
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.53389335
114PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.53121463
115STAT1_17558387_ChIP-Seq_HELA_Human0.52908114
116GATA6_25053715_ChIP-Seq_YYC3_Human0.52819134
117MYC_19915707_ChIP-ChIP_AK7_Human0.52092725
118ESET_19884257_ChIP-Seq_ESCs_Mouse0.51755361
119* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51699404
120LXR_22292898_ChIP-Seq_THP-1_Human0.50680250
121EGR1_19032775_ChIP-ChIP_M12_Human0.50151695
122* CBP_21632823_ChIP-Seq_H3396_Human0.48652552
123P53_21459846_ChIP-Seq_SAOS-2_Human0.48100510
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.47608593
125NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.47479090
126FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.47366741
127PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46589761
128STAT3_1855785_ChIP-Seq_MESCs_Mouse0.46524906
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.46283935
130PPAR_26484153_Chip-Seq_NCI-H1993_Human0.46051497
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.45780176
132GATA1_19941826_ChIP-Seq_K562_Human0.45407719
133PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44638205
134TAF15_26573619_Chip-Seq_HEK293_Human0.44243779
135BCAT_22108803_ChIP-Seq_LS180_Human0.43365356
136SOX2_20726797_ChIP-Seq_SW620_Human0.43027159
137GATA2_19941826_ChIP-Seq_K562_Human0.42945842
138TAF2_19829295_ChIP-Seq_ESCs_Human0.42395404
139GATA1_19941827_ChIP-Seq_MEL_Mouse0.41725244
140SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39588017
141FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.39521716
142SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.38775934
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.38639272
144ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.38389078
145ESR1_20079471_ChIP-ChIP_T-47D_Human0.37612750
146CDX2_22108803_ChIP-Seq_LS180_Human0.37463657
147GATA3_24758297_ChIP-Seq_MCF-7_Human0.37197018
148LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36167367
149MYC_27129775_Chip-Seq_CORNEA_Mouse0.35880617
150ERG_20517297_ChIP-Seq_VCAP_Human0.35770884
151ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.35410219

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.23598955
2MP0005360_urolithiasis7.65084576
3MP0005085_abnormal_gallbladder_physiolo6.39901794
4MP0005365_abnormal_bile_salt6.25098920
5MP0008875_abnormal_xenobiotic_pharmacok5.04142979
6MP0003806_abnormal_nucleotide_metabolis4.18970553
7MP0003252_abnormal_bile_duct4.05152152
8MP0010329_abnormal_lipoprotein_level3.51748122
9MP0005083_abnormal_biliary_tract3.17715285
10MP0009840_abnormal_foam_cell3.10376251
11MP0003195_calcinosis3.00175830
12MP0001666_abnormal_nutrient_absorption2.82611366
13MP0005332_abnormal_amino_acid2.80350537
14MP0004019_abnormal_vitamin_homeostasis2.28384048
15MP0000609_abnormal_liver_physiology2.13692915
16MP0002138_abnormal_hepatobiliary_system2.11951440
17MP0002118_abnormal_lipid_homeostasis2.09164958
18MP0003191_abnormal_cellular_cholesterol2.08936806
19MP0003868_abnormal_feces_composition1.91924876
20MP0005319_abnormal_enzyme/_coenzyme1.80305342
21MP0001764_abnormal_homeostasis1.64538649
22MP0009697_abnormal_copulation1.53514328
23MP0005584_abnormal_enzyme/coenzyme_acti1.52359929
24MP0009780_abnormal_chondrocyte_physiolo1.46828790
25MP0005451_abnormal_body_composition1.38406959
26MP0009643_abnormal_urine_homeostasis1.35502431
27MP0003122_maternal_imprinting1.35013835
28MP0003011_delayed_dark_adaptation1.18474235
29MP0003186_abnormal_redox_activity1.17391302
30MP0000598_abnormal_liver_morphology1.14765635
31MP0002909_abnormal_adrenal_gland1.14417090
32MP0005084_abnormal_gallbladder_morpholo1.12732574
33MP0003656_abnormal_erythrocyte_physiolo1.12452181
34MP0005647_abnormal_sex_gland1.05631527
35MP0005636_abnormal_mineral_homeostasis1.05463382
36MP0003705_abnormal_hypodermis_morpholog1.04942706
37MP0003183_abnormal_peptide_metabolism1.00086644
38MP0000604_amyloidosis0.99295889
39MP0009764_decreased_sensitivity_to0.98578284
40MP0002254_reproductive_system_inflammat0.96394259
41MP0009763_increased_sensitivity_to0.95843847
42MP0005220_abnormal_exocrine_pancreas0.93913345
43MP0000566_synostosis0.92450190
44MP0005408_hypopigmentation0.89333939
45MP0003879_abnormal_hair_cell0.89242326
46MP0009642_abnormal_blood_homeostasis0.87989914
47MP0002078_abnormal_glucose_homeostasis0.87442984
48MP0008469_abnormal_protein_level0.86700341
49MP0005379_endocrine/exocrine_gland_phen0.84788088
50MP0010368_abnormal_lymphatic_system0.83850263
51MP0006036_abnormal_mitochondrial_physio0.82312583
52MP0002876_abnormal_thyroid_physiology0.79588854
53MP0005670_abnormal_white_adipose0.78356901
54MP0009765_abnormal_xenobiotic_induced0.76064557
55MP0005376_homeostasis/metabolism_phenot0.75519729
56MP0001756_abnormal_urination0.74645492
57MP0001915_intracranial_hemorrhage0.71427514
58MP0002971_abnormal_brown_adipose0.71349093
59MP0005334_abnormal_fat_pad0.70379161
60MP0005535_abnormal_body_temperature0.69509901
61MP0001661_extended_life_span0.67593604
62MP0004130_abnormal_muscle_cell0.67349821
63MP0005448_abnormal_energy_balance0.63096921
64MP0005266_abnormal_metabolism0.62970100
65MP0003172_abnormal_lysosome_physiology0.61673913
66MP0002132_abnormal_respiratory_system0.60864573
67MP0002928_abnormal_bile_duct0.60585882
68MP0000013_abnormal_adipose_tissue0.60036534
69MP0000639_abnormal_adrenal_gland0.59707229
70MP0006035_abnormal_mitochondrial_morpho0.58168801
71MP0003329_amyloid_beta_deposits0.58000139
72MP0003690_abnormal_glial_cell0.56988767
73MP0009053_abnormal_anal_canal0.56901729
74MP0005409_darkened_coat_color0.55267236
75MP0002136_abnormal_kidney_physiology0.54139016
76MP0002693_abnormal_pancreas_physiology0.53609952
77MP0002837_dystrophic_cardiac_calcinosis0.49469613
78MP0004147_increased_porphyrin_level0.48768031
79MP0004043_abnormal_pH_regulation0.48035334
80MP0003953_abnormal_hormone_level0.47863115
81MP0003638_abnormal_response/metabolism_0.47737842
82MP0005646_abnormal_pituitary_gland0.47725552
83MP0002822_catalepsy0.47422138
84MP0005395_other_phenotype0.46921929
85MP0000003_abnormal_adipose_tissue0.46347315
86MP0005464_abnormal_platelet_physiology0.45599218
87MP0005645_abnormal_hypothalamus_physiol0.44132465
88MP0004264_abnormal_extraembryonic_tissu0.43935707
89MP0006054_spinal_hemorrhage0.43615755
90MP0005551_abnormal_eye_electrophysiolog0.43602641
91MP0002089_abnormal_postnatal_growth/wei0.42142923
92MP0004782_abnormal_surfactant_physiolog0.41942064
93MP0003724_increased_susceptibility_to0.40773427
94MP0008874_decreased_physiological_sensi0.39386722
95MP0008873_increased_physiological_sensi0.38943303
96MP0003718_maternal_effect0.38652787
97MP0000230_abnormal_systemic_arterial0.38296873
98MP0001944_abnormal_pancreas_morphology0.37403459
99MP0003633_abnormal_nervous_system0.37392340
100MP0005187_abnormal_penis_morphology0.37241516
101MP0005666_abnormal_adipose_tissue0.36901946
102MP0005164_abnormal_response_to0.36294335
103MP0002168_other_aberrant_phenotype0.35300880
104MP0001765_abnormal_ion_homeostasis0.35263111
105MP0004381_abnormal_hair_follicle0.34790907
106MP0005248_abnormal_Harderian_gland0.34738439
107MP0002796_impaired_skin_barrier0.34442775
108MP0003436_decreased_susceptibility_to0.34259652
109MP0001501_abnormal_sleep_pattern0.34184854
110MP0009672_abnormal_birth_weight0.34171702
111MP0009384_cardiac_valve_regurgitation0.33702789
112MP0005166_decreased_susceptibility_to0.33207405
113MP0008872_abnormal_physiological_respon0.33030678
114MP0003632_abnormal_nervous_system0.32877381
115MP0010234_abnormal_vibrissa_follicle0.32830963
116MP0003943_abnormal_hepatobiliary_system0.32547981
117MP0003959_abnormal_lean_body0.31101799
118MP0003075_altered_response_to0.31093066
119MP0000579_abnormal_nail_morphology0.31069556
120MP0002970_abnormal_white_adipose0.30765897
121MP0009115_abnormal_fat_cell0.30667045
122MP0010386_abnormal_urinary_bladder0.30009893
123MP0003123_paternal_imprinting0.29425855
124MP0000538_abnormal_urinary_bladder0.28538582
125MP0005058_abnormal_lysosome_morphology0.28374618
126MP0006082_CNS_inflammation0.28367075
127MP0005410_abnormal_fertilization0.28057543
128MP0001243_abnormal_dermal_layer0.27255002
129MP0001845_abnormal_inflammatory_respons0.27068666
130MP0001881_abnormal_mammary_gland0.26608302

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.30630114
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.26574191
3Deep venous thrombosis (HP:0002625)7.07751466
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.50129501
5Hypobetalipoproteinemia (HP:0003563)6.42149531
6Prolonged partial thromboplastin time (HP:0003645)6.31168494
7Xanthomatosis (HP:0000991)6.19417003
8Complement deficiency (HP:0004431)5.21203639
9Hyperlipoproteinemia (HP:0010980)5.20557475
10Hypolipoproteinemia (HP:0010981)4.68907401
11Joint hemorrhage (HP:0005261)4.58032513
12Hyperammonemia (HP:0001987)4.55363635
13Epidermoid cyst (HP:0200040)4.53259881
14Hyperglycinemia (HP:0002154)4.48201014
15Ketosis (HP:0001946)4.41165713
16Abnormality of the common coagulation pathway (HP:0010990)4.37092165
17Fat malabsorption (HP:0002630)4.29802837
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.27418169
19Abnormality of glutamine family amino acid metabolism (HP:0010902)4.26948566
20Hypoglycemic coma (HP:0001325)4.19241460
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.15476261
22Conjugated hyperbilirubinemia (HP:0002908)4.13784834
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.06373965
24Hyperglycinuria (HP:0003108)4.05429558
25Abnormality of methionine metabolism (HP:0010901)4.00981327
26Abnormality of serine family amino acid metabolism (HP:0010894)4.00681022
27Abnormality of glycine metabolism (HP:0010895)4.00681022
28Hypoalphalipoproteinemia (HP:0003233)3.92979306
29Abnormality of complement system (HP:0005339)3.78164300
30Abnormality of the intrinsic pathway (HP:0010989)3.74665010
31Abnormality of pyrimidine metabolism (HP:0004353)3.66459268
32Hypercholesterolemia (HP:0003124)3.61077940
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.42135635
34Ketoacidosis (HP:0001993)3.39831044
35Abnormality of fatty-acid metabolism (HP:0004359)3.39279418
36Hyperbilirubinemia (HP:0002904)3.38553441
37Nephritis (HP:0000123)3.17420720
38Abnormality of nucleobase metabolism (HP:0010932)3.11013608
39Osteomalacia (HP:0002749)3.10835825
40Steatorrhea (HP:0002570)3.09819204
41Delayed CNS myelination (HP:0002188)3.09420930
42Abnormality of serum amino acid levels (HP:0003112)3.00414796
43Hepatocellular carcinoma (HP:0001402)2.90806180
44Hypoglycemic seizures (HP:0002173)2.90171244
45Myocardial infarction (HP:0001658)2.85736952
46Skin nodule (HP:0200036)2.84658362
47Abnormality of purine metabolism (HP:0004352)2.83290777
48Hypochromic microcytic anemia (HP:0004840)2.82171220
49Metabolic acidosis (HP:0001942)2.80894381
50Acanthocytosis (HP:0001927)2.80447683
51Spontaneous abortion (HP:0005268)2.77408912
52Hyperphosphaturia (HP:0003109)2.72185833
53Gout (HP:0001997)2.70746529
54Systemic lupus erythematosus (HP:0002725)2.63480733
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.59990952
56Dicarboxylic aciduria (HP:0003215)2.59990952
57Vascular calcification (HP:0004934)2.59584890
58Lethargy (HP:0001254)2.57349687
59Hyperinsulinemic hypoglycemia (HP:0000825)2.44618102
60Abnormal gallbladder morphology (HP:0012437)2.44187924
61Malnutrition (HP:0004395)2.42839773
62Late onset (HP:0003584)2.41782779
63Mitral stenosis (HP:0001718)2.39842462
64Irritability (HP:0000737)2.38867693
65Spastic diplegia (HP:0001264)2.34880642
66Cholelithiasis (HP:0001081)2.33376834
67Glomerulonephritis (HP:0000099)2.33275960
68Abnormal urine phosphate concentration (HP:0012599)2.31618977
69Arthropathy (HP:0003040)2.31401718
70Cerebral edema (HP:0002181)2.30418992
71Cardiovascular calcification (HP:0011915)2.29094561
72Potter facies (HP:0002009)2.25487767
73Facial shape deformation (HP:0011334)2.25487767
74Neonatal onset (HP:0003623)2.24827436
75Abnormal gallbladder physiology (HP:0012438)2.24770289
76Cholecystitis (HP:0001082)2.24770289
77Generalized aminoaciduria (HP:0002909)2.24237578
78Recurrent gram-negative bacterial infections (HP:0005420)2.23969586
79Enlarged kidneys (HP:0000105)2.22573976
80Pancreatitis (HP:0001733)2.20419076
81Sensorimotor neuropathy (HP:0007141)2.20194313
82Esophageal varix (HP:0002040)2.19463863
83Hypothermia (HP:0002045)2.17774805
84Purpura (HP:0000979)2.14238217
85Brushfield spots (HP:0001088)2.12938175
86Poikilocytosis (HP:0004447)2.07725390
87Vomiting (HP:0002013)2.07595335
88Amyloidosis (HP:0011034)2.06619077
89Hyperglycemia (HP:0003074)2.06547885
90Rickets (HP:0002748)2.05950432
91Menorrhagia (HP:0000132)2.05201068
92Symptomatic seizures (HP:0011145)2.05179949
93Opisthotonus (HP:0002179)2.02428118
94Gingival bleeding (HP:0000225)2.02043811
95Abnormality of proline metabolism (HP:0010907)1.98526552
96Hydroxyprolinuria (HP:0003080)1.98526552
97Abnormality of the gallbladder (HP:0005264)1.98148488
98Alkalosis (HP:0001948)1.96988023
99Proximal tubulopathy (HP:0000114)1.96731625
100Joint swelling (HP:0001386)1.96403642
101Fair hair (HP:0002286)1.95425185
102Thrombophlebitis (HP:0004418)1.93645059
103Hemorrhage of the eye (HP:0011885)1.93088474
104Pigmentary retinal degeneration (HP:0001146)1.91946447
105Abnormality of vitamin metabolism (HP:0100508)1.91525937
106Abnormal enzyme/coenzyme activity (HP:0012379)1.91297592
107Abnormality of vitamin B metabolism (HP:0004340)1.90787621
108Abnormality of urine glucose concentration (HP:0011016)1.90413659
109Glycosuria (HP:0003076)1.90413659
110Renal cortical cysts (HP:0000803)1.90076223
111Abnormality of transition element cation homeostasis (HP:0011030)1.85324423
112Abnormal tarsal ossification (HP:0008369)1.84287824
113Hypophosphatemic rickets (HP:0004912)1.81868570
114Abnormal cartilage morphology (HP:0002763)1.81142278
115Widely patent fontanelles and sutures (HP:0004492)1.79656209
116Hypophosphatemia (HP:0002148)1.73360691
117Pulmonary embolism (HP:0002204)1.71301767
118Bifid scrotum (HP:0000048)1.64343618
119Retinal atrophy (HP:0001105)1.57245689
120Urinary glycosaminoglycan excretion (HP:0003541)1.56557739
121Mucopolysacchariduria (HP:0008155)1.56557739
122Megaloblastic anemia (HP:0001889)1.52911389

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.59911183
2ERN14.31495799
3SIK14.26431631
4FGFR44.25336856
5INSRR3.57822452
6TAOK33.52053893
7ACVR1B3.47508835
8PIK3CG2.95811382
9ERBB42.73206196
10MAPK152.45780749
11FRK2.35857065
12MST1R2.27797821
13MAP2K42.07091242
14PKN21.97463632
15FLT31.91313612
16STK391.84506157
17MAPK111.83199997
18NTRK31.74645119
19LATS11.62457068
20PTK61.57297894
21TYK21.52692842
22NLK1.51428457
23MAP3K121.48535367
24TRIB31.47519808
25DAPK21.47106959
26WNK31.45617429
27FER1.43245199
28NEK91.32288908
29MAP4K21.28006103
30ABL21.21071798
31MAP3K71.19995579
32FGFR11.17691566
33PRKAA21.17484434
34FGFR21.14173644
35JAK21.14012664
36STK241.13758269
37CASK1.13117768
38PRKG21.12552561
39MAP3K91.11284377
40MAP3K101.10923290
41STK38L1.08686814
42KDR1.08252917
43OXSR11.06675111
44ERBB20.98624809
45PINK10.98150698
46GRK60.97683543
47DYRK1B0.95105192
48MET0.93736164
49BRSK20.93053311
50CAMKK20.92973785
51JAK10.92864923
52MST40.92636832
53TBK10.91510625
54MAP3K140.91283451
55MAP3K40.90781907
56MAP2K30.85127726
57PRKCZ0.84623825
58MAPK40.83004988
59MAP3K30.82320799
60PRKCE0.80285211
61CSK0.78504380
62PHKG10.78033065
63PHKG20.78033065
64EPHB10.77132786
65CAMK1D0.74991641
66MAP3K110.74880750
67IRAK30.74061545
68PRKAA10.73274232
69EPHA30.73002907
70WNK40.72765977
71RIPK10.72067179
72PRKACG0.71775270
73CSNK1E0.70418765
74ADRBK20.69339761
75PTK20.69321045
76LMTK20.69243216
77GSK3A0.69147678
78PRKG10.69056963
79CDK60.67491958
80WNK10.65576650
81SGK30.65081359
82PDK20.64289629
83YES10.61420156
84TIE10.60575941
85MAPK120.60224659
86RPS6KB10.60041557
87MAPKAPK30.59989952
88SGK10.59523417
89CAMK2G0.58698320
90TRPM70.58228435
91MAP2K60.57966533
92EIF2AK30.57254174
93PRKACA0.57171588
94CAMK2D0.56394228
95CDK120.55583963
96BMPR1B0.51318622
97MAPK70.50213111
98SGK20.49407651
99PDPK10.48858369
100CSNK1D0.47983606
101FGFR30.47701143
102MAP3K10.47297025
103PRKACB0.47174997
104MAP3K20.44543405
105PRKCQ0.43725068
106IGF1R0.43680945
107MTOR0.43474106
108MAP2K10.42023456
109STK30.41995308
110SGK2230.41428304
111SGK4940.41428304
112PRKCB0.40591738
113GRK10.40374441
114MAP2K20.39839344
115IKBKE0.39381889
116CSNK1A10.39084756
117TNIK0.38956834
118PAK30.38849247
119MAP3K130.38569605
120CSF1R0.37867448
121CSNK1G10.37815475
122RET0.37601391
123KSR20.37166541
124SRC0.36708687
125TGFBR20.36549967
126MAP3K50.36043430
127EIF2AK10.34953363
128MYLK0.34249632
129PRKCG0.31334138
130ICK0.30236223
131PDK10.28990539
132CAMK1G0.28609135
133AKT30.28471512
134PDK30.28404583
135PDK40.28404583
136IRAK10.28005299
137PIK3CA0.27577344
138CDK40.27420464
139PRKCA0.26526250
140EGFR0.26344655
141PBK0.25629325
142EPHA20.24610059
143PKN10.24520693
144CAMK40.22107415
145ITK0.21346699
146EPHA40.20517473

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.41442905
2Nitrogen metabolism_Homo sapiens_hsa009103.57777869
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40085027
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.19341220
5Arginine biosynthesis_Homo sapiens_hsa002202.95155731
6Tryptophan metabolism_Homo sapiens_hsa003802.74351855
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68823022
8Complement and coagulation cascades_Homo sapiens_hsa046102.63211121
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61537380
10Fatty acid degradation_Homo sapiens_hsa000712.55054927
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.48243536
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.44349188
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.29565413
14Butanoate metabolism_Homo sapiens_hsa006502.23273734
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.12513641
16Peroxisome_Homo sapiens_hsa041462.09627482
17Propanoate metabolism_Homo sapiens_hsa006401.98047461
18Histidine metabolism_Homo sapiens_hsa003401.94165675
19Chemical carcinogenesis_Homo sapiens_hsa052041.89335130
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.87123792
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.86253610
22PPAR signaling pathway_Homo sapiens_hsa033201.85879033
23Fatty acid metabolism_Homo sapiens_hsa012121.83717583
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.76525157
25beta-Alanine metabolism_Homo sapiens_hsa004101.75387423
26Caffeine metabolism_Homo sapiens_hsa002321.71814883
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67434086
28Retinol metabolism_Homo sapiens_hsa008301.67373233
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.66740991
30Staphylococcus aureus infection_Homo sapiens_hsa051501.64172544
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63276800
32Selenocompound metabolism_Homo sapiens_hsa004501.60065090
33Bile secretion_Homo sapiens_hsa049761.54317723
34Phenylalanine metabolism_Homo sapiens_hsa003601.50411877
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47562572
36Sulfur metabolism_Homo sapiens_hsa009201.42279585
37Pyruvate metabolism_Homo sapiens_hsa006201.41654181
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40494695
39Tyrosine metabolism_Homo sapiens_hsa003501.38693406
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.38136461
41Starch and sucrose metabolism_Homo sapiens_hsa005001.36442952
42Fat digestion and absorption_Homo sapiens_hsa049751.33216840
43Fatty acid elongation_Homo sapiens_hsa000621.32182058
44ABC transporters_Homo sapiens_hsa020101.28393683
45Folate biosynthesis_Homo sapiens_hsa007901.27544230
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.21021928
47Steroid biosynthesis_Homo sapiens_hsa001001.14035486
48Biosynthesis of amino acids_Homo sapiens_hsa012301.13485626
49Carbon metabolism_Homo sapiens_hsa012001.12343202
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.02374141
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99862404
52Vitamin digestion and absorption_Homo sapiens_hsa049770.98689620
53Arginine and proline metabolism_Homo sapiens_hsa003300.97503960
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94469101
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92225451
56Vitamin B6 metabolism_Homo sapiens_hsa007500.90737589
57Lysine degradation_Homo sapiens_hsa003100.87993080
58Sulfur relay system_Homo sapiens_hsa041220.83686650
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83472689
60Glycerolipid metabolism_Homo sapiens_hsa005610.72983593
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71633277
62One carbon pool by folate_Homo sapiens_hsa006700.70992242
63Glutathione metabolism_Homo sapiens_hsa004800.67847575
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58005150
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56187958
66Pentose phosphate pathway_Homo sapiens_hsa000300.54459926
67Fatty acid biosynthesis_Homo sapiens_hsa000610.50745295
68Metabolic pathways_Homo sapiens_hsa011000.46098130
69Other glycan degradation_Homo sapiens_hsa005110.37517930
70Prion diseases_Homo sapiens_hsa050200.34791977
71Galactose metabolism_Homo sapiens_hsa000520.33543596
72Sphingolipid metabolism_Homo sapiens_hsa006000.30677501
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30667926
74Fructose and mannose metabolism_Homo sapiens_hsa000510.27339582
75Ether lipid metabolism_Homo sapiens_hsa005650.26443906
76Insulin resistance_Homo sapiens_hsa049310.24351442
77Linoleic acid metabolism_Homo sapiens_hsa005910.23078692
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.21194930
79Pertussis_Homo sapiens_hsa051330.19786593
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17200954
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.16799400
82Glucagon signaling pathway_Homo sapiens_hsa049220.14180390
83N-Glycan biosynthesis_Homo sapiens_hsa005100.12848023
84Serotonergic synapse_Homo sapiens_hsa047260.03845756
85Circadian rhythm_Homo sapiens_hsa047100.03787703
86Insulin secretion_Homo sapiens_hsa049110.02906653
87AMPK signaling pathway_Homo sapiens_hsa041520.02536091
88Pancreatic secretion_Homo sapiens_hsa049720.02405166
89Bladder cancer_Homo sapiens_hsa05219-0.2271855
90Type II diabetes mellitus_Homo sapiens_hsa04930-0.2084294
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2006814
92African trypanosomiasis_Homo sapiens_hsa05143-0.1822009
93Mineral absorption_Homo sapiens_hsa04978-0.1753343
94Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1752470
95Hepatitis C_Homo sapiens_hsa05160-0.1726913
96Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1700063
97Protein digestion and absorption_Homo sapiens_hsa04974-0.1540374
98Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1391653
99Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1391520
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1034007
101Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0963389
102Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0850939
103Insulin signaling pathway_Homo sapiens_hsa04910-0.0848660
104Regulation of autophagy_Homo sapiens_hsa04140-0.0804437
105Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0755062
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0745089
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0543414
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0537612
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0490629
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0245343
111Renin-angiotensin system_Homo sapiens_hsa04614-0.0190223

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