ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	centriole replication (GO:0007099)	7.10526600
2	protoporphyrinogen IX biosynthetic process (GO:0006782)	5.42119665
3	histone H2A acetylation (GO:0043968)	5.37897028
4	centriole assembly (GO:0098534)	5.35424106
5	positive regulation of histone H3-K4 methylation (GO:0051571)	4.97026795
6	regulation of MHC class II biosynthetic process (GO:0045346)	4.89297246
7	positive regulation of histone deacetylation (GO:0031065)	4.54237802
8	N-acetylneuraminate metabolic process (GO:0006054)	4.47666903
9	protoporphyrinogen IX metabolic process (GO:0046501)	4.43487544
10	DNA methylation involved in gamete generation (GO:0043046)	4.43316151
11	behavioral response to nicotine (GO:0035095)	4.30508894
12	piRNA metabolic process (GO:0034587)	4.29211606
13	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	4.13366535
14	microtubule depolymerization (GO:0007019)	3.85423004
15	meiotic chromosome segregation (GO:0045132)	3.79594620
16	male meiosis (GO:0007140)	3.68266343
17	synapsis (GO:0007129)	3.67876186
18	regulation of hippo signaling (GO:0035330)	3.66772163
19	base-excision repair, AP site formation (GO:0006285)	3.66292838
20	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.64712153
21	isotype switching (GO:0045190)	3.64712153
22	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.64712153
23	gene silencing by RNA (GO:0031047)	3.63174210
24	detection of light stimulus involved in sensory perception (GO:0050962)	3.58258421
25	detection of light stimulus involved in visual perception (GO:0050908)	3.58258421
26	transcription from mitochondrial promoter (GO:0006390)	3.52582078
27	regulation of DNA endoreduplication (GO:0032875)	3.48416490
28	N-acetylglucosamine metabolic process (GO:0006044)	3.45409092
29	positive regulation of protein deacetylation (GO:0090312)	3.42409465
30	pyrimidine dimer repair (GO:0006290)	3.29855247
31	regulation of histone H3-K4 methylation (GO:0051569)	3.27654353
32	somatic diversification of immunoglobulins (GO:0016445)	3.26708664
33	cellular extravasation (GO:0045123)	3.25795457
34	auditory receptor cell stereocilium organization (GO:0060088)	3.20417670
35	reciprocal meiotic recombination (GO:0007131)	3.19106682
36	reciprocal DNA recombination (GO:0035825)	3.19106682
37	sister chromatid cohesion (GO:0007062)	3.15317296
38	somatic recombination of immunoglobulin gene segments (GO:0016447)	3.12508355
39	microtubule polymerization or depolymerization (GO:0031109)	3.07711210
40	double-strand break repair via homologous recombination (GO:0000724)	3.02348551
41	amino sugar catabolic process (GO:0046348)	3.01386718
42	regulation of RNA export from nucleus (GO:0046831)	3.01070569
43	inner ear receptor stereocilium organization (GO:0060122)	3.00095904
44	response to pheromone (GO:0019236)	2.99829350
45	recombinational repair (GO:0000725)	2.98468041
46	regulation of helicase activity (GO:0051095)	2.96935016
47	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	2.96858529
48	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	2.93397691
49	sperm-egg recognition (GO:0035036)	2.91080774
50	replication fork processing (GO:0031297)	2.88403247
51	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.87162988
52	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.87162988
53	aspartate family amino acid catabolic process (GO:0009068)	2.83723924
54	behavioral response to ethanol (GO:0048149)	2.81122262
55	tachykinin receptor signaling pathway (GO:0007217)	2.80762319
56	monoubiquitinated protein deubiquitination (GO:0035520)	2.79932155
57	DNA deamination (GO:0045006)	2.79455410
58	prenylation (GO:0097354)	2.78626380
59	protein prenylation (GO:0018342)	2.78626380
60	centrosome organization (GO:0051297)	2.78430386
61	nuclear pore organization (GO:0006999)	2.77161851
62	regulation of neurotransmitter uptake (GO:0051580)	2.75759712
63	mitochondrial RNA metabolic process (GO:0000959)	2.74142661
64	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.73735916
65	protein localization to cilium (GO:0061512)	2.72931877
66	maturation of 5.8S rRNA (GO:0000460)	2.72903195
67	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.72740337
68	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.72740337
69	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.71952130
70	DNA double-strand break processing (GO:0000729)	2.71841118
71	double-strand break repair (GO:0006302)	2.70897912
72	protein deneddylation (GO:0000338)	2.70853672
73	binding of sperm to zona pellucida (GO:0007339)	2.70846093
74	photoreceptor cell maintenance (GO:0045494)	2.70589380
75	attachment of spindle microtubules to kinetochore (GO:0008608)	2.70224211
76	DNA damage response, signal transduction resulting in transcription (GO:0042772)	2.69797711
77	short-chain fatty acid metabolic process (GO:0046459)	2.69669740
78	retinal cone cell development (GO:0046549)	2.68912592
79	protein K11-linked deubiquitination (GO:0035871)	2.67710440
80	microtubule organizing center organization (GO:0031023)	2.66287551
81	response to misfolded protein (GO:0051788)	2.64713082
82	positive regulation of histone methylation (GO:0031062)	2.64089587
83	response to folic acid (GO:0051593)	2.63856540
84	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.61155948
85	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.61155948
86	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.61155948
87	kynurenine metabolic process (GO:0070189)	2.60241373
88	resolution of meiotic recombination intermediates (GO:0000712)	2.58672360
89	indolalkylamine metabolic process (GO:0006586)	2.57751190
90	regulation of histone H3-K9 methylation (GO:0051570)	2.55665651
91	regulation of histone deacetylation (GO:0031063)	2.55571957
92	purine deoxyribonucleotide catabolic process (GO:0009155)	2.55516116
93	DNA strand renaturation (GO:0000733)	2.55202593
94	heme biosynthetic process (GO:0006783)	2.54493826
95	glucosamine-containing compound metabolic process (GO:1901071)	2.53636934
96	thalamus development (GO:0021794)	2.53585410
97	serotonin receptor signaling pathway (GO:0007210)	2.52800678
98	nuclear pore complex assembly (GO:0051292)	2.52393104
99	DNA methylation (GO:0006306)	2.50512320
100	DNA alkylation (GO:0006305)	2.50512320

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.94448444
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.86435575
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.64820810
4	GATA1_22025678_ChIP-Seq_K562_Human	3.09443821
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.67155967
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.65375288
7	VDR_22108803_ChIP-Seq_LS180_Human	2.61112225
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.59763288
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.55079911
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.42494059
11	ER_23166858_ChIP-Seq_MCF-7_Human	2.38244831
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.35390200
13	FUS_26573619_Chip-Seq_HEK293_Human	2.34259867
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.17904153
15	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.15981260
16	EWS_26573619_Chip-Seq_HEK293_Human	2.13391349
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.05549018
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.04024030
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.03144141
20	P300_19829295_ChIP-Seq_ESCs_Human	1.89281546
21	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.86799089
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.84375749
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.83214214
24	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.82300743
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.78281677
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.77732681
27	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.75009026
28	STAT3_23295773_ChIP-Seq_U87_Human	1.73806929
29	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.73244497
30	E2F7_22180533_ChIP-Seq_HELA_Human	1.73162662
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.70933950
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.70386954
33	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.69486221
34	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.62317384
35	TCF4_23295773_ChIP-Seq_U87_Human	1.62304833
36	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.61520087
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.60675352
38	MYC_18940864_ChIP-ChIP_HL60_Human	1.59152435
39	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.57869529
40	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.57154351
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.52195122
42	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.50582055
43	TAF15_26573619_Chip-Seq_HEK293_Human	1.49443380
44	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.48797786
45	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.41554091
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.40108980
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40108980
48	NANOG_19829295_ChIP-Seq_ESCs_Human	1.39989781
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.39989781
50	VDR_23849224_ChIP-Seq_CD4+_Human	1.33423976
51	TCF4_22108803_ChIP-Seq_LS180_Human	1.31502292
52	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.31259836
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31094483
54	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.30567272
55	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.28527511
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28516111
57	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.27796843
58	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.26836123
59	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26209647
60	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.25682263
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25060774
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24891720
63	AR_25329375_ChIP-Seq_VCAP_Human	1.24291667
64	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.24022416
65	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.23838720
66	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.20554223
67	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.20505618
68	TP53_22573176_ChIP-Seq_HFKS_Human	1.20273007
69	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.20208149
70	CDX2_22108803_ChIP-Seq_LS180_Human	1.18854692
71	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.18114497
72	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.17911750
73	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.17023529
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.16490168
75	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.16115678
76	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.14917763
77	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.14423204
78	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.13447685
79	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.12521051
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.12372689
81	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11940449
82	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.11894806
83	NCOR_22424771_ChIP-Seq_293T_Human	1.09993798
84	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.09217533
85	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.07454296
86	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.07454296
87	HOXB7_26014856_ChIP-Seq_BT474_Human	1.07343744
88	FOXP3_21729870_ChIP-Seq_TREG_Human	1.07108337
89	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.06778874
90	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05865722
91	RXR_22108803_ChIP-Seq_LS180_Human	1.05780315
92	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.05091943
93	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.05010109
94	P53_22387025_ChIP-Seq_ESCs_Mouse	1.03734477
95	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02789768
96	JUN_21703547_ChIP-Seq_K562_Human	1.01860434
97	P300_18555785_Chip-Seq_ESCs_Mouse	1.01240446
98	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.00436296
99	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.00061548
100	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.98968288

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005083_abnormal_biliary_tract	5.03697941
2	MP0008058_abnormal_DNA_repair	4.55802806
3	MP0008057_abnormal_DNA_replication	4.29244780
4	MP0008877_abnormal_DNA_methylation	3.20258222
5	MP0010094_abnormal_chromosome_stability	2.97644964
6	MP0003252_abnormal_bile_duct	2.80018834
7	MP0005670_abnormal_white_adipose	2.60760755
8	MP0008995_early_reproductive_senescence	2.48188367
9	MP0008007_abnormal_cellular_replicative	2.46682927
10	MP0008961_abnormal_basal_metabolism	2.45700300
11	MP0003786_premature_aging	2.40068952
12	MP0004043_abnormal_pH_regulation	2.37402777
13	MP0003718_maternal_effect	2.08929458
14	MP0005551_abnormal_eye_electrophysiolog	2.00156478
15	MP0009697_abnormal_copulation	1.95969893
16	MP0005085_abnormal_gallbladder_physiolo	1.92404169
17	MP0005367_renal/urinary_system_phenotyp	1.84942555
18	MP0000516_abnormal_urinary_system	1.84942555
19	MP0008872_abnormal_physiological_respon	1.81481981
20	MP0000372_irregular_coat_pigmentation	1.72968946
21	MP0001529_abnormal_vocalization	1.69337722
22	MP0001501_abnormal_sleep_pattern	1.59986075
23	MP0003195_calcinosis	1.56297471
24	MP0005646_abnormal_pituitary_gland	1.52460424
25	MP0001929_abnormal_gametogenesis	1.51400517
26	MP0003111_abnormal_nucleus_morphology	1.51265570
27	MP0003698_abnormal_male_reproductive	1.49420297
28	MP0001984_abnormal_olfaction	1.45229350
29	MP0005397_hematopoietic_system_phenotyp	1.43182904
30	MP0001545_abnormal_hematopoietic_system	1.43182904
31	MP0004808_abnormal_hematopoietic_stem	1.40955136
32	MP0005253_abnormal_eye_physiology	1.31974313
33	MP0005167_abnormal_blood-brain_barrier	1.30273407
34	MP0002210_abnormal_sex_determination	1.29352836
35	MP0003077_abnormal_cell_cycle	1.28480979
36	MP0002736_abnormal_nociception_after	1.24171094
37	MP0006035_abnormal_mitochondrial_morpho	1.21186299
38	MP0010386_abnormal_urinary_bladder	1.20981325
39	MP0005365_abnormal_bile_salt	1.19972333
40	MP0006276_abnormal_autonomic_nervous	1.18806030
41	MP0009046_muscle_twitch	1.17148014
42	MP0005266_abnormal_metabolism	1.16446306
43	MP0005410_abnormal_fertilization	1.15649841
44	MP0000653_abnormal_sex_gland	1.15050229
45	MP0000427_abnormal_hair_cycle	1.13081546
46	MP0000631_abnormal_neuroendocrine_gland	1.10588034
47	MP0003567_abnormal_fetal_cardiomyocyte	1.10271266
48	MP0002272_abnormal_nervous_system	1.09687781
49	MP0001502_abnormal_circadian_rhythm	1.08711377
50	MP0005187_abnormal_penis_morphology	1.08367097
51	MP0006072_abnormal_retinal_apoptosis	1.06942668
52	MP0001145_abnormal_male_reproductive	1.06351700
53	MP0004147_increased_porphyrin_level	1.04071719
54	MP0001486_abnormal_startle_reflex	1.02979362
55	MP0004142_abnormal_muscle_tone	1.01944251
56	MP0008775_abnormal_heart_ventricle	1.01806010
57	MP0005084_abnormal_gallbladder_morpholo	1.00880004
58	MP0002138_abnormal_hepatobiliary_system	1.00143318
59	MP0005395_other_phenotype	0.99200857
60	MP0008875_abnormal_xenobiotic_pharmacok	0.98559119
61	MP0003943_abnormal_hepatobiliary_system	0.97192775
62	MP0005645_abnormal_hypothalamus_physiol	0.95272121
63	MP0000383_abnormal_hair_follicle	0.95206770
64	MP0003693_abnormal_embryo_hatching	0.95012726
65	MP0002184_abnormal_innervation	0.94247871
66	MP0001968_abnormal_touch/_nociception	0.93984060
67	MP0010307_abnormal_tumor_latency	0.92622883
68	MP0005220_abnormal_exocrine_pancreas	0.92411776
69	MP0003136_yellow_coat_color	0.92260154
70	MP0002332_abnormal_exercise_endurance	0.90349859
71	MP0000003_abnormal_adipose_tissue	0.89328514
72	MP0009745_abnormal_behavioral_response	0.85298926
73	MP0003880_abnormal_central_pattern	0.83441086
74	MP0004782_abnormal_surfactant_physiolog	0.82820894
75	MP0002751_abnormal_autonomic_nervous	0.82530060
76	MP0002928_abnormal_bile_duct	0.82489941
77	MP0002095_abnormal_skin_pigmentation	0.80906654
78	MP0010678_abnormal_skin_adnexa	0.79477858
79	MP0001119_abnormal_female_reproductive	0.78736244
80	MP0004215_abnormal_myocardial_fiber	0.78458469
81	MP0002160_abnormal_reproductive_system	0.78296116
82	MP0005377_hearing/vestibular/ear_phenot	0.77964576
83	MP0003878_abnormal_ear_physiology	0.77964576
84	MP0001764_abnormal_homeostasis	0.77259590
85	MP0000647_abnormal_sebaceous_gland	0.73607015
86	MP0002234_abnormal_pharynx_morphology	0.72439672
87	MP0006292_abnormal_olfactory_placode	0.71134531
88	MP0004742_abnormal_vestibular_system	0.71085596
89	MP0005310_abnormal_salivary_gland	0.71056820
90	MP0002102_abnormal_ear_morphology	0.70885921
91	MP0004145_abnormal_muscle_electrophysio	0.69149875
92	MP0002229_neurodegeneration	0.68795911
93	MP0002970_abnormal_white_adipose	0.68778509
94	MP0002161_abnormal_fertility/fecundity	0.67736881
95	MP0005332_abnormal_amino_acid	0.66053897
96	MP0004885_abnormal_endolymph	0.65984983
97	MP0004957_abnormal_blastocyst_morpholog	0.65163570
98	MP0010329_abnormal_lipoprotein_level	0.65146743
99	MP0003937_abnormal_limbs/digits/tail_de	0.64996137
100	MP0000778_abnormal_nervous_system	0.62823498

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Attenuation of retinal blood vessels (HP:0007843)	4.15622394
2	Pancreatic cysts (HP:0001737)	3.70618624
3	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.67518617
4	Chromsome breakage (HP:0040012)	3.59187475
5	Volvulus (HP:0002580)	3.41632544
6	Abnormality of the labia minora (HP:0012880)	3.29347154
7	Abnormality of the renal cortex (HP:0011035)	3.26844459
8	Pancreatic fibrosis (HP:0100732)	3.26510916
9	Neonatal respiratory distress (HP:0002643)	3.23761601
10	True hermaphroditism (HP:0010459)	3.11729707
11	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.06542687
12	Tubulointerstitial nephritis (HP:0001970)	3.05714867
13	Nephronophthisis (HP:0000090)	3.04000630
14	Abnormality of the renal medulla (HP:0100957)	3.00879760
15	Bony spicule pigmentary retinopathy (HP:0007737)	3.00602058
16	Neoplasm of the adrenal cortex (HP:0100641)	2.99420487
17	Molar tooth sign on MRI (HP:0002419)	2.98172905
18	Abnormality of midbrain morphology (HP:0002418)	2.98172905
19	Abnormality of chromosome stability (HP:0003220)	2.92757208
20	Congenital stationary night blindness (HP:0007642)	2.88123358
21	Pendular nystagmus (HP:0012043)	2.81857660
22	Abolished electroretinogram (ERG) (HP:0000550)	2.80666999
23	Tubulointerstitial abnormality (HP:0001969)	2.73954767
24	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.65542967
25	Abnormality of alanine metabolism (HP:0010916)	2.65542967
26	Hyperalaninemia (HP:0003348)	2.65542967
27	Small hand (HP:0200055)	2.65469856
28	Meckel diverticulum (HP:0002245)	2.63397774
29	Fair hair (HP:0002286)	2.62189632
30	Abnormality of the preputium (HP:0100587)	2.57416588
31	Abnormality of the ileum (HP:0001549)	2.53342615
32	Urethral obstruction (HP:0000796)	2.53222789
33	Cystic liver disease (HP:0006706)	2.52147664
34	Sloping forehead (HP:0000340)	2.49855234
35	Renal cortical cysts (HP:0000803)	2.44457981
36	Protruding tongue (HP:0010808)	2.42454029
37	Gaze-evoked nystagmus (HP:0000640)	2.38166426
38	Partial agenesis of the corpus callosum (HP:0001338)	2.35038566
39	Abnormality of the prostate (HP:0008775)	2.32222450
40	Severe visual impairment (HP:0001141)	2.30623587
41	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.28472934
42	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.25387140
43	Duodenal stenosis (HP:0100867)	2.25369105
44	Small intestinal stenosis (HP:0012848)	2.25369105
45	Alopecia of scalp (HP:0002293)	2.24335472
46	Genetic anticipation (HP:0003743)	2.22928306
47	Abnormality of DNA repair (HP:0003254)	2.21234880
48	Chronic hepatic failure (HP:0100626)	2.18522475
49	Congenital hepatic fibrosis (HP:0002612)	2.16675791
50	Tubulointerstitial fibrosis (HP:0005576)	2.15672440
51	Abnormal rod and cone electroretinograms (HP:0008323)	2.15348244
52	Sclerocornea (HP:0000647)	2.14682949
53	Progressive cerebellar ataxia (HP:0002073)	2.14213246
54	Clubbing of toes (HP:0100760)	2.13836141
55	Hyperkalemia (HP:0002153)	2.13436963
56	Keratoconus (HP:0000563)	2.10945399
57	Increased corneal curvature (HP:0100692)	2.10945399
58	Proximal tubulopathy (HP:0000114)	2.10796794
59	Birth length less than 3rd percentile (HP:0003561)	2.08744722
60	Abnormality of the duodenum (HP:0002246)	2.06027265
61	Microvesicular hepatic steatosis (HP:0001414)	2.04760814
62	Postaxial foot polydactyly (HP:0001830)	2.04751830
63	Prostate neoplasm (HP:0100787)	2.04238740
64	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.00123132
65	Tubular atrophy (HP:0000092)	1.98850997
66	Abnormality of chloride homeostasis (HP:0011422)	1.97540867
67	Optic nerve hypoplasia (HP:0000609)	1.96907594
68	Squamous cell carcinoma (HP:0002860)	1.95039836
69	Absent speech (HP:0001344)	1.93422828
70	Medial flaring of the eyebrow (HP:0010747)	1.93170867
71	Aplasia/Hypoplasia of the nipples (HP:0006709)	1.91328323
72	Type 2 muscle fiber atrophy (HP:0003554)	1.90200874
73	Astigmatism (HP:0000483)	1.89457455
74	Generalized hypopigmentation of hair (HP:0011358)	1.86988395
75	Myelodysplasia (HP:0002863)	1.85631954
76	Type II lissencephaly (HP:0007260)	1.84584900
77	Anencephaly (HP:0002323)	1.82113540
78	3-Methylglutaconic aciduria (HP:0003535)	1.81056853
79	Preaxial hand polydactyly (HP:0001177)	1.80841144
80	Generalized aminoaciduria (HP:0002909)	1.79162585
81	Furrowed tongue (HP:0000221)	1.78903969
82	Fatigable weakness (HP:0003473)	1.77734601
83	Abnormality of the neuromuscular junction (HP:0003398)	1.77734601
84	Patellar aplasia (HP:0006443)	1.77439797
85	Oligodactyly (hands) (HP:0001180)	1.74306274
86	Abnormality of macular pigmentation (HP:0008002)	1.73927176
87	Short tibia (HP:0005736)	1.72854898
88	Hyperventilation (HP:0002883)	1.71586406
89	Abnormality of the labia majora (HP:0012881)	1.71411911
90	Prominent nasal bridge (HP:0000426)	1.71401526
91	Abnormality of the carotid arteries (HP:0005344)	1.70459211
92	Acute lymphatic leukemia (HP:0006721)	1.69683597
93	Aganglionic megacolon (HP:0002251)	1.68451427
94	Aplasia/Hypoplasia of the patella (HP:0006498)	1.68389798
95	Type II diabetes mellitus (HP:0005978)	1.67929996
96	Poikiloderma (HP:0001029)	1.67777629
97	Intestinal atresia (HP:0011100)	1.66774052
98	Oligohydramnios (HP:0001562)	1.64054032
99	Decreased central vision (HP:0007663)	1.63781254
100	Broad-based gait (HP:0002136)	1.62995073

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CCNB1	5.68301832
2	FRK	5.33675233
3	NEK2	4.81498940
4	CAMKK2	3.20472734
5	NUAK1	2.83423271
6	CAMK1D	2.55584774
7	TAF1	2.45362154
8	BMPR1B	2.34921010
9	WNK4	2.06198270
10	VRK2	2.05327313
11	TIE1	2.04147215
12	BRSK2	1.96689010
13	CASK	1.85210533
14	CAMK1G	1.76143260
15	MAP3K4	1.66231221
16	WNK3	1.55842024
17	ACVR1B	1.43232255
18	ADRBK2	1.39406939
19	MKNK2	1.36549317
20	GRK1	1.28296351
21	INSRR	1.26241302
22	FGFR2	1.23049655
23	TRIM28	1.18728756
24	CHEK2	1.16585337
25	TXK	1.15448190
26	ERBB3	1.13063050
27	PLK3	1.12633390
28	EIF2AK3	1.08396307
29	MAP3K7	1.07530162
30	BUB1	1.06315476
31	PLK4	1.02551229
32	EPHA4	1.02406008
33	NTRK3	0.99498978
34	TGFBR1	0.97198765
35	SRPK1	0.96131764
36	ZAK	0.95492666
37	PIK3CG	0.92100627
38	PBK	0.85143346
39	CDK8	0.84083861
40	DYRK2	0.83999100
41	WEE1	0.83947846
42	NEK1	0.83933146
43	PLK2	0.82382457
44	MAPK13	0.82335138
45	MKNK1	0.79695475
46	TTK	0.78376981
47	ATR	0.77697356
48	ATM	0.77466690
49	CSNK1G2	0.73384670
50	CSNK1G3	0.73170138
51	EIF2AK2	0.73125685
52	CAMK1	0.73001599
53	VRK1	0.72977005
54	BCR	0.71886462
55	CHUK	0.71769701
56	TAOK3	0.70871997
57	STK39	0.69829346
58	CSNK1A1L	0.68551314
59	CAMKK1	0.66292619
60	CSNK1G1	0.65603885
61	MAPKAPK5	0.64644361
62	BMPR2	0.61474874
63	PLK1	0.59701777
64	GRK5	0.57958258
65	CHEK1	0.57603825
66	EIF2AK1	0.57421282
67	PKN1	0.57229147
68	PRKCE	0.56215154
69	TEC	0.55425709
70	MAP3K12	0.53674359
71	MAP2K7	0.53459057
72	NME1	0.52390327
73	RPS6KB2	0.52254850
74	DYRK3	0.51940447
75	AURKB	0.50252489
76	DAPK1	0.49734717
77	PRKACB	0.49249278
78	BRD4	0.48907002
79	AURKA	0.48157906
80	MARK1	0.48132692
81	MAP4K2	0.46895920
82	MUSK	0.46189522
83	MST4	0.44844619
84	CSNK1E	0.44472302
85	FER	0.43850404
86	PTK2B	0.43468490
87	NEK6	0.42752450
88	SMG1	0.41571927
89	CDC7	0.41542890
90	CAMK4	0.38606260
91	TRPM7	0.38556846
92	TLK1	0.37782983
93	BRSK1	0.36160295
94	IRAK1	0.35835751
95	CDK9	0.35719215
96	PDK2	0.35178683
97	PAK3	0.34847571
98	CDK1	0.34783453
99	OXSR1	0.34106353
100	CDK7	0.30932442

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	3.36213194
2	Fanconi anemia pathway_Homo sapiens_hsa03460	3.09513373
3	Non-homologous end-joining_Homo sapiens_hsa03450	3.09028777
4	Phototransduction_Homo sapiens_hsa04744	3.00740330
5	Basal transcription factors_Homo sapiens_hsa03022	2.88247572
6	Renin-angiotensin system_Homo sapiens_hsa04614	2.68144968
7	Propanoate metabolism_Homo sapiens_hsa00640	2.47703795
8	Nicotine addiction_Homo sapiens_hsa05033	2.44310286
9	Caffeine metabolism_Homo sapiens_hsa00232	2.43838455
10	Selenocompound metabolism_Homo sapiens_hsa00450	2.17029939
11	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	2.07098503
12	Taste transduction_Homo sapiens_hsa04742	2.02438576
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.97710851
14	Butanoate metabolism_Homo sapiens_hsa00650	1.91740145
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.91691768
16	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.86276830
17	Olfactory transduction_Homo sapiens_hsa04740	1.78930870
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.76943485
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.73856337
20	One carbon pool by folate_Homo sapiens_hsa00670	1.71069201
21	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.70729722
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.69962997
23	RNA transport_Homo sapiens_hsa03013	1.67999357
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.67831840
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.58793304
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.57027520
27	RNA degradation_Homo sapiens_hsa03018	1.50424635
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.46484913
29	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.43476764
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.40506442
31	Base excision repair_Homo sapiens_hsa03410	1.37415938
32	Mismatch repair_Homo sapiens_hsa03430	1.29884687
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.29761105
34	DNA replication_Homo sapiens_hsa03030	1.28600236
35	Nucleotide excision repair_Homo sapiens_hsa03420	1.19456588
36	Spliceosome_Homo sapiens_hsa03040	1.19019172
37	Pyruvate metabolism_Homo sapiens_hsa00620	1.15607056
38	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.15021077
39	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.12299790
40	Lysine degradation_Homo sapiens_hsa00310	1.11150781
41	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.10233753
42	ABC transporters_Homo sapiens_hsa02010	1.09436339
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.08427186
44	Protein export_Homo sapiens_hsa03060	1.03885182
45	Glutamatergic synapse_Homo sapiens_hsa04724	1.00172631
46	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.95454302
47	Cell cycle_Homo sapiens_hsa04110	0.94857063
48	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.94378038
49	RNA polymerase_Homo sapiens_hsa03020	0.90102023
50	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.89496445
51	Pyrimidine metabolism_Homo sapiens_hsa00240	0.86342042
52	Regulation of autophagy_Homo sapiens_hsa04140	0.86257212
53	Morphine addiction_Homo sapiens_hsa05032	0.86207547
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.85513086
55	Retinol metabolism_Homo sapiens_hsa00830	0.84262092
56	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.83508740
57	Circadian entrainment_Homo sapiens_hsa04713	0.82434019
58	Purine metabolism_Homo sapiens_hsa00230	0.80706836
59	mRNA surveillance pathway_Homo sapiens_hsa03015	0.79723008
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.78694856
61	Asthma_Homo sapiens_hsa05310	0.77018955
62	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.76693085
63	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.76632125
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76359541
65	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.72626620
66	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.71768832
67	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.70321669
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.70090531
69	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.69368158
70	GABAergic synapse_Homo sapiens_hsa04727	0.67936098
71	Calcium signaling pathway_Homo sapiens_hsa04020	0.66704148
72	Circadian rhythm_Homo sapiens_hsa04710	0.66399100
73	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.66374706
74	Arginine and proline metabolism_Homo sapiens_hsa00330	0.64345497
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.63257958
76	Serotonergic synapse_Homo sapiens_hsa04726	0.61055886
77	Peroxisome_Homo sapiens_hsa04146	0.60409902
78	Oocyte meiosis_Homo sapiens_hsa04114	0.56453058
79	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.53025988
80	Metabolic pathways_Homo sapiens_hsa01100	0.51674497
81	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.47400526
82	Long-term depression_Homo sapiens_hsa04730	0.46277090
83	Cocaine addiction_Homo sapiens_hsa05030	0.45237605
84	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.44948841
85	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.44369989
86	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.43635163
87	Amphetamine addiction_Homo sapiens_hsa05031	0.39132086
88	Histidine metabolism_Homo sapiens_hsa00340	0.38296358
89	p53 signaling pathway_Homo sapiens_hsa04115	0.36999880
90	Fatty acid degradation_Homo sapiens_hsa00071	0.33899811
91	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.31982389
92	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.31064077
93	Salivary secretion_Homo sapiens_hsa04970	0.29399581
94	Sphingolipid metabolism_Homo sapiens_hsa00600	0.28805701
95	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.26874183
96	Proteasome_Homo sapiens_hsa03050	0.26130221
97	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.25513514
98	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.23732931
99	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.16543569
100	Fat digestion and absorption_Homo sapiens_hsa04975	0.16429992

AACSP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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