AAAS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the WD-repeat family of regulatory proteins and may be involved in normal development of the peripheral and central nervous system. The encoded protein is part of the nuclear pore complex and is anchored there by NDC1. Defects in this gene are a cause of achalasia-addisonianism-alacrima syndrome (AAAS), also called triple-A syndrome or Allgrove syndrome. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)7.09849703
2replication fork processing (GO:0031297)6.08645440
3transcription from mitochondrial promoter (GO:0006390)5.80073654
4DNA deamination (GO:0045006)5.65304054
5maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.45973556
6embryonic process involved in female pregnancy (GO:0060136)5.31937014
7telomere maintenance via semi-conservative replication (GO:0032201)5.16978042
8proline metabolic process (GO:0006560)5.13977085
9formation of translation preinitiation complex (GO:0001731)5.10879408
10somatic diversification of immune receptors via somatic mutation (GO:0002566)5.07622955
11somatic hypermutation of immunoglobulin genes (GO:0016446)5.07622955
12DNA strand elongation involved in DNA replication (GO:0006271)4.83251990
13DNA strand elongation (GO:0022616)4.57922754
14establishment of integrated proviral latency (GO:0075713)4.54857581
15DNA strand renaturation (GO:0000733)4.52482653
16viral mRNA export from host cell nucleus (GO:0046784)4.48149924
17positive regulation of protein homooligomerization (GO:0032464)4.48034302
18telomere maintenance via recombination (GO:0000722)4.43325202
19mitochondrial DNA metabolic process (GO:0032042)4.41120319
20nucleotide-excision repair, DNA gap filling (GO:0006297)4.40640366
21mitotic chromosome condensation (GO:0007076)4.40581061
22establishment of apical/basal cell polarity (GO:0035089)4.38259570
23mitotic G1 DNA damage checkpoint (GO:0031571)4.25272114
24regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.19608440
25regulation of integrin activation (GO:0033623)4.13580235
26base-excision repair (GO:0006284)4.12320336
27protein localization to chromosome, centromeric region (GO:0071459)4.05440843
28mitotic recombination (GO:0006312)3.98500942
29positive regulation of mitotic sister chromatid separation (GO:1901970)3.94861984
30positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.94861984
31positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.94861984
32peptidyl-arginine omega-N-methylation (GO:0035247)3.93457410
33kinetochore assembly (GO:0051382)3.90130787
34mRNA cleavage (GO:0006379)3.88926647
35regulation of translational fidelity (GO:0006450)3.88689494
36meiotic chromosome segregation (GO:0045132)3.88551726
37regulation of double-strand break repair via homologous recombination (GO:0010569)3.84667540
38oxidative demethylation (GO:0070989)3.84651541
39telomere maintenance via telomere lengthening (GO:0010833)3.81721291
40mitotic sister chromatid segregation (GO:0000070)3.80156130
41establishment of viral latency (GO:0019043)3.79226821
42negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.79160752
43G1 DNA damage checkpoint (GO:0044783)3.72051566
44kinetochore organization (GO:0051383)3.70132772
45poly(A)+ mRNA export from nucleus (GO:0016973)3.69445251
46establishment of monopolar cell polarity (GO:0061162)3.69299468
47establishment or maintenance of monopolar cell polarity (GO:0061339)3.69299468
48mitotic G1/S transition checkpoint (GO:0044819)3.68307849
49deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.66274536
50positive regulation of chromosome segregation (GO:0051984)3.66128095
51DNA replication initiation (GO:0006270)3.63612866
52regulation of protein homooligomerization (GO:0032462)3.62859964
53metaphase plate congression (GO:0051310)3.58809779
54regulation of sister chromatid cohesion (GO:0007063)3.58306159
55maturation of 5.8S rRNA (GO:0000460)3.57568368
56spliceosomal tri-snRNP complex assembly (GO:0000244)3.57193389
57non-recombinational repair (GO:0000726)3.56213875
58double-strand break repair via nonhomologous end joining (GO:0006303)3.56213875
59DNA double-strand break processing (GO:0000729)3.55090595
60establishment of protein localization to mitochondrial membrane (GO:0090151)3.54151907
61DNA topological change (GO:0006265)3.53572097
62nuclear pore complex assembly (GO:0051292)3.50953662
63termination of RNA polymerase II transcription (GO:0006369)3.50307590
64base-excision repair, AP site formation (GO:0006285)3.45571926
65L-serine metabolic process (GO:0006563)3.43471378
66dosage compensation (GO:0007549)3.38426102
67anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.37740873
68* membrane disassembly (GO:0030397)3.36586871
69* nuclear envelope disassembly (GO:0051081)3.36586871
70histone arginine methylation (GO:0034969)3.35751371
71regulation of double-strand break repair (GO:2000779)3.34429265
72negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.34253706
73DNA integration (GO:0015074)3.33693245
74negative regulation of mRNA processing (GO:0050686)3.32392665
75histone H4-K12 acetylation (GO:0043983)3.32268652
76purine nucleobase biosynthetic process (GO:0009113)3.31950865
77ribosome biogenesis (GO:0042254)3.31358469
78regulation of mitochondrial translation (GO:0070129)3.31218954
79CENP-A containing nucleosome assembly (GO:0034080)3.30984084
80DNA unwinding involved in DNA replication (GO:0006268)3.30556264
81spindle checkpoint (GO:0031577)3.28640061
82regulation of chromosome segregation (GO:0051983)3.28526476
83mitochondrial RNA metabolic process (GO:0000959)3.28452105
84regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.27457305
85pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.27253090
86negative regulation of cell cycle arrest (GO:0071157)3.25658961
87chromatin remodeling at centromere (GO:0031055)3.24601295
88regulation of posttranscriptional gene silencing (GO:0060147)3.24459184
89regulation of gene silencing by miRNA (GO:0060964)3.24459184
90regulation of gene silencing by RNA (GO:0060966)3.24459184
91mitotic spindle assembly checkpoint (GO:0007094)3.24179609
92mitotic spindle checkpoint (GO:0071174)3.23878753
93chromosome segregation (GO:0007059)3.23514620
94DNA ligation (GO:0006266)3.23112034
95peptidyl-arginine methylation (GO:0018216)3.22957982
96peptidyl-arginine N-methylation (GO:0035246)3.22957982
97sister chromatid segregation (GO:0000819)3.22926480
98negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.22853812
99negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.22853812
100negative regulation of mitotic sister chromatid segregation (GO:0033048)3.22853812
101negative regulation of mitotic sister chromatid separation (GO:2000816)3.22853812
102negative regulation of sister chromatid segregation (GO:0033046)3.22853812
103regulation of spindle organization (GO:0090224)3.20810537
104regulation of mitotic spindle organization (GO:0060236)3.19669558
105spindle assembly checkpoint (GO:0071173)3.19414318
106negative regulation of RNA splicing (GO:0033119)3.17620796
107negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.17618324
108negative regulation of ligase activity (GO:0051352)3.17618324
109DNA replication checkpoint (GO:0000076)3.16311061
110regulation of DNA damage checkpoint (GO:2000001)3.13614941
111IMP biosynthetic process (GO:0006188)3.13171629
112protein localization to kinetochore (GO:0034501)3.11308660
113establishment of chromosome localization (GO:0051303)3.10374702
114Golgi transport vesicle coating (GO:0048200)3.08716514
115COPI coating of Golgi vesicle (GO:0048205)3.08716514
116oxidative phosphorylation (GO:0006119)3.07892907
117positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07013012
118negative regulation of JAK-STAT cascade (GO:0046426)3.06452651
119DNA replication-dependent nucleosome organization (GO:0034723)3.06332605
120cullin deneddylation (GO:0010388)3.05501289
121chromosome condensation (GO:0030261)3.04890666
122nuclear pore organization (GO:0006999)3.00521408
123mitotic metaphase plate congression (GO:0007080)3.00393969
124nodal signaling pathway (GO:0038092)3.00384729
125regulation of RNA export from nucleus (GO:0046831)2.97350501
126metallo-sulfur cluster assembly (GO:0031163)2.96949374
127iron-sulfur cluster assembly (GO:0016226)2.96949374
128nucleobase biosynthetic process (GO:0046112)2.96597557
129histone H2A acetylation (GO:0043968)2.95358531
130DNA replication-independent nucleosome organization (GO:0034724)2.95307639
131DNA replication-independent nucleosome assembly (GO:0006336)2.95307639
132mRNA export from nucleus (GO:0006406)2.93014097
133trophectodermal cell differentiation (GO:0001829)2.91975353
134resolution of meiotic recombination intermediates (GO:0000712)2.90602035
135mitochondrial DNA replication (GO:0006264)2.90163885
136regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.89121143
137* mitotic nuclear envelope disassembly (GO:0007077)2.89103254
138ribosome assembly (GO:0042255)2.88368636
139embryonic placenta development (GO:0001892)2.88062331
140tRNA aminoacylation for protein translation (GO:0006418)2.87501784
141DNA duplex unwinding (GO:0032508)2.87438409
142heterochromatin organization (GO:0070828)2.87109420
143regulation of mitotic metaphase/anaphase transition (GO:0030071)2.86685586
144regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.86685586
145negative regulation of chromosome segregation (GO:0051985)2.86637774
146DNA geometric change (GO:0032392)2.85929536
147regulation of sister chromatid segregation (GO:0033045)2.85672983
148regulation of mitotic sister chromatid separation (GO:0010965)2.85672983
149regulation of mitotic sister chromatid segregation (GO:0033047)2.85672983
150nucleobase-containing small molecule interconversion (GO:0015949)2.85672777
151positive regulation of protein oligomerization (GO:0032461)2.85083299
152pseudouridine synthesis (GO:0001522)2.83770747
153spliceosomal snRNP assembly (GO:0000387)2.83458706
154attachment of spindle microtubules to kinetochore (GO:0008608)2.83354285
155nuclear envelope reassembly (GO:0031468)2.83205899
156mitotic nuclear envelope reassembly (GO:0007084)2.83205899
157protein deneddylation (GO:0000338)2.82372596
158rRNA processing (GO:0006364)2.82169300
159protein localization to chromosome (GO:0034502)2.81989969
160RNA export from nucleus (GO:0006405)2.81893281
161transcription-coupled nucleotide-excision repair (GO:0006283)2.81364258
162DNA replication-dependent nucleosome assembly (GO:0006335)2.81112307

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.40756268
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.90896006
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.36504961
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.26511081
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.91714334
6* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.68937835
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61525952
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.61466281
9* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.60813058
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55239343
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.30961402
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.30808948
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.30808948
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.30808948
15ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.19659567
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.13026357
17* ETS1_20019798_ChIP-Seq_JURKAT_Human2.10774775
18NANOG_18555785_ChIP-Seq_MESCs_Mouse1.96462851
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95612540
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94608528
21E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92740263
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.89476593
23VDR_21846776_ChIP-Seq_THP-1_Human1.88527056
24* EST1_17652178_ChIP-ChIP_JURKAT_Human1.88396698
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.87701950
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.84698554
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.83957835
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.82988386
29* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82955298
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82323486
31KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.81535014
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.78501852
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.77198083
34* XRN2_22483619_ChIP-Seq_HELA_Human1.76906083
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76313262
36MYC_22102868_ChIP-Seq_BL_Human1.76265680
37DCP1A_22483619_ChIP-Seq_HELA_Human1.71814417
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69969692
39* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.69079837
40* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.69024982
41SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.66799568
42* GABP_19822575_ChIP-Seq_HepG2_Human1.66181338
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.65664875
44* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62720694
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.62648839
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60324609
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58801385
48CIITA_25753668_ChIP-Seq_RAJI_Human1.58366015
49TCF3_18692474_ChIP-Seq_MEFs_Mouse1.55263224
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.52398061
51TTF2_22483619_ChIP-Seq_HELA_Human1.51996552
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50536987
53* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.49813011
54* VDR_23849224_ChIP-Seq_CD4+_Human1.48748381
55* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48567352
56TCF3_18692474_ChIP-Seq_MESCs_Mouse1.48304927
57NANOG_21062744_ChIP-ChIP_HESCs_Human1.47651430
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44360608
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43144000
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42468400
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.40994613
62POU5F1_16518401_ChIP-PET_MESCs_Mouse1.39399341
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38915892
64KDM5A_27292631_Chip-Seq_BREAST_Human1.38683097
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37839939
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37731563
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.35429656
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35262206
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35172459
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.32220124
71* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.31976311
72KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28800282
73* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28581388
74AR_21909140_ChIP-Seq_LNCAP_Human1.28002068
75FOXP3_21729870_ChIP-Seq_TREG_Human1.26029034
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25364872
77* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25325158
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23259316
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22242622
80SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19672821
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19577647
82ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18823098
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18237295
84* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18109398
85* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.17087158
86EGR1_19374776_ChIP-ChIP_THP-1_Human1.16583206
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15796525
88TFEB_21752829_ChIP-Seq_HELA_Human1.14477975
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13910681
90SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13386149
91* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13225269
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12321777
93* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.11527014
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09983321
95OCT4_18692474_ChIP-Seq_MEFs_Mouse1.09784495
96SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09013261
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08712366
98NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.07978092
99SRF_21415370_ChIP-Seq_HL-1_Mouse1.07902825
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06501085
101CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05391909
102ZNF263_19887448_ChIP-Seq_K562_Human1.04288018
103* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04224161
104PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02933529
105YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02709066
106SOX2_18692474_ChIP-Seq_MESCs_Mouse1.02707993
107CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02411819
108* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02074959
109* ELK1_19687146_ChIP-ChIP_HELA_Human1.01932946
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00969033
111* FOXP1_21924763_ChIP-Seq_HESCs_Human1.00761161
112* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99368561
113PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98415702
114HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97780442
115TET1_21451524_ChIP-Seq_MESCs_Mouse0.95575305
116GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94502150
117LXR_22292898_ChIP-Seq_THP-1_Human0.93981085
118SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92572708
119TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90859776
120NANOG_18692474_ChIP-Seq_MESCs_Mouse0.90828668
121TP63_19390658_ChIP-ChIP_HaCaT_Human0.90711579
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90394791
123HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90121337
124* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.89686160
125EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89423358
126SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88597702
127SALL1_21062744_ChIP-ChIP_HESCs_Human0.87429062
128ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87238944

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.08290725
2MP0010094_abnormal_chromosome_stability4.01895856
3MP0004957_abnormal_blastocyst_morpholog3.54342228
4MP0003693_abnormal_embryo_hatching3.42155293
5MP0003111_abnormal_nucleus_morphology3.41726701
6MP0010030_abnormal_orbit_morphology3.08919791
7MP0009278_abnormal_bone_marrow3.04628164
8MP0003077_abnormal_cell_cycle2.91578345
9MP0008058_abnormal_DNA_repair2.80500221
10MP0005171_absent_coat_pigmentation2.65818528
11MP0010352_gastrointestinal_tract_polyps2.42638317
12MP0008932_abnormal_embryonic_tissue2.36952800
13MP0003786_premature_aging2.34847200
14MP0004233_abnormal_muscle_weight2.17588542
15MP0008877_abnormal_DNA_methylation2.06847441
16MP0003890_abnormal_embryonic-extraembry2.06167985
17MP0001545_abnormal_hematopoietic_system2.06045617
18MP0005397_hematopoietic_system_phenotyp2.06045617
19MP0009697_abnormal_copulation1.97739788
20MP0004133_heterotaxia1.93932509
21MP0001730_embryonic_growth_arrest1.90263277
22MP0000350_abnormal_cell_proliferation1.88087217
23MP0000490_abnormal_crypts_of1.87157709
24MP0001697_abnormal_embryo_size1.85457193
25MP0002009_preneoplasia1.83756091
26MP0008995_early_reproductive_senescence1.80222783
27MP0006036_abnormal_mitochondrial_physio1.78388405
28MP0002653_abnormal_ependyma_morphology1.75873525
29MP0002086_abnormal_extraembryonic_tissu1.73926144
30MP0002084_abnormal_developmental_patter1.71563277
31MP0001672_abnormal_embryogenesis/_devel1.69717399
32MP0005380_embryogenesis_phenotype1.69717399
33MP0002085_abnormal_embryonic_tissue1.69188232
34MP0008007_abnormal_cellular_replicative1.64992409
35MP0003119_abnormal_digestive_system1.63470316
36MP0005076_abnormal_cell_differentiation1.62505002
37MP0001293_anophthalmia1.60272192
38MP0005451_abnormal_body_composition1.59234589
39MP0004197_abnormal_fetal_growth/weight/1.58406784
40MP0006035_abnormal_mitochondrial_morpho1.57518017
41MP0010307_abnormal_tumor_latency1.55789189
42MP0002396_abnormal_hematopoietic_system1.55415276
43MP0000678_abnormal_parathyroid_gland1.55251052
44MP0003567_abnormal_fetal_cardiomyocyte1.54009467
45MP0008260_abnormal_autophagy1.47495479
46MP0009672_abnormal_birth_weight1.46010532
47MP0005174_abnormal_tail_pigmentation1.43427073
48MP0002080_prenatal_lethality1.42597537
49MP0003984_embryonic_growth_retardation1.41419188
50MP0002019_abnormal_tumor_incidence1.40259836
51MP0002088_abnormal_embryonic_growth/wei1.36157562
52MP0003283_abnormal_digestive_organ1.34793351
53MP0003718_maternal_effect1.34746781
54MP0001661_extended_life_span1.31906717
55MP0001529_abnormal_vocalization1.27304002
56MP0005075_abnormal_melanosome_morpholog1.26187877
57MP0008789_abnormal_olfactory_epithelium1.25269272
58MP0002249_abnormal_larynx_morphology1.24007893
59MP0000313_abnormal_cell_death1.21480851
60MP0003453_abnormal_keratinocyte_physiol1.18452572
61MP0002282_abnormal_trachea_morphology1.17869538
62MP0000537_abnormal_urethra_morphology1.17632760
63MP0002234_abnormal_pharynx_morphology1.16967623
64MP0009333_abnormal_splenocyte_physiolog1.16659368
65MP0001764_abnormal_homeostasis1.16552679
66MP0001346_abnormal_lacrimal_gland1.15546894
67MP0002111_abnormal_tail_morphology1.14890829
68MP0003186_abnormal_redox_activity1.14391097
69MP0005083_abnormal_biliary_tract1.13026812
70MP0000015_abnormal_ear_pigmentation1.12285496
71MP0005394_taste/olfaction_phenotype1.11718858
72MP0005499_abnormal_olfactory_system1.11718858
73MP0006072_abnormal_retinal_apoptosis1.10348347
74MP0001727_abnormal_embryo_implantation1.07538052
75MP0000371_diluted_coat_color1.07457278
76MP0005058_abnormal_lysosome_morphology1.03529496
77MP0000751_myopathy1.02547528
78MP0002269_muscular_atrophy0.97392321
79MP0000566_synostosis0.96299202
80MP0003806_abnormal_nucleotide_metabolis0.95180284
81MP0001145_abnormal_male_reproductive0.94745097
82MP0002697_abnormal_eye_size0.93831637
83MP0000470_abnormal_stomach_morphology0.93054617
84MP0004264_abnormal_extraembryonic_tissu0.91499678
85MP0005023_abnormal_wound_healing0.90957544
86MP0003941_abnormal_skin_development0.90828613
87MP0000049_abnormal_middle_ear0.86303795
88MP0009053_abnormal_anal_canal0.86157036
89MP0002210_abnormal_sex_determination0.85506094
90MP0002932_abnormal_joint_morphology0.85383877
91MP0005266_abnormal_metabolism0.84571036
92MP0003315_abnormal_perineum_morphology0.84487614
93MP0003566_abnormal_cell_adhesion0.84179763
94MP0002075_abnormal_coat/hair_pigmentati0.83431999
95MP0000689_abnormal_spleen_morphology0.83231516
96MP0005384_cellular_phenotype0.81757822
97MP0002938_white_spotting0.81583893
98MP0004185_abnormal_adipocyte_glucose0.81010768
99MP0003172_abnormal_lysosome_physiology0.80733557
100MP0001849_ear_inflammation0.80133457
101MP0003763_abnormal_thymus_physiology0.79251378
102MP0000703_abnormal_thymus_morphology0.78906164
103MP0003937_abnormal_limbs/digits/tail_de0.78684860
104MP0005501_abnormal_skin_physiology0.76574494
105MP0002405_respiratory_system_inflammati0.76152124
106MP0002114_abnormal_axial_skeleton0.73751224
107MP0000685_abnormal_immune_system0.73442613
108MP0004858_abnormal_nervous_system0.73380422
109MP0003385_abnormal_body_wall0.72902460
110MP0002722_abnormal_immune_system0.72638205
111MP0000653_abnormal_sex_gland0.72174476
112MP0003698_abnormal_male_reproductive0.71926642
113* MP0002161_abnormal_fertility/fecundity0.71346657
114MP0003861_abnormal_nervous_system0.70908026
115MP0000477_abnormal_intestine_morphology0.70696030
116MP0003755_abnormal_palate_morphology0.70625367
117MP0005330_cardiomyopathy0.70511227
118MP0001186_pigmentation_phenotype0.70232482
119MP0001929_abnormal_gametogenesis0.70081699
120MP0002398_abnormal_bone_marrow0.69887073
121MP0005220_abnormal_exocrine_pancreas0.69740688
122MP0000762_abnormal_tongue_morphology0.69265361
123MP0002796_impaired_skin_barrier0.68576573
124MP0000432_abnormal_head_morphology0.68487752
125MP0003935_abnormal_craniofacial_develop0.68047921
126MP0003828_pulmonary_edema0.67171028
127MP0009703_decreased_birth_body0.66730302
128MP0005621_abnormal_cell_physiology0.66667801
129MP0003123_paternal_imprinting0.66440334
130MP0005623_abnormal_meninges_morphology0.66051418
131MP0002233_abnormal_nose_morphology0.65969930
132MP0006292_abnormal_olfactory_placode0.64940217
133* MP0003699_abnormal_female_reproductive0.64477237
134MP0001915_intracranial_hemorrhage0.64072803
135MP0000579_abnormal_nail_morphology0.63926338
136MP0004808_abnormal_hematopoietic_stem0.63666142
137MP0002970_abnormal_white_adipose0.62733779
138MP0003115_abnormal_respiratory_system0.61895724
139MP0003943_abnormal_hepatobiliary_system0.61590417
140MP0001119_abnormal_female_reproductive0.61296100
141MP0000516_abnormal_urinary_system0.61009964
142MP0005367_renal/urinary_system_phenotyp0.61009964
143MP0003705_abnormal_hypodermis_morpholog0.60218602
144MP0000358_abnormal_cell_content/0.59002273
145MP0002132_abnormal_respiratory_system0.58490181
146MP0003936_abnormal_reproductive_system0.57783863

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)4.92214526
2Microvesicular hepatic steatosis (HP:0001414)4.73269458
3Facial hemangioma (HP:0000329)4.48366869
4Rectal fistula (HP:0100590)4.34531344
5Rectovaginal fistula (HP:0000143)4.34531344
6Abnormal gallbladder physiology (HP:0012438)4.21271050
7Cholecystitis (HP:0001082)4.21271050
8Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.20031022
9Abnormality of glycolysis (HP:0004366)4.05162310
10Poikiloderma (HP:0001029)4.02070722
11Concave nail (HP:0001598)4.00102925
12Pustule (HP:0200039)3.96383698
13Absent radius (HP:0003974)3.92840082
14Intestinal fistula (HP:0100819)3.88532333
15Selective tooth agenesis (HP:0001592)3.81146262
16Annular pancreas (HP:0001734)3.78897098
17Tongue fasciculations (HP:0001308)3.76948109
18Aplasia/hypoplasia of the humerus (HP:0006507)3.75589663
19Vaginal fistula (HP:0004320)3.74980621
20Patellar aplasia (HP:0006443)3.72103497
21Absent forearm bone (HP:0003953)3.67944366
22Aplasia involving forearm bones (HP:0009822)3.67944366
23Short humerus (HP:0005792)3.65064373
24Absent thumb (HP:0009777)3.57900231
25Increased serum pyruvate (HP:0003542)3.52660162
26Aplasia/Hypoplasia of the patella (HP:0006498)3.44690175
27Muscle fibrillation (HP:0010546)3.44509837
28Squamous cell carcinoma (HP:0002860)3.39549749
29Ulnar bowing (HP:0003031)3.38840383
30Ragged-red muscle fibers (HP:0003200)3.37983644
31Broad distal phalanx of finger (HP:0009836)3.35975919
32Hypochromic microcytic anemia (HP:0004840)3.32174689
33Increased IgM level (HP:0003496)3.31933771
34Basal cell carcinoma (HP:0002671)3.24624719
35Birth length less than 3rd percentile (HP:0003561)3.20295315
36Alopecia of scalp (HP:0002293)3.16527488
37Breast hypoplasia (HP:0003187)3.15794559
38Premature graying of hair (HP:0002216)3.07156328
39Abnormality of the labia minora (HP:0012880)3.00857392
40Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.98084234
41Vertebral hypoplasia (HP:0008417)2.98084234
42Increased nuchal translucency (HP:0010880)2.94443328
43Abnormal mitochondria in muscle tissue (HP:0008316)2.93262581
44Abnormal hemoglobin (HP:0011902)2.86091315
45Intestinal atresia (HP:0011100)2.79503752
46Cortical dysplasia (HP:0002539)2.73403441
47Abnormality of the ileum (HP:0001549)2.72279164
48Hypoplasia of the capital femoral epiphysis (HP:0003090)2.71739818
49Acute necrotizing encephalopathy (HP:0006965)2.71324516
50Turricephaly (HP:0000262)2.70083868
51Progressive muscle weakness (HP:0003323)2.68683237
52Ependymoma (HP:0002888)2.62318893
53Cholelithiasis (HP:0001081)2.61082153
54Congenital hip dislocation (HP:0001374)2.56804236
55Abnormality of male internal genitalia (HP:0000022)2.56633093
56Male infertility (HP:0003251)2.55244733
57Coronal craniosynostosis (HP:0004440)2.54422812
58Abnormality of the astrocytes (HP:0100707)2.54203471
59Astrocytoma (HP:0009592)2.54203471
60Acute encephalopathy (HP:0006846)2.53808298
61Volvulus (HP:0002580)2.51258983
62Abnormal number of incisors (HP:0011064)2.48719660
63Broad alveolar ridges (HP:0000187)2.47541360
64Degeneration of anterior horn cells (HP:0002398)2.45535246
65Abnormality of the anterior horn cell (HP:0006802)2.45535246
66Decreased activity of mitochondrial respiratory chain (HP:0008972)2.42404537
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.42404537
68Type I transferrin isoform profile (HP:0003642)2.42200924
69Mitochondrial inheritance (HP:0001427)2.42089098
70Albinism (HP:0001022)2.41630155
71Abnormality of reticulocytes (HP:0004312)2.41005236
72Hypoplasia of the radius (HP:0002984)2.38870770
73Acute lymphatic leukemia (HP:0006721)2.37208966
74Short chin (HP:0000331)2.36958580
75Hepatocellular necrosis (HP:0001404)2.34147969
76Anteriorly placed anus (HP:0001545)2.32768484
77Abnormal lung lobation (HP:0002101)2.32737960
78Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.32374301
79Absent epiphyses (HP:0010577)2.32374301
80Capillary hemangiomas (HP:0005306)2.31450316
81Gout (HP:0001997)2.31299439
82Exercise intolerance (HP:0003546)2.31075146
83Abnormal gallbladder morphology (HP:0012437)2.30880623
84Abnormality of the preputium (HP:0100587)2.30743112
85Neoplasm of the oral cavity (HP:0100649)2.29544052
86Abnormal umbilical cord blood vessels (HP:0011403)2.27168013
87Single umbilical artery (HP:0001195)2.27168013
88Abnormality of the fetal cardiovascular system (HP:0010948)2.27168013
89Spinal muscular atrophy (HP:0007269)2.27098620
90Increased CSF lactate (HP:0002490)2.26159281
91Rhabdomyosarcoma (HP:0002859)2.24877420
92Reticulocytosis (HP:0001923)2.24097121
93Short thumb (HP:0009778)2.23709490
94Hypochromic anemia (HP:0001931)2.23518953
95Increased serum lactate (HP:0002151)2.20677869
96Vertebral fusion (HP:0002948)2.20084500
97Hepatic necrosis (HP:0002605)2.19918658
98Abnormality of the aortic arch (HP:0012303)2.19836384
99Cerebral edema (HP:0002181)2.19238524
100IgA deficiency (HP:0002720)2.17543190
101Lactic acidosis (HP:0003128)2.16703783
102Bifid uvula (HP:0000193)2.14390520
103Medulloblastoma (HP:0002885)2.13389618
104Cerebral hypomyelination (HP:0006808)2.11797562
105Spastic diplegia (HP:0001264)2.11283626
106Horseshoe kidney (HP:0000085)2.11218481
107Abnormality of the umbilical cord (HP:0010881)2.10637368
108Hypotelorism (HP:0000601)2.10562331
109Duodenal stenosis (HP:0100867)2.10239633
110Small intestinal stenosis (HP:0012848)2.10239633
111Chromsome breakage (HP:0040012)2.09744121
112Short 5th finger (HP:0009237)2.09572764
113Muscle fiber atrophy (HP:0100295)2.08608062
114Truncus arteriosus (HP:0001660)2.08537245
115Glioma (HP:0009733)2.07753412
116Chromosomal breakage induced by crosslinking agents (HP:0003221)2.07568997
117Tubulointerstitial nephritis (HP:0001970)2.07148941
118Colon cancer (HP:0003003)2.06956938
119Secondary amenorrhea (HP:0000869)2.06567105
120Diaphragmatic weakness (HP:0009113)2.05585311
121Abdominal situs inversus (HP:0003363)2.05428841
122Abnormality of abdominal situs (HP:0011620)2.05428841
123Premature skin wrinkling (HP:0100678)2.05426384
124Joint stiffness (HP:0001387)2.02589768
125Myopathic facies (HP:0002058)2.02488605
126Progressive external ophthalmoplegia (HP:0000590)2.01954269
127Reticulocytopenia (HP:0001896)2.00322128
128Nonimmune hydrops fetalis (HP:0001790)1.99998385
129Hypoplastic pelvis (HP:0008839)1.99559469
130Aplasia/Hypoplasia of the sacrum (HP:0008517)1.98642061
131Myelodysplasia (HP:0002863)1.98122101
132Abnormality of the gallbladder (HP:0005264)1.97762457
133Carpal bone hypoplasia (HP:0001498)1.96100243
134Gastrointestinal atresia (HP:0002589)1.94848111
135Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94048111
136Abnormal protein N-linked glycosylation (HP:0012347)1.94048111
137Abnormal protein glycosylation (HP:0012346)1.94048111
138Abnormal glycosylation (HP:0012345)1.94048111
139Bowed forearm bones (HP:0003956)1.93388568
140Bowing of the arm (HP:0006488)1.93388568
141Progressive macrocephaly (HP:0004481)1.93019720
142Abnormality of cochlea (HP:0000375)1.91801389
143Seborrheic dermatitis (HP:0001051)1.91454319
144Impulsivity (HP:0100710)1.91336059
145Abnormality of cells of the erythroid lineage (HP:0012130)1.91308859
146Rough bone trabeculation (HP:0100670)1.90990902
147Hypotrichosis (HP:0001006)1.89899989
148Increased number of teeth (HP:0011069)1.89626599
149Aplasia/Hypoplasia of the uvula (HP:0010293)1.89616793
150Premature ovarian failure (HP:0008209)1.89604244
151Increased intramyocellular lipid droplets (HP:0012240)1.89175447
152Meckel diverticulum (HP:0002245)1.88754708
153Aplasia of the musculature (HP:0100854)1.88221912
154Abnormal number of erythroid precursors (HP:0012131)1.88064361
155Testicular atrophy (HP:0000029)1.88018060
156Aplasia/Hypoplasia involving the musculature (HP:0001460)1.87479345
157Supernumerary spleens (HP:0009799)1.86363672
158Missing ribs (HP:0000921)1.85324118
159Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.85276868
160Choanal stenosis (HP:0000452)1.85276617
161High anterior hairline (HP:0009890)1.84737984
162Overriding aorta (HP:0002623)1.83549707
163Breech presentation (HP:0001623)1.82935063
164Abnormality of chromosome stability (HP:0003220)1.80883564
165Increased hepatocellular lipid droplets (HP:0006565)1.79611350
166Nephroblastoma (Wilms tumor) (HP:0002667)1.78240557
167Hyperacusis (HP:0010780)1.76666822
168Insomnia (HP:0100785)1.75906288
169Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.72790891
170Shoulder girdle muscle weakness (HP:0003547)1.71051252
171Sloping forehead (HP:0000340)1.69532520
172Abnormality of methionine metabolism (HP:0010901)1.69386487
173Respiratory difficulties (HP:0002880)1.69031277
174Abnormality of the carotid arteries (HP:0005344)1.67744864
175Emotional lability (HP:0000712)1.67569089

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.69620077
2VRK24.32857332
3DDR23.91086486
4MAP3K63.60414849
5PBK3.22317717
6MAPK153.20025184
7MAP3K113.03044449
8PIM22.66501393
9SMG12.59649138
10BUB12.49439913
11WEE12.49159828
12MATK2.43186643
13CDK72.41205021
14CDC72.36943228
15PINK12.29641110
16TYRO32.10793821
17DAPK12.07558967
18FGR2.03432203
19STK161.90535410
20TRIB31.89929100
21PLK11.78299218
22NEK21.77104136
23BMX1.73277265
24NEK11.63899515
25YES11.63254870
26PIM11.62862439
27UHMK11.62012667
28CHEK21.59150350
29CCNB11.53966731
30CSK1.52916416
31CDK121.51101501
32CDK61.50911176
33EIF2AK11.49215453
34PRKD21.49195407
35BCKDK1.48146869
36AKT31.47707047
37NME11.43274620
38PDGFRA1.43251831
39DYRK1B1.42988715
40TRPM71.42391709
41ZAK1.39832470
42EPHA21.37334957
43ATR1.32112222
44LATS21.31170005
45TTK1.30335879
46KDR1.28996872
47RPS6KB21.26635196
48DYRK31.25617305
49TAF11.23323794
50MAP3K101.12816434
51BRSK21.05891645
52RPS6KC11.05610706
53RPS6KL11.05610706
54TESK21.05223892
55AURKB1.03622838
56PKN21.02252540
57PDK21.01052737
58EEF2K1.00703550
59CSNK1G30.99745699
60STK100.98491806
61AURKA0.97490133
62RPS6KA60.92269499
63TESK10.91536248
64ACVR1B0.90758831
65CHEK10.85612888
66TAOK20.85529560
67MAPK110.84525065
68CLK10.84296838
69SRPK10.83396378
70CDK20.80794315
71CDK40.80599831
72EIF2AK20.79570093
73TSSK60.79441485
74NME20.77265570
75CDC42BPA0.75979225
76MAP3K80.75028337
77MTOR0.74673046
78LRRK20.72135815
79CSNK1G10.71842634
80GSK3A0.68590508
81CSNK1A1L0.68492623
82LIMK10.68472306
83CSNK2A10.68089279
84IRAK30.67439352
85PAK40.66790594
86BRSK10.65009423
87ATM0.64701724
88NUAK10.60989926
89CDK80.58678466
90MAP4K20.57901764
91RPS6KA10.57885572
92ALK0.57450119
93CSNK2A20.57032193
94PRKD30.56833722
95BRD40.56670737
96AKT20.56302304
97TLK10.55974724
98BRAF0.54403378
99FLT30.53819227
100CDK11A0.53653336
101VRK10.52902280
102PAK10.52793127
103CDK90.52013168
104MKNK10.51875647
105STK30.50840929
106EIF2AK30.50446195
107CDK10.49968647
108RAF10.49023149
109STK40.47176903
110CSNK1G20.47031201
111CDK150.46696718
112PLK40.46047280
113PLK30.44542553
114TRIM280.43950163
115CDK180.43649427
116MAP4K10.42696941
117CDK140.40504828
118ILK0.39025979
119LYN0.38358290
120MAPK10.38058329
121MAPKAPK30.37244055
122MKNK20.35602945
123DYRK20.35422498
124RPS6KB10.35092561
125SCYL20.34971509
126RPS6KA50.34483002
127DAPK30.33711927
128MAPK140.33276831
129MAPKAPK20.32972633
130MELK0.32771595
131PASK0.32208073
132PRKAA10.31582576
133MAPK30.31452757
134MAPKAPK50.30231376
135PRKCI0.30069527
136PAK20.29921863
137ERN10.28617703
138RPS6KA40.28197801
139EGFR0.27215770
140PRKDC0.27017076
141PHKG20.26140969
142PHKG10.26140969

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.39344542
2DNA replication_Homo sapiens_hsa030305.25050407
3Base excision repair_Homo sapiens_hsa034104.49902087
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.30475002
5Nucleotide excision repair_Homo sapiens_hsa034203.06588808
6Homologous recombination_Homo sapiens_hsa034403.00884149
7Spliceosome_Homo sapiens_hsa030403.00061257
8* RNA transport_Homo sapiens_hsa030132.73260222
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.47218317
10Fatty acid biosynthesis_Homo sapiens_hsa000612.47182524
11Cell cycle_Homo sapiens_hsa041102.43236145
12Fanconi anemia pathway_Homo sapiens_hsa034602.36382397
13Ribosome_Homo sapiens_hsa030102.35096728
14Proteasome_Homo sapiens_hsa030502.13818440
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.07214535
16One carbon pool by folate_Homo sapiens_hsa006702.00483945
17mRNA surveillance pathway_Homo sapiens_hsa030152.00199357
18p53 signaling pathway_Homo sapiens_hsa041151.95388118
19RNA polymerase_Homo sapiens_hsa030201.93362707
20Fatty acid elongation_Homo sapiens_hsa000621.64989923
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62783887
22Pyrimidine metabolism_Homo sapiens_hsa002401.55025666
23Pyruvate metabolism_Homo sapiens_hsa006201.49249631
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.40342177
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.40337148
26Biosynthesis of amino acids_Homo sapiens_hsa012301.38122804
27Non-homologous end-joining_Homo sapiens_hsa034501.35797885
28RNA degradation_Homo sapiens_hsa030181.30185797
29Basal transcription factors_Homo sapiens_hsa030221.28794781
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27479865
31Parkinsons disease_Homo sapiens_hsa050121.21506025
32Hippo signaling pathway_Homo sapiens_hsa043901.20293529
33Notch signaling pathway_Homo sapiens_hsa043301.19917964
34Huntingtons disease_Homo sapiens_hsa050161.16515529
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.15834922
36Folate biosynthesis_Homo sapiens_hsa007901.14854898
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11212819
38mTOR signaling pathway_Homo sapiens_hsa041501.09057577
39Hedgehog signaling pathway_Homo sapiens_hsa043401.08636842
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07215220
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07158057
42Oocyte meiosis_Homo sapiens_hsa041141.03765515
43Sulfur relay system_Homo sapiens_hsa041221.03355428
44Oxidative phosphorylation_Homo sapiens_hsa001901.03224829
45Arginine and proline metabolism_Homo sapiens_hsa003300.96813401
46Adherens junction_Homo sapiens_hsa045200.94394617
47Steroid biosynthesis_Homo sapiens_hsa001000.94155905
48TGF-beta signaling pathway_Homo sapiens_hsa043500.92879227
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91765345
50Epstein-Barr virus infection_Homo sapiens_hsa051690.89713912
51Bladder cancer_Homo sapiens_hsa052190.89173167
52Fructose and mannose metabolism_Homo sapiens_hsa000510.87793158
53Shigellosis_Homo sapiens_hsa051310.85561607
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83768967
55Primary immunodeficiency_Homo sapiens_hsa053400.83751885
56Viral carcinogenesis_Homo sapiens_hsa052030.83208594
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82312054
58Propanoate metabolism_Homo sapiens_hsa006400.77512640
59Circadian rhythm_Homo sapiens_hsa047100.77071618
60Basal cell carcinoma_Homo sapiens_hsa052170.74484380
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71718056
62MicroRNAs in cancer_Homo sapiens_hsa052060.71064465
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71025430
64Herpes simplex infection_Homo sapiens_hsa051680.70187482
65Small cell lung cancer_Homo sapiens_hsa052220.64480664
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.64392922
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63799250
68Legionellosis_Homo sapiens_hsa051340.62927851
69Metabolic pathways_Homo sapiens_hsa011000.62190660
70HTLV-I infection_Homo sapiens_hsa051660.61440327
71Thyroid cancer_Homo sapiens_hsa052160.61168846
72Colorectal cancer_Homo sapiens_hsa052100.61027354
73Other glycan degradation_Homo sapiens_hsa005110.58888296
74Purine metabolism_Homo sapiens_hsa002300.58296449
75Wnt signaling pathway_Homo sapiens_hsa043100.57975556
76Alcoholism_Homo sapiens_hsa050340.57022226
77Glutathione metabolism_Homo sapiens_hsa004800.56996463
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56979260
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55512256
80Galactose metabolism_Homo sapiens_hsa000520.52231246
81Alzheimers disease_Homo sapiens_hsa050100.52185549
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.52183629
83Selenocompound metabolism_Homo sapiens_hsa004500.49411412
84Lysine degradation_Homo sapiens_hsa003100.48190891
85Peroxisome_Homo sapiens_hsa041460.45248115
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44520943
87Viral myocarditis_Homo sapiens_hsa054160.44113767
88Phenylalanine metabolism_Homo sapiens_hsa003600.44029912
89Chronic myeloid leukemia_Homo sapiens_hsa052200.42254312
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40791530
91Arginine biosynthesis_Homo sapiens_hsa002200.40259763
92Protein export_Homo sapiens_hsa030600.39804711
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39526799
94Acute myeloid leukemia_Homo sapiens_hsa052210.38069026
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37961400
96Pentose phosphate pathway_Homo sapiens_hsa000300.37276580
97VEGF signaling pathway_Homo sapiens_hsa043700.36820305
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36600462
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36448785
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36443660
101Systemic lupus erythematosus_Homo sapiens_hsa053220.35306310
102Tight junction_Homo sapiens_hsa045300.33991393
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33658764
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32072791
105Hepatitis B_Homo sapiens_hsa051610.30989528
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.30528449
107Apoptosis_Homo sapiens_hsa042100.30244872
108Tyrosine metabolism_Homo sapiens_hsa003500.29601652
109Antigen processing and presentation_Homo sapiens_hsa046120.28454613
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28151920
111HIF-1 signaling pathway_Homo sapiens_hsa040660.26168517
112Butanoate metabolism_Homo sapiens_hsa006500.25043023
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.23792381
114Carbon metabolism_Homo sapiens_hsa012000.23765374
115Pathways in cancer_Homo sapiens_hsa052000.23545675
116Measles_Homo sapiens_hsa051620.23282975
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23106470
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21980203
119Sulfur metabolism_Homo sapiens_hsa009200.21798604
120N-Glycan biosynthesis_Homo sapiens_hsa005100.21747322
121Vitamin B6 metabolism_Homo sapiens_hsa007500.20416033
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19097606
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17639106
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.17381288
125Fatty acid degradation_Homo sapiens_hsa000710.17100660
126Proteoglycans in cancer_Homo sapiens_hsa052050.15749281
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.14942284
128AMPK signaling pathway_Homo sapiens_hsa041520.14887508
129Fatty acid metabolism_Homo sapiens_hsa012120.14151099
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.13401139
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.12771194
132Non-small cell lung cancer_Homo sapiens_hsa052230.11219688
133Prostate cancer_Homo sapiens_hsa052150.10773971
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.10480738
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.09984896
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.09917041

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