ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	activated T cell proliferation (GO:0050798)	5.89682963
2	positive regulation of gamma-delta T cell activation (GO:0046645)	5.37272618
3	negative T cell selection (GO:0043383)	5.07556838
4	regulation of B cell receptor signaling pathway (GO:0050855)	4.97811418
5	negative regulation of cell killing (GO:0031342)	4.90091470
6	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	4.90091470
7	negative thymic T cell selection (GO:0045060)	4.65678856
8	positive T cell selection (GO:0043368)	4.60241448
9	regulation of gamma-delta T cell differentiation (GO:0045586)	4.50129906
10	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	4.45858891
11	cilium or flagellum-dependent cell motility (GO:0001539)	4.31818246
12	cellular response to interleukin-15 (GO:0071350)	4.24209951
13	hepatocyte apoptotic process (GO:0097284)	4.19995771
14	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.14599620
15	positive thymic T cell selection (GO:0045059)	4.08618194
16	positive regulation of granulocyte differentiation (GO:0030854)	3.97204268
17	regulation of gamma-delta T cell activation (GO:0046643)	3.96534872
18	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	3.89526557
19	response to interleukin-15 (GO:0070672)	3.53988804
20	T cell selection (GO:0045058)	3.46913728
21	interferon-gamma production (GO:0032609)	3.46297852
22	regulation of skeletal muscle contraction (GO:0014819)	3.31210068
23	thymic T cell selection (GO:0045061)	3.28745748
24	regulation of B cell differentiation (GO:0045577)	3.27978048
25	behavioral response to nicotine (GO:0035095)	3.23685298
26	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	3.21511015
27	positive regulation of B cell differentiation (GO:0045579)	3.20726379
28	synapsis (GO:0007129)	3.16545214
29	adenosine metabolic process (GO:0046085)	3.14199064
30	regulation of granulocyte differentiation (GO:0030852)	3.13120599
31	purinergic nucleotide receptor signaling pathway (GO:0035590)	3.10709550
32	epithelial cilium movement (GO:0003351)	3.05892346
33	protein K48-linked deubiquitination (GO:0071108)	3.03157459
34	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.02769550
35	regulation of regulatory T cell differentiation (GO:0045589)	3.00727302
36	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.96933933
37	N-terminal protein amino acid acetylation (GO:0006474)	2.90034995
38	T cell migration (GO:0072678)	2.89828334
39	indolalkylamine metabolic process (GO:0006586)	2.87353509
40	negative regulation of T cell mediated immunity (GO:0002710)	2.87352099
41	negative regulation of lymphocyte mediated immunity (GO:0002707)	2.87324836
42	establishment of protein localization to Golgi (GO:0072600)	2.85972441
43	tachykinin receptor signaling pathway (GO:0007217)	2.85774405
44	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	2.82277731
45	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	2.81572612
46	multicellular organism reproduction (GO:0032504)	2.80262888
47	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.78600415
48	reciprocal meiotic recombination (GO:0007131)	2.78285807
49	reciprocal DNA recombination (GO:0035825)	2.78285807
50	piRNA metabolic process (GO:0034587)	2.77223543
51	cilium movement (GO:0003341)	2.76255006
52	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.75064152
53	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.74522980
54	regulation of isotype switching to IgG isotypes (GO:0048302)	2.72854616
55	microtubule nucleation (GO:0007020)	2.70748599
56	negative regulation of T cell apoptotic process (GO:0070233)	2.69651834
57	histone H3-K9 modification (GO:0061647)	2.67362373
58	leukocyte aggregation (GO:0070486)	2.67336143
59	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.67227800
60	purine nucleotide salvage (GO:0032261)	2.66346882
61	mast cell degranulation (GO:0043303)	2.65269849
62	mast cell activation involved in immune response (GO:0002279)	2.65269849
63	regulation of alpha-beta T cell proliferation (GO:0046640)	2.62332063
64	mast cell activation (GO:0045576)	2.62257980
65	regulation of T cell mediated cytotoxicity (GO:0001914)	2.61513880
66	protein K63-linked deubiquitination (GO:0070536)	2.61201048
67	organic cation transport (GO:0015695)	2.59914868
68	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	2.58365485
69	axoneme assembly (GO:0035082)	2.57522436
70	DNA deamination (GO:0045006)	2.57345370
71	histone H3-K36 demethylation (GO:0070544)	2.54164570
72	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.54072868
73	T cell receptor signaling pathway (GO:0050852)	2.53668362
74	tryptophan metabolic process (GO:0006568)	2.53656018
75	neural tube formation (GO:0001841)	2.49597283
76	sulfur amino acid catabolic process (GO:0000098)	2.48404395
77	negative regulation of adaptive immune response based on somatic recombination of immune receptors b	2.48197266
78	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.47859189
79	dopamine transport (GO:0015872)	2.47687232
80	DNA methylation involved in gamete generation (GO:0043046)	2.46115154
81	regulation of inositol phosphate biosynthetic process (GO:0010919)	2.45723611
82	B cell receptor signaling pathway (GO:0050853)	2.45325203
83	antigen receptor-mediated signaling pathway (GO:0050851)	2.43580346
84	T cell proliferation (GO:0042098)	2.43570584
85	positive regulation of catecholamine secretion (GO:0033605)	2.42975034
86	protein targeting to Golgi (GO:0000042)	2.42586921
87	histone-serine phosphorylation (GO:0035404)	2.42525625
88	antigen processing and presentation of endogenous antigen (GO:0019883)	2.41520180
89	male meiosis (GO:0007140)	2.41353692
90	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.40736620
91	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.39464179
92	detection of light stimulus involved in sensory perception (GO:0050962)	2.38995344
93	detection of light stimulus involved in visual perception (GO:0050908)	2.38995344
94	T cell differentiation (GO:0030217)	2.38367883
95	negative regulation of innate immune response (GO:0045824)	2.38228893
96	motile cilium assembly (GO:0044458)	2.36595572
97	alpha-beta T cell differentiation (GO:0046632)	2.36509122
98	histone H3-K9 methylation (GO:0051567)	2.35410102
99	histone mRNA catabolic process (GO:0071044)	2.33059762
100	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.32997743

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.30327961
2	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	4.21448803
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.86352979
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.50610103
5	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.94954308
6	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.68411158
7	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.65071995
8	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.51634097
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.48216559
10	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.27672518
11	RUNX_20019798_ChIP-Seq_JUKART_Human	2.25788108
12	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.21731520
13	MYB_26560356_Chip-Seq_TH2_Human	2.19334157
14	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.10475211
15	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.04453174
16	ER_23166858_ChIP-Seq_MCF-7_Human	2.02950676
17	VDR_22108803_ChIP-Seq_LS180_Human	2.00281342
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.92573002
19	ZNF274_21170338_ChIP-Seq_K562_Hela	1.91080450
20	GATA3_27048872_Chip-Seq_THYMUS_Human	1.86744165
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.83975476
22	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.82866338
23	AR_21572438_ChIP-Seq_LNCaP_Human	1.80981766
24	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.79449115
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.78985914
26	SCL_19346495_ChIP-Seq_HPC-7_Human	1.78756448
27	BCAT_22108803_ChIP-Seq_LS180_Human	1.76897347
28	TAF15_26573619_Chip-Seq_HEK293_Human	1.71037041
29	GATA3_26560356_Chip-Seq_TH2_Human	1.70875806
30	EWS_26573619_Chip-Seq_HEK293_Human	1.69180008
31	FUS_26573619_Chip-Seq_HEK293_Human	1.63896904
32	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.62825031
33	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	1.60205312
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.57814128
35	MYB_26560356_Chip-Seq_TH1_Human	1.53687965
36	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.49634752
37	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.49419724
38	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.46575428
39	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.46513902
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.46300630
41	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.45523262
42	EZH2_22144423_ChIP-Seq_EOC_Human	1.42978109
43	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.42728698
44	STAT3_23295773_ChIP-Seq_U87_Human	1.38549535
45	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.37897160
46	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.36991285
47	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.28885291
48	P300_19829295_ChIP-Seq_ESCs_Human	1.27578545
49	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.27541158
50	MAF_26560356_Chip-Seq_TH2_Human	1.25954416
51	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.25210262
52	UTX_26944678_Chip-Seq_JUKART_Human	1.23598833
53	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.23032990
54	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.22834237
55	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.22803334
56	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.21996984
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.21996984
58	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.19759214
59	RUNX2_22187159_ChIP-Seq_PCA_Human	1.18139490
60	GATA3_26560356_Chip-Seq_TH1_Human	1.15216788
61	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.14856418
62	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.14488929
63	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13988203
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13988203
65	SMAD4_21799915_ChIP-Seq_A2780_Human	1.13168816
66	RXR_22108803_ChIP-Seq_LS180_Human	1.12662085
67	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.12410435
68	GATA1_22025678_ChIP-Seq_K562_Human	1.11523223
69	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.11185439
70	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.11157813
71	TP53_22573176_ChIP-Seq_HFKS_Human	1.10696380
72	CIITA_25753668_ChIP-Seq_RAJI_Human	1.10565883
73	NANOG_20526341_ChIP-Seq_ESCs_Human	1.08289668
74	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.07897041
75	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.05002655
76	SPI1_23127762_ChIP-Seq_K562_Human	1.04901696
77	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.03967774
78	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.03882103
79	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02453893
80	IRF1_19129219_ChIP-ChIP_H3396_Human	1.01876601
81	AR_25329375_ChIP-Seq_VCAP_Human	1.00897919
82	OCT4_20526341_ChIP-Seq_ESCs_Human	1.00624683
83	IRF8_27001747_Chip-Seq_BMDM_Mouse	0.99607988
84	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.97686855
85	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.97532965
86	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.97382290
87	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.97201949
88	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.95957224
89	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.95876898
90	TCF4_23295773_ChIP-Seq_U87_Human	0.95842717
91	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.95227402
92	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.94113102
93	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.93516796
94	CDX2_22108803_ChIP-Seq_LS180_Human	0.93440659
95	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.92945720
96	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.92618841
97	MAF_26560356_Chip-Seq_TH1_Human	0.92510429
98	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.92454887
99	TBL1_22424771_ChIP-Seq_293T_Human	0.92310725
100	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.91263292

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001986_abnormal_taste_sensitivity	4.98329987
2	MP0003763_abnormal_thymus_physiology	3.68359762
3	MP0003724_increased_susceptibility_to	3.15008354
4	MP0005671_abnormal_response_to	2.66488086
5	MP0004381_abnormal_hair_follicle	2.58076548
6	MP0001661_extended_life_span	2.57159797
7	MP0000569_abnormal_digit_pigmentation	2.54114684
8	MP0008057_abnormal_DNA_replication	2.53061376
9	MP0008877_abnormal_DNA_methylation	2.47885158
10	MP0008995_early_reproductive_senescence	2.38093698
11	MP0001800_abnormal_humoral_immune	2.22560754
12	MP0005646_abnormal_pituitary_gland	2.20754032
13	MP0005174_abnormal_tail_pigmentation	2.18873494
14	MP0005423_abnormal_somatic_nervous	2.13432757
15	MP0005410_abnormal_fertilization	2.11478349
16	MP0003787_abnormal_imprinting	2.06117009
17	MP0005171_absent_coat_pigmentation	1.96823979
18	MP0000703_abnormal_thymus_morphology	1.92468487
19	MP0001835_abnormal_antigen_presentation	1.81713227
20	MP0004130_abnormal_muscle_cell	1.77162896
21	MP0002723_abnormal_immune_serum	1.77117299
22	MP0002132_abnormal_respiratory_system	1.74291369
23	MP0002736_abnormal_nociception_after	1.64646240
24	MP0008004_abnormal_stomach_pH	1.62640425
25	MP0005253_abnormal_eye_physiology	1.61031371
26	MP0002420_abnormal_adaptive_immunity	1.60958719
27	MP0001819_abnormal_immune_cell	1.57180622
28	MP0001968_abnormal_touch/_nociception	1.57090268
29	MP0005000_abnormal_immune_tolerance	1.53076771
30	MP0002398_abnormal_bone_marrow	1.52259809
31	MP0005551_abnormal_eye_electrophysiolog	1.50062375
32	MP0001919_abnormal_reproductive_system	1.49445486
33	MP0003136_yellow_coat_color	1.44320743
34	MP0005075_abnormal_melanosome_morpholog	1.40469237
35	MP0002405_respiratory_system_inflammati	1.39619843
36	MP0002722_abnormal_immune_system	1.39189405
37	MP0000689_abnormal_spleen_morphology	1.38725353
38	MP0005389_reproductive_system_phenotype	1.36199575
39	MP0000716_abnormal_immune_system	1.35962041
40	MP0001764_abnormal_homeostasis	1.35534556
41	MP0003315_abnormal_perineum_morphology	1.33382135
42	MP0003806_abnormal_nucleotide_metabolis	1.33038775
43	MP0002009_preneoplasia	1.32689008
44	MP0006276_abnormal_autonomic_nervous	1.31387997
45	MP0002160_abnormal_reproductive_system	1.31375616
46	MP0002452_abnormal_antigen_presenting	1.30710096
47	MP0004484_altered_response_of	1.27920241
48	MP0001929_abnormal_gametogenesis	1.27087099
49	MP0003698_abnormal_male_reproductive	1.26186564
50	MP0005647_abnormal_sex_gland	1.25709220
51	MP0003880_abnormal_central_pattern	1.24847982
52	MP0009785_altered_susceptibility_to	1.24265438
53	MP0002102_abnormal_ear_morphology	1.23434979
54	MP0003646_muscle_fatigue	1.22913593
55	MP0005025_abnormal_response_to	1.21798002
56	MP0005464_abnormal_platelet_physiology	1.20664366
57	MP0006072_abnormal_retinal_apoptosis	1.18268921
58	MP0001984_abnormal_olfaction	1.13126110
59	MP0005310_abnormal_salivary_gland	1.12774682
60	MP0002127_abnormal_cardiovascular_syste	1.11397551
61	MP0002419_abnormal_innate_immunity	1.09554426
62	MP0006082_CNS_inflammation	1.09289811
63	MP0003436_decreased_susceptibility_to	1.08980388
64	MP0005670_abnormal_white_adipose	1.08776935
65	MP0005360_urolithiasis	1.06426973
66	MP0008872_abnormal_physiological_respon	1.02323570
67	MP0002429_abnormal_blood_cell	1.00029926
68	MP0001851_eye_inflammation	0.99895933
69	MP0003121_genomic_imprinting	0.99162779
70	MP0001486_abnormal_startle_reflex	0.95476217
71	MP0003866_abnormal_defecation	0.92462531
72	MP0000465_gastrointestinal_hemorrhage	0.92332018
73	MP0004215_abnormal_myocardial_fiber	0.91409620
74	MP0001119_abnormal_female_reproductive	0.89845702
75	MP0000653_abnormal_sex_gland	0.84970356
76	MP0001845_abnormal_inflammatory_respons	0.84274621
77	MP0001145_abnormal_male_reproductive	0.84042227
78	MP0002210_abnormal_sex_determination	0.83377722
79	MP0009333_abnormal_splenocyte_physiolog	0.83311585
80	MP0008875_abnormal_xenobiotic_pharmacok	0.81633641
81	MP0003878_abnormal_ear_physiology	0.75440405
82	MP0005377_hearing/vestibular/ear_phenot	0.75440405
83	MP0000015_abnormal_ear_pigmentation	0.75428203
84	MP0002019_abnormal_tumor_incidence	0.75024452
85	MP0002166_altered_tumor_susceptibility	0.74718848
86	MP0005083_abnormal_biliary_tract	0.73993839
87	MP0010094_abnormal_chromosome_stability	0.73401135
88	MP0005266_abnormal_metabolism	0.70697403
89	MP0005085_abnormal_gallbladder_physiolo	0.70025074
90	MP0005387_immune_system_phenotype	0.69827835
91	MP0001790_abnormal_immune_system	0.69827835
92	MP0003656_abnormal_erythrocyte_physiolo	0.69558478
93	MP0005376_homeostasis/metabolism_phenot	0.69485352
94	MP0002148_abnormal_hypersensitivity_rea	0.69374398
95	MP0000013_abnormal_adipose_tissue	0.68431743
96	MP0001485_abnormal_pinna_reflex	0.67968960
97	MP0010155_abnormal_intestine_physiology	0.66340030
98	MP0009764_decreased_sensitivity_to	0.62126495
99	MP0001529_abnormal_vocalization	0.61380126
100	MP0001905_abnormal_dopamine_level	0.60012158

Predicted human phenotypes

Rank	Gene Set	Z-score
1	T lymphocytopenia (HP:0005403)	4.60864254
2	Abnormality of T cell number (HP:0011839)	4.17418407
3	Abnormality of eosinophils (HP:0001879)	3.57005213
4	Severe combined immunodeficiency (HP:0004430)	3.53201919
5	Panhypogammaglobulinemia (HP:0003139)	3.45097255
6	Attenuation of retinal blood vessels (HP:0007843)	3.41715513
7	Volvulus (HP:0002580)	3.41362673
8	Facial diplegia (HP:0001349)	3.27636962
9	Spontaneous hematomas (HP:0007420)	3.22493178
10	Stomach cancer (HP:0012126)	3.07548176
11	Congenital sensorineural hearing impairment (HP:0008527)	3.02404370
12	Pancreatic cysts (HP:0001737)	3.01098833
13	True hermaphroditism (HP:0010459)	2.96325240
14	Eosinophilia (HP:0001880)	2.94251800
15	Hypoplasia of the thymus (HP:0000778)	2.92413748
16	Chronic hepatic failure (HP:0100626)	2.90600027
17	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.81499702
18	Absent/shortened dynein arms (HP:0200106)	2.81499702
19	Thyroiditis (HP:0100646)	2.80834282
20	Recurrent cutaneous fungal infections (HP:0011370)	2.75690987
21	Chronic mucocutaneous candidiasis (HP:0002728)	2.75690987
22	Granulocytopenia (HP:0001913)	2.75065786
23	Stomatitis (HP:0010280)	2.68080702
24	IgG deficiency (HP:0004315)	2.65794640
25	Elevated erythrocyte sedimentation rate (HP:0003565)	2.63454809
26	Leukocytosis (HP:0001974)	2.63325879
27	Congenital stationary night blindness (HP:0007642)	2.59048888
28	Pancreatic fibrosis (HP:0100732)	2.58999511
29	Genetic anticipation (HP:0003743)	2.56171244
30	Combined immunodeficiency (HP:0005387)	2.52678675
31	Pustule (HP:0200039)	2.47431848
32	Colitis (HP:0002583)	2.46562012
33	Abnormality of T cells (HP:0002843)	2.46246589
34	Dyskinesia (HP:0100660)	2.44766613
35	Recurrent fungal infections (HP:0002841)	2.39921348
36	Absent speech (HP:0001344)	2.38816763
37	Abnormality of the columella (HP:0009929)	2.38585818
38	Recurrent abscess formation (HP:0002722)	2.37829421
39	Conjunctival telangiectasia (HP:0000524)	2.34574979
40	Encephalitis (HP:0002383)	2.34486387
41	Reduced antithrombin III activity (HP:0001976)	2.28257379
42	Hemiplegia (HP:0002301)	2.26848457
43	Progressive cerebellar ataxia (HP:0002073)	2.25148725
44	Postural instability (HP:0002172)	2.22174266
45	Recurrent bacterial skin infections (HP:0005406)	2.21968529
46	Abnormality of B cell number (HP:0010975)	2.21170579
47	Facial hemangioma (HP:0000329)	2.20915561
48	Constricted visual fields (HP:0001133)	2.19797887
49	Abnormality of alanine metabolism (HP:0010916)	2.19719902
50	Hyperalaninemia (HP:0003348)	2.19719902
51	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.19719902
52	Bony spicule pigmentary retinopathy (HP:0007737)	2.18025970
53	Atonic seizures (HP:0010819)	2.16625543
54	Male pseudohermaphroditism (HP:0000037)	2.15647508
55	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.14189829
56	Abnormal ciliary motility (HP:0012262)	2.14050713
57	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.13864195
58	Myositis (HP:0100614)	2.12589907
59	Chronic otitis media (HP:0000389)	2.11990681
60	Hyperglycinemia (HP:0002154)	2.09168108
61	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.08314992
62	Tented upper lip vermilion (HP:0010804)	2.07991515
63	Abnormal respiratory motile cilium morphology (HP:0005938)	2.07657979
64	Abnormal respiratory epithelium morphology (HP:0012253)	2.07657979
65	Colon cancer (HP:0003003)	2.03079985
66	Pigmentary retinal degeneration (HP:0001146)	2.02620225
67	Molar tooth sign on MRI (HP:0002419)	2.01955914
68	Abnormality of midbrain morphology (HP:0002418)	2.01955914
69	Abnormality of the fingertips (HP:0001211)	2.01029917
70	Gingival bleeding (HP:0000225)	2.00867591
71	Clumsiness (HP:0002312)	1.99423836
72	Anorexia (HP:0002039)	1.98399268
73	Cystic liver disease (HP:0006706)	1.96116997
74	Widely spaced teeth (HP:0000687)	1.94356108
75	B lymphocytopenia (HP:0010976)	1.92978693
76	Autoimmune hemolytic anemia (HP:0001890)	1.91373718
77	Long clavicles (HP:0000890)	1.91089525
78	Abolished electroretinogram (ERG) (HP:0000550)	1.88564359
79	Epistaxis (HP:0000421)	1.87777078
80	Gastrointestinal infarctions (HP:0005244)	1.87624607
81	Truncal obesity (HP:0001956)	1.87441388
82	High anterior hairline (HP:0009890)	1.86744283
83	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.86688712
84	Small hand (HP:0200055)	1.86498802
85	Inflammation of the large intestine (HP:0002037)	1.85900660
86	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.85851924
87	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.85851924
88	Keratoconjunctivitis (HP:0001096)	1.83783094
89	Basal cell carcinoma (HP:0002671)	1.83569002
90	Protruding tongue (HP:0010808)	1.83545991
91	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.82783715
92	Macular degeneration (HP:0000608)	1.81829658
93	Febrile seizures (HP:0002373)	1.80502109
94	Decreased central vision (HP:0007663)	1.79857090
95	Anencephaly (HP:0002323)	1.79796239
96	Choroideremia (HP:0001139)	1.79753357
97	Recurrent skin infections (HP:0001581)	1.79645166
98	Abnormality of the intrinsic pathway (HP:0010989)	1.78266840
99	Recurrent viral infections (HP:0004429)	1.75524009
100	Dyschromatopsia (HP:0007641)	1.73575265

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	4.18115265
2	FRK	3.64598919
3	GRK6	3.62753424
4	TXK	3.23806155
5	MARK3	2.88302467
6	TAOK3	2.32158691
7	MAP4K1	2.30657716
8	MAP4K2	2.13539744
9	BTK	1.94421823
10	ADRBK2	1.86954799
11	BLK	1.83590715
12	FES	1.83264637
13	OBSCN	1.77066191
14	LATS1	1.76357867
15	BCKDK	1.71641097
16	ITK	1.70852100
17	FGR	1.63146167
18	ACVR1B	1.62222360
19	IKBKE	1.61530840
20	TEC	1.61309975
21	TNK2	1.51749075
22	WNK3	1.51117377
23	JAK3	1.49434707
24	SYK	1.43658652
25	MAPK15	1.42566934
26	PTK2B	1.41914385
27	ZAK	1.41036940
28	NLK	1.36041414
29	ZAP70	1.30520546
30	NUAK1	1.30174004
31	CAMKK2	1.24996288
32	PRKCQ	1.23337657
33	CSK	1.19310990
34	CSNK1A1L	1.16117995
35	CSNK1G3	1.11127739
36	PIK3CG	1.09957669
37	SGK2	1.08456374
38	SGK223	1.06871353
39	SGK494	1.06871353
40	MAP2K7	1.04704038
41	LCK	1.03137279
42	JAK1	0.99691042
43	NEK6	0.99021753
44	CDK3	0.98377359
45	LYN	0.97237271
46	GRK5	0.96758277
47	CSNK1G1	0.96511645
48	IKBKB	0.90982076
49	STK38	0.89818652
50	YES1	0.84977634
51	TRIM28	0.80565946
52	HCK	0.78282736
53	MAP2K3	0.78204721
54	BMPR1B	0.75671273
55	NEK2	0.75530839
56	EPHA4	0.75236431
57	NTRK3	0.74176067
58	MAP3K7	0.74099477
59	ADRBK1	0.72520458
60	FGFR2	0.70729352
61	STK11	0.70286393
62	CSNK1G2	0.68676111
63	STK4	0.67899346
64	MAP3K5	0.67402266
65	STK38L	0.64477808
66	PDK1	0.64413351
67	MAP3K13	0.62334483
68	MELK	0.61984972
69	CDK4	0.59633998
70	NTRK2	0.58437935
71	CCNB1	0.58353039
72	MAPK13	0.55516942
73	TNIK	0.54966096
74	IRAK2	0.54312164
75	EGFR	0.53692450
76	RPS6KB1	0.53589453
77	RIPK4	0.53533554
78	PAK3	0.52880389
79	KDR	0.51396981
80	MAP3K10	0.50585286
81	PIM1	0.49838984
82	CAMK1	0.47506034
83	SGK3	0.46976561
84	FGFR3	0.45762198
85	ATR	0.43986897
86	RPS6KA5	0.43685366
87	PLK2	0.43259216
88	CSNK1D	0.42653745
89	TLK1	0.41456055
90	INSRR	0.41083911
91	MUSK	0.40232413
92	CDC7	0.39066478
93	DYRK1B	0.38983181
94	SIK2	0.37859485
95	MAPK11	0.36293424
96	CHUK	0.35983169
97	CDK9	0.35879291
98	MAP3K3	0.35688374
99	MAP3K1	0.34811607
100	PDK2	0.34575157

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	4.36627268
2	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	3.19245517
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.70054486
4	T cell receptor signaling pathway_Homo sapiens_hsa04660	2.32778767
5	Graft-versus-host disease_Homo sapiens_hsa05332	2.23440013
6	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	2.13825716
7	Butanoate metabolism_Homo sapiens_hsa00650	1.78578017
8	Regulation of autophagy_Homo sapiens_hsa04140	1.75889247
9	Olfactory transduction_Homo sapiens_hsa04740	1.71537522
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.66765640
11	Phototransduction_Homo sapiens_hsa04744	1.60290605
12	Nitrogen metabolism_Homo sapiens_hsa00910	1.54240114
13	Fanconi anemia pathway_Homo sapiens_hsa03460	1.43010276
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.40543687
15	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.38082047
16	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.34155528
17	Allograft rejection_Homo sapiens_hsa05330	1.33796015
18	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.30903187
19	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.29487113
20	Taste transduction_Homo sapiens_hsa04742	1.28215945
21	Propanoate metabolism_Homo sapiens_hsa00640	1.28048849
22	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.26517471
23	Morphine addiction_Homo sapiens_hsa05032	1.21829268
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.19830085
25	Measles_Homo sapiens_hsa05162	1.19461788
26	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.19186787
27	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.18133477
28	Chemical carcinogenesis_Homo sapiens_hsa05204	1.12110728
29	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.11572341
30	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.11176429
31	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.08621071
32	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.08476342
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.06217855
34	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.06077312
35	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.05882534
36	Platelet activation_Homo sapiens_hsa04611	1.03666540
37	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.02501497
38	Circadian rhythm_Homo sapiens_hsa04710	1.00931919
39	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.00100663
40	Glycerolipid metabolism_Homo sapiens_hsa00561	0.95686815
41	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.94947219
42	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.93946180
43	ABC transporters_Homo sapiens_hsa02010	0.93920647
44	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.91617915
45	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.91556786
46	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.91087251
47	Calcium signaling pathway_Homo sapiens_hsa04020	0.90741280
48	Non-homologous end-joining_Homo sapiens_hsa03450	0.88376671
49	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.87881386
50	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.87657977
51	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.85756480
52	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.85164992
53	Homologous recombination_Homo sapiens_hsa03440	0.82862237
54	Herpes simplex infection_Homo sapiens_hsa05168	0.81946837
55	Nicotine addiction_Homo sapiens_hsa05033	0.80223024
56	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.80061828
57	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.79886773
58	Cholinergic synapse_Homo sapiens_hsa04725	0.79827478
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.79038743
60	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.78128179
61	Antigen processing and presentation_Homo sapiens_hsa04612	0.76213395
62	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.74168528
63	Lysine degradation_Homo sapiens_hsa00310	0.72808459
64	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.70690606
65	Osteoclast differentiation_Homo sapiens_hsa04380	0.69384011
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.68322694
67	Chemokine signaling pathway_Homo sapiens_hsa04062	0.67948239
68	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.66901951
69	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.65270803
70	Circadian entrainment_Homo sapiens_hsa04713	0.64801709
71	Base excision repair_Homo sapiens_hsa03410	0.62210776
72	Peroxisome_Homo sapiens_hsa04146	0.62185460
73	Non-small cell lung cancer_Homo sapiens_hsa05223	0.61930303
74	Viral myocarditis_Homo sapiens_hsa05416	0.61871071
75	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.61251956
76	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.60844311
77	Apoptosis_Homo sapiens_hsa04210	0.60544030
78	GABAergic synapse_Homo sapiens_hsa04727	0.59741447
79	FoxO signaling pathway_Homo sapiens_hsa04068	0.59495357
80	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.58473018
81	Leishmaniasis_Homo sapiens_hsa05140	0.58022095
82	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.57651958
83	Renin secretion_Homo sapiens_hsa04924	0.57477277
84	Salivary secretion_Homo sapiens_hsa04970	0.57407208
85	Choline metabolism in cancer_Homo sapiens_hsa05231	0.57182189
86	Ether lipid metabolism_Homo sapiens_hsa00565	0.56941806
87	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.56300996
88	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.55816811
89	Arginine biosynthesis_Homo sapiens_hsa00220	0.55329037
90	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.55321067
91	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.55038939
92	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.54131589
93	Type I diabetes mellitus_Homo sapiens_hsa04940	0.52979449
94	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.52237048
95	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.51018763
96	Serotonergic synapse_Homo sapiens_hsa04726	0.48807481
97	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.48144197
98	Retinol metabolism_Homo sapiens_hsa00830	0.47422114
99	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.45701568
100	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.45487727

A2MP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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