Rank | Gene Set | Z-score |
---|---|---|
1 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 7.81912496 |
2 | neuronal action potential (GO:0019228) | 7.51934699 |
3 | detection of temperature stimulus involved in sensory perception of pain (GO:0050965) | 7.07047689 |
4 | detection of temperature stimulus involved in sensory perception (GO:0050961) | 7.07047689 |
5 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 6.56838233 |
6 | negative regulation of dendrite morphogenesis (GO:0050774) | 6.52382415 |
7 | detection of temperature stimulus (GO:0016048) | 6.50447108 |
8 | peripheral nervous system neuron development (GO:0048935) | 6.30374139 |
9 | adenosine metabolic process (GO:0046085) | 6.21808744 |
10 | negative regulation of complement activation (GO:0045916) | 5.94915173 |
11 | neurofilament cytoskeleton organization (GO:0060052) | 5.71976896 |
12 | behavioral response to pain (GO:0048266) | 5.61543371 |
13 | response to pain (GO:0048265) | 5.21139547 |
14 | urinary tract smooth muscle contraction (GO:0014848) | 5.02544507 |
15 | membrane depolarization during action potential (GO:0086010) | 4.95194218 |
16 | phospholipase C-activating dopamine receptor signaling pathway (GO:0060158) | 4.81271045 |
17 | negative regulation of protein activation cascade (GO:2000258) | 4.77642225 |
18 | positive regulation of muscle hypertrophy (GO:0014742) | 4.53833040 |
19 | positive regulation of cardiac muscle hypertrophy (GO:0010613) | 4.53833040 |
20 | regulation of platelet aggregation (GO:0090330) | 4.38428500 |
21 | potassium ion export (GO:0071435) | 4.34125289 |
22 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 4.21650038 |
23 | response to ATP (GO:0033198) | 4.10541896 |
24 | regulation of sensory perception of pain (GO:0051930) | 4.10470229 |
25 | regulation of sensory perception (GO:0051931) | 4.10470229 |
26 | proline transport (GO:0015824) | 4.03813504 |
27 | negative regulation of humoral immune response (GO:0002921) | 4.01496923 |
28 | negative regulation of dendrite development (GO:2000171) | 3.98224902 |
29 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 3.95910664 |
30 | enteric nervous system development (GO:0048484) | 3.93033979 |
31 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.85857785 |
32 | cornea development in camera-type eye (GO:0061303) | 3.80167521 |
33 | dopamine receptor signaling pathway (GO:0007212) | 3.74605505 |
34 | peristalsis (GO:0030432) | 3.73716372 |
35 | detection of mechanical stimulus involved in sensory perception (GO:0050974) | 3.71740442 |
36 | cell migration in hindbrain (GO:0021535) | 3.69938670 |
37 | negative regulation of homotypic cell-cell adhesion (GO:0034111) | 3.68982870 |
38 | action potential (GO:0001508) | 3.62023225 |
39 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 3.61245441 |
40 | cell communication involved in cardiac conduction (GO:0086065) | 3.60939785 |
41 | cellular response to prostaglandin stimulus (GO:0071379) | 3.45789901 |
42 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 3.40316173 |
43 | neuromuscular synaptic transmission (GO:0007274) | 3.37544957 |
44 | membrane repolarization (GO:0086009) | 3.36017292 |
45 | regulation of homotypic cell-cell adhesion (GO:0034110) | 3.34900268 |
46 | regulation of collateral sprouting (GO:0048670) | 3.33942183 |
47 | establishment of mitochondrion localization (GO:0051654) | 3.31675450 |
48 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 3.30398307 |
49 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.29006914 |
50 | sodium ion transmembrane transport (GO:0035725) | 3.28900412 |
51 | retinal ganglion cell axon guidance (GO:0031290) | 3.26382582 |
52 | sensory perception of taste (GO:0050909) | 3.17373748 |
53 | cellular response to nicotine (GO:0071316) | 3.15921690 |
54 | vesicle transport along microtubule (GO:0047496) | 3.15884420 |
55 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.14744593 |
56 | response to water (GO:0009415) | 3.12212773 |
57 | nerve growth factor signaling pathway (GO:0038180) | 3.11904815 |
58 | positive regulation of amino acid transport (GO:0051957) | 3.11837462 |
59 | regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664) | 3.05143480 |
60 | axon cargo transport (GO:0008088) | 3.05120860 |
61 | regulation of amyloid precursor protein catabolic process (GO:1902991) | 3.01592893 |
62 | negative regulation of calcium ion transport into cytosol (GO:0010523) | 2.98448819 |
63 | termination of signal transduction (GO:0023021) | 2.98427307 |
64 | regulation of cardiac muscle hypertrophy (GO:0010611) | 2.97000580 |
65 | regulation of membrane depolarization (GO:0003254) | 2.96409283 |
66 | regulation of synaptic vesicle exocytosis (GO:2000300) | 2.92400579 |
67 | mesenchymal-epithelial cell signaling (GO:0060638) | 2.88686984 |
68 | negative regulation of microtubule polymerization (GO:0031115) | 2.88519513 |
69 | cellular response to ATP (GO:0071318) | 2.87044089 |
70 | multicellular organismal response to stress (GO:0033555) | 2.83896915 |
71 | regulation of muscle hypertrophy (GO:0014743) | 2.82692794 |
72 | membrane budding (GO:0006900) | 2.81923822 |
73 | termination of G-protein coupled receptor signaling pathway (GO:0038032) | 2.80646484 |
74 | peptidyl-tyrosine autophosphorylation (GO:0038083) | 2.79419502 |
75 | organelle transport along microtubule (GO:0072384) | 2.78947515 |
76 | cellular potassium ion homeostasis (GO:0030007) | 2.76415709 |
77 | synaptic vesicle maturation (GO:0016188) | 2.74812326 |
78 | actin filament depolymerization (GO:0030042) | 2.71151772 |
79 | acrosome reaction (GO:0007340) | 2.70620963 |
80 | glutamate secretion (GO:0014047) | 2.70432955 |
81 | plasma membrane repair (GO:0001778) | 2.67730367 |
82 | sodium ion export (GO:0071436) | 2.65316093 |
83 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 2.64887144 |
84 | sensory perception of pain (GO:0019233) | 2.64011612 |
85 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 2.60819388 |
86 | mitochondrion transport along microtubule (GO:0047497) | 2.60819388 |
87 | regulation of cardiac muscle contraction (GO:0055117) | 2.60527152 |
88 | negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067) | 2.60385244 |
89 | respiratory burst (GO:0045730) | 2.59838442 |
90 | neuron fate specification (GO:0048665) | 2.59660880 |
91 | membrane depolarization (GO:0051899) | 2.54728113 |
92 | activated T cell proliferation (GO:0050798) | 2.54124340 |
93 | regulation of cell communication by electrical coupling (GO:0010649) | 2.53664122 |
94 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 2.53097208 |
95 | regulation of neurological system process (GO:0031644) | 2.51737168 |
96 | intermediate filament-based process (GO:0045103) | 2.50723348 |
97 | detection of chemical stimulus involved in sensory perception (GO:0050907) | 2.48904645 |
98 | inactivation of MAPK activity (GO:0000188) | 2.48793357 |
99 | neuronal action potential propagation (GO:0019227) | 2.48533748 |
100 | positive regulation of calcium-mediated signaling (GO:0050850) | 2.47908859 |
Rank | Gene Set | Z-score |
---|---|---|
1 | VDR_22108803_ChIP-Seq_LS180_Human | 3.18656069 |
2 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 2.49532308 |
3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.43638286 |
4 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.39948555 |
5 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.36765890 |
6 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 2.31564741 |
7 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.28776295 |
8 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.21136407 |
9 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.18756777 |
10 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.17312852 |
11 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.16804682 |
12 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.13875103 |
13 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.13875103 |
14 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.09906831 |
15 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.07402635 |
16 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.05598449 |
17 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.98856473 |
18 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.93871545 |
19 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.92936820 |
20 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.91893884 |
21 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.88198391 |
22 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.76779680 |
23 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.72677763 |
24 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.69401117 |
25 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.69144231 |
26 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.63020601 |
27 | EGR1_19032775_ChIP-ChIP_M12_Human | 1.62291334 |
28 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.62219610 |
29 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.60820661 |
30 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.55873681 |
31 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.54089285 |
32 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.52418334 |
33 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.51802068 |
34 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.51624980 |
35 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.50365455 |
36 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.49717065 |
37 | * SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.45913871 |
38 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.42157622 |
39 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.41871785 |
40 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.41593070 |
41 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.41284179 |
42 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.40219583 |
43 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.38925070 |
44 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.38294331 |
45 | KDM2B_26808549_Chip-Seq_K562_Human | 1.36308014 |
46 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.35116230 |
47 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.32630575 |
48 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.28782281 |
49 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.24060152 |
50 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.23954843 |
51 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.23853334 |
52 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.23841697 |
53 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.21579175 |
54 | SOX2_20726797_ChIP-Seq_SW620_Human | 1.20302923 |
55 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 1.18756862 |
56 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 1.18680820 |
57 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.18067538 |
58 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.16616042 |
59 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.13185413 |
60 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.11903749 |
61 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.11376341 |
62 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.09178774 |
63 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.09159111 |
64 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.08261954 |
65 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.07786329 |
66 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.05065786 |
67 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.04322007 |
68 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.04322007 |
69 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.04251058 |
70 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.03563739 |
71 | CJUN_26792858_Chip-Seq_BT549_Human | 1.02775749 |
72 | STAT3_23295773_ChIP-Seq_U87_Human | 1.02027958 |
73 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.01984955 |
74 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.00674043 |
75 | AR_25329375_ChIP-Seq_VCAP_Human | 0.99505779 |
76 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.98474267 |
77 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.98194538 |
78 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.98149967 |
79 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 0.96444149 |
80 | RXR_22108803_ChIP-Seq_LS180_Human | 0.96303193 |
81 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.96086745 |
82 | DROSHA_22980978_ChIP-Seq_HELA_Human | 0.95925778 |
83 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.94357930 |
84 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.94246310 |
85 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.93934944 |
86 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 0.93622743 |
87 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 0.92714499 |
88 | P300_19829295_ChIP-Seq_ESCs_Human | 0.91281689 |
89 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.89737651 |
90 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.89297176 |
91 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.88206732 |
92 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.86829233 |
93 | AR_19668381_ChIP-Seq_PC3_Human | 0.86333328 |
94 | KDM2B_26808549_Chip-Seq_REH_Human | 0.86060174 |
95 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 0.85877672 |
96 | RUNX_20019798_ChIP-Seq_JUKART_Human | 0.85245638 |
97 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.84146327 |
98 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.83892104 |
99 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.83803794 |
100 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 0.81975971 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0001968_abnormal_touch/_nociception | 8.75990829 |
2 | MP0002736_abnormal_nociception_after | 8.38184328 |
3 | MP0002735_abnormal_chemical_nociception | 7.56461807 |
4 | MP0001986_abnormal_taste_sensitivity | 6.52056404 |
5 | MP0002733_abnormal_thermal_nociception | 4.43250355 |
6 | MP0004270_analgesia | 4.00526463 |
7 | MP0002734_abnormal_mechanical_nocicepti | 3.99993069 |
8 | MP0001970_abnormal_pain_threshold | 3.57233879 |
9 | MP0004858_abnormal_nervous_system | 3.43269815 |
10 | MP0006276_abnormal_autonomic_nervous | 2.99884199 |
11 | MP0002272_abnormal_nervous_system | 2.12356037 |
12 | MP0002067_abnormal_sensory_capabilities | 1.90332549 |
13 | MP0002184_abnormal_innervation | 1.74045202 |
14 | MP0001270_distended_abdomen | 1.73848873 |
15 | MP0002751_abnormal_autonomic_nervous | 1.59516971 |
16 | MP0003656_abnormal_erythrocyte_physiolo | 1.59333604 |
17 | MP0004859_abnormal_synaptic_plasticity | 1.32100226 |
18 | MP0001348_abnormal_lacrimal_gland | 1.25446632 |
19 | MP0003635_abnormal_synaptic_transmissio | 1.20280316 |
20 | MP0000372_irregular_coat_pigmentation | 1.17579403 |
21 | MP0003045_fibrosis | 1.13228134 |
22 | MP0010771_integument_phenotype | 1.11824048 |
23 | MP0001984_abnormal_olfaction | 1.09861682 |
24 | MP0004811_abnormal_neuron_physiology | 1.09733600 |
25 | MP0001299_abnormal_eye_distance/ | 1.09369034 |
26 | MP0005423_abnormal_somatic_nervous | 1.05114111 |
27 | MP0000920_abnormal_myelination | 1.04386969 |
28 | MP0000955_abnormal_spinal_cord | 1.01452912 |
29 | MP0008260_abnormal_autophagy | 1.00096433 |
30 | MP0003329_amyloid_beta_deposits | 0.94116453 |
31 | MP0002064_seizures | 0.88854536 |
32 | MP0002882_abnormal_neuron_morphology | 0.87824721 |
33 | MP0008004_abnormal_stomach_pH | 0.84816418 |
34 | MP0003634_abnormal_glial_cell | 0.84592962 |
35 | MP0010234_abnormal_vibrissa_follicle | 0.84395968 |
36 | MP0000778_abnormal_nervous_system | 0.81676517 |
37 | MP0003633_abnormal_nervous_system | 0.81524242 |
38 | MP0002063_abnormal_learning/memory/cond | 0.80535823 |
39 | MP0000747_muscle_weakness | 0.79598541 |
40 | MP0009745_abnormal_behavioral_response | 0.77266189 |
41 | MP0000427_abnormal_hair_cycle | 0.76058070 |
42 | MP0005083_abnormal_biliary_tract | 0.75323037 |
43 | MP0009046_muscle_twitch | 0.75299407 |
44 | MP0002572_abnormal_emotion/affect_behav | 0.72059307 |
45 | MP0000534_abnormal_ureter_morphology | 0.71651777 |
46 | MP0008874_decreased_physiological_sensi | 0.69280285 |
47 | MP0000604_amyloidosis | 0.67566055 |
48 | MP0002229_neurodegeneration | 0.67221866 |
49 | MP0003300_gastrointestinal_ulcer | 0.66584459 |
50 | MP0003631_nervous_system_phenotype | 0.66171076 |
51 | MP0002752_abnormal_somatic_nervous | 0.65169876 |
52 | MP0009780_abnormal_chondrocyte_physiolo | 0.63873357 |
53 | MP0003880_abnormal_central_pattern | 0.63484769 |
54 | MP0003950_abnormal_plasma_membrane | 0.63372570 |
55 | MP0000538_abnormal_urinary_bladder | 0.62401137 |
56 | MP0004742_abnormal_vestibular_system | 0.58639489 |
57 | MP0002066_abnormal_motor_capabilities/c | 0.56794780 |
58 | MP0005165_increased_susceptibility_to | 0.53812214 |
59 | MP0004142_abnormal_muscle_tone | 0.53637406 |
60 | MP0000749_muscle_degeneration | 0.49484802 |
61 | MP0003566_abnormal_cell_adhesion | 0.48805542 |
62 | MP0005171_absent_coat_pigmentation | 0.47791208 |
63 | MP0008569_lethality_at_weaning | 0.47487880 |
64 | MP0002557_abnormal_social/conspecific_i | 0.47051508 |
65 | MP0003183_abnormal_peptide_metabolism | 0.46048947 |
66 | MP0005408_hypopigmentation | 0.45867850 |
67 | MP0002148_abnormal_hypersensitivity_rea | 0.45775176 |
68 | MP0003172_abnormal_lysosome_physiology | 0.45725898 |
69 | MP0001905_abnormal_dopamine_level | 0.45647118 |
70 | MP0004924_abnormal_behavior | 0.44783023 |
71 | MP0005386_behavior/neurological_phenoty | 0.44783023 |
72 | MP0001664_abnormal_digestion | 0.44344894 |
73 | MP0002909_abnormal_adrenal_gland | 0.43052743 |
74 | MP0010386_abnormal_urinary_bladder | 0.42842691 |
75 | MP0003632_abnormal_nervous_system | 0.40072462 |
76 | MP0004510_myositis | 0.40015415 |
77 | MP0000569_abnormal_digit_pigmentation | 0.39409328 |
78 | MP0004036_abnormal_muscle_relaxation | 0.38452086 |
79 | MP0004145_abnormal_muscle_electrophysio | 0.37435722 |
80 | MP0008961_abnormal_basal_metabolism | 0.36638443 |
81 | MP0005464_abnormal_platelet_physiology | 0.36191044 |
82 | MP0001943_abnormal_respiration | 0.34152331 |
83 | MP0003091_abnormal_cell_migration | 0.33698117 |
84 | MP0002166_altered_tumor_susceptibility | 0.32765079 |
85 | MP0004085_abnormal_heartbeat | 0.31323240 |
86 | MP0001440_abnormal_grooming_behavior | 0.31286888 |
87 | MP0002972_abnormal_cardiac_muscle | 0.30406802 |
88 | MP0000015_abnormal_ear_pigmentation | 0.30356884 |
89 | MP0009765_abnormal_xenobiotic_induced | 0.28693219 |
90 | MP0009379_abnormal_foot_pigmentation | 0.27645593 |
91 | MP0001756_abnormal_urination | 0.27261777 |
92 | MP0002896_abnormal_bone_mineralization | 0.27177110 |
93 | MP0002837_dystrophic_cardiac_calcinosis | 0.26621182 |
94 | MP0003806_abnormal_nucleotide_metabolis | 0.26285008 |
95 | MP0004147_increased_porphyrin_level | 0.26155144 |
96 | MP0009278_abnormal_bone_marrow | 0.25179646 |
97 | MP0005310_abnormal_salivary_gland | 0.23989938 |
98 | MP0001486_abnormal_startle_reflex | 0.23722565 |
99 | MP0000751_myopathy | 0.23580570 |
100 | MP0002069_abnormal_eating/drinking_beha | 0.23185257 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Dysautonomia (HP:0002459) | 7.56964035 |
2 | Ulnar claw (HP:0001178) | 7.00903492 |
3 | Abnormality of pain sensation (HP:0010832) | 5.69570665 |
4 | Impaired pain sensation (HP:0007328) | 5.69570665 |
5 | Insidious onset (HP:0003587) | 5.39780238 |
6 | Termporal pattern (HP:0011008) | 5.39780238 |
7 | Segmental peripheral demyelination/remyelination (HP:0003481) | 5.28412257 |
8 | Abnormal autonomic nervous system physiology (HP:0012332) | 4.53047527 |
9 | Action tremor (HP:0002345) | 4.30920145 |
10 | Decreased number of peripheral myelinated nerve fibers (HP:0003380) | 3.96998177 |
11 | Ankle clonus (HP:0011448) | 3.88441253 |
12 | Hammertoe (HP:0001765) | 3.83344731 |
13 | Pheochromocytoma (HP:0002666) | 3.81084453 |
14 | Myokymia (HP:0002411) | 3.74957182 |
15 | Supranuclear gaze palsy (HP:0000605) | 3.70172107 |
16 | Foot dorsiflexor weakness (HP:0009027) | 3.69144829 |
17 | Onion bulb formation (HP:0003383) | 3.66515166 |
18 | Steppage gait (HP:0003376) | 3.65936095 |
19 | Neuroendocrine neoplasm (HP:0100634) | 3.56861618 |
20 | Focal seizures (HP:0007359) | 3.56637644 |
21 | Submucous cleft hard palate (HP:0000176) | 3.48092127 |
22 | Hypomagnesemia (HP:0002917) | 3.44769442 |
23 | Abnormality of the corticospinal tract (HP:0002492) | 3.40445522 |
24 | Failure to thrive in infancy (HP:0001531) | 3.39118120 |
25 | Abnormality of the foot musculature (HP:0001436) | 3.25192367 |
26 | Autoamputation (HP:0001218) | 3.05873808 |
27 | Abnormality of magnesium homeostasis (HP:0004921) | 3.04646221 |
28 | Hyporeflexia of lower limbs (HP:0002600) | 3.04252279 |
29 | Atonic seizures (HP:0010819) | 2.96045061 |
30 | Abnormality of the vocal cords (HP:0008777) | 2.95413651 |
31 | Distal sensory impairment (HP:0002936) | 2.94056794 |
32 | Peripheral hypomyelination (HP:0007182) | 2.87642145 |
33 | Thyroid carcinoma (HP:0002890) | 2.79945619 |
34 | Potter facies (HP:0002009) | 2.75312274 |
35 | Facial shape deformation (HP:0011334) | 2.75312274 |
36 | Distal arthrogryposis (HP:0005684) | 2.73865945 |
37 | Hypothermia (HP:0002045) | 2.71710649 |
38 | Chin dimple (HP:0010751) | 2.70795719 |
39 | Decreased motor nerve conduction velocity (HP:0003431) | 2.67285594 |
40 | Sensory axonal neuropathy (HP:0003390) | 2.66760184 |
41 | Thoracolumbar scoliosis (HP:0002944) | 2.66511724 |
42 | Spastic gait (HP:0002064) | 2.57459263 |
43 | Myotonia (HP:0002486) | 2.56810222 |
44 | Hypoventilation (HP:0002791) | 2.54650129 |
45 | Impaired proprioception (HP:0010831) | 2.54487795 |
46 | Increased CSF protein (HP:0002922) | 2.53440508 |
47 | Arthropathy (HP:0003040) | 2.50002518 |
48 | Scanning speech (HP:0002168) | 2.46208335 |
49 | Upper limb muscle weakness (HP:0003484) | 2.42437834 |
50 | Urinary urgency (HP:0000012) | 2.39448150 |
51 | Dialeptic seizures (HP:0011146) | 2.36576494 |
52 | Peripheral demyelination (HP:0011096) | 2.29746030 |
53 | Bradycardia (HP:0001662) | 2.22965344 |
54 | Aqueductal stenosis (HP:0002410) | 2.21860777 |
55 | Truncal ataxia (HP:0002078) | 2.21671558 |
56 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.19683919 |
57 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.19683919 |
58 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.17076773 |
59 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 2.16743405 |
60 | Hand muscle atrophy (HP:0009130) | 2.13834745 |
61 | Hypercortisolism (HP:0001578) | 2.10712042 |
62 | Progressive cerebellar ataxia (HP:0002073) | 2.08200756 |
63 | Lower limb muscle weakness (HP:0007340) | 2.04860988 |
64 | Distal lower limb muscle weakness (HP:0009053) | 2.04801212 |
65 | Axonal loss (HP:0003447) | 2.04419709 |
66 | Lower limb asymmetry (HP:0100559) | 2.04316955 |
67 | Anosmia (HP:0000458) | 2.03289407 |
68 | Abnormal hair whorl (HP:0010721) | 2.02983392 |
69 | Cerebral hemorrhage (HP:0001342) | 2.01077808 |
70 | Febrile seizures (HP:0002373) | 2.00563879 |
71 | Hypoplasia of the brainstem (HP:0002365) | 1.99014498 |
72 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 1.99014498 |
73 | Urinary bladder sphincter dysfunction (HP:0002839) | 1.98217791 |
74 | Bowel diverticulosis (HP:0005222) | 1.96749713 |
75 | Clonus (HP:0002169) | 1.96573932 |
76 | Exotropia (HP:0000577) | 1.96206949 |
77 | Areflexia of lower limbs (HP:0002522) | 1.94006713 |
78 | Torticollis (HP:0000473) | 1.92841546 |
79 | Postural tremor (HP:0002174) | 1.90334760 |
80 | Ventricular fibrillation (HP:0001663) | 1.90099259 |
81 | Curly hair (HP:0002212) | 1.85868818 |
82 | Anhidrosis (HP:0000970) | 1.83569165 |
83 | Absence seizures (HP:0002121) | 1.82788553 |
84 | Pes cavus (HP:0001761) | 1.79852830 |
85 | Mask-like facies (HP:0000298) | 1.78589793 |
86 | Episodic fever (HP:0001954) | 1.77203451 |
87 | Distal upper limb amyotrophy (HP:0007149) | 1.74155577 |
88 | Upper limb amyotrophy (HP:0009129) | 1.74155577 |
89 | Overlapping toe (HP:0001845) | 1.73335033 |
90 | Recurrent corneal erosions (HP:0000495) | 1.70180170 |
91 | Focal motor seizures (HP:0011153) | 1.69230177 |
92 | Megalencephaly (HP:0001355) | 1.66803117 |
93 | Rapidly progressive (HP:0003678) | 1.65879651 |
94 | Poor speech (HP:0002465) | 1.65251827 |
95 | Abnormality of calcium-phosphate metabolism (HP:0100530) | 1.64202920 |
96 | Abnormality of the ischium (HP:0003174) | 1.62814864 |
97 | Paraplegia (HP:0010550) | 1.62652253 |
98 | Knee flexion contracture (HP:0006380) | 1.61220010 |
99 | Neoplasm of the thyroid gland (HP:0100031) | 1.61121797 |
100 | Slow progression (HP:0003677) | 1.60342468 |
Rank | Gene Set | Z-score |
---|---|---|
1 | KSR2 | 4.60156251 |
2 | NTRK1 | 4.28690752 |
3 | RIPK4 | 4.14348826 |
4 | LIMK1 | 3.41274519 |
5 | MAP3K2 | 3.34509277 |
6 | MAP3K9 | 2.90797311 |
7 | LMTK2 | 2.42411434 |
8 | ARAF | 2.34840707 |
9 | MATK | 2.26306051 |
10 | STK39 | 2.22113873 |
11 | RET | 2.17094875 |
12 | EPHA3 | 2.15542295 |
13 | MARK3 | 2.14203022 |
14 | EPHB1 | 1.94999745 |
15 | MINK1 | 1.76794616 |
16 | GRK5 | 1.75179463 |
17 | PAK6 | 1.74203480 |
18 | SGK494 | 1.63596868 |
19 | SGK223 | 1.63596868 |
20 | NTRK3 | 1.63142433 |
21 | MAP2K1 | 1.39532658 |
22 | MAP2K2 | 1.39334113 |
23 | RPS6KA2 | 1.38895015 |
24 | MAP3K1 | 1.35998155 |
25 | ADRBK2 | 1.29495619 |
26 | PHKG2 | 1.25646915 |
27 | PHKG1 | 1.25646915 |
28 | YES1 | 1.21151933 |
29 | PRKCE | 1.20194825 |
30 | WNK1 | 1.14105261 |
31 | SGK2 | 1.13323065 |
32 | RAF1 | 1.11486081 |
33 | MAP3K12 | 1.10178300 |
34 | FGFR3 | 1.09654133 |
35 | FGFR2 | 1.07687938 |
36 | MET | 1.04869168 |
37 | FRK | 1.00674745 |
38 | PAK3 | 0.99566760 |
39 | FER | 0.98763852 |
40 | FGFR4 | 0.93395878 |
41 | WNK4 | 0.91817102 |
42 | SGK3 | 0.91061256 |
43 | TRPM7 | 0.87131336 |
44 | PRKG2 | 0.83415043 |
45 | LATS2 | 0.83218290 |
46 | DAPK2 | 0.82201736 |
47 | DYRK2 | 0.80879255 |
48 | MAP3K13 | 0.80807810 |
49 | PRKCG | 0.77957128 |
50 | CSNK1A1L | 0.76349527 |
51 | PRKCH | 0.75802044 |
52 | ADRBK1 | 0.73549935 |
53 | KSR1 | 0.71952922 |
54 | ERBB3 | 0.71224641 |
55 | UHMK1 | 0.71104803 |
56 | PDGFRB | 0.70796793 |
57 | CDK5 | 0.68580727 |
58 | TESK1 | 0.67594286 |
59 | ROCK2 | 0.66476501 |
60 | PRKCZ | 0.63455560 |
61 | SCYL2 | 0.63174538 |
62 | PIM2 | 0.61012423 |
63 | CDK14 | 0.60927311 |
64 | PTK2 | 0.55591050 |
65 | PDK1 | 0.55417760 |
66 | CSNK1G3 | 0.55000138 |
67 | HIPK2 | 0.54164773 |
68 | MARK1 | 0.53952042 |
69 | CSNK1G2 | 0.53681792 |
70 | FYN | 0.53134552 |
71 | DMPK | 0.51604639 |
72 | PRKD3 | 0.51423661 |
73 | PDGFRA | 0.50508901 |
74 | BRAF | 0.50084307 |
75 | MAP2K4 | 0.49538429 |
76 | JAK2 | 0.48845928 |
77 | CDK3 | 0.48155091 |
78 | ROCK1 | 0.48073472 |
79 | CDC42BPA | 0.46608741 |
80 | ERBB2 | 0.46597951 |
81 | JAK3 | 0.44873080 |
82 | MAPK13 | 0.43133034 |
83 | CASK | 0.41930565 |
84 | SRC | 0.41846424 |
85 | CAMK2A | 0.40836617 |
86 | JAK1 | 0.39297873 |
87 | MAPKAPK5 | 0.37635674 |
88 | IGF1R | 0.36670758 |
89 | CAMK2G | 0.35489941 |
90 | PDPK1 | 0.34647140 |
91 | CAMK2D | 0.34443179 |
92 | MST1R | 0.34305147 |
93 | LRRK2 | 0.33243697 |
94 | EPHB2 | 0.32839533 |
95 | TYK2 | 0.32674330 |
96 | LCK | 0.31972704 |
97 | PRKCD | 0.28305272 |
98 | IRAK1 | 0.27504051 |
99 | PRKCA | 0.26408063 |
100 | BCR | 0.26335548 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 2.93084002 |
2 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.83873264 |
3 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 2.66021034 |
4 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 2.29316013 |
5 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.20611561 |
6 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 2.14041018 |
7 | Olfactory transduction_Homo sapiens_hsa04740 | 2.01824585 |
8 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.68689442 |
9 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.65690585 |
10 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 1.64675979 |
11 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.56900593 |
12 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 1.54116329 |
13 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.48243970 |
14 | Insulin secretion_Homo sapiens_hsa04911 | 1.47803900 |
15 | Taste transduction_Homo sapiens_hsa04742 | 1.47311456 |
16 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.46328054 |
17 | Endometrial cancer_Homo sapiens_hsa05213 | 1.45085809 |
18 | Long-term depression_Homo sapiens_hsa04730 | 1.41955658 |
19 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.41261832 |
20 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.37881491 |
21 | Renin-angiotensin system_Homo sapiens_hsa04614 | 1.36144570 |
22 | Thyroid cancer_Homo sapiens_hsa05216 | 1.33392413 |
23 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.32540253 |
24 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.32455029 |
25 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.32311631 |
26 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.30699429 |
27 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.29786630 |
28 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.29315666 |
29 | Salmonella infection_Homo sapiens_hsa05132 | 1.27614178 |
30 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.27531307 |
31 | Glioma_Homo sapiens_hsa05214 | 1.25407369 |
32 | Long-term potentiation_Homo sapiens_hsa04720 | 1.21675056 |
33 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.19472546 |
34 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 1.17894581 |
35 | Circadian entrainment_Homo sapiens_hsa04713 | 1.17563264 |
36 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.15566064 |
37 | Salivary secretion_Homo sapiens_hsa04970 | 1.11856069 |
38 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.10357951 |
39 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.10091973 |
40 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.08416865 |
41 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.08323398 |
42 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 1.05762300 |
43 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 1.05604888 |
44 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.02860614 |
45 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.99063595 |
46 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.97568931 |
47 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.96700986 |
48 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.95294144 |
49 | Melanogenesis_Homo sapiens_hsa04916 | 0.92015947 |
50 | Amoebiasis_Homo sapiens_hsa05146 | 0.91921101 |
51 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.91608972 |
52 | Phagosome_Homo sapiens_hsa04145 | 0.90961200 |
53 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.90849007 |
54 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.90601284 |
55 | Gap junction_Homo sapiens_hsa04540 | 0.89623844 |
56 | Morphine addiction_Homo sapiens_hsa05032 | 0.89238814 |
57 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.89074952 |
58 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.88328813 |
59 | Melanoma_Homo sapiens_hsa05218 | 0.87311213 |
60 | Mineral absorption_Homo sapiens_hsa04978 | 0.86061008 |
61 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.85858049 |
62 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.83997486 |
63 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.83601332 |
64 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.83115962 |
65 | GABAergic synapse_Homo sapiens_hsa04727 | 0.82963379 |
66 | Axon guidance_Homo sapiens_hsa04360 | 0.82339859 |
67 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.80156432 |
68 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.79052404 |
69 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.78157121 |
70 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.78111809 |
71 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.76980782 |
72 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.76182384 |
73 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.74430459 |
74 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.73874262 |
75 | Endocytosis_Homo sapiens_hsa04144 | 0.72109956 |
76 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.70171532 |
77 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.68692294 |
78 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.67719349 |
79 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.67408900 |
80 | Colorectal cancer_Homo sapiens_hsa05210 | 0.65128811 |
81 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.64922933 |
82 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.62248461 |
83 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.61878492 |
84 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.61632411 |
85 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.59217527 |
86 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.59136179 |
87 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.57304298 |
88 | Phototransduction_Homo sapiens_hsa04744 | 0.56783795 |
89 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.55717793 |
90 | Shigellosis_Homo sapiens_hsa05131 | 0.55006170 |
91 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.54230941 |
92 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.54224289 |
93 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.53873923 |
94 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.52711667 |
95 | Hepatitis C_Homo sapiens_hsa05160 | 0.51627762 |
96 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.50630367 |
97 | Viral myocarditis_Homo sapiens_hsa05416 | 0.50579468 |
98 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.50552935 |
99 | Platelet activation_Homo sapiens_hsa04611 | 0.50527029 |
100 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.49128356 |