A3GALT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)7.81912496
2neuronal action potential (GO:0019228)7.51934699
3detection of temperature stimulus involved in sensory perception of pain (GO:0050965)7.07047689
4detection of temperature stimulus involved in sensory perception (GO:0050961)7.07047689
5bundle of His cell to Purkinje myocyte communication (GO:0086069)6.56838233
6negative regulation of dendrite morphogenesis (GO:0050774)6.52382415
7detection of temperature stimulus (GO:0016048)6.50447108
8peripheral nervous system neuron development (GO:0048935)6.30374139
9adenosine metabolic process (GO:0046085)6.21808744
10negative regulation of complement activation (GO:0045916)5.94915173
11neurofilament cytoskeleton organization (GO:0060052)5.71976896
12behavioral response to pain (GO:0048266)5.61543371
13response to pain (GO:0048265)5.21139547
14urinary tract smooth muscle contraction (GO:0014848)5.02544507
15membrane depolarization during action potential (GO:0086010)4.95194218
16phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.81271045
17negative regulation of protein activation cascade (GO:2000258)4.77642225
18positive regulation of muscle hypertrophy (GO:0014742)4.53833040
19positive regulation of cardiac muscle hypertrophy (GO:0010613)4.53833040
20regulation of platelet aggregation (GO:0090330)4.38428500
21potassium ion export (GO:0071435)4.34125289
22positive regulation of synaptic transmission, GABAergic (GO:0032230)4.21650038
23response to ATP (GO:0033198)4.10541896
24regulation of sensory perception of pain (GO:0051930)4.10470229
25regulation of sensory perception (GO:0051931)4.10470229
26proline transport (GO:0015824)4.03813504
27negative regulation of humoral immune response (GO:0002921)4.01496923
28negative regulation of dendrite development (GO:2000171)3.98224902
29adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.95910664
30enteric nervous system development (GO:0048484)3.93033979
31negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.85857785
32cornea development in camera-type eye (GO:0061303)3.80167521
33dopamine receptor signaling pathway (GO:0007212)3.74605505
34peristalsis (GO:0030432)3.73716372
35detection of mechanical stimulus involved in sensory perception (GO:0050974)3.71740442
36cell migration in hindbrain (GO:0021535)3.69938670
37negative regulation of homotypic cell-cell adhesion (GO:0034111)3.68982870
38action potential (GO:0001508)3.62023225
39negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.61245441
40cell communication involved in cardiac conduction (GO:0086065)3.60939785
41cellular response to prostaglandin stimulus (GO:0071379)3.45789901
42neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.40316173
43neuromuscular synaptic transmission (GO:0007274)3.37544957
44membrane repolarization (GO:0086009)3.36017292
45regulation of homotypic cell-cell adhesion (GO:0034110)3.34900268
46regulation of collateral sprouting (GO:0048670)3.33942183
47establishment of mitochondrion localization (GO:0051654)3.31675450
48positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.30398307
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.29006914
50sodium ion transmembrane transport (GO:0035725)3.28900412
51retinal ganglion cell axon guidance (GO:0031290)3.26382582
52sensory perception of taste (GO:0050909)3.17373748
53cellular response to nicotine (GO:0071316)3.15921690
54vesicle transport along microtubule (GO:0047496)3.15884420
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.14744593
56response to water (GO:0009415)3.12212773
57nerve growth factor signaling pathway (GO:0038180)3.11904815
58positive regulation of amino acid transport (GO:0051957)3.11837462
59regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.05143480
60axon cargo transport (GO:0008088)3.05120860
61regulation of amyloid precursor protein catabolic process (GO:1902991)3.01592893
62negative regulation of calcium ion transport into cytosol (GO:0010523)2.98448819
63termination of signal transduction (GO:0023021)2.98427307
64regulation of cardiac muscle hypertrophy (GO:0010611)2.97000580
65regulation of membrane depolarization (GO:0003254)2.96409283
66regulation of synaptic vesicle exocytosis (GO:2000300)2.92400579
67mesenchymal-epithelial cell signaling (GO:0060638)2.88686984
68negative regulation of microtubule polymerization (GO:0031115)2.88519513
69cellular response to ATP (GO:0071318)2.87044089
70multicellular organismal response to stress (GO:0033555)2.83896915
71regulation of muscle hypertrophy (GO:0014743)2.82692794
72membrane budding (GO:0006900)2.81923822
73termination of G-protein coupled receptor signaling pathway (GO:0038032)2.80646484
74peptidyl-tyrosine autophosphorylation (GO:0038083)2.79419502
75organelle transport along microtubule (GO:0072384)2.78947515
76cellular potassium ion homeostasis (GO:0030007)2.76415709
77synaptic vesicle maturation (GO:0016188)2.74812326
78actin filament depolymerization (GO:0030042)2.71151772
79acrosome reaction (GO:0007340)2.70620963
80glutamate secretion (GO:0014047)2.70432955
81plasma membrane repair (GO:0001778)2.67730367
82sodium ion export (GO:0071436)2.65316093
83positive regulation of potassium ion transmembrane transport (GO:1901381)2.64887144
84sensory perception of pain (GO:0019233)2.64011612
85establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.60819388
86mitochondrion transport along microtubule (GO:0047497)2.60819388
87regulation of cardiac muscle contraction (GO:0055117)2.60527152
88negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.60385244
89respiratory burst (GO:0045730)2.59838442
90neuron fate specification (GO:0048665)2.59660880
91membrane depolarization (GO:0051899)2.54728113
92activated T cell proliferation (GO:0050798)2.54124340
93regulation of cell communication by electrical coupling (GO:0010649)2.53664122
94regulation of short-term neuronal synaptic plasticity (GO:0048172)2.53097208
95regulation of neurological system process (GO:0031644)2.51737168
96intermediate filament-based process (GO:0045103)2.50723348
97detection of chemical stimulus involved in sensory perception (GO:0050907)2.48904645
98inactivation of MAPK activity (GO:0000188)2.48793357
99neuronal action potential propagation (GO:0019227)2.48533748
100positive regulation of calcium-mediated signaling (GO:0050850)2.47908859

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.18656069
2ESR1_20079471_ChIP-ChIP_T-47D_Human2.49532308
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.43638286
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.39948555
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.36765890
6ESR2_21235772_ChIP-Seq_MCF-7_Human2.31564741
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28776295
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.21136407
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18756777
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17312852
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16804682
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13875103
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13875103
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09906831
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07402635
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.05598449
17ZNF263_19887448_ChIP-Seq_K562_Human1.98856473
18WT1_19549856_ChIP-ChIP_CCG9911_Human1.93871545
19EZH2_22144423_ChIP-Seq_EOC_Human1.92936820
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91893884
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.88198391
22AHR_22903824_ChIP-Seq_MCF-7_Human1.76779680
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.72677763
24SMAD4_21799915_ChIP-Seq_A2780_Human1.69401117
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69144231
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63020601
27EGR1_19032775_ChIP-ChIP_M12_Human1.62291334
28AR_21572438_ChIP-Seq_LNCaP_Human1.62219610
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.60820661
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.55873681
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54089285
32NR3C1_23031785_ChIP-Seq_PC12_Mouse1.52418334
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51802068
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51624980
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50365455
36SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49717065
37* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45913871
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42157622
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.41871785
40TCF4_18268006_ChIP-ChIP_LS174T_Human1.41593070
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41284179
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.40219583
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.38925070
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38294331
45KDM2B_26808549_Chip-Seq_K562_Human1.36308014
46GBX2_23144817_ChIP-Seq_PC3_Human1.35116230
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32630575
48REST_21632747_ChIP-Seq_MESCs_Mouse1.28782281
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24060152
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.23954843
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23853334
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23841697
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21579175
54SOX2_20726797_ChIP-Seq_SW620_Human1.20302923
55SMAD3_21741376_ChIP-Seq_ESCs_Human1.18756862
56SMAD4_21741376_ChIP-Seq_HESCs_Human1.18680820
57TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18067538
58REST_18959480_ChIP-ChIP_MESCs_Mouse1.16616042
59CTCF_27219007_Chip-Seq_Bcells_Human1.13185413
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.11903749
61STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11376341
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.09178774
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09159111
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08261954
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07786329
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05065786
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04322007
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04322007
69SMAD4_21741376_ChIP-Seq_EPCs_Human1.04251058
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03563739
71CJUN_26792858_Chip-Seq_BT549_Human1.02775749
72STAT3_23295773_ChIP-Seq_U87_Human1.02027958
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01984955
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.00674043
75AR_25329375_ChIP-Seq_VCAP_Human0.99505779
76TAF15_26573619_Chip-Seq_HEK293_Human0.98474267
77CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98194538
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98149967
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96444149
80RXR_22108803_ChIP-Seq_LS180_Human0.96303193
81YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96086745
82DROSHA_22980978_ChIP-Seq_HELA_Human0.95925778
83KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94357930
84CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94246310
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93934944
86SOX2_21211035_ChIP-Seq_LN229_Gbm0.93622743
87RARB_27405468_Chip-Seq_BRAIN_Mouse0.92714499
88P300_19829295_ChIP-Seq_ESCs_Human0.91281689
89P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89737651
90OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89297176
91SMAD3_21741376_ChIP-Seq_EPCs_Human0.88206732
92ZNF274_21170338_ChIP-Seq_K562_Hela0.86829233
93AR_19668381_ChIP-Seq_PC3_Human0.86333328
94KDM2B_26808549_Chip-Seq_REH_Human0.86060174
95RING1B_27294783_Chip-Seq_NPCs_Mouse0.85877672
96RUNX_20019798_ChIP-Seq_JUKART_Human0.85245638
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84146327
98KLF4_19829295_ChIP-Seq_ESCs_Human0.83892104
99TET1_21490601_ChIP-Seq_MESCs_Mouse0.83803794
100RING1B_27294783_Chip-Seq_ESCs_Mouse0.81975971

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception8.75990829
2MP0002736_abnormal_nociception_after8.38184328
3MP0002735_abnormal_chemical_nociception7.56461807
4MP0001986_abnormal_taste_sensitivity6.52056404
5MP0002733_abnormal_thermal_nociception4.43250355
6MP0004270_analgesia4.00526463
7MP0002734_abnormal_mechanical_nocicepti3.99993069
8MP0001970_abnormal_pain_threshold3.57233879
9MP0004858_abnormal_nervous_system3.43269815
10MP0006276_abnormal_autonomic_nervous2.99884199
11MP0002272_abnormal_nervous_system2.12356037
12MP0002067_abnormal_sensory_capabilities1.90332549
13MP0002184_abnormal_innervation1.74045202
14MP0001270_distended_abdomen1.73848873
15MP0002751_abnormal_autonomic_nervous1.59516971
16MP0003656_abnormal_erythrocyte_physiolo1.59333604
17MP0004859_abnormal_synaptic_plasticity1.32100226
18MP0001348_abnormal_lacrimal_gland1.25446632
19MP0003635_abnormal_synaptic_transmissio1.20280316
20MP0000372_irregular_coat_pigmentation1.17579403
21MP0003045_fibrosis1.13228134
22MP0010771_integument_phenotype1.11824048
23MP0001984_abnormal_olfaction1.09861682
24MP0004811_abnormal_neuron_physiology1.09733600
25MP0001299_abnormal_eye_distance/1.09369034
26MP0005423_abnormal_somatic_nervous1.05114111
27MP0000920_abnormal_myelination1.04386969
28MP0000955_abnormal_spinal_cord1.01452912
29MP0008260_abnormal_autophagy1.00096433
30MP0003329_amyloid_beta_deposits0.94116453
31MP0002064_seizures0.88854536
32MP0002882_abnormal_neuron_morphology0.87824721
33MP0008004_abnormal_stomach_pH0.84816418
34MP0003634_abnormal_glial_cell0.84592962
35MP0010234_abnormal_vibrissa_follicle0.84395968
36MP0000778_abnormal_nervous_system0.81676517
37MP0003633_abnormal_nervous_system0.81524242
38MP0002063_abnormal_learning/memory/cond0.80535823
39MP0000747_muscle_weakness0.79598541
40MP0009745_abnormal_behavioral_response0.77266189
41MP0000427_abnormal_hair_cycle0.76058070
42MP0005083_abnormal_biliary_tract0.75323037
43MP0009046_muscle_twitch0.75299407
44MP0002572_abnormal_emotion/affect_behav0.72059307
45MP0000534_abnormal_ureter_morphology0.71651777
46MP0008874_decreased_physiological_sensi0.69280285
47MP0000604_amyloidosis0.67566055
48MP0002229_neurodegeneration0.67221866
49MP0003300_gastrointestinal_ulcer0.66584459
50MP0003631_nervous_system_phenotype0.66171076
51MP0002752_abnormal_somatic_nervous0.65169876
52MP0009780_abnormal_chondrocyte_physiolo0.63873357
53MP0003880_abnormal_central_pattern0.63484769
54MP0003950_abnormal_plasma_membrane0.63372570
55MP0000538_abnormal_urinary_bladder0.62401137
56MP0004742_abnormal_vestibular_system0.58639489
57MP0002066_abnormal_motor_capabilities/c0.56794780
58MP0005165_increased_susceptibility_to0.53812214
59MP0004142_abnormal_muscle_tone0.53637406
60MP0000749_muscle_degeneration0.49484802
61MP0003566_abnormal_cell_adhesion0.48805542
62MP0005171_absent_coat_pigmentation0.47791208
63MP0008569_lethality_at_weaning0.47487880
64MP0002557_abnormal_social/conspecific_i0.47051508
65MP0003183_abnormal_peptide_metabolism0.46048947
66MP0005408_hypopigmentation0.45867850
67MP0002148_abnormal_hypersensitivity_rea0.45775176
68MP0003172_abnormal_lysosome_physiology0.45725898
69MP0001905_abnormal_dopamine_level0.45647118
70MP0004924_abnormal_behavior0.44783023
71MP0005386_behavior/neurological_phenoty0.44783023
72MP0001664_abnormal_digestion0.44344894
73MP0002909_abnormal_adrenal_gland0.43052743
74MP0010386_abnormal_urinary_bladder0.42842691
75MP0003632_abnormal_nervous_system0.40072462
76MP0004510_myositis0.40015415
77MP0000569_abnormal_digit_pigmentation0.39409328
78MP0004036_abnormal_muscle_relaxation0.38452086
79MP0004145_abnormal_muscle_electrophysio0.37435722
80MP0008961_abnormal_basal_metabolism0.36638443
81MP0005464_abnormal_platelet_physiology0.36191044
82MP0001943_abnormal_respiration0.34152331
83MP0003091_abnormal_cell_migration0.33698117
84MP0002166_altered_tumor_susceptibility0.32765079
85MP0004085_abnormal_heartbeat0.31323240
86MP0001440_abnormal_grooming_behavior0.31286888
87MP0002972_abnormal_cardiac_muscle0.30406802
88MP0000015_abnormal_ear_pigmentation0.30356884
89MP0009765_abnormal_xenobiotic_induced0.28693219
90MP0009379_abnormal_foot_pigmentation0.27645593
91MP0001756_abnormal_urination0.27261777
92MP0002896_abnormal_bone_mineralization0.27177110
93MP0002837_dystrophic_cardiac_calcinosis0.26621182
94MP0003806_abnormal_nucleotide_metabolis0.26285008
95MP0004147_increased_porphyrin_level0.26155144
96MP0009278_abnormal_bone_marrow0.25179646
97MP0005310_abnormal_salivary_gland0.23989938
98MP0001486_abnormal_startle_reflex0.23722565
99MP0000751_myopathy0.23580570
100MP0002069_abnormal_eating/drinking_beha0.23185257

Predicted human phenotypes

RankGene SetZ-score
1Dysautonomia (HP:0002459)7.56964035
2Ulnar claw (HP:0001178)7.00903492
3Abnormality of pain sensation (HP:0010832)5.69570665
4Impaired pain sensation (HP:0007328)5.69570665
5Insidious onset (HP:0003587)5.39780238
6Termporal pattern (HP:0011008)5.39780238
7Segmental peripheral demyelination/remyelination (HP:0003481)5.28412257
8Abnormal autonomic nervous system physiology (HP:0012332)4.53047527
9Action tremor (HP:0002345)4.30920145
10Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.96998177
11Ankle clonus (HP:0011448)3.88441253
12Hammertoe (HP:0001765)3.83344731
13Pheochromocytoma (HP:0002666)3.81084453
14Myokymia (HP:0002411)3.74957182
15Supranuclear gaze palsy (HP:0000605)3.70172107
16Foot dorsiflexor weakness (HP:0009027)3.69144829
17Onion bulb formation (HP:0003383)3.66515166
18Steppage gait (HP:0003376)3.65936095
19Neuroendocrine neoplasm (HP:0100634)3.56861618
20Focal seizures (HP:0007359)3.56637644
21Submucous cleft hard palate (HP:0000176)3.48092127
22Hypomagnesemia (HP:0002917)3.44769442
23Abnormality of the corticospinal tract (HP:0002492)3.40445522
24Failure to thrive in infancy (HP:0001531)3.39118120
25Abnormality of the foot musculature (HP:0001436)3.25192367
26Autoamputation (HP:0001218)3.05873808
27Abnormality of magnesium homeostasis (HP:0004921)3.04646221
28Hyporeflexia of lower limbs (HP:0002600)3.04252279
29Atonic seizures (HP:0010819)2.96045061
30Abnormality of the vocal cords (HP:0008777)2.95413651
31Distal sensory impairment (HP:0002936)2.94056794
32Peripheral hypomyelination (HP:0007182)2.87642145
33Thyroid carcinoma (HP:0002890)2.79945619
34Potter facies (HP:0002009)2.75312274
35Facial shape deformation (HP:0011334)2.75312274
36Distal arthrogryposis (HP:0005684)2.73865945
37Hypothermia (HP:0002045)2.71710649
38Chin dimple (HP:0010751)2.70795719
39Decreased motor nerve conduction velocity (HP:0003431)2.67285594
40Sensory axonal neuropathy (HP:0003390)2.66760184
41Thoracolumbar scoliosis (HP:0002944)2.66511724
42Spastic gait (HP:0002064)2.57459263
43Myotonia (HP:0002486)2.56810222
44Hypoventilation (HP:0002791)2.54650129
45Impaired proprioception (HP:0010831)2.54487795
46Increased CSF protein (HP:0002922)2.53440508
47Arthropathy (HP:0003040)2.50002518
48Scanning speech (HP:0002168)2.46208335
49Upper limb muscle weakness (HP:0003484)2.42437834
50Urinary urgency (HP:0000012)2.39448150
51Dialeptic seizures (HP:0011146)2.36576494
52Peripheral demyelination (HP:0011096)2.29746030
53Bradycardia (HP:0001662)2.22965344
54Aqueductal stenosis (HP:0002410)2.21860777
55Truncal ataxia (HP:0002078)2.21671558
56Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.19683919
57Degeneration of the lateral corticospinal tracts (HP:0002314)2.19683919
58Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.17076773
59Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.16743405
60Hand muscle atrophy (HP:0009130)2.13834745
61Hypercortisolism (HP:0001578)2.10712042
62Progressive cerebellar ataxia (HP:0002073)2.08200756
63Lower limb muscle weakness (HP:0007340)2.04860988
64Distal lower limb muscle weakness (HP:0009053)2.04801212
65Axonal loss (HP:0003447)2.04419709
66Lower limb asymmetry (HP:0100559)2.04316955
67Anosmia (HP:0000458)2.03289407
68Abnormal hair whorl (HP:0010721)2.02983392
69Cerebral hemorrhage (HP:0001342)2.01077808
70Febrile seizures (HP:0002373)2.00563879
71Hypoplasia of the brainstem (HP:0002365)1.99014498
72Aplasia/Hypoplasia of the brainstem (HP:0007362)1.99014498
73Urinary bladder sphincter dysfunction (HP:0002839)1.98217791
74Bowel diverticulosis (HP:0005222)1.96749713
75Clonus (HP:0002169)1.96573932
76Exotropia (HP:0000577)1.96206949
77Areflexia of lower limbs (HP:0002522)1.94006713
78Torticollis (HP:0000473)1.92841546
79Postural tremor (HP:0002174)1.90334760
80Ventricular fibrillation (HP:0001663)1.90099259
81Curly hair (HP:0002212)1.85868818
82Anhidrosis (HP:0000970)1.83569165
83Absence seizures (HP:0002121)1.82788553
84Pes cavus (HP:0001761)1.79852830
85Mask-like facies (HP:0000298)1.78589793
86Episodic fever (HP:0001954)1.77203451
87Distal upper limb amyotrophy (HP:0007149)1.74155577
88Upper limb amyotrophy (HP:0009129)1.74155577
89Overlapping toe (HP:0001845)1.73335033
90Recurrent corneal erosions (HP:0000495)1.70180170
91Focal motor seizures (HP:0011153)1.69230177
92Megalencephaly (HP:0001355)1.66803117
93Rapidly progressive (HP:0003678)1.65879651
94Poor speech (HP:0002465)1.65251827
95Abnormality of calcium-phosphate metabolism (HP:0100530)1.64202920
96Abnormality of the ischium (HP:0003174)1.62814864
97Paraplegia (HP:0010550)1.62652253
98Knee flexion contracture (HP:0006380)1.61220010
99Neoplasm of the thyroid gland (HP:0100031)1.61121797
100Slow progression (HP:0003677)1.60342468

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KSR24.60156251
2NTRK14.28690752
3RIPK44.14348826
4LIMK13.41274519
5MAP3K23.34509277
6MAP3K92.90797311
7LMTK22.42411434
8ARAF2.34840707
9MATK2.26306051
10STK392.22113873
11RET2.17094875
12EPHA32.15542295
13MARK32.14203022
14EPHB11.94999745
15MINK11.76794616
16GRK51.75179463
17PAK61.74203480
18SGK4941.63596868
19SGK2231.63596868
20NTRK31.63142433
21MAP2K11.39532658
22MAP2K21.39334113
23RPS6KA21.38895015
24MAP3K11.35998155
25ADRBK21.29495619
26PHKG21.25646915
27PHKG11.25646915
28YES11.21151933
29PRKCE1.20194825
30WNK11.14105261
31SGK21.13323065
32RAF11.11486081
33MAP3K121.10178300
34FGFR31.09654133
35FGFR21.07687938
36MET1.04869168
37FRK1.00674745
38PAK30.99566760
39FER0.98763852
40FGFR40.93395878
41WNK40.91817102
42SGK30.91061256
43TRPM70.87131336
44PRKG20.83415043
45LATS20.83218290
46DAPK20.82201736
47DYRK20.80879255
48MAP3K130.80807810
49PRKCG0.77957128
50CSNK1A1L0.76349527
51PRKCH0.75802044
52ADRBK10.73549935
53KSR10.71952922
54ERBB30.71224641
55UHMK10.71104803
56PDGFRB0.70796793
57CDK50.68580727
58TESK10.67594286
59ROCK20.66476501
60PRKCZ0.63455560
61SCYL20.63174538
62PIM20.61012423
63CDK140.60927311
64PTK20.55591050
65PDK10.55417760
66CSNK1G30.55000138
67HIPK20.54164773
68MARK10.53952042
69CSNK1G20.53681792
70FYN0.53134552
71DMPK0.51604639
72PRKD30.51423661
73PDGFRA0.50508901
74BRAF0.50084307
75MAP2K40.49538429
76JAK20.48845928
77CDK30.48155091
78ROCK10.48073472
79CDC42BPA0.46608741
80ERBB20.46597951
81JAK30.44873080
82MAPK130.43133034
83CASK0.41930565
84SRC0.41846424
85CAMK2A0.40836617
86JAK10.39297873
87MAPKAPK50.37635674
88IGF1R0.36670758
89CAMK2G0.35489941
90PDPK10.34647140
91CAMK2D0.34443179
92MST1R0.34305147
93LRRK20.33243697
94EPHB20.32839533
95TYK20.32674330
96LCK0.31972704
97PRKCD0.28305272
98IRAK10.27504051
99PRKCA0.26408063
100BCR0.26335548

Predicted pathways (KEGG)

RankGene SetZ-score
1Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.93084002
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.83873264
3Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.66021034
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.29316013
5Synaptic vesicle cycle_Homo sapiens_hsa047212.20611561
6Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047502.14041018
7Olfactory transduction_Homo sapiens_hsa047402.01824585
8Phosphatidylinositol signaling system_Homo sapiens_hsa040701.68689442
9Dorso-ventral axis formation_Homo sapiens_hsa043201.65690585
10Choline metabolism in cancer_Homo sapiens_hsa052311.64675979
11Graft-versus-host disease_Homo sapiens_hsa053321.56900593
12Phospholipase D signaling pathway_Homo sapiens_hsa040721.54116329
13Serotonergic synapse_Homo sapiens_hsa047261.48243970
14Insulin secretion_Homo sapiens_hsa049111.47803900
15Taste transduction_Homo sapiens_hsa047421.47311456
16Glutamatergic synapse_Homo sapiens_hsa047241.46328054
17Endometrial cancer_Homo sapiens_hsa052131.45085809
18Long-term depression_Homo sapiens_hsa047301.41955658
19Cholinergic synapse_Homo sapiens_hsa047251.41261832
20VEGF signaling pathway_Homo sapiens_hsa043701.37881491
21Renin-angiotensin system_Homo sapiens_hsa046141.36144570
22Thyroid cancer_Homo sapiens_hsa052161.33392413
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32540253
24Neurotrophin signaling pathway_Homo sapiens_hsa047221.32455029
25GnRH signaling pathway_Homo sapiens_hsa049121.32311631
26ErbB signaling pathway_Homo sapiens_hsa040121.30699429
27Dopaminergic synapse_Homo sapiens_hsa047281.29786630
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29315666
29Salmonella infection_Homo sapiens_hsa051321.27614178
30Steroid biosynthesis_Homo sapiens_hsa001001.27531307
31Glioma_Homo sapiens_hsa052141.25407369
32Long-term potentiation_Homo sapiens_hsa047201.21675056
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19472546
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.17894581
35Circadian entrainment_Homo sapiens_hsa047131.17563264
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15566064
37Salivary secretion_Homo sapiens_hsa049701.11856069
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10357951
39Collecting duct acid secretion_Homo sapiens_hsa049661.10091973
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08416865
41Vibrio cholerae infection_Homo sapiens_hsa051101.08323398
42Sphingolipid signaling pathway_Homo sapiens_hsa040711.05762300
43Prolactin signaling pathway_Homo sapiens_hsa049171.05604888
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02860614
45Estrogen signaling pathway_Homo sapiens_hsa049150.99063595
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.97568931
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96700986
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95294144
49Melanogenesis_Homo sapiens_hsa049160.92015947
50Amoebiasis_Homo sapiens_hsa051460.91921101
51mTOR signaling pathway_Homo sapiens_hsa041500.91608972
52Phagosome_Homo sapiens_hsa041450.90961200
53Type II diabetes mellitus_Homo sapiens_hsa049300.90849007
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90601284
55Gap junction_Homo sapiens_hsa045400.89623844
56Morphine addiction_Homo sapiens_hsa050320.89238814
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89074952
58Glycerophospholipid metabolism_Homo sapiens_hsa005640.88328813
59Melanoma_Homo sapiens_hsa052180.87311213
60Mineral absorption_Homo sapiens_hsa049780.86061008
61Ras signaling pathway_Homo sapiens_hsa040140.85858049
62Glycerolipid metabolism_Homo sapiens_hsa005610.83997486
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83601332
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83115962
65GABAergic synapse_Homo sapiens_hsa047270.82963379
66Axon guidance_Homo sapiens_hsa043600.82339859
67Rap1 signaling pathway_Homo sapiens_hsa040150.80156432
68Pancreatic secretion_Homo sapiens_hsa049720.79052404
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78157121
70Thyroid hormone synthesis_Homo sapiens_hsa049180.78111809
71Non-small cell lung cancer_Homo sapiens_hsa052230.76980782
72Pancreatic cancer_Homo sapiens_hsa052120.76182384
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74430459
74Gastric acid secretion_Homo sapiens_hsa049710.73874262
75Endocytosis_Homo sapiens_hsa041440.72109956
76Insulin signaling pathway_Homo sapiens_hsa049100.70171532
77Renal cell carcinoma_Homo sapiens_hsa052110.68692294
78Chemokine signaling pathway_Homo sapiens_hsa040620.67719349
79Oxytocin signaling pathway_Homo sapiens_hsa049210.67408900
80Colorectal cancer_Homo sapiens_hsa052100.65128811
81T cell receptor signaling pathway_Homo sapiens_hsa046600.64922933
82Chronic myeloid leukemia_Homo sapiens_hsa052200.62248461
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61878492
84Acute myeloid leukemia_Homo sapiens_hsa052210.61632411
85African trypanosomiasis_Homo sapiens_hsa051430.59217527
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59136179
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.57304298
88Phototransduction_Homo sapiens_hsa047440.56783795
89Proteoglycans in cancer_Homo sapiens_hsa052050.55717793
90Shigellosis_Homo sapiens_hsa051310.55006170
91Protein digestion and absorption_Homo sapiens_hsa049740.54230941
92MAPK signaling pathway_Homo sapiens_hsa040100.54224289
93Regulation of autophagy_Homo sapiens_hsa041400.53873923
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52711667
95Hepatitis C_Homo sapiens_hsa051600.51627762
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50630367
97Viral myocarditis_Homo sapiens_hsa054160.50579468
98Ether lipid metabolism_Homo sapiens_hsa005650.50552935
99Platelet activation_Homo sapiens_hsa046110.50527029
100B cell receptor signaling pathway_Homo sapiens_hsa046620.49128356

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