A4GNT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein from the glycosyltransferase 32 family. The enzyme catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. It forms a unique glycan, GlcNAcalpha1-->4Galbeta-->R and is largely associated with the Golgi apparatus membrane. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.54189248
2L-phenylalanine catabolic process (GO:0006559)6.54189248
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.34941290
4L-phenylalanine metabolic process (GO:0006558)6.34941290
5aromatic amino acid family catabolic process (GO:0009074)6.34921992
6tryptophan catabolic process (GO:0006569)6.04561320
7indole-containing compound catabolic process (GO:0042436)6.04561320
8indolalkylamine catabolic process (GO:0046218)6.04561320
9glyoxylate metabolic process (GO:0046487)5.80414352
10tryptophan metabolic process (GO:0006568)5.60310080
11kynurenine metabolic process (GO:0070189)5.49042581
12lysine metabolic process (GO:0006553)5.37561658
13lysine catabolic process (GO:0006554)5.37561658
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.29250463
15sulfur amino acid catabolic process (GO:0000098)5.28384625
16bile acid biosynthetic process (GO:0006699)5.26369736
17cysteine metabolic process (GO:0006534)5.23291220
18alpha-linolenic acid metabolic process (GO:0036109)5.14360310
19cellular ketone body metabolic process (GO:0046950)5.02093561
20plasma lipoprotein particle clearance (GO:0034381)4.97207406
21amino-acid betaine metabolic process (GO:0006577)4.89510326
22drug transmembrane transport (GO:0006855)4.89264066
23regulation of plasminogen activation (GO:0010755)4.81309072
24bile acid metabolic process (GO:0008206)4.79898895
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.79570134
26serine family amino acid catabolic process (GO:0009071)4.72184580
27cellular glucuronidation (GO:0052695)4.64461318
28positive regulation of steroid metabolic process (GO:0045940)4.54525111
29aromatic amino acid family metabolic process (GO:0009072)4.53996699
30homocysteine metabolic process (GO:0050667)4.53845922
31bile acid and bile salt transport (GO:0015721)4.48194871
32glutamate metabolic process (GO:0006536)4.46374159
33regulation of lipoprotein particle clearance (GO:0010984)4.43143091
34negative regulation of lipase activity (GO:0060192)4.39013124
35peptidyl-glutamic acid carboxylation (GO:0017187)4.38810294
36protein carboxylation (GO:0018214)4.38810294
37negative regulation of sterol transport (GO:0032372)4.38764617
38negative regulation of cholesterol transport (GO:0032375)4.38764617
39urea metabolic process (GO:0019627)4.35879465
40urea cycle (GO:0000050)4.35879465
41urate metabolic process (GO:0046415)4.34595604
42alpha-amino acid catabolic process (GO:1901606)4.33420057
43drug catabolic process (GO:0042737)4.32609080
44ketone body metabolic process (GO:1902224)4.30981195
45short-chain fatty acid metabolic process (GO:0046459)4.29315279
46glucuronate metabolic process (GO:0019585)4.28900829
47uronic acid metabolic process (GO:0006063)4.28900829
48high-density lipoprotein particle remodeling (GO:0034375)4.28842646
49ethanol oxidation (GO:0006069)4.23811772
50signal peptide processing (GO:0006465)4.22450563
51regulation of triglyceride catabolic process (GO:0010896)4.21254353
52maintenance of gastrointestinal epithelium (GO:0030277)4.14777723
53cellular amino acid catabolic process (GO:0009063)4.14333332
54indolalkylamine metabolic process (GO:0006586)4.13972826
55acylglycerol homeostasis (GO:0055090)4.12746622
56triglyceride homeostasis (GO:0070328)4.12746622
57regulation of response to osmotic stress (GO:0047484)4.10361447
58flavonoid metabolic process (GO:0009812)4.09567807
59negative regulation of fibrinolysis (GO:0051918)4.08175483
60hyperosmotic salinity response (GO:0042538)4.07320754
61cellular modified amino acid catabolic process (GO:0042219)4.07180960
62amine catabolic process (GO:0009310)4.07030584
63cellular biogenic amine catabolic process (GO:0042402)4.07030584
64regulation of fibrinolysis (GO:0051917)4.05989164
65nitrogen cycle metabolic process (GO:0071941)4.04296840
66drug transport (GO:0015893)4.02213032
67cell adhesion mediated by integrin (GO:0033627)4.02187224
68negative regulation of catenin import into nucleus (GO:0035414)4.01881141
69phospholipid efflux (GO:0033700)3.98777819
70regulation of cholesterol esterification (GO:0010872)3.91319736
71very-low-density lipoprotein particle assembly (GO:0034379)3.90276416
72tyrosine metabolic process (GO:0006570)3.89848565
73fatty acid oxidation (GO:0019395)3.89435218
74fatty acid beta-oxidation (GO:0006635)3.89255206
75serine family amino acid metabolic process (GO:0009069)3.88862889
76fibrinolysis (GO:0042730)3.87975149
77aspartate family amino acid catabolic process (GO:0009068)3.85635225
78low-density lipoprotein particle remodeling (GO:0034374)3.84966573
79carnitine metabolic process (GO:0009437)3.84717682
80regulation of bile acid biosynthetic process (GO:0070857)3.83692316
81plasma lipoprotein particle assembly (GO:0034377)3.81886011
82glutathione derivative biosynthetic process (GO:1901687)3.81591946
83glutathione derivative metabolic process (GO:1901685)3.81591946
84lipid oxidation (GO:0034440)3.81163208
85benzene-containing compound metabolic process (GO:0042537)3.80838297
86tonic smooth muscle contraction (GO:0014820)3.80483541
87regulation of protein activation cascade (GO:2000257)3.78918797
88reverse cholesterol transport (GO:0043691)3.78600091
89aldehyde catabolic process (GO:0046185)3.76735683
90organic acid catabolic process (GO:0016054)3.76666171
91carboxylic acid catabolic process (GO:0046395)3.76666171
92coenzyme catabolic process (GO:0009109)3.74819177
93negative regulation of blood coagulation (GO:0030195)3.74214864
94negative regulation of hemostasis (GO:1900047)3.74214864
95negative regulation of coagulation (GO:0050819)3.71947704
96negative regulation of receptor-mediated endocytosis (GO:0048261)3.70935647
97regulation of cholesterol biosynthetic process (GO:0045540)3.70255059
98complement activation, alternative pathway (GO:0006957)3.69114203
99acetyl-CoA metabolic process (GO:0006084)3.68943197
100monocarboxylic acid catabolic process (GO:0072329)3.67749600
101plasma lipoprotein particle remodeling (GO:0034369)3.66494719
102protein-lipid complex remodeling (GO:0034368)3.66494719
103macromolecular complex remodeling (GO:0034367)3.66494719
104regulation of cholesterol homeostasis (GO:2000188)3.65813637
105valine metabolic process (GO:0006573)3.63057842
106glycine metabolic process (GO:0006544)3.62547703
107heme transport (GO:0015886)3.61784542
108lipopolysaccharide biosynthetic process (GO:0009103)3.60447343
109negative regulation of lipid transport (GO:0032369)3.59549048
110very long-chain fatty acid metabolic process (GO:0000038)3.58427326
111fatty acid catabolic process (GO:0009062)3.57187107
112exogenous drug catabolic process (GO:0042738)3.56603609
113imidazole-containing compound metabolic process (GO:0052803)3.56093392
1142-oxoglutarate metabolic process (GO:0006103)3.54651586
115regulation of complement activation (GO:0030449)3.52333228
116branched-chain amino acid catabolic process (GO:0009083)3.50366655
117positive regulation of cellular amide metabolic process (GO:0034250)3.49925798
118positive regulation of lipoprotein lipase activity (GO:0051006)3.48427526
119positive regulation of triglyceride lipase activity (GO:0061365)3.48427526
120artery smooth muscle contraction (GO:0014824)3.47818300
121protein-lipid complex assembly (GO:0065005)3.44306840
122negative regulation of fatty acid biosynthetic process (GO:0045717)3.43494811
123dicarboxylic acid biosynthetic process (GO:0043650)3.42619269
124regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.41602765
125cholesterol homeostasis (GO:0042632)3.39880828
126positive regulation of cellular response to insulin stimulus (GO:1900078)3.39809629
127branched-chain amino acid metabolic process (GO:0009081)3.39205398
128phospholipid homeostasis (GO:0055091)3.38885802
129negative regulation of fatty acid transport (GO:2000192)3.38522866
130negative regulation of digestive system process (GO:0060457)3.38333661
131negative regulation of wound healing (GO:0061045)3.35135884
132regulation of cholesterol metabolic process (GO:0090181)3.33906116
133plasma lipoprotein particle organization (GO:0071827)3.30508934
134cholesterol efflux (GO:0033344)3.28957128
135peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.28579581
136positive regulation of extracellular matrix organization (GO:1903055)3.28268522
137positive regulation of fatty acid biosynthetic process (GO:0045723)3.20911290
138lipopolysaccharide metabolic process (GO:0008653)3.17945727
139regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.16622176
140positive regulation of insulin receptor signaling pathway (GO:0046628)3.16394997
141protein-lipid complex subunit organization (GO:0071825)3.13124967
142regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.10859211
143regulation of apoptotic cell clearance (GO:2000425)3.08124395
144positive regulation of smooth muscle cell migration (GO:0014911)3.03585437
145positive regulation of receptor biosynthetic process (GO:0010870)2.99928394
146hypotonic response (GO:0006971)2.98842636
147positive regulation of steroid biosynthetic process (GO:0010893)2.90553308
148positive regulation of hormone metabolic process (GO:0032352)2.86252991
149lipoprotein metabolic process (GO:0042157)2.85826460
150endodermal cell differentiation (GO:0035987)2.85675171
151regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.85430039
152gap junction assembly (GO:0016264)2.83863293
153exocrine pancreas development (GO:0031017)2.80752263
154positive regulation of hormone biosynthetic process (GO:0046886)2.79437669
155omega-hydroxylase P450 pathway (GO:0097267)2.79183520
156fatty acid homeostasis (GO:0055089)2.73219720
157glomerular basement membrane development (GO:0032836)2.73000815
158regulation of triglyceride metabolic process (GO:0090207)2.71727967
159axon regeneration (GO:0031103)2.71622054
160regulation of lipoprotein lipase activity (GO:0051004)2.71233990
161complement activation, classical pathway (GO:0006958)2.70988203
162basement membrane organization (GO:0071711)2.65137310
163positive regulation of blood coagulation (GO:0030194)2.64176155
164positive regulation of hemostasis (GO:1900048)2.64176155
165positive regulation of coagulation (GO:0050820)2.62330891
166respiratory tube development (GO:0030323)2.62267382
167positive regulation of wound healing (GO:0090303)2.59825153
168regulation of cholesterol transport (GO:0032374)2.58980347
169regulation of sterol transport (GO:0032371)2.58980347
170branch elongation of an epithelium (GO:0060602)2.56887060
171oxidative demethylation (GO:0070989)2.56631064
172peptide biosynthetic process (GO:0043043)2.56609448
173peptidyl-glutamic acid modification (GO:0018200)2.55930780
174protein activation cascade (GO:0072376)2.55644641
175vascular endothelial growth factor signaling pathway (GO:0038084)2.55331024
176regulation of metalloenzyme activity (GO:0048552)2.54167675

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.40744339
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.71287678
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.87596565
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.48019504
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.37220785
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.32114187
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.23588763
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.65593996
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.52685007
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.28922492
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.56597556
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.46843275
13* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.21007562
14TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.20543806
15CLOCK_20551151_ChIP-Seq_293T_Human2.12203987
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.10299925
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.06576018
18ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.04771833
19ESR1_15608294_ChIP-ChIP_MCF-7_Human1.92979735
20GATA4_25053715_ChIP-Seq_YYC3_Human1.88144828
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.85753662
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.68419274
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67405787
24CJUN_26792858_Chip-Seq_BT549_Human1.55718180
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.55294126
26DROSHA_22980978_ChIP-Seq_HELA_Human1.54998446
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.54933977
28FOXA2_19822575_ChIP-Seq_HepG2_Human1.50910048
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50525741
30FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47820956
31CDX2_20551321_ChIP-Seq_CACO-2_Human1.45791429
32DNAJC2_21179169_ChIP-ChIP_NT2_Human1.45218093
33JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44990978
34ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.44657312
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42653306
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40279291
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.38074477
38TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37076922
39VDR_22108803_ChIP-Seq_LS180_Human1.36902420
40HNF4A_19822575_ChIP-Seq_HepG2_Human1.36524686
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31678181
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30543664
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.29907513
44CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.29417296
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28950861
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.28173568
47KAP1_22055183_ChIP-Seq_ESCs_Mouse1.26733008
48JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26014900
49SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25932815
50ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25784701
51HTT_18923047_ChIP-ChIP_STHdh_Human1.24712043
52SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23153101
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23056001
54TP53_18474530_ChIP-ChIP_U2OS_Human1.22062934
55SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21662471
56SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18666643
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18472479
58EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.16031276
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14261375
60VDR_24787735_ChIP-Seq_THP-1_Human1.13385011
61AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13283954
62SOX2_20726797_ChIP-Seq_SW620_Human1.10838872
63SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09922976
64MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09683046
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07872603
66NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07227038
67BCAT_22108803_ChIP-Seq_LS180_Human1.06236653
68SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05985111
69BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04141409
70SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03348560
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01376926
72BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.00349263
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99217984
74ESR1_20079471_ChIP-ChIP_T-47D_Human0.98318193
75GATA6_25053715_ChIP-Seq_YYC3_Human0.97615220
76EP300_21415370_ChIP-Seq_HL-1_Mouse0.97511822
77EGR1_19032775_ChIP-ChIP_M12_Human0.95475293
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92919936
79NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92233752
80ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91839500
81JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91248976
82ELK3_25401928_ChIP-Seq_HUVEC_Human0.89869234
83FOXH1_21741376_ChIP-Seq_EPCs_Human0.89422099
84SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88834816
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88296328
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87319718
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86588593
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85682828
89RAD21_21589869_ChIP-Seq_MESCs_Mouse0.85577927
90RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85398561
91GBX2_23144817_ChIP-Seq_PC3_Human0.84322391
92ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83920032
93SMAD3_21741376_ChIP-Seq_HESCs_Human0.83553158
94STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83323048
95TP63_17297297_ChIP-ChIP_HaCaT_Human0.82919895
96ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.82886479
97* STAT1_17558387_ChIP-Seq_HELA_Human0.82605477
98LXR_22292898_ChIP-Seq_THP-1_Human0.82428496
99FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82216043
100RAC3_21632823_ChIP-Seq_H3396_Human0.82196014
101HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82055864
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.81470014
103BRD4_25478319_ChIP-Seq_HGPS_Human0.81188376
104FOXA1_25552417_ChIP-Seq_VCAP_Human0.81031538
105CDX2_19796622_ChIP-Seq_MESCs_Mouse0.80875192
106PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.79990324
107GATA1_19941826_ChIP-Seq_K562_Human0.78954212
108EZH2_27294783_Chip-Seq_ESCs_Mouse0.78659916
109GATA2_21666600_ChIP-Seq_HMVEC_Human0.78434286
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.78201949
111PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78093703
112RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.76955356
113EZH2_18974828_ChIP-Seq_MESCs_Mouse0.76852830
114PIAS1_25552417_ChIP-Seq_VCAP_Human0.76294184
115TAF15_26573619_Chip-Seq_HEK293_Human0.75376652
116P53_21459846_ChIP-Seq_SAOS-2_Human0.74364400
117CEBPB_22108803_ChIP-Seq_LS180_Human0.73867582
118CDX2_22108803_ChIP-Seq_LS180_Human0.73829801
119Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72516528
120SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.72386203
121IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.71948377
122IGF1R_20145208_ChIP-Seq_DFB_Human0.70917889
123RXR_22108803_ChIP-Seq_LS180_Human0.69562613
124AHR_22903824_ChIP-Seq_MCF-7_Human0.69152732
125ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.68833654
126CBP_21632823_ChIP-Seq_H3396_Human0.68208718
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.68104214
128ZNF217_24962896_ChIP-Seq_MCF-7_Human0.66668926
129FOXO3_23340844_ChIP-Seq_DLD1_Human0.66463531
130EZH2_27294783_Chip-Seq_NPCs_Mouse0.66303510
131FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.64738232
132NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64281535
133NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64281535
134EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.64246341
135OCT4_21477851_ChIP-Seq_ESCs_Mouse0.64001400
136STAT6_21828071_ChIP-Seq_BEAS2B_Human0.63962024
137GATA3_24758297_ChIP-Seq_MCF-7_Human0.63587261
138MYC_19915707_ChIP-ChIP_AK7_Human0.62527884
139SALL4_18804426_ChIP-ChIP_XEN_Mouse0.62366652
140CRX_20693478_ChIP-Seq_RETINA_Mouse0.62099781
141SUZ12_27294783_Chip-Seq_NPCs_Mouse0.61951435
142PCGF2_27294783_Chip-Seq_NPCs_Mouse0.61122927
143SRY_22984422_ChIP-ChIP_TESTIS_Rat0.60845339
144NFE2_27457419_Chip-Seq_LIVER_Mouse0.60256211
145AUTS2_25519132_ChIP-Seq_293T-REX_Human0.59714768
146SMAD4_21741376_ChIP-Seq_HESCs_Human0.59144870
147ESET_19884257_ChIP-Seq_ESCs_Mouse0.58964803
148ARNT_22903824_ChIP-Seq_MCF-7_Human0.57816110
149ERG_21242973_ChIP-ChIP_JURKAT_Human0.57748397
150NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57447821
151RACK7_27058665_Chip-Seq_MCF-7_Human0.57115010
152KDM2B_26808549_Chip-Seq_REH_Human0.56024680
153FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.55848462
154* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.55048172
155AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.54818918
156AR_20517297_ChIP-Seq_VCAP_Human0.53715815
157RARA_24833708_ChIP-Seq_LIVER_Mouse0.53330323

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.29459691
2MP0002139_abnormal_hepatobiliary_system7.13485999
3MP0008004_abnormal_stomach_pH6.11799474
4MP0005085_abnormal_gallbladder_physiolo5.68014704
5MP0005365_abnormal_bile_salt5.12790961
6MP0008875_abnormal_xenobiotic_pharmacok4.39834921
7MP0003806_abnormal_nucleotide_metabolis4.38210074
8MP0008438_abnormal_cutaneous_collagen3.81295440
9MP0009840_abnormal_foam_cell3.53707870
10MP0001958_emphysema3.35882438
11MP0000566_synostosis3.31993841
12MP0010386_abnormal_urinary_bladder3.31494032
13MP0003252_abnormal_bile_duct3.25238044
14MP0003279_aneurysm3.15597675
15MP0001666_abnormal_nutrient_absorption2.99666947
16MP0010329_abnormal_lipoprotein_level2.93543795
17MP0005083_abnormal_biliary_tract2.84874520
18MP0001984_abnormal_olfaction2.76117371
19MP0004272_abnormal_basement_membrane2.74807580
20MP0005503_abnormal_tendon_morphology2.71717177
21MP0005332_abnormal_amino_acid2.69562540
22MP0004019_abnormal_vitamin_homeostasis2.68449016
23MP0003195_calcinosis2.64071740
24MP0000751_myopathy2.57077684
25MP0004883_abnormal_blood_vessel2.25088466
26MP0005275_abnormal_skin_tensile2.13131206
27MP0001664_abnormal_digestion2.07523038
28MP0005451_abnormal_body_composition2.00552878
29MP0005164_abnormal_response_to1.94345939
30MP0003191_abnormal_cellular_cholesterol1.93663251
31MP0003868_abnormal_feces_composition1.90801485
32MP0002138_abnormal_hepatobiliary_system1.87769483
33MP0000003_abnormal_adipose_tissue1.87553051
34MP0001873_stomach_inflammation1.78332710
35MP0002118_abnormal_lipid_homeostasis1.76250939
36MP0000609_abnormal_liver_physiology1.63410743
37MP0009643_abnormal_urine_homeostasis1.62596405
38MP0002736_abnormal_nociception_after1.60706228
39MP0006054_spinal_hemorrhage1.47688990
40MP0005584_abnormal_enzyme/coenzyme_acti1.46766706
41MP0010234_abnormal_vibrissa_follicle1.45595469
42MP0004043_abnormal_pH_regulation1.43276918
43MP0005595_abnormal_vascular_smooth1.41111893
44MP0003705_abnormal_hypodermis_morpholog1.40676628
45MP0005319_abnormal_enzyme/_coenzyme1.39400053
46MP0000013_abnormal_adipose_tissue1.37759456
47MP0005058_abnormal_lysosome_morphology1.35142468
48MP0000470_abnormal_stomach_morphology1.33374111
49MP0005636_abnormal_mineral_homeostasis1.30770408
50MP0003566_abnormal_cell_adhesion1.27978303
51MP0003011_delayed_dark_adaptation1.27498306
52MP0000767_abnormal_smooth_muscle1.25036219
53MP0002102_abnormal_ear_morphology1.20842354
54MP0002295_abnormal_pulmonary_circulatio1.19849812
55MP0002876_abnormal_thyroid_physiology1.17745781
56MP0003186_abnormal_redox_activity1.15912391
57MP0005375_adipose_tissue_phenotype1.14205331
58MP0002735_abnormal_chemical_nociception1.09801482
59MP0005023_abnormal_wound_healing1.09740216
60MP0009053_abnormal_anal_canal1.08960552
61MP0005508_abnormal_skeleton_morphology1.07637248
62MP0001663_abnormal_digestive_system1.07493101
63MP0005381_digestive/alimentary_phenotyp1.03265489
64MP0003115_abnormal_respiratory_system1.01870841
65MP0001764_abnormal_homeostasis1.01076532
66MP0000249_abnormal_blood_vessel1.00774552
67MP0003879_abnormal_hair_cell0.99454730
68MP0009780_abnormal_chondrocyte_physiolo0.98545034
69MP0000462_abnormal_digestive_system0.95975600
70MP0001756_abnormal_urination0.92198746
71MP0003656_abnormal_erythrocyte_physiolo0.91218764
72MP0002254_reproductive_system_inflammat0.88235807
73MP0002060_abnormal_skin_morphology0.87966289
74MP0002998_abnormal_bone_remodeling0.84068418
75MP0004381_abnormal_hair_follicle0.83719550
76MP0009764_decreased_sensitivity_to0.83677366
77MP0002136_abnormal_kidney_physiology0.83514857
78MP0000343_altered_response_to0.81714434
79MP0009642_abnormal_blood_homeostasis0.80165287
80MP0000920_abnormal_myelination0.78944604
81MP0002108_abnormal_muscle_morphology0.77723409
82MP0006082_CNS_inflammation0.77004423
83MP0001765_abnormal_ion_homeostasis0.76801947
84MP0004264_abnormal_extraembryonic_tissu0.76694168
85MP0000639_abnormal_adrenal_gland0.75426204
86MP0000598_abnormal_liver_morphology0.74802373
87MP0005165_increased_susceptibility_to0.74259870
88MP0003122_maternal_imprinting0.73242877
89MP0006036_abnormal_mitochondrial_physio0.72433695
90MP0003385_abnormal_body_wall0.72215029
91MP0005647_abnormal_sex_gland0.71635381
92MP0001533_abnormal_skeleton_physiology0.71298618
93MP0002909_abnormal_adrenal_gland0.69954422
94MP0002078_abnormal_glucose_homeostasis0.68916623
95MP0000477_abnormal_intestine_morphology0.68652989
96MP0001542_abnormal_bone_strength0.66982264
97MP0000604_amyloidosis0.66470801
98MP0001486_abnormal_startle_reflex0.65706831
99MP0009115_abnormal_fat_cell0.65161126
100MP0005084_abnormal_gallbladder_morpholo0.64344839
101MP0003634_abnormal_glial_cell0.63411626
102MP0003724_increased_susceptibility_to0.62896057
103MP0005334_abnormal_fat_pad0.62317888
104MP0009278_abnormal_bone_marrow0.61833594
105MP0009763_increased_sensitivity_to0.61830340
106MP0001348_abnormal_lacrimal_gland0.61005470
107MP0000538_abnormal_urinary_bladder0.60875196
108MP0005390_skeleton_phenotype0.60834920
109MP0009697_abnormal_copulation0.59804801
110MP0008469_abnormal_protein_level0.59784046
111MP0002796_impaired_skin_barrier0.59606302
112MP0000579_abnormal_nail_morphology0.58536474
113MP0001879_abnormal_lymphatic_vessel0.58437587
114MP0003943_abnormal_hepatobiliary_system0.57637339
115MP0002168_other_aberrant_phenotype0.57335300
116MP0005535_abnormal_body_temperature0.57256175
117MP0004233_abnormal_muscle_weight0.57034496
118MP0001661_extended_life_span0.56716906
119MP0005266_abnormal_metabolism0.56163828
120MP0004185_abnormal_adipocyte_glucose0.55920356
121MP0005646_abnormal_pituitary_gland0.55830493
122MP0008775_abnormal_heart_ventricle0.55236185
123MP0002128_abnormal_blood_circulation0.54928605
124MP0010368_abnormal_lymphatic_system0.54296755
125MP0003953_abnormal_hormone_level0.54128393
126MP0004130_abnormal_muscle_cell0.52830548
127MP0009765_abnormal_xenobiotic_induced0.52777302
128MP0005220_abnormal_exocrine_pancreas0.52478918
129MP0003300_gastrointestinal_ulcer0.52244000
130MP0005408_hypopigmentation0.51277580
131MP0005376_homeostasis/metabolism_phenot0.50569131
132MP0003638_abnormal_response/metabolism_0.50146008
133MP0010155_abnormal_intestine_physiology0.47345519
134MP0003718_maternal_effect0.46064011
135MP0003329_amyloid_beta_deposits0.44523763
136MP0002971_abnormal_brown_adipose0.43324909
137MP0000230_abnormal_systemic_arterial0.42098362
138MP0005166_decreased_susceptibility_to0.41647254
139MP0000647_abnormal_sebaceous_gland0.41395300
140MP0004782_abnormal_surfactant_physiolog0.40917297
141MP0005395_other_phenotype0.40408251
142MP0002837_dystrophic_cardiac_calcinosis0.39406236
143MP0005167_abnormal_blood-brain_barrier0.38899889
144MP0003075_altered_response_to0.38350284
145MP0002822_catalepsy0.36908309
146MP0000467_abnormal_esophagus_morphology0.36550702
147MP0005448_abnormal_energy_balance0.35627828
148MP0002928_abnormal_bile_duct0.34842833
149MP0009384_cardiac_valve_regurgitation0.33802470
150MP0008874_decreased_physiological_sensi0.33206396
151MP0003690_abnormal_glial_cell0.33202145
152MP0001243_abnormal_dermal_layer0.33051314
153MP0002970_abnormal_white_adipose0.32948854
154MP0004147_increased_porphyrin_level0.32760532
155MP0005666_abnormal_adipose_tissue0.32233247
156MP0008873_increased_physiological_sensi0.31234685

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.16643312
2Deep venous thrombosis (HP:0002625)5.95455331
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.82137282
4Menstrual irregularities (HP:0000858)5.53834505
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.36694162
6Hyperglycinuria (HP:0003108)5.30518748
7Abnormality of glutamine family amino acid metabolism (HP:0010902)5.20767015
8Xanthomatosis (HP:0000991)4.78521782
9Prolonged partial thromboplastin time (HP:0003645)4.72866932
10Abnormality of glycine metabolism (HP:0010895)4.71939966
11Abnormality of serine family amino acid metabolism (HP:0010894)4.71939966
12Abnormality of pyrimidine metabolism (HP:0004353)4.69952083
13Hypobetalipoproteinemia (HP:0003563)4.67309097
14Growth hormone excess (HP:0000845)4.63724258
15Premature rupture of membranes (HP:0001788)4.51121399
16Ketosis (HP:0001946)4.26594674
17Hyperglycinemia (HP:0002154)4.24516568
18Bilateral sensorineural hearing impairment (HP:0008619)4.19875207
19Abnormality of nucleobase metabolism (HP:0010932)4.15134391
20Hyperammonemia (HP:0001987)4.04491821
21Gout (HP:0001997)4.01047206
22Abnormality of fatty-acid metabolism (HP:0004359)3.98977347
23Abnormal glucose tolerance (HP:0001952)3.94486509
24Ketoacidosis (HP:0001993)3.89668355
25Abnormality of purine metabolism (HP:0004352)3.87725544
26Joint hemorrhage (HP:0005261)3.86129978
27Hyperlipoproteinemia (HP:0010980)3.82257562
28Abnormality of sulfur amino acid metabolism (HP:0004339)3.79783707
29Systemic lupus erythematosus (HP:0002725)3.76714100
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.74333650
31Glucose intolerance (HP:0000833)3.67354861
32Delayed CNS myelination (HP:0002188)3.63128492
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.61698692
34Mitral stenosis (HP:0001718)3.61165794
35Distal lower limb muscle weakness (HP:0009053)3.60767725
36Complement deficiency (HP:0004431)3.57326421
37Fat malabsorption (HP:0002630)3.57240196
38Conjugated hyperbilirubinemia (HP:0002908)3.57054100
39Broad metatarsal (HP:0001783)3.55411052
40Hypolipoproteinemia (HP:0010981)3.52968307
41Protrusio acetabuli (HP:0003179)3.51629838
42Abnormality of proline metabolism (HP:0010907)3.51600183
43Hydroxyprolinuria (HP:0003080)3.51600183
44Stridor (HP:0010307)3.39883523
45Muscle fiber splitting (HP:0003555)3.37880322
46Asymmetry of the thorax (HP:0001555)3.36660194
47Hypoglycemic coma (HP:0001325)3.33847041
48Malnutrition (HP:0004395)3.29370381
49Hyperuricemia (HP:0002149)3.26056993
50Increased purine levels (HP:0004368)3.26056993
51Carpal bone hypoplasia (HP:0001498)3.22372667
52Diaphragmatic weakness (HP:0009113)3.18728171
53Vascular calcification (HP:0004934)3.15150001
54Abnormality of the distal phalanges of the toes (HP:0010182)3.15087890
55Hypoalphalipoproteinemia (HP:0003233)3.13785885
56Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.12310582
57Abnormality of serum amino acid levels (HP:0003112)3.10236839
58Metabolic acidosis (HP:0001942)3.10127356
59Upper limb amyotrophy (HP:0009129)3.06752022
60Distal upper limb amyotrophy (HP:0007149)3.06752022
61Epidermoid cyst (HP:0200040)3.01370117
62Hand muscle atrophy (HP:0009130)3.00258654
63Abnormality of the middle phalanges of the toes (HP:0010183)2.97105180
64Aortic dissection (HP:0002647)2.92245022
65Dicarboxylic aciduria (HP:0003215)2.86405284
66Abnormality of dicarboxylic acid metabolism (HP:0010995)2.86405284
67Proximal tubulopathy (HP:0000114)2.84544947
68Cardiovascular calcification (HP:0011915)2.83266112
69Hepatocellular carcinoma (HP:0001402)2.82908003
70Late onset (HP:0003584)2.80668834
71Hyperbilirubinemia (HP:0002904)2.80458701
72Abnormality of methionine metabolism (HP:0010901)2.79138657
73Aortic aneurysm (HP:0004942)2.78181045
74Abnormality of the common coagulation pathway (HP:0010990)2.75343020
75Abnormality of the intrinsic pathway (HP:0010989)2.74672766
76Spinal muscular atrophy (HP:0007269)2.72760577
77Lethargy (HP:0001254)2.68380788
78Aplasia of the musculature (HP:0100854)2.64881066
79Limb-girdle muscle atrophy (HP:0003797)2.64875539
80Abnormality of vitamin metabolism (HP:0100508)2.63502117
81Neonatal short-limb short stature (HP:0008921)2.61335905
82Nonimmune hydrops fetalis (HP:0001790)2.59957457
83Vacuolated lymphocytes (HP:0001922)2.59751567
84Thin bony cortex (HP:0002753)2.57448592
85Alkalosis (HP:0001948)2.57223059
86Spastic diplegia (HP:0001264)2.57080965
87Steatorrhea (HP:0002570)2.54063681
88Abnormality of complement system (HP:0005339)2.51777567
89Mesangial abnormality (HP:0001966)2.50928582
90Facial shape deformation (HP:0011334)2.50573168
91Potter facies (HP:0002009)2.50573168
92Neurofibrillary tangles (HP:0002185)2.47293438
93Increased variability in muscle fiber diameter (HP:0003557)2.45013548
94Glomerulonephritis (HP:0000099)2.44526305
95Hypoglycemic seizures (HP:0002173)2.43675041
96Spinal cord compression (HP:0002176)2.43034642
97Aplasia/Hypoplasia involving the musculature (HP:0001460)2.34676371
98Renal cortical cysts (HP:0000803)2.33610491
99Aortic valve stenosis (HP:0001650)2.33132599
100Generalized aminoaciduria (HP:0002909)2.31217867
101Hypercholesterolemia (HP:0003124)2.30592857
102Impaired pain sensation (HP:0007328)2.30589189
103Abnormality of pain sensation (HP:0010832)2.30589189
104Pancreatitis (HP:0001733)2.26935809
105Sensorimotor neuropathy (HP:0007141)2.26536327
106Abnormality of glycolipid metabolism (HP:0010969)2.26340378
107Abnormality of liposaccharide metabolism (HP:0010968)2.26340378
108Abnormality of glycosphingolipid metabolism (HP:0004343)2.26340378
109Enlarged kidneys (HP:0000105)2.26051527
110Rickets (HP:0002748)2.25677458
111Vertebral compression fractures (HP:0002953)2.25671984
112Oligomenorrhea (HP:0000876)2.24359835
113Abnormality of carpal bone ossification (HP:0006257)2.22431905
114Vascular tortuosity (HP:0004948)2.21759828
115Hyperactive renin-angiotensin system (HP:0000841)2.20657180
116Duplicated collecting system (HP:0000081)2.20131745
117Abnormality of urine glucose concentration (HP:0011016)2.20118758
118Glycosuria (HP:0003076)2.20118758
119Chromosomal breakage induced by crosslinking agents (HP:0003221)2.19665180
120Abnormality of chloride homeostasis (HP:0011422)2.19606252
121Pulmonary artery stenosis (HP:0004415)2.18170566
122Metabolic alkalosis (HP:0200114)2.16686336
123Peritonitis (HP:0002586)2.16134902
124Ileus (HP:0002595)2.16134514
125Reticulocytopenia (HP:0001896)2.15579244
126Vomiting (HP:0002013)2.14632089
127Obstructive sleep apnea (HP:0002870)2.13890768
128Torticollis (HP:0000473)2.12157478
129Right ventricular cardiomyopathy (HP:0011663)2.11944422
130Esophageal varix (HP:0002040)2.11691915
131Shallow orbits (HP:0000586)2.11681722
132Hypokalemic alkalosis (HP:0001949)2.11210477
133Sleep apnea (HP:0010535)2.10894834
134Polycythemia (HP:0001901)2.10590168
135Megaloblastic anemia (HP:0001889)2.09918592
136Abnormality of alanine metabolism (HP:0010916)2.09389689
137Hyperalaninemia (HP:0003348)2.09389689
138Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09389689
139Hemorrhage of the eye (HP:0011885)2.09059672
140Menorrhagia (HP:0000132)2.08433687
141Abnormality of the vitamin B12 metabolism (HP:0004341)2.08102444
142Round ear (HP:0100830)2.08039883
143Abnormality of vitamin B metabolism (HP:0004340)2.06644209
144Cerebral edema (HP:0002181)2.05836594
145Aortic regurgitation (HP:0001659)2.04105678
146Amyloidosis (HP:0011034)2.02861223
147Brushfield spots (HP:0001088)2.02272853
148Abnormality of dentin (HP:0010299)2.01871000
149Neonatal onset (HP:0003623)1.98633548
150J-shaped sella turcica (HP:0002680)1.98123523
151Hypophosphatemic rickets (HP:0004912)1.96895853
152Abnormality of skeletal muscle fiber size (HP:0012084)1.96656821
153Wrist flexion contracture (HP:0001239)1.96588222
154Myocardial infarction (HP:0001658)1.96279511
155Flat acetabular roof (HP:0003180)1.95659125
156Abnormal gallbladder physiology (HP:0012438)1.95045725
157Cholecystitis (HP:0001082)1.95045725
158Arterial tortuosity (HP:0005116)1.95032906
159Status epilepticus (HP:0002133)1.94983442
160Hyperventilation (HP:0002883)1.94554481
161Limited hip movement (HP:0008800)1.93155697
162Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.92693825
163Abnormal ossification of hand bones (HP:0005921)1.92107736
164Nephrolithiasis (HP:0000787)1.91646625
165Irritability (HP:0000737)1.90191304
166Purpura (HP:0000979)1.89228439
167Gowers sign (HP:0003391)1.88695151
168Abnormality of the calf musculature (HP:0001430)1.88564057
169Natal tooth (HP:0000695)1.87810391
170Symptomatic seizures (HP:0011145)1.86511427
171Coxa vara (HP:0002812)1.85658848
172Joint stiffness (HP:0001387)1.82831140
173Acanthocytosis (HP:0001927)1.82523196
174Cervical subluxation (HP:0003308)1.82146973
175Soft skin (HP:0000977)1.80921858
176Left ventricular hypertrophy (HP:0001712)1.80809976
177Biconcave vertebral bodies (HP:0004586)1.80524684
178Knee flexion contracture (HP:0006380)1.78484145
179Bladder diverticulum (HP:0000015)1.78287349
180Rough bone trabeculation (HP:0100670)1.76003925
181Tubulointerstitial fibrosis (HP:0005576)1.75862208

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB45.16210715
2BCKDK4.67476623
3TAOK33.93349032
4WNK43.54461573
5MST1R3.46978679
6WNK33.41516377
7EIF2AK13.16412149
8LATS12.77414116
9FGFR42.75162765
10PIK3CG2.55436529
11PDK42.48813730
12PDK32.48813730
13CCNB12.35809352
14MAP3K122.34412994
15OXSR12.34299029
16SIK12.25653499
17MAP3K92.22862588
18TESK12.21722394
19FRK2.20568895
20LMTK21.96359764
21LIMK11.95483468
22ERN11.91089946
23STK391.87390714
24KIT1.87355252
25INSRR1.83922749
26DDR21.74972176
27NUAK11.74308086
28NEK91.71060914
29TTN1.70579082
30PDK21.51877914
31MAP3K131.51183631
32MAP2K61.47529893
33TNK21.41944628
34RIPK11.40396099
35PTK2B1.35517490
36EPHB21.31990896
37NTRK11.31270596
38PDGFRB1.28451872
39PKN21.27461269
40MET1.20353300
41BLK1.19463055
42PTK61.13500572
43MST41.10132795
44PRKCG1.07542611
45EPHA41.06135352
46KSR21.06117722
47EPHA21.04437951
48SRPK11.00077915
49MAP2K41.00012625
50MAPK130.99311913
51TYK20.98145161
52PDPK10.95824396
53CDK120.95416038
54PAK20.91948778
55TLK10.88584780
56PRKAA20.88305982
57CAMK2B0.87724478
58STK160.86559445
59PDK10.85936254
60GRK10.84546282
61MAPK70.79987799
62CDC42BPA0.79338102
63STK380.77127641
64ERBB20.76938383
65FLT30.76142694
66ADRBK10.75150589
67ZAP700.74413169
68MARK10.72352712
69ERBB30.71097107
70PRKG20.69485484
71PAK40.68932453
72CSF1R0.68491316
73MAP3K60.67756009
74DYRK1A0.67243394
75TRIB30.66450211
76KSR10.64701393
77MAP2K10.64474745
78PRPF4B0.64375264
79GRK60.63277842
80ABL20.62935984
81MAP3K70.62483112
82TESK20.62474790
83SRC0.61687502
84MAPK110.60674742
85PRKAA10.59744366
86PRKACB0.59030263
87WNK10.58880150
88MYLK0.57662974
89MAPKAPK30.56256671
90EPHB10.55367859
91INSR0.55057799
92DAPK20.54318521
93MUSK0.54061055
94DAPK30.53022988
95MAP3K140.52631102
96JAK10.52143733
97TEC0.50887111
98MAP3K110.50656936
99CDK60.50205536
100PIM20.49836609
101JAK20.49768970
102PRKACA0.49349401
103RPS6KA20.49342055
104CSNK1D0.48366737
105MAP2K20.47593693
106CDK40.46865893
107PTK20.46621482
108CDK80.44569986
109TRPM70.43717169
110JAK30.43485903
111MAP3K30.42819166
112CDK90.42754483
113IGF1R0.41122817
114PRKCZ0.40679372
115CAMK2A0.40562295
116MAP3K20.40559248
117PRKD20.39388326
118GRK70.39051776
119MAP3K10.38348971
120GSK3A0.37840602
121MAP3K100.37767132
122FYN0.37246298
123PRKCE0.36609045
124MAP2K30.35487996
125MAP4K10.35092498
126PRKCQ0.34984947
127PRKACG0.34450336
128TIE10.33722503
129PAK30.33719372
130MOS0.33179423
131EPHA30.32539779
132TGFBR20.32392726
133FER0.31965454
134ARAF0.31843307
135BMX0.31613178
136MAPK40.29438114
137SGK10.28433724
138KDR0.27465513
139MAPK120.27381135
140LRRK20.27357865
141SGK4940.26756635
142SGK2230.26756635
143CSK0.26011997
144STK100.25875071
145EIF2AK20.25075265
146FGFR20.24515437
147CAMK2G0.21078988
148ROCK10.20533081
149PDGFRA0.17700997
150PRKCA0.17236192
151PRKCI0.16764295
152STK38L0.15581547
153PIK3CA0.14610417

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.66663913
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.47992713
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.76184644
4Tryptophan metabolism_Homo sapiens_hsa003802.75765235
5Fatty acid degradation_Homo sapiens_hsa000712.67581235
6Nitrogen metabolism_Homo sapiens_hsa009102.65604111
7Butanoate metabolism_Homo sapiens_hsa006502.60109991
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.58162623
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.56909942
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.45935709
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.45755570
12Arginine biosynthesis_Homo sapiens_hsa002202.42721315
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.41460847
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.35854965
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23344431
16Propanoate metabolism_Homo sapiens_hsa006402.21860938
17Sulfur metabolism_Homo sapiens_hsa009202.19232523
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.10759455
19Chemical carcinogenesis_Homo sapiens_hsa052042.08968754
20Peroxisome_Homo sapiens_hsa041462.07611979
21beta-Alanine metabolism_Homo sapiens_hsa004102.07084135
22Histidine metabolism_Homo sapiens_hsa003402.06246800
23Retinol metabolism_Homo sapiens_hsa008301.88398911
24Fatty acid metabolism_Homo sapiens_hsa012121.87390131
25Complement and coagulation cascades_Homo sapiens_hsa046101.86925519
26ECM-receptor interaction_Homo sapiens_hsa045121.85672314
27PPAR signaling pathway_Homo sapiens_hsa033201.75304674
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.72708792
29Fat digestion and absorption_Homo sapiens_hsa049751.72353177
30Bile secretion_Homo sapiens_hsa049761.71578340
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62705838
32Pyruvate metabolism_Homo sapiens_hsa006201.61265788
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.61127834
34Vitamin digestion and absorption_Homo sapiens_hsa049771.58071655
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.48877690
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.47866905
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.43605106
38Phenylalanine metabolism_Homo sapiens_hsa003601.42393341
39N-Glycan biosynthesis_Homo sapiens_hsa005101.40271892
40Glutathione metabolism_Homo sapiens_hsa004801.31455018
41Fatty acid elongation_Homo sapiens_hsa000621.28360566
42Starch and sucrose metabolism_Homo sapiens_hsa005001.26321909
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25899012
44Lysosome_Homo sapiens_hsa041421.25373762
45Pertussis_Homo sapiens_hsa051331.23964789
46Tyrosine metabolism_Homo sapiens_hsa003501.23907113
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21845366
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21569718
49ABC transporters_Homo sapiens_hsa020101.21215693
50Arginine and proline metabolism_Homo sapiens_hsa003301.20883033
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.19463428
52Carbon metabolism_Homo sapiens_hsa012001.17193232
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16811829
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16472150
55Vibrio cholerae infection_Homo sapiens_hsa051101.15411129
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12338058
57Amoebiasis_Homo sapiens_hsa051461.11584550
58Staphylococcus aureus infection_Homo sapiens_hsa051501.10158153
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09028228
60Maturity onset diabetes of the young_Homo sapiens_hsa049501.05077648
61Selenocompound metabolism_Homo sapiens_hsa004501.03873299
62Caffeine metabolism_Homo sapiens_hsa002321.01716685
63Folate biosynthesis_Homo sapiens_hsa007901.01405590
64Lysine degradation_Homo sapiens_hsa003100.99656934
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.98944001
66Focal adhesion_Homo sapiens_hsa045100.98855036
67Biosynthesis of amino acids_Homo sapiens_hsa012300.98194758
68Phagosome_Homo sapiens_hsa041450.96178898
69Melanoma_Homo sapiens_hsa052180.94801587
70Glycerolipid metabolism_Homo sapiens_hsa005610.91565293
71Linoleic acid metabolism_Homo sapiens_hsa005910.89897765
72Sulfur relay system_Homo sapiens_hsa041220.85372321
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83332348
74Sphingolipid metabolism_Homo sapiens_hsa006000.79394336
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78412404
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78352176
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73827416
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73019597
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71397310
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67259444
81Dilated cardiomyopathy_Homo sapiens_hsa054140.67107892
82Steroid biosynthesis_Homo sapiens_hsa001000.63923707
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60227776
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59494451
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57443023
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57094649
87Pentose phosphate pathway_Homo sapiens_hsa000300.56804016
88Rap1 signaling pathway_Homo sapiens_hsa040150.56648039
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54757005
90Ras signaling pathway_Homo sapiens_hsa040140.50034899
91Vitamin B6 metabolism_Homo sapiens_hsa007500.47699710
92Gastric acid secretion_Homo sapiens_hsa049710.47584003
93Metabolic pathways_Homo sapiens_hsa011000.45890421
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43779558
95Nicotine addiction_Homo sapiens_hsa050330.42740516
96Collecting duct acid secretion_Homo sapiens_hsa049660.40167013
97One carbon pool by folate_Homo sapiens_hsa006700.39833507
98Cocaine addiction_Homo sapiens_hsa050300.38140806
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36998764
100Malaria_Homo sapiens_hsa051440.35172690
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34994498
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.33686638
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33599666
104Arachidonic acid metabolism_Homo sapiens_hsa005900.33041064
105Fatty acid biosynthesis_Homo sapiens_hsa000610.31493374
106Mineral absorption_Homo sapiens_hsa049780.31400248
107Rheumatoid arthritis_Homo sapiens_hsa053230.30290586
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30103037
109Ether lipid metabolism_Homo sapiens_hsa005650.28154170
110Fructose and mannose metabolism_Homo sapiens_hsa000510.27900626
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.22992909
112Insulin resistance_Homo sapiens_hsa049310.14235934
113Thyroid hormone synthesis_Homo sapiens_hsa049180.14143881
114Galactose metabolism_Homo sapiens_hsa000520.12501010
115Protein digestion and absorption_Homo sapiens_hsa049740.10098400
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.08590730
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07388847
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.06320724
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.05887585
120Prion diseases_Homo sapiens_hsa050200.03301398
121Pancreatic secretion_Homo sapiens_hsa049720.01995752
122Glucagon signaling pathway_Homo sapiens_hsa049220.01152652
123Other glycan degradation_Homo sapiens_hsa005110.00183982
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1543159
125Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1536172
126Oxidative phosphorylation_Homo sapiens_hsa00190-0.1520995
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1258884
128Hepatitis C_Homo sapiens_hsa05160-0.0938621
129Renin-angiotensin system_Homo sapiens_hsa04614-0.0672578
130Asthma_Homo sapiens_hsa05310-0.0635426
131AMPK signaling pathway_Homo sapiens_hsa04152-0.0462515
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0458257
133Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0349105

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