A2M

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* negative regulation of protein activation cascade (GO:2000258)7.16291921
2* negative regulation of complement activation (GO:0045916)7.10522283
3ovulation from ovarian follicle (GO:0001542)6.25945586
4complement activation, alternative pathway (GO:0006957)6.21627079
5very-low-density lipoprotein particle assembly (GO:0034379)5.85898076
6parturition (GO:0007567)5.82305875
7progesterone metabolic process (GO:0042448)5.72203074
8gamma-aminobutyric acid transport (GO:0015812)5.49789775
9* negative regulation of humoral immune response (GO:0002921)5.38592515
10reverse cholesterol transport (GO:0043691)4.86073814
11phospholipid homeostasis (GO:0055091)4.77507334
12complement activation, classical pathway (GO:0006958)4.72758240
13regulation of lipoprotein metabolic process (GO:0050746)4.64718025
14purine nucleotide salvage (GO:0032261)4.57089963
15positive regulation of respiratory burst (GO:0060267)4.52445586
16intestinal cholesterol absorption (GO:0030299)4.41738631
17branching involved in salivary gland morphogenesis (GO:0060445)4.34945505
18* protein activation cascade (GO:0072376)4.34630977
19complement activation (GO:0006956)4.25851475
20regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.14065943
21* regulation of protein activation cascade (GO:2000257)4.00545531
22high-density lipoprotein particle remodeling (GO:0034375)3.99393967
23negative regulation of fibrinolysis (GO:0051918)3.99108441
24negative regulation of cholesterol transport (GO:0032375)3.98182474
25negative regulation of sterol transport (GO:0032372)3.98182474
26positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.91720833
27regulation of cholesterol homeostasis (GO:2000188)3.80548324
28positive regulation of extracellular matrix organization (GO:1903055)3.79394254
29* regulation of complement activation (GO:0030449)3.79325516
30positive regulation of lipoprotein lipase activity (GO:0051006)3.78700350
31positive regulation of triglyceride lipase activity (GO:0061365)3.78700350
32surfactant homeostasis (GO:0043129)3.75277215
33basement membrane organization (GO:0071711)3.73688416
34cellular hyperosmotic response (GO:0071474)3.73160318
35acute-phase response (GO:0006953)3.73132105
36erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.72544113
37L-phenylalanine catabolic process (GO:0006559)3.72544113
38* regulation of humoral immune response (GO:0002920)3.69618111
39plasma lipoprotein particle remodeling (GO:0034369)3.61518001
40protein-lipid complex remodeling (GO:0034368)3.61518001
41macromolecular complex remodeling (GO:0034367)3.61518001
42ethanol oxidation (GO:0006069)3.60297052
43cytoskeletal anchoring at plasma membrane (GO:0007016)3.59203820
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.58476799
45L-phenylalanine metabolic process (GO:0006558)3.58476799
46plasma lipoprotein particle assembly (GO:0034377)3.57473762
47plasma lipoprotein particle clearance (GO:0034381)3.55570054
48protein-lipid complex assembly (GO:0065005)3.54792859
49ovulation (GO:0030728)3.52729413
50C21-steroid hormone metabolic process (GO:0008207)3.48480282
51negative regulation of smooth muscle cell differentiation (GO:0051151)3.46093835
52regulation of G0 to G1 transition (GO:0070316)3.45476577
53fibrinolysis (GO:0042730)3.41230579
54cholesterol efflux (GO:0033344)3.40127887
55negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.39513702
56regulation of cholesterol biosynthetic process (GO:0045540)3.38236261
57triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.35230185
58lipoprotein metabolic process (GO:0042157)3.35217915
59regulation of fibrinolysis (GO:0051917)3.33519748
60response to histamine (GO:0034776)3.32102815
61intestinal absorption (GO:0050892)3.31845558
62protein-lipid complex subunit organization (GO:0071825)3.24568438
63plasma lipoprotein particle organization (GO:0071827)3.23963114
64regulation of bile acid biosynthetic process (GO:0070857)3.18328984
65diacylglycerol metabolic process (GO:0046339)3.17596248
66pinocytosis (GO:0006907)3.16920365
67positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.16794715
68phospholipid efflux (GO:0033700)3.16709043
69positive regulation of phagocytosis (GO:0050766)3.14256598
70positive regulation of fatty acid biosynthetic process (GO:0045723)3.14187926
71positive regulation of chemokine secretion (GO:0090197)3.13654830
72regulation of apoptotic cell clearance (GO:2000425)3.13326985
73positive regulation of steroid metabolic process (GO:0045940)3.12321974
74negative regulation of leukocyte chemotaxis (GO:0002689)3.11869206
75regulation of extracellular matrix organization (GO:1903053)3.09633880
76opsonization (GO:0008228)3.09444075
77regulation of macrophage chemotaxis (GO:0010758)3.07963020
78cholesterol homeostasis (GO:0042632)3.06829164
79regulation of plasminogen activation (GO:0010755)3.05576730
80sterol homeostasis (GO:0055092)3.03172338
81negative regulation of norepinephrine secretion (GO:0010700)3.03002036
82regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.01390763
83cellular response to cholesterol (GO:0071397)3.00441613
84renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.99731576
85inner ear receptor cell development (GO:0060119)2.98817260
86negative regulation of catenin import into nucleus (GO:0035414)2.97264539
87negative regulation of lipase activity (GO:0060192)2.91804205
88positive regulation of lipid storage (GO:0010884)2.90892265
89chemical homeostasis within a tissue (GO:0048875)2.87798024
90cell volume homeostasis (GO:0006884)2.87796778
91ethanol metabolic process (GO:0006067)2.83262174
92glutamate metabolic process (GO:0006536)2.83039041
93acylglycerol homeostasis (GO:0055090)2.82658056
94triglyceride homeostasis (GO:0070328)2.82658056
95cell proliferation involved in metanephros development (GO:0072203)2.82503208
96alpha-linolenic acid metabolic process (GO:0036109)2.82058420
97blood vessel maturation (GO:0001955)2.80188010
98negative regulation of lipid transport (GO:0032369)2.79838186
994-hydroxyproline metabolic process (GO:0019471)2.79584537
100regulation of cholesterol metabolic process (GO:0090181)2.77985517
101acylglycerol catabolic process (GO:0046464)2.77696785
102neutral lipid catabolic process (GO:0046461)2.77696785
103lung epithelium development (GO:0060428)2.77308055
104regulation of chemokine secretion (GO:0090196)2.77177080
105response to mercury ion (GO:0046689)2.76769076
106positive regulation of hemostasis (GO:1900048)2.76324494
107positive regulation of blood coagulation (GO:0030194)2.76324494
108apoptotic cell clearance (GO:0043277)2.74811499
109regulation of glucose import in response to insulin stimulus (GO:2001273)2.72752702
110positive regulation of p38MAPK cascade (GO:1900745)2.71318236
111negative regulation of coagulation (GO:0050819)2.70045662
112low-density lipoprotein particle clearance (GO:0034383)2.69568445
113negative regulation of wound healing (GO:0061045)2.69484606
114negative regulation of blood coagulation (GO:0030195)2.68559806
115negative regulation of hemostasis (GO:1900047)2.68559806
116regulation of extracellular matrix disassembly (GO:0010715)2.66664326
117acute inflammatory response (GO:0002526)2.66505748
118alanine transport (GO:0032328)2.66455130
119peptidyl-glutamic acid carboxylation (GO:0017187)2.64510891
120protein carboxylation (GO:0018214)2.64510891
121embryonic retina morphogenesis in camera-type eye (GO:0060059)2.63472953
122positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.61835625
123positive regulation of wound healing (GO:0090303)2.61494893
124dicarboxylic acid biosynthetic process (GO:0043650)2.61179233
125low-density lipoprotein particle remodeling (GO:0034374)2.61103567
126sodium ion export (GO:0071436)2.59061176
127negative regulation of sodium ion transport (GO:0010766)2.57399086
128regulation of transforming growth factor beta2 production (GO:0032909)2.56814980
129vitamin D metabolic process (GO:0042359)2.56035273
130positive regulation of osteoblast proliferation (GO:0033690)2.54797459
131angiogenesis involved in wound healing (GO:0060055)2.53551037
132substrate adhesion-dependent cell spreading (GO:0034446)2.51802539
133gap junction assembly (GO:0016264)2.51577059
134uterus development (GO:0060065)2.50414926
135positive regulation of cellular response to insulin stimulus (GO:1900078)2.49419365
136cellular modified amino acid catabolic process (GO:0042219)2.48833204
137regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.48731269
138sterol transport (GO:0015918)2.44700482
139cholesterol transport (GO:0030301)2.44700482
140* blood coagulation, intrinsic pathway (GO:0007597)2.42922951
141keratan sulfate catabolic process (GO:0042340)2.42299101
142cellular response to cadmium ion (GO:0071276)2.41538924
143regulation of tight junction assembly (GO:2000810)2.40980988
144bundle of His cell to Purkinje myocyte communication (GO:0086069)2.39931782
145positive regulation of coagulation (GO:0050820)2.39510881
146embryonic digestive tract development (GO:0048566)2.38919512
147vitamin A metabolic process (GO:0006776)2.38617528
148regulation of cholesterol esterification (GO:0010872)2.37941388
149cellular response to sterol (GO:0036315)2.37620917
150regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.36481535
151lens fiber cell development (GO:0070307)2.36095560
152layer formation in cerebral cortex (GO:0021819)2.34731464
153regulation of cholesterol storage (GO:0010885)2.33772293
154paraxial mesoderm development (GO:0048339)2.31648952
155regulation of hair follicle development (GO:0051797)2.30526473
156lipoprotein transport (GO:0042953)2.30184538

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.55514981
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.33387580
3ESR1_15608294_ChIP-ChIP_MCF-7_Human2.77287641
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.69924365
5CLOCK_20551151_ChIP-Seq_293T_Human2.60306127
6* CDX2_19796622_ChIP-Seq_MESCs_Mouse2.59458142
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.43709303
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.38946165
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.32382380
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.30949852
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26487672
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.19933402
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.16721957
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.16116771
15AR_21572438_ChIP-Seq_LNCaP_Human2.15928793
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.14160302
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.08699113
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.04707310
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.96234625
20* HNF4A_19822575_ChIP-Seq_HepG2_Human1.94387263
21ZNF263_19887448_ChIP-Seq_K562_Human1.82727500
22SALL4_18804426_ChIP-ChIP_XEN_Mouse1.81699481
23SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.70785764
24BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.70002669
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.68991155
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.65577639
27EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.65141869
28TCF4_18268006_ChIP-ChIP_LS174T_Human1.64803777
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.61386198
30PPAR_26484153_Chip-Seq_NCI-H1993_Human1.59647805
31CDX2_20551321_ChIP-Seq_CACO-2_Human1.58842237
32GATA1_19941826_ChIP-Seq_K562_Human1.57603682
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.57306701
34ESR1_20079471_ChIP-ChIP_T-47D_Human1.56736147
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.56302788
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53233418
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51653428
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.51139684
39TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.49916243
40TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.49611202
41NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.49136044
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49068304
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47901418
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47047719
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44382353
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44107130
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.41404934
48KDM2B_26808549_Chip-Seq_K562_Human1.40034970
49ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.38451433
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37341329
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36795474
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36795474
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34030299
54* FOXA2_19822575_ChIP-Seq_HepG2_Human1.33332565
55ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33248608
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.31148209
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30881142
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30564688
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.30249922
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30171791
61TBX20_22328084_ChIP-Seq_HEART_Mouse1.29916625
62TBX20_22080862_ChIP-Seq_HEART_Mouse1.29916625
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27997569
64LXR_22292898_ChIP-Seq_THP-1_Human1.27316731
65TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26609816
66NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25736750
67NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25736750
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24985175
69SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.24387876
70FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23682553
71GATA4_25053715_ChIP-Seq_YYC3_Human1.23148103
72* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.21670367
73NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21399167
74SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21394874
75* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20420808
76SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18918433
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18578959
78SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13729571
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.12160758
80CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12059253
81DROSHA_22980978_ChIP-Seq_HELA_Human1.11729320
82TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11552278
83SOX2_20726797_ChIP-Seq_SW620_Human1.10660649
84MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10535254
85P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09616018
86SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08954548
87KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08689144
88BP1_19119308_ChIP-ChIP_Hs578T_Human1.07274055
89NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07090602
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06528946
91SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06022841
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05020441
93WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04580752
94SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03023207
95FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.02964522
96IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00421856
97NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00293436
98NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99914384
99ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99909796
100SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99290597
101TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98778219
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98681361
103TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97505729
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97374036
105SMAD3_21741376_ChIP-Seq_HESCs_Human0.96970858
106SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95681693
107SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95279023
108* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95065883
109AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94730012
110RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94576434
111POU5F1_16518401_ChIP-PET_MESCs_Mouse0.94283624
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.94271263
113EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94108821
114RACK7_27058665_Chip-Seq_MCF-7_Human0.92518022
115* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91672957
116CJUN_26792858_Chip-Seq_BT549_Human0.91536557
117CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90352690
118RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89553800
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89444878
120EGR1_19032775_ChIP-ChIP_M12_Human0.89001566
121SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88385944
122SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88045473
123SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88045473
124KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87512149
125AHR_22903824_ChIP-Seq_MCF-7_Human0.87492188
126FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86989046
127IRF8_22096565_ChIP-ChIP_GC-B_Human0.86946741
128EGR1_19374776_ChIP-ChIP_THP-1_Human0.86896963
129SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.86890764
130GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.86801999
131ARNT_22903824_ChIP-Seq_MCF-7_Human0.86026766
132DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84529684
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82863055
134CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82056814
135IRF8_27001747_Chip-Seq_BMDM_Mouse0.81765855
136GATA6_25053715_ChIP-Seq_YYC3_Human0.81310264
137TP53_16413492_ChIP-PET_HCT116_Human0.77340042
138PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.76776643
139DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.75596329
140PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73583239
141FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.72434278
142VDR_24787735_ChIP-Seq_THP-1_Human0.72272745
143ELK3_25401928_ChIP-Seq_HUVEC_Human0.71396291
144STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.70859687

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage5.72922243
2MP0002139_abnormal_hepatobiliary_system5.19360578
3MP0002254_reproductive_system_inflammat5.15157400
4MP0005360_urolithiasis4.09133150
5MP0003195_calcinosis3.61680960
6MP0008438_abnormal_cutaneous_collagen3.57237634
7MP0003122_maternal_imprinting3.40268983
8MP0004272_abnormal_basement_membrane3.35604037
9MP0005164_abnormal_response_to3.09771748
10MP0005058_abnormal_lysosome_morphology3.09496128
11MP0005085_abnormal_gallbladder_physiolo3.04072624
12MP0004858_abnormal_nervous_system2.79667409
13MP0001666_abnormal_nutrient_absorption2.77887882
14MP0003705_abnormal_hypodermis_morpholog2.76892023
15MP0005623_abnormal_meninges_morphology2.57420886
16MP0003566_abnormal_cell_adhesion2.51434125
17MP0000604_amyloidosis2.45948300
18MP0001915_intracranial_hemorrhage2.28360870
19MP0004885_abnormal_endolymph2.25612339
20MP0003868_abnormal_feces_composition2.20369051
21MP0005409_darkened_coat_color2.17434474
22MP0003121_genomic_imprinting2.10725926
23MP0004084_abnormal_cardiac_muscle2.09968234
24MP0008875_abnormal_xenobiotic_pharmacok2.09143527
25MP0002837_dystrophic_cardiac_calcinosis1.95746253
26MP0003123_paternal_imprinting1.91520208
27MP0003191_abnormal_cellular_cholesterol1.85163487
28MP0003690_abnormal_glial_cell1.72897663
29MP0005451_abnormal_body_composition1.71230238
30MP0001958_emphysema1.71021324
31MP0010329_abnormal_lipoprotein_level1.69434978
32MP0005257_abnormal_intraocular_pressure1.68380596
33MP0003091_abnormal_cell_migration1.67918056
34MP0004264_abnormal_extraembryonic_tissu1.67478234
35MP0003011_delayed_dark_adaptation1.61675601
36MP0009840_abnormal_foam_cell1.59475329
37MP0005408_hypopigmentation1.58088902
38MP0003279_aneurysm1.57844000
39MP0004782_abnormal_surfactant_physiolog1.56046120
40MP0002118_abnormal_lipid_homeostasis1.55978695
41MP0003567_abnormal_fetal_cardiomyocyte1.55951061
42MP0004859_abnormal_synaptic_plasticity1.54082799
43MP0004883_abnormal_blood_vessel1.50013308
44MP0002086_abnormal_extraembryonic_tissu1.49486884
45MP0005171_absent_coat_pigmentation1.48998924
46MP0010234_abnormal_vibrissa_follicle1.48300232
47MP0008775_abnormal_heart_ventricle1.47075660
48MP0005167_abnormal_blood-brain_barrier1.45877448
49MP0000609_abnormal_liver_physiology1.42892723
50MP0002877_abnormal_melanocyte_morpholog1.40960187
51MP0002933_joint_inflammation1.40651453
52MP0000566_synostosis1.37943102
53MP0001661_extended_life_span1.37202484
54MP0003300_gastrointestinal_ulcer1.35403125
55MP0003329_amyloid_beta_deposits1.32115324
56MP0003632_abnormal_nervous_system1.31089275
57MP0003950_abnormal_plasma_membrane1.24485668
58MP0003252_abnormal_bile_duct1.23670095
59MP0002138_abnormal_hepatobiliary_system1.22174459
60MP0003075_altered_response_to1.20940514
61MP0005332_abnormal_amino_acid1.19413294
62MP0002971_abnormal_brown_adipose1.18200282
63MP0001299_abnormal_eye_distance/1.17810080
64MP0010368_abnormal_lymphatic_system1.17195875
65MP0002128_abnormal_blood_circulation1.16185663
66MP0005023_abnormal_wound_healing1.15941809
67MP0003303_peritoneal_inflammation1.15112146
68MP0006138_congestive_heart_failure1.13123290
69MP0000013_abnormal_adipose_tissue1.11474961
70MP0005464_abnormal_platelet_physiology1.10314932
71MP0002089_abnormal_postnatal_growth/wei1.05729116
72MP0003172_abnormal_lysosome_physiology1.05671455
73MP0000639_abnormal_adrenal_gland1.05292278
74MP0001849_ear_inflammation1.04483698
75MP0004036_abnormal_muscle_relaxation1.04449064
76MP0003136_yellow_coat_color1.04082692
77MP0009115_abnormal_fat_cell1.01058639
78MP0003634_abnormal_glial_cell0.99551995
79MP0010678_abnormal_skin_adnexa0.95129111
80MP0005376_homeostasis/metabolism_phenot0.94484291
81MP0005083_abnormal_biliary_tract0.91841883
82MP0005377_hearing/vestibular/ear_phenot0.91379794
83MP0003878_abnormal_ear_physiology0.91379794
84MP0005666_abnormal_adipose_tissue0.90971489
85MP0002132_abnormal_respiratory_system0.90437310
86MP0002896_abnormal_bone_mineralization0.90164684
87MP0003183_abnormal_peptide_metabolism0.89273912
88MP0005670_abnormal_white_adipose0.88798409
89MP0003724_increased_susceptibility_to0.88433890
90MP0004147_increased_porphyrin_level0.88256650
91MP0000920_abnormal_myelination0.87488944
92MP0002998_abnormal_bone_remodeling0.87462617
93MP0000003_abnormal_adipose_tissue0.87285674
94MP0005365_abnormal_bile_salt0.86491705
95MP0004019_abnormal_vitamin_homeostasis0.86464554
96MP0008004_abnormal_stomach_pH0.85809392
97MP0002909_abnormal_adrenal_gland0.85689739
98MP0001542_abnormal_bone_strength0.85370240
99MP0004197_abnormal_fetal_growth/weight/0.84029380
100MP0001756_abnormal_urination0.83011669
101MP0009643_abnormal_urine_homeostasis0.82413383
102MP0003941_abnormal_skin_development0.82320667
103MP0009384_cardiac_valve_regurgitation0.80969712
104MP0005375_adipose_tissue_phenotype0.80885969
105MP0001533_abnormal_skeleton_physiology0.80179902
106MP0005330_cardiomyopathy0.80069531
107MP0003656_abnormal_erythrocyte_physiolo0.79783512
108MP0000249_abnormal_blood_vessel0.79757685
109MP0003633_abnormal_nervous_system0.79251534
110MP0000767_abnormal_smooth_muscle0.78548164
111MP0004185_abnormal_adipocyte_glucose0.78497261
112MP0003631_nervous_system_phenotype0.77502815
113MP0000598_abnormal_liver_morphology0.77443108
114MP0004484_altered_response_of0.76681370
115MP0005248_abnormal_Harderian_gland0.76139671
116MP0009053_abnormal_anal_canal0.75857341
117MP0002282_abnormal_trachea_morphology0.75762015
118MP0005187_abnormal_penis_morphology0.74840091
119MP0002295_abnormal_pulmonary_circulatio0.74278976
120MP0001614_abnormal_blood_vessel0.74056706
121MP0009780_abnormal_chondrocyte_physiolo0.73346922
122MP0005503_abnormal_tendon_morphology0.72848451
123MP0000751_myopathy0.72810451
124MP0010630_abnormal_cardiac_muscle0.72437538
125MP0005275_abnormal_skin_tensile0.72405039
126MP0003942_abnormal_urinary_system0.71637333
127MP0002269_muscular_atrophy0.70372191
128MP0000569_abnormal_digit_pigmentation0.70119918
129MP0003879_abnormal_hair_cell0.69705932
130MP0005076_abnormal_cell_differentiation0.69380471
131MP0009697_abnormal_copulation0.69379670
132MP0003115_abnormal_respiratory_system0.69141675
133MP0000383_abnormal_hair_follicle0.68596298
134MP0005508_abnormal_skeleton_morphology0.68020193
135MP0008469_abnormal_protein_level0.67779317
136MP0002133_abnormal_respiratory_system0.67401149
137MP0005388_respiratory_system_phenotype0.67401149
138MP0003436_decreased_susceptibility_to0.66920687
139MP0005165_increased_susceptibility_to0.66404846
140MP0000428_abnormal_craniofacial_morphol0.66379110
141MP0002925_abnormal_cardiovascular_devel0.66251258
142MP0005584_abnormal_enzyme/coenzyme_acti0.65957716
143MP0001177_atelectasis0.65260143
144MP0004130_abnormal_muscle_cell0.65201535
145MP0003453_abnormal_keratinocyte_physiol0.64994846
146MP0004233_abnormal_muscle_weight0.64760918
147MP0001879_abnormal_lymphatic_vessel0.63701970
148MP0005319_abnormal_enzyme/_coenzyme0.62909999
149MP0006082_CNS_inflammation0.62842330

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)8.21901213
2Glomerulonephritis (HP:0000099)6.55619685
3Abnormality of complement system (HP:0005339)6.42952459
4Prolonged partial thromboplastin time (HP:0003645)5.58808465
5Joint hemorrhage (HP:0005261)5.33094522
6Right ventricular cardiomyopathy (HP:0011663)5.08726136
7Deep venous thrombosis (HP:0002625)4.07425455
8Absent frontal sinuses (HP:0002688)4.03650982
9Nephritis (HP:0000123)3.84148519
10Premature rupture of membranes (HP:0001788)3.83520738
11Shallow orbits (HP:0000586)3.80086454
12Hypoalphalipoproteinemia (HP:0003233)3.78483472
13Hypercholesterolemia (HP:0003124)3.76438335
14Hemorrhage of the eye (HP:0011885)3.60404912
15Broad metatarsal (HP:0001783)3.44056836
16Hemiplegia (HP:0002301)3.40984185
17Abnormality of monocarboxylic acid metabolism (HP:0010996)3.36618395
18Abnormality of the common coagulation pathway (HP:0010990)3.31497618
19Enlarged penis (HP:0000040)3.24011659
20Hyporeflexia of lower limbs (HP:0002600)3.18089982
21Purpura (HP:0000979)3.16602361
22Abnormality of aromatic amino acid family metabolism (HP:0004338)3.12437425
23Recurrent gram-negative bacterial infections (HP:0005420)3.11796680
24Systemic lupus erythematosus (HP:0002725)3.08791255
25Myocardial infarction (HP:0001658)3.07324003
26Spondylolisthesis (HP:0003302)3.05489731
27Coronal craniosynostosis (HP:0004440)3.04987833
28Mitral stenosis (HP:0001718)3.03720252
29Epidermoid cyst (HP:0200040)3.00640311
30Cerebral aneurysm (HP:0004944)2.97794368
31Hypolipoproteinemia (HP:0010981)2.96877302
32Turricephaly (HP:0000262)2.95994238
33Gingival bleeding (HP:0000225)2.90530854
34Menorrhagia (HP:0000132)2.90344103
35Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.88103365
36Cervical subluxation (HP:0003308)2.86313740
37Skin nodule (HP:0200036)2.85574305
38Abnormality of proline metabolism (HP:0010907)2.85479887
39Hydroxyprolinuria (HP:0003080)2.85479887
40Xanthomatosis (HP:0000991)2.83868025
41Confusion (HP:0001289)2.83065632
42Radial bowing (HP:0002986)2.81584410
43Abnormality of carpal bone ossification (HP:0006257)2.80399700
44Mesangial abnormality (HP:0001966)2.78870056
45Small epiphyses (HP:0010585)2.78726220
46Flat acetabular roof (HP:0003180)2.77902309
47Protrusio acetabuli (HP:0003179)2.67988607
48Hepatoblastoma (HP:0002884)2.63298662
49Conjugated hyperbilirubinemia (HP:0002908)2.60859889
50Ulnar bowing (HP:0003031)2.60653558
51Delayed closure of the anterior fontanelle (HP:0001476)2.58519457
52Vascular calcification (HP:0004934)2.55476984
53Intrahepatic cholestasis (HP:0001406)2.50964578
54Epiphyseal dysplasia (HP:0002656)2.49264478
55Bronchomalacia (HP:0002780)2.48868264
56Selective tooth agenesis (HP:0001592)2.44417560
57Osteolytic defects of the hand bones (HP:0009699)2.42325579
58Osteolytic defects of the phalanges of the hand (HP:0009771)2.42325579
59Fat malabsorption (HP:0002630)2.41879267
60Abnormal tarsal ossification (HP:0008369)2.39281052
61Increased CSF protein (HP:0002922)2.39025927
62Thrombophlebitis (HP:0004418)2.31601554
63Persistence of primary teeth (HP:0006335)2.31259248
64Aqueductal stenosis (HP:0002410)2.30505429
65Cardiovascular calcification (HP:0011915)2.30395766
66Abnormality of the lumbar spine (HP:0100712)2.29583475
67Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.29463106
68Broad palm (HP:0001169)2.28590203
69Mucopolysacchariduria (HP:0008155)2.26768833
70Urinary glycosaminoglycan excretion (HP:0003541)2.26768833
71Abnormal ossification of hand bones (HP:0005921)2.26766471
72Bowing of the arm (HP:0006488)2.25592348
73Bowed forearm bones (HP:0003956)2.25592348
74Spontaneous abortion (HP:0005268)2.24502007
75Arterial tortuosity (HP:0005116)2.24136680
76Potter facies (HP:0002009)2.22991317
77Facial shape deformation (HP:0011334)2.22991317
78Back pain (HP:0003418)2.20495165
79Flared iliac wings (HP:0002869)2.19325118
80Abnormality of glutamine family amino acid metabolism (HP:0010902)2.19024159
81Upper limb amyotrophy (HP:0009129)2.16095744
82Distal upper limb amyotrophy (HP:0007149)2.16095744
83Wormian bones (HP:0002645)2.15154190
84Abnormality of the frontal sinuses (HP:0002687)2.15087645
85Hyperlipoproteinemia (HP:0010980)2.14578557
86Abnormal hand bone ossification (HP:0010660)2.14354255
87Interstitial pulmonary disease (HP:0006530)2.13383424
88Cerebral inclusion bodies (HP:0100314)2.12753812
89Humeroradial synostosis (HP:0003041)2.12710367
90Synostosis involving the elbow (HP:0003938)2.12710367
91Limb-girdle muscle atrophy (HP:0003797)2.11842704
92Relative macrocephaly (HP:0004482)2.11302628
93Dysostosis multiplex (HP:0000943)2.09950145
94Tarsal synostosis (HP:0008368)2.09632704
95Megalencephaly (HP:0001355)2.08841506
96Blue sclerae (HP:0000592)2.07361232
97Pseudobulbar signs (HP:0002200)2.05299790
98Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.05157211
99Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05080567
100Abnormality of polysaccharide metabolism (HP:0011012)2.05080567
101Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05080567
102Prenatal maternal abnormality (HP:0002686)2.03948650
103Hemiparesis (HP:0001269)2.02594585
104Aortic aneurysm (HP:0004942)1.99188903
105Wide anterior fontanel (HP:0000260)1.99136207
106Vascular tortuosity (HP:0004948)1.98914595
107Acanthocytosis (HP:0001927)1.98658939
108Autoimmune thrombocytopenia (HP:0001973)1.98616240
109Broad thumb (HP:0011304)1.96085225
110Cupped ribs (HP:0000887)1.92325755
111Exercise-induced muscle cramps (HP:0003710)1.91681455
112Arthropathy (HP:0003040)1.91323132
113Short hallux (HP:0010109)1.90911907
114Broad alveolar ridges (HP:0000187)1.90878147
115Oligodactyly (hands) (HP:0001180)1.89005573
116Synostosis involving bones of the lower limbs (HP:0009138)1.88570603
117Synostosis involving bones of the feet (HP:0009140)1.88570603
118Aortic dissection (HP:0002647)1.87723459
119Tetraplegia (HP:0002445)1.87073530
120Dysdiadochokinesis (HP:0002075)1.86891969
121Spastic diplegia (HP:0001264)1.86685406
122Pili torti (HP:0003777)1.86639943
123Insomnia (HP:0100785)1.85925949
124Abnormality of the intrinsic pathway (HP:0010989)1.85510538
125Reticulocytosis (HP:0001923)1.85139909
126Abnormal delivery (HP:0001787)1.84711287
127Vertebral compression fractures (HP:0002953)1.84378979
128Esophageal varix (HP:0002040)1.83698579
129Poikilocytosis (HP:0004447)1.82510977
130Aneurysm (HP:0002617)1.82434863
131Neurofibrillary tangles (HP:0002185)1.81992077
132Hypoplasia of the iris (HP:0007676)1.80601139
133Action tremor (HP:0002345)1.80559293
134Polycythemia (HP:0001901)1.80343615
135Pulmonary embolism (HP:0002204)1.80329179
136Abnormality of the acetabulum (HP:0003170)1.80247488
137Hepatocellular carcinoma (HP:0001402)1.79509150
138Alacrima (HP:0000522)1.78888503
139Hypophosphatemic rickets (HP:0004912)1.77967285
140Peritonitis (HP:0002586)1.77906904
141Scanning speech (HP:0002168)1.76044724
142Vacuolated lymphocytes (HP:0001922)1.75244570
143Aplasia/Hypoplasia of the hallux (HP:0008362)1.74521661
144Ovoid vertebral bodies (HP:0003300)1.74158998
145Focal segmental glomerulosclerosis (HP:0000097)1.74134949
146Intention tremor (HP:0002080)1.74074595
147Hypoglycemic coma (HP:0001325)1.74036785
148Hyperextensible skin (HP:0000974)1.72485950
149Ankle contracture (HP:0006466)1.71920750
150Asymmetry of the thorax (HP:0001555)1.71750877
151Hand muscle atrophy (HP:0009130)1.71375833
152Joint swelling (HP:0001386)1.71248504
153Scapular winging (HP:0003691)1.70739550
154Epistaxis (HP:0000421)1.69002714
155Striae distensae (HP:0001065)1.68560203
156Coxa vara (HP:0002812)1.67145616
157Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.66749422
158Hypoglycemic seizures (HP:0002173)1.66554086
159Supranuclear gaze palsy (HP:0000605)1.66017995
160Rickets (HP:0002748)1.63697794
161Hypobetalipoproteinemia (HP:0003563)1.62709594
162Pancreatic islet-cell hyperplasia (HP:0004510)1.61526231
163Submucous cleft hard palate (HP:0000176)1.61061662
164Abnormality of the peritoneum (HP:0002585)1.60790055
165Neonatal death (HP:0003811)1.60562336
166Amyloidosis (HP:0011034)1.59328574
167Hypoplasia of the capital femoral epiphysis (HP:0003090)1.59150276
168Abnormality of the wing of the ilium (HP:0011867)1.58712918
169Neonatal short-limb short stature (HP:0008921)1.58545595
170Abnormal foot bone ossification (HP:0010675)1.56179903
171Abnormality of the nasal septum (HP:0000419)1.55398831
172Abnormality of liposaccharide metabolism (HP:0010968)1.55381539
173Abnormality of glycosphingolipid metabolism (HP:0004343)1.55381539
174Abnormality of glycolipid metabolism (HP:0010969)1.55381539

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.48007093
2TRIB33.39318339
3SCYL22.82508368
4ICK2.78749309
5ERN12.62406714
6TIE12.60932816
7PDGFRA2.50619759
8BMX2.41104368
9LMTK22.16655141
10PTK62.11736651
11ROCK22.06135615
12FGFR11.98713954
13PAK41.94923440
14TYRO31.87008404
15RIPK11.76947081
16PIK3CA1.72913352
17DDR21.67495624
18LIMK11.65779534
19FER1.64714076
20AKT31.59859760
21EPHB21.59142245
22EPHB11.53201247
23LATS11.52049051
24RET1.50631558
25RPS6KB21.49201608
26LATS21.48969199
27SIK11.46899268
28KSR21.44898654
29TYK21.44516194
30WNK41.42281228
31PAK61.38933686
32ROCK11.37335702
33PTK21.35002244
34PRKAA21.33203899
35FGFR21.32798613
36LRRK21.31187128
37KSR11.31030076
38PAK31.30131883
39TGFBR21.28693619
40AKT21.28211467
41MET1.24890794
42NTRK21.21937763
43NEK91.21419804
44PDPK11.20795127
45NTRK11.15093394
46NEK11.15002267
47PHKG21.12853304
48PHKG11.12853304
49WNK11.08221273
50ERBB21.04242135
51MAP3K91.04240104
52FGFR41.03227156
53TRPM71.02845619
54PDK10.97929892
55CDC42BPA0.93452993
56NTRK30.93332700
57MAP2K10.92580752
58ALK0.90225650
59PLK20.89286350
60CSF1R0.87924590
61MYLK0.87155282
62FGR0.86698031
63MATK0.86242442
64MARK20.85522438
65TTN0.85346060
66SGK20.85274960
67MAP3K60.84572714
68MTOR0.83210826
69PDGFRB0.82833641
70MAPK120.82633396
71MOS0.80919547
72MARK30.79270983
73MAPK110.79031824
74CDK120.78382034
75CAMK1D0.77441579
76PDK20.76489649
77EEF2K0.74876047
78MAP3K80.74441608
79MAP3K20.73438387
80CAMKK10.70814618
81SGK10.70507952
82MAP3K10.70106339
83GSK3A0.69539841
84STK380.68395739
85MAP3K30.67646122
86NLK0.67282537
87IRAK30.67209646
88CDK60.66750299
89ZAP700.65829396
90SRC0.63770512
91DMPK0.63443324
92MST1R0.62636096
93FGFR30.60793127
94DYRK1B0.60179064
95MAP3K100.59588403
96PAK20.58264861
97SGK4940.58264193
98SGK2230.58264193
99PRKD30.57449918
100CSK0.57170338
101STK100.56892187
102INSR0.56753889
103IGF1R0.55826842
104PRKACB0.54970370
105BLK0.53965192
106PRKCH0.52591621
107EPHA30.51895521
108PRKD10.51831831
109EGFR0.49510913
110STK38L0.49083894
111CDK150.48847443
112MARK10.48807963
113CDK50.47720074
114MINK10.47166032
115PRKCE0.46625598
116MAP3K130.46535404
117DAPK20.45625980
118JAK20.44684076
119MAP3K70.44039581
120MAP3K140.43514305
121PRKAA10.43028775
122INSRR0.42791315
123SGK30.42445452
124MAP2K30.41723936
125RPS6KB10.41528942
126CDK180.41063870
127PRKACG0.40899136
128CAMK1G0.40763435
129YES10.40066029
130MAPKAPK30.39785139
131SIK20.38900277
132CDK11A0.37700136
133JAK10.37555842
134MAP3K40.36849308
135RPS6KA20.36088961
136PRKG10.34620301
137FYN0.34022857
138MAPK30.31628243
139PRPF4B0.30187908
140KDR0.29722901
141MAPKAPK20.29669898

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.80173869
2* Complement and coagulation cascades_Homo sapiens_hsa046103.21482269
3Other glycan degradation_Homo sapiens_hsa005112.44552825
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.01489520
5ECM-receptor interaction_Homo sapiens_hsa045121.99114712
6Histidine metabolism_Homo sapiens_hsa003401.95295358
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.90271768
8Phenylalanine metabolism_Homo sapiens_hsa003601.89040932
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.86950333
10Pentose and glucuronate interconversions_Homo sapiens_hsa000401.78075179
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.68307819
12Arginine biosynthesis_Homo sapiens_hsa002201.66663438
13Tyrosine metabolism_Homo sapiens_hsa003501.62635862
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.61272035
15Pertussis_Homo sapiens_hsa051331.57204454
16Arginine and proline metabolism_Homo sapiens_hsa003301.56520355
17Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.52778071
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.52277872
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49621349
20Fatty acid degradation_Homo sapiens_hsa000711.45741396
21Retinol metabolism_Homo sapiens_hsa008301.44964787
22ABC transporters_Homo sapiens_hsa020101.43852325
23Tryptophan metabolism_Homo sapiens_hsa003801.42825395
24Proteoglycans in cancer_Homo sapiens_hsa052051.35570160
25PPAR signaling pathway_Homo sapiens_hsa033201.29962341
26Bile secretion_Homo sapiens_hsa049761.28352085
27Fatty acid metabolism_Homo sapiens_hsa012121.25167265
28Focal adhesion_Homo sapiens_hsa045101.25081823
29Dilated cardiomyopathy_Homo sapiens_hsa054141.24101298
30Fat digestion and absorption_Homo sapiens_hsa049751.21095609
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.20012860
32Chemical carcinogenesis_Homo sapiens_hsa052041.19778609
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16187470
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12321823
35Renin-angiotensin system_Homo sapiens_hsa046141.10383982
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10285755
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09510307
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05458646
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05396264
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04785160
41Staphylococcus aureus infection_Homo sapiens_hsa051501.03534338
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98287839
43Lysine degradation_Homo sapiens_hsa003100.97030007
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96525184
45Central carbon metabolism in cancer_Homo sapiens_hsa052300.95216179
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.92620226
47Amoebiasis_Homo sapiens_hsa051460.92436096
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91398998
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89185032
50Lysosome_Homo sapiens_hsa041420.88734881
51Vitamin digestion and absorption_Homo sapiens_hsa049770.88283186
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.86607478
53Galactose metabolism_Homo sapiens_hsa000520.85589398
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84349108
55Thyroid hormone synthesis_Homo sapiens_hsa049180.83589408
56Hippo signaling pathway_Homo sapiens_hsa043900.82171722
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.80909602
58Vitamin B6 metabolism_Homo sapiens_hsa007500.79681798
59Prion diseases_Homo sapiens_hsa050200.78170683
60Dorso-ventral axis formation_Homo sapiens_hsa043200.77838105
61Adherens junction_Homo sapiens_hsa045200.76170608
62Fatty acid biosynthesis_Homo sapiens_hsa000610.74803209
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74522883
64Butanoate metabolism_Homo sapiens_hsa006500.74522121
65Small cell lung cancer_Homo sapiens_hsa052220.74025694
66Renal cell carcinoma_Homo sapiens_hsa052110.73360986
67Gap junction_Homo sapiens_hsa045400.73162415
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72704445
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72147059
70Systemic lupus erythematosus_Homo sapiens_hsa053220.69567420
71Steroid biosynthesis_Homo sapiens_hsa001000.69469416
72Ras signaling pathway_Homo sapiens_hsa040140.66974918
73Mineral absorption_Homo sapiens_hsa049780.66913039
74Starch and sucrose metabolism_Homo sapiens_hsa005000.66363360
75HIF-1 signaling pathway_Homo sapiens_hsa040660.66115755
76Rap1 signaling pathway_Homo sapiens_hsa040150.66038510
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64758929
78Biosynthesis of amino acids_Homo sapiens_hsa012300.63701579
79Fructose and mannose metabolism_Homo sapiens_hsa000510.62306119
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61836178
81Glioma_Homo sapiens_hsa052140.61767513
82GABAergic synapse_Homo sapiens_hsa047270.60783375
83Protein digestion and absorption_Homo sapiens_hsa049740.58727832
84Pentose phosphate pathway_Homo sapiens_hsa000300.58345185
85Carbon metabolism_Homo sapiens_hsa012000.58015253
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56416340
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56174759
88Tight junction_Homo sapiens_hsa045300.55814210
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54875574
90Long-term potentiation_Homo sapiens_hsa047200.54625399
91Long-term depression_Homo sapiens_hsa047300.54249380
92Pancreatic cancer_Homo sapiens_hsa052120.54218460
93Ovarian steroidogenesis_Homo sapiens_hsa049130.53772679
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53502213
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51940512
96Thyroid cancer_Homo sapiens_hsa052160.51581422
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51411414
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51027156
99Bladder cancer_Homo sapiens_hsa052190.50984415
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50401622
101Melanogenesis_Homo sapiens_hsa049160.49531639
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.49243010
103Chronic myeloid leukemia_Homo sapiens_hsa052200.48682102
104Peroxisome_Homo sapiens_hsa041460.48309055
105Alcoholism_Homo sapiens_hsa050340.48262693
106Endometrial cancer_Homo sapiens_hsa052130.47868955
107Estrogen signaling pathway_Homo sapiens_hsa049150.47546081
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.47420601
109Glycerolipid metabolism_Homo sapiens_hsa005610.46949446
110Sphingolipid metabolism_Homo sapiens_hsa006000.46909174
111Gastric acid secretion_Homo sapiens_hsa049710.46375764
112Glutamatergic synapse_Homo sapiens_hsa047240.45895494
113Insulin resistance_Homo sapiens_hsa049310.45882998
114beta-Alanine metabolism_Homo sapiens_hsa004100.45798776
115VEGF signaling pathway_Homo sapiens_hsa043700.43516109
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.42979564
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40838945
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40502888
119Insulin signaling pathway_Homo sapiens_hsa049100.40348042
120Phagosome_Homo sapiens_hsa041450.40042063
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39842012
122Synaptic vesicle cycle_Homo sapiens_hsa047210.39665576
123TGF-beta signaling pathway_Homo sapiens_hsa043500.38476055
124Glucagon signaling pathway_Homo sapiens_hsa049220.37443635
125Renin secretion_Homo sapiens_hsa049240.37300122
126N-Glycan biosynthesis_Homo sapiens_hsa005100.36363684
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36019928
128Propanoate metabolism_Homo sapiens_hsa006400.34552811
129Malaria_Homo sapiens_hsa051440.33970544
130AMPK signaling pathway_Homo sapiens_hsa041520.32174035
131Platelet activation_Homo sapiens_hsa046110.31430190
132Pyruvate metabolism_Homo sapiens_hsa006200.27893643
133Leishmaniasis_Homo sapiens_hsa051400.27022656
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.26424849
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26122377
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.25269963
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24822089
138Toxoplasmosis_Homo sapiens_hsa051450.23798871
139Caffeine metabolism_Homo sapiens_hsa002320.21337812
140Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.21315450
141Circadian rhythm_Homo sapiens_hsa047100.20847617
142Arachidonic acid metabolism_Homo sapiens_hsa005900.19174697
143African trypanosomiasis_Homo sapiens_hsa051430.18455604
144Vascular smooth muscle contraction_Homo sapiens_hsa042700.17553839

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