A4GALT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. This protein, a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1branching involved in prostate gland morphogenesis (GO:0060442)5.99755893
2maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.54362068
3positive regulation of steroid hormone secretion (GO:2000833)4.48537023
4desmosome organization (GO:0002934)4.40953645
5keratan sulfate catabolic process (GO:0042340)4.39062316
6artery development (GO:0060840)4.38644640
7galactose catabolic process (GO:0019388)4.29250764
8prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.22348185
9prostate gland epithelium morphogenesis (GO:0060740)4.21617823
10Golgi transport vesicle coating (GO:0048200)4.12442146
11COPI coating of Golgi vesicle (GO:0048205)4.12442146
12barbed-end actin filament capping (GO:0051016)4.10238122
13protein retention in ER lumen (GO:0006621)4.09460438
14mitotic cell cycle arrest (GO:0071850)4.08557306
15negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.05864213
16notochord development (GO:0030903)4.05437047
17adhesion of symbiont to host cell (GO:0044650)4.04233636
18virion attachment to host cell (GO:0019062)4.04233636
19intestinal epithelial cell development (GO:0060576)4.00816476
20protein heterotrimerization (GO:0070208)3.99424129
21anterior/posterior axis specification, embryo (GO:0008595)3.98904475
22activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.95403557
23UDP-N-acetylglucosamine metabolic process (GO:0006047)3.95285030
24regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.94191082
25nucleotide-sugar biosynthetic process (GO:0009226)3.91934677
26apoptotic process involved in morphogenesis (GO:0060561)3.91597300
27positive regulation of Cdc42 GTPase activity (GO:0043089)3.73609758
28adhesion of symbiont to host (GO:0044406)3.73480219
29GDP-mannose metabolic process (GO:0019673)3.67108592
30protein localization to endosome (GO:0036010)3.66927223
31positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.64159884
32hypotonic response (GO:0006971)3.59517206
33atrioventricular valve morphogenesis (GO:0003181)3.58447624
34mannose metabolic process (GO:0006013)3.56952131
35epithelial cell maturation (GO:0002070)3.55127438
36collagen fibril organization (GO:0030199)3.49150468
37mammary gland development (GO:0030879)3.49052265
38cell-substrate junction assembly (GO:0007044)3.48597798
39cell migration involved in heart development (GO:0060973)3.47453761
40adherens junction assembly (GO:0034333)3.40118636
41skin morphogenesis (GO:0043589)3.35522313
42stress fiber assembly (GO:0043149)3.35108225
43regulation of early endosome to late endosome transport (GO:2000641)3.34818312
44fucose catabolic process (GO:0019317)3.34573479
45L-fucose metabolic process (GO:0042354)3.34573479
46L-fucose catabolic process (GO:0042355)3.34573479
47cellular response to ATP (GO:0071318)3.27493493
48collagen catabolic process (GO:0030574)3.26547933
49focal adhesion assembly (GO:0048041)3.25407998
50cell-substrate adherens junction assembly (GO:0007045)3.25407998
51embryonic process involved in female pregnancy (GO:0060136)3.24001841
52regulation of membrane protein ectodomain proteolysis (GO:0051043)3.23876925
53response to testosterone (GO:0033574)3.23792427
54extracellular fibril organization (GO:0043206)3.23760129
55vascular endothelial growth factor signaling pathway (GO:0038084)3.22711601
56regulation of cardioblast differentiation (GO:0051890)3.22239322
57bundle of His cell to Purkinje myocyte communication (GO:0086069)3.17594185
58collagen metabolic process (GO:0032963)3.16912904
59apoptotic cell clearance (GO:0043277)3.16505385
60cytoskeletal anchoring at plasma membrane (GO:0007016)3.16477608
61dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.16049332
62positive regulation of endothelial cell apoptotic process (GO:2000353)3.15219896
63multicellular organismal catabolic process (GO:0044243)3.12461116
64embryo implantation (GO:0007566)3.09890517
65branching involved in mammary gland duct morphogenesis (GO:0060444)3.08965998
66regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.08367771
67multicellular organismal macromolecule metabolic process (GO:0044259)3.06970910
68activation of MAPKKK activity (GO:0000185)3.06242132
69sarcomere organization (GO:0045214)3.05563607
70activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.05221351
71regulation of apoptotic process involved in morphogenesis (GO:1902337)3.01064115
72pinocytosis (GO:0006907)3.00470653
73fucose metabolic process (GO:0006004)3.00428781
74fibril organization (GO:0097435)2.99853898
75planar cell polarity pathway involved in neural tube closure (GO:0090179)2.97701830
76establishment of apical/basal cell polarity (GO:0035089)2.97414031
77cyclooxygenase pathway (GO:0019371)2.95001361
78cartilage condensation (GO:0001502)2.92165714
79cell aggregation (GO:0098743)2.92165714
80cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.92146838
81hemidesmosome assembly (GO:0031581)2.91647953
82regulation of translational fidelity (GO:0006450)2.90534939
83multicellular organismal metabolic process (GO:0044236)2.90030141
84positive regulation of receptor recycling (GO:0001921)2.89707273
85regulation of SMAD protein import into nucleus (GO:0060390)2.89638681
86intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.89509095
87positive regulation of nuclease activity (GO:0032075)2.89379604
88proline biosynthetic process (GO:0006561)2.88956688
89vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.88173775
90establishment or maintenance of monopolar cell polarity (GO:0061339)2.88063055
91establishment of monopolar cell polarity (GO:0061162)2.88063055
92nucleotide-sugar metabolic process (GO:0009225)2.87478826
93endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.82529174
94bone trabecula formation (GO:0060346)2.81050451
95regulation of receptor binding (GO:1900120)2.80937729
96negative regulation of adherens junction organization (GO:1903392)2.80525835
97negative regulation of focal adhesion assembly (GO:0051895)2.80525835
98negative regulation of cell junction assembly (GO:1901889)2.80525835
99N-glycan processing (GO:0006491)2.80423027
100apoptotic process involved in development (GO:1902742)2.79235875
101extracellular matrix disassembly (GO:0022617)2.78598716
102regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.76755138
103positive regulation of SMAD protein import into nucleus (GO:0060391)2.74949144
104endoplasmic reticulum unfolded protein response (GO:0030968)2.74111647
105embryonic skeletal joint morphogenesis (GO:0060272)2.73833241
106hyaluronan catabolic process (GO:0030214)2.71398195
107negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.70282930
108cellular response to unfolded protein (GO:0034620)2.70085376
109tooth mineralization (GO:0034505)2.69362348
110low-density lipoprotein particle clearance (GO:0034383)2.67783838
111regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.65746711
112regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.65293831
113regulation of nuclease activity (GO:0032069)2.65046819
114valine metabolic process (GO:0006573)2.64450956
115pathway-restricted SMAD protein phosphorylation (GO:0060389)2.63925338
116epithelial cell-cell adhesion (GO:0090136)2.63825529
117ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.63088589
118glycoprotein catabolic process (GO:0006516)2.62760117
119regulation of posttranscriptional gene silencing (GO:0060147)2.61819787
120regulation of gene silencing by miRNA (GO:0060964)2.61819787
121regulation of gene silencing by RNA (GO:0060966)2.61819787
122branching involved in salivary gland morphogenesis (GO:0060445)2.61804766
123decidualization (GO:0046697)2.61066940
124regulation of vitamin D biosynthetic process (GO:0060556)2.60026200
125basement membrane organization (GO:0071711)2.59342559
126cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.59235608
127peptidyl-proline hydroxylation (GO:0019511)2.59059226
128interleukin-6-mediated signaling pathway (GO:0070102)2.57272023
129pentose-phosphate shunt (GO:0006098)2.56349791
130regulation of the force of heart contraction (GO:0002026)2.55332455
131semaphorin-plexin signaling pathway (GO:0071526)2.55002042
132negative regulation of protein autophosphorylation (GO:0031953)2.54683771
133wound healing, spreading of epidermal cells (GO:0035313)2.54121349
134regulation of steroid hormone secretion (GO:2000831)2.53084972
135extracellular matrix assembly (GO:0085029)2.53011206
136galactose metabolic process (GO:0006012)2.51980686
137positive regulation of natural killer cell differentiation (GO:0032825)2.51861562
138positive regulation of catenin import into nucleus (GO:0035413)2.51719131
139diaphragm development (GO:0060539)2.51589113
140type B pancreatic cell proliferation (GO:0044342)2.49813605
141cranial suture morphogenesis (GO:0060363)2.49655670
142cellular response to topologically incorrect protein (GO:0035967)2.49185728
143interferon-gamma secretion (GO:0072643)2.48937305
144endothelial cell morphogenesis (GO:0001886)2.48764614
145negative regulation of viral release from host cell (GO:1902187)2.47339290
146cardiac myofibril assembly (GO:0055003)2.46774284
147positive regulation of blood vessel endothelial cell migration (GO:0043536)2.45790311
148response to endoplasmic reticulum stress (GO:0034976)2.45540871
149chondrocyte development (GO:0002063)2.45392780
150endodermal cell differentiation (GO:0035987)2.45032291
151negative regulation of androgen receptor signaling pathway (GO:0060766)2.43948263
152lung secretory cell differentiation (GO:0061140)2.43717389
153paraxial mesoderm development (GO:0048339)2.43278137
154ER-nucleus signaling pathway (GO:0006984)2.43123663
155venous blood vessel morphogenesis (GO:0048845)2.42046753
156diol metabolic process (GO:0034311)2.41128745
157replicative senescence (GO:0090399)2.40716449
158response to laminar fluid shear stress (GO:0034616)2.40694822
159regulation of hippo signaling (GO:0035330)2.40682140
160regulation of tight junction assembly (GO:2000810)2.39059740
161cell migration involved in gastrulation (GO:0042074)2.38439521
162heart trabecula formation (GO:0060347)2.38423815
163retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.37442200
164hormone catabolic process (GO:0042447)2.37116252
165endothelial cell chemotaxis (GO:0035767)2.36639278
166glomerular basement membrane development (GO:0032836)2.36163476
167retina vasculature morphogenesis in camera-type eye (GO:0061299)2.36147736
168regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.34966942
169maternal placenta development (GO:0001893)2.32665675
170regulation of response to osmotic stress (GO:0047484)2.32111071
171modulation by symbiont of host cellular process (GO:0044068)2.31395881
172craniofacial suture morphogenesis (GO:0097094)2.28454426
173trabecula formation (GO:0060343)2.28371240
174glucose catabolic process (GO:0006007)2.28279901
175endocytic recycling (GO:0032456)2.26025165
176branching involved in labyrinthine layer morphogenesis (GO:0060670)2.25106882
177negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.23850779
178surfactant homeostasis (GO:0043129)2.23471317
179regulation of metalloenzyme activity (GO:0048552)2.22375671

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.13276319
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.13276319
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.13276319
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.08523759
5NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.60772611
6* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.42695605
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.25045555
8E2F7_22180533_ChIP-Seq_HELA_Human3.17704939
9TRIM28_21343339_ChIP-Seq_HEK293_Human3.09852101
10SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.59333512
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.52269004
12LXR_22292898_ChIP-Seq_THP-1_Human2.51498013
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.47266285
14STAT3_1855785_ChIP-Seq_MESCs_Mouse2.46302946
15NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.38194207
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.33298842
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.33146956
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.29676023
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.26320628
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.25750587
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.24719243
22ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.21912172
23* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.19131366
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.16734326
25TCF3_18692474_ChIP-Seq_MEFs_Mouse2.16599363
26HIF1A_21447827_ChIP-Seq_MCF-7_Human2.10609569
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.07025401
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.02380171
29KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.00859790
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.95564121
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.93334631
32* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.92832921
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.92530943
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88228862
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.86807355
36NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.86744050
37SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.85824503
38SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.85824503
39VDR_21846776_ChIP-Seq_THP-1_Human1.81952506
40SOX2_20726797_ChIP-Seq_SW620_Human1.80314819
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79942013
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.79486646
43CLOCK_20551151_ChIP-Seq_293T_Human1.79180298
44NANOG_18692474_ChIP-Seq_MEFs_Mouse1.77611832
45* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75171546
46UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.68976245
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66576305
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66037552
49SALL4_18804426_ChIP-ChIP_XEN_Mouse1.65989867
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.58781228
51AR_21909140_ChIP-Seq_LNCAP_Human1.57923510
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.57694900
53* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.56520870
54NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.55125028
55ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.54294086
56SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.51744959
57MYC_19079543_ChIP-ChIP_MESCs_Mouse1.51624887
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.50909414
59TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49057876
60KDM2B_26808549_Chip-Seq_K562_Human1.47559267
61MYC_18555785_ChIP-Seq_MESCs_Mouse1.46471165
62SOX2_18692474_ChIP-Seq_MEFs_Mouse1.46075695
63* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.45170602
64KDM2B_26808549_Chip-Seq_DND41_Human1.45024706
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.44963793
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44759182
67TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.44293409
68CDX2_20551321_ChIP-Seq_CACO-2_Human1.43380422
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41864579
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40564481
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.40268533
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37613531
73MYC_22102868_ChIP-Seq_BL_Human1.36431606
74TCF7_22412390_ChIP-Seq_EML_Mouse1.35973034
75TBX20_22080862_ChIP-Seq_HEART_Mouse1.34936715
76TBX20_22328084_ChIP-Seq_HEART_Mouse1.34936715
77SA1_27219007_Chip-Seq_ERYTHROID_Human1.34678908
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33771978
79CJUN_26792858_Chip-Seq_BT549_Human1.33367076
80* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33070956
81TET1_21451524_ChIP-Seq_MESCs_Mouse1.32583417
82EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.31490263
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30737641
84* SMC4_20622854_ChIP-Seq_HELA_Human1.30091910
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.29858635
86EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.28616757
87ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28490892
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27493905
89PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26000536
90KAP1_27257070_Chip-Seq_ESCs_Mouse1.25717186
91GATA3_24758297_ChIP-Seq_MCF-7_Human1.25200698
92* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24826901
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24630743
94* RUNX1_27514584_Chip-Seq_MCF-7_Human1.22818537
95P68_20966046_ChIP-Seq_HELA_Human1.22741767
96ESR1_20079471_ChIP-ChIP_T-47D_Human1.21516466
97* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20932241
98ATF3_27146783_Chip-Seq_COLON_Human1.19673343
99CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18981411
100* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18622508
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15989285
102RACK7_27058665_Chip-Seq_MCF-7_Human1.15784588
103FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15686363
104* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15201748
105ZNF263_19887448_ChIP-Seq_K562_Human1.13782126
106SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13406061
107* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12624132
108NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12194083
109* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.11878931
110WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11747376
111RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11074875
112CREB1_26743006_Chip-Seq_LNCaP_Human1.10862352
113GATA6_25053715_ChIP-Seq_YYC3_Human1.09686064
114ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.09507913
115SMC1_22415368_ChIP-Seq_MEFs_Mouse1.09257557
116UBF1/2_26484160_Chip-Seq_HMECs_Human1.09162896
117TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08855935
118SMC3_22415368_ChIP-Seq_MEFs_Mouse1.08676793
119DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07956853
120GATA4_25053715_ChIP-Seq_YYC3_Human1.06138083
121JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04440292
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03263909
123TP63_22573176_ChIP-Seq_HFKS_Human1.02776782
124OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02565945
125POU5F1_16518401_ChIP-PET_MESCs_Mouse1.02464666
126VDR_24763502_ChIP-Seq_THP-1_Human1.01211589
127ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00677120
128ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99752570
129RXR_22158963_ChIP-Seq_LIVER_Mouse0.99658884
130BCOR_27268052_Chip-Seq_Bcells_Human0.99537855
131PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99033826
132CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99007133
133* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98802469
134NANOG_16518401_ChIP-PET_MESCs_Mouse0.98762050
135DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98451458
136FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98087678
137PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98043452
138BRD4_25478319_ChIP-Seq_HGPS_Human0.97239987
139SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97081129
140CTCF_27219007_Chip-Seq_Bcells_Human0.96934551
141NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96432433
142MYC_19030024_ChIP-ChIP_MESCs_Mouse0.96401992
143TET1_21490601_ChIP-Seq_MESCs_Mouse0.96244094
144CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95192052
145STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.95152249
146GATA1_19941826_ChIP-Seq_K562_Human0.94857060
147FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94576369
148KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94270813
149FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.93878174
150NCOR1_26117541_ChIP-Seq_K562_Human0.93256268
151* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92922552
152PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.92917943
153TP53_22127205_ChIP-Seq_IMR90_Human0.91534396
154ELF1_20517297_ChIP-Seq_JURKAT_Human0.91383146
155TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90964675
156GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90178472
157JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87658531
158ELK3_25401928_ChIP-Seq_HUVEC_Human0.87192411
159ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87190845
160* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86645724
161POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.85552495
162ELK1_22589737_ChIP-Seq_MCF10A_Human0.85534804
163NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.85410113
164CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84774765
165CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.84683546

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.84039493
2MP0005275_abnormal_skin_tensile3.21733956
3MP0006054_spinal_hemorrhage3.05937228
4MP0005503_abnormal_tendon_morphology2.84609940
5MP0000751_myopathy2.73806319
6MP0004272_abnormal_basement_membrane2.59003646
7MP0005310_abnormal_salivary_gland2.58772470
8MP0005058_abnormal_lysosome_morphology2.46405979
9MP0004510_myositis2.42963148
10MP0003705_abnormal_hypodermis_morpholog2.29293847
11MP0010386_abnormal_urinary_bladder2.28135580
12MP0009840_abnormal_foam_cell2.27964738
13MP0003566_abnormal_cell_adhesion2.23239472
14MP0000516_abnormal_urinary_system2.12956618
15MP0005367_renal/urinary_system_phenotyp2.12956618
16MP0002166_altered_tumor_susceptibility2.10759105
17MP0003279_aneurysm2.10707906
18MP0010352_gastrointestinal_tract_polyps2.09495968
19MP0001958_emphysema2.05447406
20MP0003453_abnormal_keratinocyte_physiol2.04710228
21MP0000537_abnormal_urethra_morphology2.02736994
22MP0005023_abnormal_wound_healing2.01541683
23MP0005451_abnormal_body_composition1.93117770
24MP0003941_abnormal_skin_development1.90703326
25MP0002009_preneoplasia1.89156697
26MP0003303_peritoneal_inflammation1.89082296
27MP0008004_abnormal_stomach_pH1.86466117
28MP0004264_abnormal_extraembryonic_tissu1.85311940
29MP0002254_reproductive_system_inflammat1.76660906
30MP0010234_abnormal_vibrissa_follicle1.72507836
31MP0002006_tumorigenesis1.71464734
32MP0005508_abnormal_skeleton_morphology1.69823407
33MP0001849_ear_inflammation1.67647210
34MP0005330_cardiomyopathy1.66685058
35MP0001542_abnormal_bone_strength1.62074663
36MP0003300_gastrointestinal_ulcer1.60332690
37MP0004233_abnormal_muscle_weight1.57606946
38MP0001756_abnormal_urination1.54913859
39MP0008260_abnormal_autophagy1.51808832
40MP0005647_abnormal_sex_gland1.51343875
41MP0003191_abnormal_cellular_cholesterol1.50959815
42MP0002060_abnormal_skin_morphology1.49362317
43MP0003315_abnormal_perineum_morphology1.47652654
44MP0002877_abnormal_melanocyte_morpholog1.47648346
45MP0004084_abnormal_cardiac_muscle1.47462232
46MP0009384_cardiac_valve_regurgitation1.46242949
47MP0000343_altered_response_to1.46230132
48MP0002295_abnormal_pulmonary_circulatio1.45751444
49MP0000767_abnormal_smooth_muscle1.39256048
50MP0005670_abnormal_white_adipose1.38726301
51MP0005165_increased_susceptibility_to1.38147067
52MP0001873_stomach_inflammation1.37767311
53MP0005164_abnormal_response_to1.36832427
54MP0000538_abnormal_urinary_bladder1.36113780
55MP0005501_abnormal_skin_physiology1.34944977
56MP0002282_abnormal_trachea_morphology1.33461657
57MP0004134_abnormal_chest_morphology1.30368444
58MP0000613_abnormal_salivary_gland1.29841321
59MP0004087_abnormal_muscle_fiber1.29780029
60MP0005375_adipose_tissue_phenotype1.28209813
61MP0000163_abnormal_cartilage_morphology1.27508876
62MP0004858_abnormal_nervous_system1.27391119
63MP0003950_abnormal_plasma_membrane1.26738959
64MP0000762_abnormal_tongue_morphology1.24221655
65MP0005623_abnormal_meninges_morphology1.22904598
66MP0000003_abnormal_adipose_tissue1.22758618
67MP0005666_abnormal_adipose_tissue1.22543031
68MP0009780_abnormal_chondrocyte_physiolo1.22315411
69MP0000749_muscle_degeneration1.22133315
70MP0002896_abnormal_bone_mineralization1.20025296
71MP0000759_abnormal_skeletal_muscle1.19674642
72MP0000534_abnormal_ureter_morphology1.16250240
73MP0004185_abnormal_adipocyte_glucose1.15773754
74MP0010368_abnormal_lymphatic_system1.14007553
75MP0000013_abnormal_adipose_tissue1.13604109
76MP0000733_abnormal_muscle_development1.12993029
77MP0002115_abnormal_skeleton_extremities1.12125432
78MP0010630_abnormal_cardiac_muscle1.11919571
79MP0000747_muscle_weakness1.11574974
80MP0010030_abnormal_orbit_morphology1.10954473
81MP0002972_abnormal_cardiac_muscle1.10505512
82MP0001765_abnormal_ion_homeostasis1.10010054
83MP0006138_congestive_heart_failure1.07866263
84MP0004036_abnormal_muscle_relaxation1.06745890
85MP0002113_abnormal_skeleton_development1.03213156
86MP0005390_skeleton_phenotype1.02818331
87MP0002933_joint_inflammation1.02597614
88MP0001243_abnormal_dermal_layer1.01557693
89MP0002332_abnormal_exercise_endurance1.01254444
90MP0001919_abnormal_reproductive_system1.00224991
91MP0002111_abnormal_tail_morphology0.99178275
92MP0000627_abnormal_mammary_gland0.99113788
93MP0003091_abnormal_cell_migration0.97065031
94MP0001879_abnormal_lymphatic_vessel0.96740650
95MP0003448_altered_tumor_morphology0.96650584
96MP0002160_abnormal_reproductive_system0.96644482
97MP0003075_altered_response_to0.95898002
98MP0003828_pulmonary_edema0.94944882
99MP0000750_abnormal_muscle_regeneration0.94226210
100MP0002132_abnormal_respiratory_system0.93188683
101MP0002089_abnormal_postnatal_growth/wei0.91574143
102MP0005595_abnormal_vascular_smooth0.91219597
103MP0001216_abnormal_epidermal_layer0.91112702
104MP0002136_abnormal_kidney_physiology0.90852072
105MP0003045_fibrosis0.90785509
106MP0005389_reproductive_system_phenotype0.90556647
107MP0004957_abnormal_blastocyst_morpholog0.89978126
108MP0002796_impaired_skin_barrier0.89756349
109MP0004947_skin_inflammation0.89714417
110MP0003724_increased_susceptibility_to0.89030521
111MP0003186_abnormal_redox_activity0.88489010
112MP0000858_altered_metastatic_potential0.88252980
113MP0002086_abnormal_extraembryonic_tissu0.86746749
114MP0009278_abnormal_bone_marrow0.85386451
115MP0003936_abnormal_reproductive_system0.85315587
116MP0001348_abnormal_lacrimal_gland0.84769398
117MP0000467_abnormal_esophagus_morphology0.84719832
118MP0004883_abnormal_blood_vessel0.84143678
119MP0002108_abnormal_muscle_morphology0.83893336
120MP0005076_abnormal_cell_differentiation0.83756445
121MP0002396_abnormal_hematopoietic_system0.82695567
122MP0001915_intracranial_hemorrhage0.82558643
123MP0009250_abnormal_appendicular_skeleto0.81988810
124MP0002837_dystrophic_cardiac_calcinosis0.81750997
125MP0003693_abnormal_embryo_hatching0.80888147
126MP0003795_abnormal_bone_structure0.80351973
127MP0000490_abnormal_crypts_of0.80040110
128MP0001533_abnormal_skeleton_physiology0.79524352
129MP0002109_abnormal_limb_morphology0.79273998
130MP0005257_abnormal_intraocular_pressure0.79069042
131MP0003890_abnormal_embryonic-extraembry0.78705068
132MP0000681_abnormal_thyroid_gland0.78509906
133MP0003329_amyloid_beta_deposits0.78125131
134MP0009333_abnormal_splenocyte_physiolog0.77453176
135MP0005083_abnormal_biliary_tract0.77419736
136MP0002269_muscular_atrophy0.76153834
137MP0003937_abnormal_limbs/digits/tail_de0.75690637
138MP0000678_abnormal_parathyroid_gland0.75518381
139MP0010771_integument_phenotype0.75359699
140MP0001299_abnormal_eye_distance/0.74849500
141MP0003718_maternal_effect0.74750623
142MP0000462_abnormal_digestive_system0.73657944
143MP0002925_abnormal_cardiovascular_devel0.73434431
144MP0002148_abnormal_hypersensitivity_rea0.73431851
145MP0009931_abnormal_skin_appearance0.73283606
146MP0003436_decreased_susceptibility_to0.73236343
147MP0005620_abnormal_muscle_contractility0.71686684
148MP0001614_abnormal_blood_vessel0.70888002
149MP0002106_abnormal_muscle_physiology0.70858581
150MP0002277_abnormal_respiratory_mucosa0.70843572
151MP0000432_abnormal_head_morphology0.70482723
152MP0002998_abnormal_bone_remodeling0.70004900
153MP0002135_abnormal_kidney_morphology0.67330019
154MP0001346_abnormal_lacrimal_gland0.66638717
155MP0010155_abnormal_intestine_physiology0.65794562
156MP0002114_abnormal_axial_skeleton0.65220569
157MP0009643_abnormal_urine_homeostasis0.64689683

Predicted human phenotypes

RankGene SetZ-score
1Hypoplastic ischia (HP:0003175)4.08297971
2Cervical subluxation (HP:0003308)4.00715050
3Abnormality of the ischium (HP:0003174)3.78699155
4Aortic dissection (HP:0002647)3.69732490
5Aortic aneurysm (HP:0004942)3.66150414
6Short hallux (HP:0010109)3.36892271
7Vertebral compression fractures (HP:0002953)3.31482424
8Ankle contracture (HP:0006466)3.18896842
9Premature rupture of membranes (HP:0001788)3.18059410
10Epiphyseal dysplasia (HP:0002656)3.17849101
11Irregular epiphyses (HP:0010582)3.16645117
12Aplasia/Hypoplasia of the hallux (HP:0008362)3.08052534
13Thoracolumbar scoliosis (HP:0002944)2.90266101
14Protrusio acetabuli (HP:0003179)2.88197921
15Short humerus (HP:0005792)2.87803464
16Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.87802213
17Shawl scrotum (HP:0000049)2.83976133
18Aplasia/hypoplasia of the humerus (HP:0006507)2.80899168
19Distal lower limb amyotrophy (HP:0008944)2.80678175
20Increased variability in muscle fiber diameter (HP:0003557)2.80559065
21Ventricular tachycardia (HP:0004756)2.79422976
22Asymmetric septal hypertrophy (HP:0001670)2.74257322
23Abnormality of cochlea (HP:0000375)2.72309413
24Muscle fiber splitting (HP:0003555)2.70296855
25Metaphyseal cupping (HP:0003021)2.69189135
26Abnormal tarsal ossification (HP:0008369)2.66077056
27Vascular tortuosity (HP:0004948)2.65297772
28Abnormality of the proximal phalanges of the hand (HP:0009834)2.64082919
29Vitreoretinal degeneration (HP:0000655)2.63204403
30Bladder diverticulum (HP:0000015)2.61922573
31Abnormal foot bone ossification (HP:0010675)2.60889190
32Upper limb amyotrophy (HP:0009129)2.60872229
33Distal upper limb amyotrophy (HP:0007149)2.60872229
34Broad metatarsal (HP:0001783)2.51811302
35Ulnar bowing (HP:0003031)2.49343337
36Short nail (HP:0001799)2.49275792
37Abnormality of glycolipid metabolism (HP:0010969)2.49251932
38Abnormality of liposaccharide metabolism (HP:0010968)2.49251932
39Abnormality of glycosphingolipid metabolism (HP:0004343)2.49251932
40Radial bowing (HP:0002986)2.47529516
41Shallow orbits (HP:0000586)2.46924610
42Abnormality of skeletal muscle fiber size (HP:0012084)2.46128112
43Coxa valga (HP:0002673)2.45475432
44Flat capital femoral epiphysis (HP:0003370)2.45405161
45Cupped ribs (HP:0000887)2.44179586
46Genu recurvatum (HP:0002816)2.43037508
47Natal tooth (HP:0000695)2.42197745
48Aplasia of the musculature (HP:0100854)2.41881435
49Neonatal short-limb short stature (HP:0008921)2.41611065
50Absent frontal sinuses (HP:0002688)2.40880567
51Mesomelia (HP:0003027)2.37592966
52Osteolytic defects of the hand bones (HP:0009699)2.36822642
53Osteolytic defects of the phalanges of the hand (HP:0009771)2.36822642
54Increased connective tissue (HP:0009025)2.35393740
55Achilles tendon contracture (HP:0001771)2.35157671
56Platyspondyly (HP:0000926)2.35098698
57Testicular atrophy (HP:0000029)2.33745974
58Centrally nucleated skeletal muscle fibers (HP:0003687)2.31883641
59Emphysema (HP:0002097)2.31247122
60Elbow flexion contracture (HP:0002987)2.30816541
61Distal lower limb muscle weakness (HP:0009053)2.30412234
62Wormian bones (HP:0002645)2.28421338
63Atrophic scars (HP:0001075)2.27295750
64Sudden death (HP:0001699)2.27102136
65Trismus (HP:0000211)2.26470761
66Abnormality of the nasal mucosa (HP:0000433)2.22684417
67Dilatation of the ascending aorta (HP:0005111)2.20749118
68Cerebral aneurysm (HP:0004944)2.20406273
69Hyporeflexia of lower limbs (HP:0002600)2.19687048
70Slender build (HP:0001533)2.18454284
71Follicular hyperkeratosis (HP:0007502)2.17083264
72Lipoatrophy (HP:0100578)2.16384253
73Round ear (HP:0100830)2.14931941
74Arterial tortuosity (HP:0005116)2.14868737
75Delayed epiphyseal ossification (HP:0002663)2.12805518
76Advanced eruption of teeth (HP:0006288)2.11261338
77Axonal loss (HP:0003447)2.11028018
78Difficulty climbing stairs (HP:0003551)2.10459956
79Flat acetabular roof (HP:0003180)2.09923233
80Right ventricular cardiomyopathy (HP:0011663)2.06686964
81Absent toe (HP:0010760)2.05587421
82Breast hypoplasia (HP:0003187)2.05485168
83Hypoplastic scapulae (HP:0000882)2.04707827
84Aplasia/Hypoplasia of the scapulae (HP:0006713)2.04707827
85Beaking of vertebral bodies (HP:0004568)2.04570799
86Diaphragmatic weakness (HP:0009113)2.03577775
87Spondylolisthesis (HP:0003302)2.03295790
88Mitral regurgitation (HP:0001653)2.03160863
89Spinal rigidity (HP:0003306)2.02142516
90Knee flexion contracture (HP:0006380)2.01942971
91Aplastic anemia (HP:0001915)1.98988025
92Bulbar palsy (HP:0001283)1.98792994
93Wrist flexion contracture (HP:0001239)1.98185395
94Soft skin (HP:0000977)1.97674047
95Alopecia of scalp (HP:0002293)1.97411995
96Joint laxity (HP:0001388)1.97358565
97Abnormality of the Achilles tendon (HP:0005109)1.97173846
98Carpal synostosis (HP:0009702)1.96679937
99Gastrointestinal stroma tumor (HP:0100723)1.96412134
100Thin bony cortex (HP:0002753)1.95973386
101Abnormality of the 2nd finger (HP:0004100)1.95266323
102Abnormality of the distal phalanges of the toes (HP:0010182)1.95080798
103Dysostosis multiplex (HP:0000943)1.94838336
104Abnormal vertebral ossification (HP:0100569)1.94305723
105Spinal muscular atrophy (HP:0007269)1.94146872
106Nuclear cataract (HP:0100018)1.94044590
107Carpal bone hypoplasia (HP:0001498)1.93413418
108Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.92551455
109Synostosis of carpal bones (HP:0005048)1.92004354
110Type 1 muscle fiber predominance (HP:0003803)1.91969025
111Hyperacusis (HP:0010780)1.91444634
112Hydroxyprolinuria (HP:0003080)1.91006512
113Abnormality of proline metabolism (HP:0010907)1.91006512
114Widely patent fontanelles and sutures (HP:0004492)1.90592865
115Fused cervical vertebrae (HP:0002949)1.88836170
116Ragged-red muscle fibers (HP:0003200)1.88615729
117Nonimmune hydrops fetalis (HP:0001790)1.88544029
118Limited hip movement (HP:0008800)1.88349388
119Ulnar deviation of the wrist (HP:0003049)1.87933403
120Bundle branch block (HP:0011710)1.87525526
121Flattened epiphyses (HP:0003071)1.86267463
122Small epiphyses (HP:0010585)1.86096606
123Biconcave vertebral bodies (HP:0004586)1.85742192
124Stillbirth (HP:0003826)1.84500437
125Acanthosis nigricans (HP:0000956)1.83619855
126Hip contracture (HP:0003273)1.82933975
127Aneurysm (HP:0002617)1.82825545
128Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.82082977
129Vertebral hypoplasia (HP:0008417)1.82082977
130Blue sclerae (HP:0000592)1.81997056
131Genu varum (HP:0002970)1.81445596
132Wide cranial sutures (HP:0010537)1.81423820
133Myopathic facies (HP:0002058)1.80117933
134Congenital, generalized hypertrichosis (HP:0004540)1.79998754
135Selective tooth agenesis (HP:0001592)1.79928958
136Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.78925390
137Abnormal hemoglobin (HP:0011902)1.78143677
138Abnormality of the acetabulum (HP:0003170)1.78009694
139Hypercortisolism (HP:0001578)1.77534055
140Persistence of primary teeth (HP:0006335)1.77155227
141Abnormality of the umbilical cord (HP:0010881)1.76977636
142Osteoarthritis (HP:0002758)1.76213132
143Hypoplasia of the ulna (HP:0003022)1.75215967
144Abnormality of polysaccharide metabolism (HP:0011012)1.74432290
145Abnormality of glycosaminoglycan metabolism (HP:0004371)1.74432290
146Abnormality of mucopolysaccharide metabolism (HP:0011020)1.74432290
147Abnormality of the calf musculature (HP:0001430)1.74139023
148Abnormality of the calcaneus (HP:0008364)1.74031513
149Aortic regurgitation (HP:0001659)1.73356627
150Mildly elevated creatine phosphokinase (HP:0008180)1.73244109
151Joint stiffness (HP:0001387)1.72786822
152Generalized amyotrophy (HP:0003700)1.72409160
153Hand muscle atrophy (HP:0009130)1.72040012
154Stridor (HP:0010307)1.71817209
155Fragile skin (HP:0001030)1.71576156
156Polycythemia (HP:0001901)1.71491945
157Abnormality of secondary sexual hair (HP:0009888)1.71015677
158Abnormality of the axillary hair (HP:0100134)1.71015677
159Mucopolysacchariduria (HP:0008155)1.70567562
160Urinary glycosaminoglycan excretion (HP:0003541)1.70567562
161Bowed forearm bones (HP:0003956)1.70561712
162Bowing of the arm (HP:0006488)1.70561712
163Abnormality of dentin (HP:0010299)1.70545205
164Hyperextensible skin (HP:0000974)1.70140150
165Long toe (HP:0010511)1.69387752
166Lower limb amyotrophy (HP:0007210)1.68743809
167Esophageal varix (HP:0002040)1.63031919

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT36.26723927
2MST43.78714590
3EPHA23.71795743
4TRIB33.51593407
5FRK3.37039308
6LATS13.27983219
7SMG13.05752196
8DDR22.84129269
9PRPF4B2.82751273
10MYLK2.72813090
11MAPKAPK32.60122049
12PDK22.56076075
13ERN12.38341703
14STK38L2.32582546
15TTN2.16770614
16TAOK22.02262438
17RPS6KB21.87413062
18KDR1.83435494
19MAP3K31.83388621
20ICK1.73502547
21STK391.69515266
22CDC42BPA1.69072889
23TGFBR21.68764255
24FER1.65302736
25EEF2K1.63218503
26PDGFRA1.62579069
27SCYL21.60842814
28TRPM71.59684151
29LATS21.59524093
30TAOK31.51336610
31STK101.45227164
32LMTK21.44937939
33PBK1.44139098
34MATK1.43181874
35DMPK1.38752252
36NUAK11.38195677
37ZAK1.36550155
38TIE11.27886345
39STK31.23553600
40PIM21.22655873
41TBK11.21452841
42MET1.17960244
43PRKCI1.15172929
44MAP3K61.03603609
45CDK120.98996705
46JAK30.97535033
47TGFBR10.96727588
48TESK20.96417119
49TNK20.95775308
50MUSK0.94104101
51PKN20.92854399
52TAOK10.92578278
53TESK10.91270614
54PIK3CG0.90433843
55FGFR40.89072514
56EPHB10.89034877
57ABL20.88807328
58NEK90.87597320
59MST1R0.86655584
60DAPK30.85179045
61PRKD20.84769346
62LRRK20.83570823
63MAP2K30.83494499
64MAP3K130.80834331
65CDK70.80161242
66OXSR10.78616193
67GRK10.78184301
68PINK10.76933716
69IRAK30.76883737
70MAP3K10.75191294
71MAP3K20.71317033
72GRK50.70540239
73STK40.70301582
74PAK40.69393866
75EIF2AK30.69322263
76PLK40.68502678
77MOS0.68023673
78PAK20.67324920
79PHKG20.67110496
80PHKG10.67110496
81ILK0.64207413
82BCKDK0.63356139
83LIMK10.60984666
84PIM10.60496560
85EPHB20.59776856
86MAP2K20.59220402
87MARK20.59119700
88GRK70.58871499
89PRKG20.58345212
90STK240.58142826
91NME10.56960175
92MAPK150.56441970
93PDPK10.54704180
94RPS6KC10.54443543
95RPS6KL10.54443543
96RIPK10.52823554
97CAMK2G0.52230197
98PAK10.51627502
99NEK60.51455076
100MAPK110.51231293
101AURKB0.50792780
102SIK10.50412084
103ROCK20.49784617
104STK380.48455676
105EIF2AK20.46877406
106YES10.46424668
107RPS6KA60.46086173
108TTK0.46037599
109PRKD10.45962241
110AURKA0.45934958
111MAP3K70.44903999
112MAP3K80.44835759
113FLT30.44348000
114IKBKB0.43211931
115NTRK10.42832504
116MAPK70.42446351
117NME20.42437379
118HIPK20.41299774
119BRSK20.40852640
120MTOR0.40623904
121PTK20.39538586
122JAK10.38959159
123MELK0.38828117
124PDGFRB0.38749582
125MAPKAPK20.38051669
126ARAF0.37559017
127MAPK40.37458083
128MAP3K140.36324707
129ROCK10.36195626
130BRAF0.35782690
131EIF2AK10.33985995
132BMX0.33939598
133ADRBK10.33375347
134MAP3K90.32098434
135MAP2K10.31501815
136PTK60.31482543
137RPS6KA20.30452572
138MAP3K110.29992698
139WEE10.29936508
140CHUK0.29592013
141BMPR1B0.28585661
142PDK30.28540687
143PDK40.28540687
144AKT20.28295317
145PLK10.27234571
146PIK3CA0.25465448
147CSK0.23149804

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.16802169
2Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.84495324
3* Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.68467344
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.66882588
5Other glycan degradation_Homo sapiens_hsa005112.55303109
6Folate biosynthesis_Homo sapiens_hsa007902.39646286
7Protein digestion and absorption_Homo sapiens_hsa049742.15724612
8Dilated cardiomyopathy_Homo sapiens_hsa054142.13633823
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07102682
10Focal adhesion_Homo sapiens_hsa045102.04528373
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.93288919
12TGF-beta signaling pathway_Homo sapiens_hsa043501.91711972
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.84315409
14Adherens junction_Homo sapiens_hsa045201.81063323
15Pentose phosphate pathway_Homo sapiens_hsa000301.80607392
16Renin-angiotensin system_Homo sapiens_hsa046141.77561131
17N-Glycan biosynthesis_Homo sapiens_hsa005101.74289867
18Small cell lung cancer_Homo sapiens_hsa052221.74094378
19Hippo signaling pathway_Homo sapiens_hsa043901.67465611
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66331937
21Prion diseases_Homo sapiens_hsa050201.63560909
22Central carbon metabolism in cancer_Homo sapiens_hsa052301.58892178
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44996253
24Arachidonic acid metabolism_Homo sapiens_hsa005901.43896028
25Bladder cancer_Homo sapiens_hsa052191.42823806
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.42443918
27Protein export_Homo sapiens_hsa030601.41356453
28Amoebiasis_Homo sapiens_hsa051461.40876213
29PI3K-Akt signaling pathway_Homo sapiens_hsa041511.37474211
30Prostate cancer_Homo sapiens_hsa052151.35703624
31Fructose and mannose metabolism_Homo sapiens_hsa000511.34681220
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.33637894
33Tight junction_Homo sapiens_hsa045301.33547789
34Melanoma_Homo sapiens_hsa052181.31615027
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.30949522
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27721487
37Sulfur relay system_Homo sapiens_hsa041221.25989098
38Sulfur metabolism_Homo sapiens_hsa009201.21088128
39Malaria_Homo sapiens_hsa051441.18503378
40Thyroid cancer_Homo sapiens_hsa052161.18410912
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18096681
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17745311
43Apoptosis_Homo sapiens_hsa042101.13603910
44Proteoglycans in cancer_Homo sapiens_hsa052051.13325875
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12003868
46Phenylalanine metabolism_Homo sapiens_hsa003601.11723825
47Lysosome_Homo sapiens_hsa041421.11553066
48p53 signaling pathway_Homo sapiens_hsa041151.08760098
49Sphingolipid metabolism_Homo sapiens_hsa006001.07496816
50Mismatch repair_Homo sapiens_hsa034301.07323577
51Vibrio cholerae infection_Homo sapiens_hsa051101.06551645
52Pathways in cancer_Homo sapiens_hsa052001.05155306
53Insulin signaling pathway_Homo sapiens_hsa049101.04849492
54Glutathione metabolism_Homo sapiens_hsa004800.99203955
55Nucleotide excision repair_Homo sapiens_hsa034200.97201097
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96833270
57Base excision repair_Homo sapiens_hsa034100.94659174
58Viral myocarditis_Homo sapiens_hsa054160.94522583
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94060861
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.93885583
61Homologous recombination_Homo sapiens_hsa034400.92482916
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90163597
63One carbon pool by folate_Homo sapiens_hsa006700.89286453
64Pertussis_Homo sapiens_hsa051330.88074442
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87785899
66VEGF signaling pathway_Homo sapiens_hsa043700.87673997
67Insulin resistance_Homo sapiens_hsa049310.87222237
68MicroRNAs in cancer_Homo sapiens_hsa052060.86020634
69Endometrial cancer_Homo sapiens_hsa052130.85710307
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85597664
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.84829799
72Legionellosis_Homo sapiens_hsa051340.83830537
73Toxoplasmosis_Homo sapiens_hsa051450.83496457
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83493854
75Carbon metabolism_Homo sapiens_hsa012000.83471906
76Biosynthesis of amino acids_Homo sapiens_hsa012300.82733738
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82516886
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.82453813
79AMPK signaling pathway_Homo sapiens_hsa041520.80918542
80Arginine and proline metabolism_Homo sapiens_hsa003300.80551283
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80457724
82Osteoclast differentiation_Homo sapiens_hsa043800.79802322
83Basal cell carcinoma_Homo sapiens_hsa052170.77624355
84Pancreatic cancer_Homo sapiens_hsa052120.77558298
85TNF signaling pathway_Homo sapiens_hsa046680.76895552
86Renal cell carcinoma_Homo sapiens_hsa052110.75959517
87Ribosome_Homo sapiens_hsa030100.75401444
88Shigellosis_Homo sapiens_hsa051310.75073974
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74598879
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74061093
91Endocytosis_Homo sapiens_hsa041440.73211620
92DNA replication_Homo sapiens_hsa030300.71369633
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70829485
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70518432
95Hepatitis C_Homo sapiens_hsa051600.69847259
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69745640
97Fanconi anemia pathway_Homo sapiens_hsa034600.68775694
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68754380
99Cell cycle_Homo sapiens_hsa041100.67182768
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.66128952
101Hematopoietic cell lineage_Homo sapiens_hsa046400.65448620
102RNA transport_Homo sapiens_hsa030130.65398576
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64926761
104HTLV-I infection_Homo sapiens_hsa051660.64415286
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64102517
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63811695
107Phagosome_Homo sapiens_hsa041450.63433036
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.63407911
109Antigen processing and presentation_Homo sapiens_hsa046120.63390699
110Rheumatoid arthritis_Homo sapiens_hsa053230.62761214
111Viral carcinogenesis_Homo sapiens_hsa052030.62442284
112Mineral absorption_Homo sapiens_hsa049780.62257837
113B cell receptor signaling pathway_Homo sapiens_hsa046620.61949018
114Proteasome_Homo sapiens_hsa030500.61916546
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59718100
116HIF-1 signaling pathway_Homo sapiens_hsa040660.59681215
117Chronic myeloid leukemia_Homo sapiens_hsa052200.57079774
118Galactose metabolism_Homo sapiens_hsa000520.57060013
119Influenza A_Homo sapiens_hsa051640.56542963
120Rap1 signaling pathway_Homo sapiens_hsa040150.55999328
121Acute myeloid leukemia_Homo sapiens_hsa052210.54197657
122Wnt signaling pathway_Homo sapiens_hsa043100.53868638
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.53678921
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53349673
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53201065
126GnRH signaling pathway_Homo sapiens_hsa049120.52260028
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.51987926
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51914655
129RNA polymerase_Homo sapiens_hsa030200.50146578
130PPAR signaling pathway_Homo sapiens_hsa033200.49082522
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.48269591
132Hepatitis B_Homo sapiens_hsa051610.47951244
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47690017
134Notch signaling pathway_Homo sapiens_hsa043300.47641026
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44757582
136Colorectal cancer_Homo sapiens_hsa052100.44065863
137MAPK signaling pathway_Homo sapiens_hsa040100.42284048
138mTOR signaling pathway_Homo sapiens_hsa041500.42267910
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.40949728
140Salmonella infection_Homo sapiens_hsa051320.40081934
141Inositol phosphate metabolism_Homo sapiens_hsa005620.39954721
142Hedgehog signaling pathway_Homo sapiens_hsa043400.39136929
143NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35983650

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