AADAC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)8.34601955
2L-phenylalanine catabolic process (GO:0006559)7.56658731
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.56658731
4L-phenylalanine metabolic process (GO:0006558)7.25891152
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.25891152
6aromatic amino acid family catabolic process (GO:0009074)6.83524803
7omega-hydroxylase P450 pathway (GO:0097267)6.82888387
8drug metabolic process (GO:0017144)6.34717708
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.24845142
10tryptophan catabolic process (GO:0006569)6.19226483
11indole-containing compound catabolic process (GO:0042436)6.19226483
12indolalkylamine catabolic process (GO:0046218)6.19226483
13kynurenine metabolic process (GO:0070189)6.03155668
14bile acid biosynthetic process (GO:0006699)5.96302143
15glyoxylate metabolic process (GO:0046487)5.91423605
16tryptophan metabolic process (GO:0006568)5.83452788
17urea metabolic process (GO:0019627)5.67248749
18urea cycle (GO:0000050)5.67248749
19negative regulation of fibrinolysis (GO:0051918)5.53072252
20hormone catabolic process (GO:0042447)5.49798403
21high-density lipoprotein particle remodeling (GO:0034375)5.48774350
22alpha-linolenic acid metabolic process (GO:0036109)5.48048820
23cysteine metabolic process (GO:0006534)5.45882412
24sulfur amino acid catabolic process (GO:0000098)5.35483662
25regulation of fibrinolysis (GO:0051917)5.34591137
26complement activation, alternative pathway (GO:0006957)5.30333559
27regulation of protein activation cascade (GO:2000257)5.28178548
28peptidyl-glutamic acid carboxylation (GO:0017187)5.26941235
29protein carboxylation (GO:0018214)5.26941235
30nitrogen cycle metabolic process (GO:0071941)5.21600552
31daunorubicin metabolic process (GO:0044597)5.19777241
32polyketide metabolic process (GO:0030638)5.19777241
33doxorubicin metabolic process (GO:0044598)5.19777241
34oxidative demethylation (GO:0070989)5.13178854
35serine family amino acid catabolic process (GO:0009071)5.12229895
36phenylpropanoid metabolic process (GO:0009698)5.10204907
37bile acid metabolic process (GO:0008206)5.06456651
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.97860692
39aromatic amino acid family metabolic process (GO:0009072)4.97829434
40homocysteine metabolic process (GO:0050667)4.94645968
41regulation of complement activation (GO:0030449)4.94057314
42reverse cholesterol transport (GO:0043691)4.82207293
43regulation of cholesterol esterification (GO:0010872)4.79584823
44lysine catabolic process (GO:0006554)4.79578655
45lysine metabolic process (GO:0006553)4.79578655
46tyrosine metabolic process (GO:0006570)4.73436709
47protein-lipid complex remodeling (GO:0034368)4.72487977
48macromolecular complex remodeling (GO:0034367)4.72487977
49plasma lipoprotein particle remodeling (GO:0034369)4.72487977
50amino-acid betaine metabolic process (GO:0006577)4.66094638
51alpha-amino acid catabolic process (GO:1901606)4.64632072
52fat-soluble vitamin biosynthetic process (GO:0042362)4.63898000
53aminoglycoside antibiotic metabolic process (GO:0030647)4.59601558
54acylglycerol homeostasis (GO:0055090)4.59335656
55triglyceride homeostasis (GO:0070328)4.59335656
56phospholipid efflux (GO:0033700)4.56609454
57ethanol metabolic process (GO:0006067)4.54294725
58negative regulation of sterol transport (GO:0032372)4.52874956
59negative regulation of cholesterol transport (GO:0032375)4.52874956
60alkaloid metabolic process (GO:0009820)4.50387630
61cellular ketone body metabolic process (GO:0046950)4.50042427
62flavonoid metabolic process (GO:0009812)4.45042637
63intestinal cholesterol absorption (GO:0030299)4.44943690
64glycine metabolic process (GO:0006544)4.40527307
65indolalkylamine metabolic process (GO:0006586)4.39441142
66bile acid and bile salt transport (GO:0015721)4.38495077
67plasma lipoprotein particle clearance (GO:0034381)4.35662884
68coenzyme catabolic process (GO:0009109)4.32960001
69* regulation of triglyceride catabolic process (GO:0010896)4.30590753
70negative regulation of hemostasis (GO:1900047)4.30170598
71negative regulation of blood coagulation (GO:0030195)4.30170598
72cellular amino acid catabolic process (GO:0009063)4.29416463
73cellular biogenic amine catabolic process (GO:0042402)4.29178008
74amine catabolic process (GO:0009310)4.29178008
75cellular glucuronidation (GO:0052695)4.28379840
76serine family amino acid metabolic process (GO:0009069)4.25846124
77glutamate metabolic process (GO:0006536)4.24706917
78imidazole-containing compound metabolic process (GO:0052803)4.24213379
79cholesterol efflux (GO:0033344)4.20069270
80primary alcohol catabolic process (GO:0034310)4.18260122
81benzene-containing compound metabolic process (GO:0042537)4.15239519
82cellular modified amino acid catabolic process (GO:0042219)4.13276347
83ethanol oxidation (GO:0006069)4.10696579
84acute-phase response (GO:0006953)4.09744366
85serine family amino acid biosynthetic process (GO:0009070)4.08938516
86drug catabolic process (GO:0042737)4.08914290
87heme transport (GO:0015886)4.07155055
88plasma lipoprotein particle assembly (GO:0034377)4.03111998
89aldehyde catabolic process (GO:0046185)4.02949668
90dicarboxylic acid biosynthetic process (GO:0043650)4.02018022
91arginine metabolic process (GO:0006525)4.00549837
92fibrinolysis (GO:0042730)3.96703403
93negative regulation of coagulation (GO:0050819)3.94887302
94regulation of plasminogen activation (GO:0010755)3.94449925
95negative regulation of wound healing (GO:0061045)3.93103670
96low-density lipoprotein particle remodeling (GO:0034374)3.91127447
97ketone body metabolic process (GO:1902224)3.89557020
98intestinal absorption (GO:0050892)3.88823123
99negative regulation of protein activation cascade (GO:2000258)3.87425052
100regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.86095453
101uronic acid metabolic process (GO:0006063)3.82327160
102glucuronate metabolic process (GO:0019585)3.82327160
103blood coagulation, intrinsic pathway (GO:0007597)3.81852788
104short-chain fatty acid metabolic process (GO:0046459)3.80272452
105positive regulation of lipoprotein lipase activity (GO:0051006)3.78794813
106positive regulation of triglyceride lipase activity (GO:0061365)3.78794813
107very-low-density lipoprotein particle assembly (GO:0034379)3.78497487
108carboxylic acid catabolic process (GO:0046395)3.77431879
109organic acid catabolic process (GO:0016054)3.77431879
110acetyl-CoA metabolic process (GO:0006084)3.76577435
111cofactor catabolic process (GO:0051187)3.76123885
112cholesterol homeostasis (GO:0042632)3.75995569
113phospholipid homeostasis (GO:0055091)3.75598269
114regulation of humoral immune response (GO:0002920)3.74841032
115regulation of bile acid biosynthetic process (GO:0070857)3.72395103
116angiotensin maturation (GO:0002003)3.70639933
117xenobiotic metabolic process (GO:0006805)3.70607252
118negative regulation of lipase activity (GO:0060192)3.70488775
119sterol homeostasis (GO:0055092)3.70451879
120cytolysis (GO:0019835)3.69322154
121complement activation, classical pathway (GO:0006958)3.68846680
122complement activation (GO:0006956)3.66642559
123protein activation cascade (GO:0072376)3.66094612
124protein-lipid complex assembly (GO:0065005)3.61020651
125plasma lipoprotein particle organization (GO:0071827)3.60647669
126regulation of cholesterol homeostasis (GO:2000188)3.58388636
127exogenous drug catabolic process (GO:0042738)3.58213820
128drug transmembrane transport (GO:0006855)3.57680269
129urate metabolic process (GO:0046415)3.56955943
130steroid catabolic process (GO:0006706)3.56612871
131S-adenosylmethionine metabolic process (GO:0046500)3.55095305
132drug transport (GO:0015893)3.44259653
133NADH metabolic process (GO:0006734)3.43852606
134positive regulation of blood coagulation (GO:0030194)3.36435345
135positive regulation of hemostasis (GO:1900048)3.36435345
136glycoside metabolic process (GO:0016137)3.35636605
137fructose metabolic process (GO:0006000)3.34804768
138negative regulation of complement activation (GO:0045916)3.31843613
139lipoprotein metabolic process (GO:0042157)3.26856632
140positive regulation of fatty acid biosynthetic process (GO:0045723)3.26736557
141lipoprotein transport (GO:0042953)3.26087781

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.34382044
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.18757128
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse7.01931352
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.47567409
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.19349123
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.05981505
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.85412147
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.00012342
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.96875046
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.18280252
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.13717356
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08262932
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9514252
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96298546
15FOXA2_19822575_ChIP-Seq_HepG2_Human1.60407600
16CLOCK_20551151_ChIP-Seq_293T_Human1.51389980
17GATA1_22025678_ChIP-Seq_K562_Human1.50240448
18* HTT_18923047_ChIP-ChIP_STHdh_Human1.46674244
19* HNF4A_19822575_ChIP-Seq_HepG2_Human1.42306753
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.41017387
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30205096
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27371889
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26751966
24RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19055900
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13459322
26FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11929857
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08085367
28SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02625269
29ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02347282
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02087491
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01972289
32HNFA_21074721_ChIP-Seq_CACO-2_Human0.99519121
33TCF4_18268006_ChIP-ChIP_LS174T_Human0.99003600
34ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98149101
35ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97225391
36CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.94960847
37GATA4_25053715_ChIP-Seq_YYC3_Human0.92242174
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90386596
39GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.89801003
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89421909
41PHF8_20622853_ChIP-Seq_HELA_Human0.85276645
42AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85208361
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83834172
44KAP1_22055183_ChIP-Seq_ESCs_Mouse0.83709255
45RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81256941
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81166188
47NFYA_21822215_ChIP-Seq_K562_Human0.80289340
48GATA6_21074721_ChIP-Seq_CACO-2_Human0.79932619
49TP53_18474530_ChIP-ChIP_U2OS_Human0.79799005
50NFE2_27457419_Chip-Seq_LIVER_Mouse0.78512496
51IRF8_22096565_ChIP-ChIP_GC-B_Human0.77796099
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.76509188
53ZNF263_19887448_ChIP-Seq_K562_Human0.75781053
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75608516
55SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75513403
56SRY_22984422_ChIP-ChIP_TESTIS_Rat0.74865365
57SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72236410
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71800622
59RARA_24833708_ChIP-Seq_LIVER_Mouse0.71734977
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.71621100
61SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70358857
62AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70088186
63SOX2_21211035_ChIP-Seq_LN229_Human0.70011781
64TP63_17297297_ChIP-ChIP_HaCaT_Human0.69763476
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69202985
66ESR2_21235772_ChIP-Seq_MCF-7_Human0.68618061
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66973706
68NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66973706
69BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66389476
70CBX2_22325352_ChIP-Seq_293T-Rex_Human0.64711544
71EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.64444799
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.64192938
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.64173316
74RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63612176
75ETV1_20927104_ChIP-Seq_GIST48_Human0.63283127
76SA1_27219007_Chip-Seq_Bcells_Human0.63201089
77JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.63035487
78CDX2_20551321_ChIP-Seq_CACO-2_Human0.61689673
79PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.61593800
80RARB_24833708_ChIP-Seq_LIVER_Mouse0.61411005
81EZH2_27294783_Chip-Seq_NPCs_Mouse0.61326007
82CEBPB_22108803_ChIP-Seq_LS180_Human0.60480926
83EGR1_19032775_ChIP-ChIP_M12_Human0.59025057
84PIAS1_25552417_ChIP-Seq_VCAP_Human0.58730450
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.58685986
86SUZ12_27294783_Chip-Seq_NPCs_Mouse0.58291656
87PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.57633615
88ESR1_21235772_ChIP-Seq_MCF-7_Human0.57505279
89AR_20517297_ChIP-Seq_VCAP_Human0.56501376
90FOXA1_25552417_ChIP-Seq_VCAP_Human0.55110481
91FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.54984154
92NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.53969400
93FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.53425550
94MYC_19915707_ChIP-ChIP_AK7_Human0.52957854
95PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52728522
96STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51463786
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.51178389
98CBP_21632823_ChIP-Seq_H3396_Human0.51045739
99ESET_19884257_ChIP-Seq_ESCs_Mouse0.50629256
100STAT1_17558387_ChIP-Seq_HELA_Human0.50392488
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.50258535
102GATA6_25053715_ChIP-Seq_YYC3_Human0.48983819
103LXR_22292898_ChIP-Seq_THP-1_Human0.48685838
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.48317630
105P53_21459846_ChIP-Seq_SAOS-2_Human0.48298218
106FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.47035302
107FOXO3_23340844_ChIP-Seq_DLD1_Human0.46625450
108TAF15_26573619_Chip-Seq_HEK293_Human0.46052941
109PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45182658
110PPAR_26484153_Chip-Seq_NCI-H1993_Human0.44784430
111PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44397870
112BCAT_22108803_ChIP-Seq_LS180_Human0.44042059
113TAF2_19829295_ChIP-Seq_ESCs_Human0.43744421
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.42631154
115NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.40382753
116ESR1_20079471_ChIP-ChIP_T-47D_Human0.40378499
117GATA2_19941826_ChIP-Seq_K562_Human0.39663385
118* SOX2_20726797_ChIP-Seq_SW620_Human0.38952439
119SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38950107
120GATA1_19941827_ChIP-Seq_MEL_Mouse0.38706364
121SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.38334238
122ERG_21242973_ChIP-ChIP_JURKAT_Human0.38269146
123ERG_20517297_ChIP-Seq_VCAP_Human0.37897286
124GATA1_19941826_ChIP-Seq_K562_Human0.37685550
125FOXH1_21741376_ChIP-Seq_EPCs_Human0.36822615
126STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.36574416
127GATA3_24758297_ChIP-Seq_MCF-7_Human0.35719209
128MYC_27129775_Chip-Seq_CORNEA_Mouse0.35304341
129CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.34828927
130* CDX2_22108803_ChIP-Seq_LS180_Human0.34674943
131SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.34189753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.24047085
2MP0005360_urolithiasis7.74407708
3MP0005085_abnormal_gallbladder_physiolo6.42813912
4MP0005365_abnormal_bile_salt6.11566147
5MP0008875_abnormal_xenobiotic_pharmacok5.04926379
6MP0003806_abnormal_nucleotide_metabolis4.21024124
7MP0003252_abnormal_bile_duct3.96366070
8MP0010329_abnormal_lipoprotein_level3.52469243
9MP0009840_abnormal_foam_cell3.14567216
10MP0005083_abnormal_biliary_tract2.97361166
11MP0003195_calcinosis2.87065558
12MP0005332_abnormal_amino_acid2.84076110
13MP0001666_abnormal_nutrient_absorption2.65409498
14MP0004019_abnormal_vitamin_homeostasis2.33395866
15MP0003191_abnormal_cellular_cholesterol2.23380793
16MP0000609_abnormal_liver_physiology2.11516495
17MP0002138_abnormal_hepatobiliary_system2.07246114
18MP0002118_abnormal_lipid_homeostasis2.05795384
19MP0003868_abnormal_feces_composition1.89234766
20MP0005319_abnormal_enzyme/_coenzyme1.81355641
21MP0001764_abnormal_homeostasis1.71035451
22MP0009697_abnormal_copulation1.64844173
23MP0005584_abnormal_enzyme/coenzyme_acti1.57941038
24MP0003011_delayed_dark_adaptation1.51055190
25MP0005451_abnormal_body_composition1.46902136
26MP0009643_abnormal_urine_homeostasis1.34750864
27MP0003183_abnormal_peptide_metabolism1.31595235
28MP0003186_abnormal_redox_activity1.30853069
29MP0003656_abnormal_erythrocyte_physiolo1.22655571
30MP0000598_abnormal_liver_morphology1.14431092
31MP0003705_abnormal_hypodermis_morpholog1.13632014
32MP0005647_abnormal_sex_gland1.10712717
33MP0002254_reproductive_system_inflammat1.09111459
34MP0005636_abnormal_mineral_homeostasis1.03557315
35MP0009764_decreased_sensitivity_to1.03356270
36MP0000604_amyloidosis1.00651348
37MP0009763_increased_sensitivity_to0.98184603
38MP0010368_abnormal_lymphatic_system0.92415754
39MP0005408_hypopigmentation0.89959726
40MP0004147_increased_porphyrin_level0.88438610
41MP0008469_abnormal_protein_level0.87460644
42MP0009642_abnormal_blood_homeostasis0.86519947
43MP0006036_abnormal_mitochondrial_physio0.84935209
44MP0005084_abnormal_gallbladder_morpholo0.84385997
45MP0003879_abnormal_hair_cell0.82372728
46MP0005376_homeostasis/metabolism_phenot0.78835497
47MP0002876_abnormal_thyroid_physiology0.77487989
48MP0009765_abnormal_xenobiotic_induced0.77224529
49MP0005220_abnormal_exocrine_pancreas0.74787223
50MP0002078_abnormal_glucose_homeostasis0.74728550
51MP0005670_abnormal_white_adipose0.72961016
52MP0010155_abnormal_intestine_physiology0.69230792
53MP0001756_abnormal_urination0.68536926
54MP0002971_abnormal_brown_adipose0.68043651
55MP0005535_abnormal_body_temperature0.67140192
56MP0009053_abnormal_anal_canal0.66207987
57MP0005334_abnormal_fat_pad0.64560826
58MP0005266_abnormal_metabolism0.63287590
59MP0004130_abnormal_muscle_cell0.62331860
60MP0001661_extended_life_span0.61419463
61MP0003690_abnormal_glial_cell0.59135182
62MP0005058_abnormal_lysosome_morphology0.58295897
63MP0006035_abnormal_mitochondrial_morpho0.57856986
64MP0003329_amyloid_beta_deposits0.56143405
65MP0000639_abnormal_adrenal_gland0.55989823
66MP0002796_impaired_skin_barrier0.55538975
67MP0005187_abnormal_penis_morphology0.55250778
68MP0002136_abnormal_kidney_physiology0.54708577
69MP0004381_abnormal_hair_follicle0.52609130
70MP0003718_maternal_effect0.51728553
71MP0005448_abnormal_energy_balance0.51412971
72MP0002928_abnormal_bile_duct0.50359824
73MP0010386_abnormal_urinary_bladder0.50302106
74MP0005395_other_phenotype0.50040726
75MP0001915_intracranial_hemorrhage0.49488503
76MP0003638_abnormal_response/metabolism_0.47569467
77MP0005464_abnormal_platelet_physiology0.45938199
78MP0002822_catalepsy0.45390510
79MP0009785_altered_susceptibility_to0.45260240
80MP0000579_abnormal_nail_morphology0.43897206
81MP0005409_darkened_coat_color0.43798851
82MP0003724_increased_susceptibility_to0.43355873
83MP0008873_increased_physiological_sensi0.42659542
84MP0000538_abnormal_urinary_bladder0.42534707
85MP0008874_decreased_physiological_sensi0.41297516
86MP0004782_abnormal_surfactant_physiolog0.41275682
87MP0008872_abnormal_physiological_respon0.40978524
88MP0003953_abnormal_hormone_level0.39917542
89MP0005166_decreased_susceptibility_to0.38192990
90MP0009384_cardiac_valve_regurgitation0.37471891
91MP0005023_abnormal_wound_healing0.37000708
92MP0003959_abnormal_lean_body0.36865155
93MP0002837_dystrophic_cardiac_calcinosis0.36786802
94MP0005666_abnormal_adipose_tissue0.36684893
95MP0003436_decreased_susceptibility_to0.36610308
96MP0003075_altered_response_to0.36305085
97MP0005164_abnormal_response_to0.36220541
98MP0004043_abnormal_pH_regulation0.35407910
99MP0000230_abnormal_systemic_arterial0.34983656
100MP0009672_abnormal_birth_weight0.33637127
101MP0000566_synostosis0.32431382
102MP0005248_abnormal_Harderian_gland0.32374947
103MP0008004_abnormal_stomach_pH0.31380752
104MP0002060_abnormal_skin_morphology0.30776087
105MP0001243_abnormal_dermal_layer0.30617371
106MP0010234_abnormal_vibrissa_follicle0.30569704
107MP0002168_other_aberrant_phenotype0.30171575
108MP0001664_abnormal_digestion0.29967344
109MP0009115_abnormal_fat_cell0.29425586
110MP0000462_abnormal_digestive_system0.28482869
111MP0004264_abnormal_extraembryonic_tissu0.28428064
112MP0001765_abnormal_ion_homeostasis0.28232182
113MP0001845_abnormal_inflammatory_respons0.28211290
114MP0002132_abnormal_respiratory_system0.27929633
115MP0009379_abnormal_foot_pigmentation0.27505817
116MP0001881_abnormal_mammary_gland0.27417795
117MP0004883_abnormal_blood_vessel0.26965129
118MP0000249_abnormal_blood_vessel0.26819083
119MP0001853_heart_inflammation0.26683631
120MP0002089_abnormal_postnatal_growth/wei0.26676334
121MP0000477_abnormal_intestine_morphology0.25848411
122MP0001663_abnormal_digestive_system0.24299544
123MP0003300_gastrointestinal_ulcer0.23596479
124MP0002970_abnormal_white_adipose0.23355439
125MP0002249_abnormal_larynx_morphology0.22892937
126MP0000467_abnormal_esophagus_morphology0.21481984

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.31685964
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.29975960
3Deep venous thrombosis (HP:0002625)7.24916631
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.54008378
5Prolonged partial thromboplastin time (HP:0003645)6.43489436
6Hypobetalipoproteinemia (HP:0003563)6.35269503
7Xanthomatosis (HP:0000991)6.25959751
8Complement deficiency (HP:0004431)5.31446574
9Hyperlipoproteinemia (HP:0010980)5.28353177
10Hypolipoproteinemia (HP:0010981)4.74401673
11Joint hemorrhage (HP:0005261)4.69834747
12Hyperammonemia (HP:0001987)4.66024137
13Epidermoid cyst (HP:0200040)4.51657248
14Hyperglycinemia (HP:0002154)4.49462014
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.37461402
16Abnormality of the common coagulation pathway (HP:0010990)4.35387609
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.31538609
18Ketosis (HP:0001946)4.31337503
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.21662369
20Abnormality of aspartate family amino acid metabolism (HP:0010899)4.19178143
21Fat malabsorption (HP:0002630)4.16776150
22Abnormality of methionine metabolism (HP:0010901)4.16098892
23Hyperglycinuria (HP:0003108)4.10999062
24Hypoalphalipoproteinemia (HP:0003233)4.09664663
25Abnormality of glycine metabolism (HP:0010895)4.06619894
26Abnormality of serine family amino acid metabolism (HP:0010894)4.06619894
27Hypoglycemic coma (HP:0001325)3.88462732
28Abnormality of complement system (HP:0005339)3.87701212
29Conjugated hyperbilirubinemia (HP:0002908)3.79116821
30Abnormality of pyrimidine metabolism (HP:0004353)3.77870063
31Abnormality of the intrinsic pathway (HP:0010989)3.68457514
32Hypercholesterolemia (HP:0003124)3.52250136
33Nephritis (HP:0000123)3.50428553
34Abnormality of fatty-acid metabolism (HP:0004359)3.42945737
35Hyperbilirubinemia (HP:0002904)3.35921258
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.35205075
37Abnormality of nucleobase metabolism (HP:0010932)3.15541795
38Abnormality of serum amino acid levels (HP:0003112)3.13976523
39Ketoacidosis (HP:0001993)3.13531968
40Delayed CNS myelination (HP:0002188)3.10851719
41Steatorrhea (HP:0002570)3.10589027
42Hepatocellular carcinoma (HP:0001402)3.02066528
43Osteomalacia (HP:0002749)2.96771589
44Abnormality of vitamin metabolism (HP:0100508)2.95865331
45Spontaneous abortion (HP:0005268)2.90372747
46Hypochromic microcytic anemia (HP:0004840)2.90029879
47Reduced antithrombin III activity (HP:0001976)2.86995853
48Metabolic acidosis (HP:0001942)2.85250329
49Abnormality of purine metabolism (HP:0004352)2.84377662
50Myocardial infarction (HP:0001658)2.82177932
51Gout (HP:0001997)2.72965422
52Skin nodule (HP:0200036)2.71250243
53Systemic lupus erythematosus (HP:0002725)2.69314786
54Lethargy (HP:0001254)2.69010511
55Acanthocytosis (HP:0001927)2.68477729
56Dicarboxylic aciduria (HP:0003215)2.67164827
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.67164827
58Vascular calcification (HP:0004934)2.62823759
59Hyperphosphaturia (HP:0003109)2.56350823
60Cerebral edema (HP:0002181)2.51268324
61Spastic diplegia (HP:0001264)2.44810905
62Abnormal gallbladder morphology (HP:0012437)2.44203922
63Hypoglycemic seizures (HP:0002173)2.43600472
64Cholelithiasis (HP:0001081)2.37596540
65Irritability (HP:0000737)2.37359047
66Glomerulonephritis (HP:0000099)2.36797932
67Widely patent fontanelles and sutures (HP:0004492)2.36488853
68Neonatal onset (HP:0003623)2.36178719
69Malnutrition (HP:0004395)2.34467336
70Recurrent gram-negative bacterial infections (HP:0005420)2.33989530
71Cardiovascular calcification (HP:0011915)2.32370014
72Abnormal urine phosphate concentration (HP:0012599)2.31464403
73Elevated alkaline phosphatase (HP:0003155)2.30692313
74Cholecystitis (HP:0001082)2.30377771
75Abnormal gallbladder physiology (HP:0012438)2.30377771
76Mitral stenosis (HP:0001718)2.28399143
77Facial shape deformation (HP:0011334)2.27718310
78Potter facies (HP:0002009)2.27718310
79Generalized aminoaciduria (HP:0002909)2.26469676
80Abnormality of alkaline phosphatase activity (HP:0004379)2.21401925
81Amyloidosis (HP:0011034)2.20244469
82Pancreatitis (HP:0001733)2.18210690
83Enlarged kidneys (HP:0000105)2.15990009
84Cerebral palsy (HP:0100021)2.15861959
85Vomiting (HP:0002013)2.15710152
86Esophageal varix (HP:0002040)2.14085883
87Sensorimotor neuropathy (HP:0007141)2.13708670
88Gingival bleeding (HP:0000225)2.12529331
89Brushfield spots (HP:0001088)2.11891391
90Late onset (HP:0003584)2.10942775
91Hypophosphatemia (HP:0002148)2.10806829
92Menorrhagia (HP:0000132)2.09108738
93Alkalosis (HP:0001948)2.08570820
94Rickets (HP:0002748)2.07637124
95Poikilocytosis (HP:0004447)2.03900123
96Thrombophlebitis (HP:0004418)2.01889495
97Abnormality of the gallbladder (HP:0005264)1.99463909
98Hydroxyprolinuria (HP:0003080)1.98641410
99Abnormality of proline metabolism (HP:0010907)1.98641410
100Abnormality of the Achilles tendon (HP:0005109)1.98170558
101Opisthotonus (HP:0002179)1.97195284
102Proximal tubulopathy (HP:0000114)1.97118119
103Hyperinsulinemic hypoglycemia (HP:0000825)1.95510214
104Nephrolithiasis (HP:0000787)1.93914079
105Abnormal cartilage morphology (HP:0002763)1.93749189
106Purpura (HP:0000979)1.91796577
107Renal cortical cysts (HP:0000803)1.90932892
108Abnormal enzyme/coenzyme activity (HP:0012379)1.90804490
109Glycosuria (HP:0003076)1.90803468
110Abnormality of urine glucose concentration (HP:0011016)1.90803468
111Increased purine levels (HP:0004368)1.90763169
112Hyperuricemia (HP:0002149)1.90763169
113Hemorrhage of the eye (HP:0011885)1.88830971
114Hypophosphatemic rickets (HP:0004912)1.88071122
115Pulmonary embolism (HP:0002204)1.87434159
116Nausea (HP:0002018)1.86054751
117Abnormality of iron homeostasis (HP:0011031)1.85870200
118Abnormality of transition element cation homeostasis (HP:0011030)1.85510556
119Confusion (HP:0001289)1.81770387
120Abnormality of the vitamin B12 metabolism (HP:0004341)1.78673161
121Arthropathy (HP:0003040)1.74797807
122Pigmentary retinal degeneration (HP:0001146)1.73311384
123Joint swelling (HP:0001386)1.73307883
124Paraparesis (HP:0002385)1.72954373

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.24112519
2ACVR1B5.00185639
3FGFR44.43605365
4SIK14.23741772
5ERN14.04426625
6PDK23.33055523
7ERBB43.11141491
8TAOK33.04817668
9INSRR2.93089609
10EPHA22.84296339
11MST1R2.69230777
12PRPF4B2.53927808
13MAP3K122.37211390
14MAP2K42.18909057
15PKN22.11885447
16MAPK112.05131279
17PRKG21.88118469
18PIK3CG1.83475264
19FLT31.83445965
20FRK1.83198712
21LATS11.79827828
22TYK21.65912816
23ABL21.52797959
24DAPK21.48118587
25NEK91.46889265
26PTK61.46863599
27MYLK1.46574665
28AKT31.46199808
29TRIB31.45048546
30FGFR21.31541672
31MAP3K71.27084643
32STK38L1.26492244
33JAK21.22490814
34PRKAA21.18185044
35KDR1.16723551
36TESK21.13741675
37GRK61.13372833
38ERBB21.12168340
39PINK11.08500719
40TBK11.01892094
41SCYL21.01043816
42NLK0.99810927
43MET0.97455479
44MAPK40.96666848
45MAP3K140.96464289
46MAP3K30.96375806
47MAP3K10.95136314
48MAP3K100.93629700
49MAP2K30.93492462
50MAPK150.91852206
51JAK10.91392552
52PRKCZ0.90720222
53STK390.90182961
54ICK0.88855358
55LMTK20.88108830
56IRAK30.87266283
57MAPKAPK30.86473518
58MAP2K60.81044801
59FER0.79092006
60CDK60.78796791
61PRKACG0.78652657
62EIF2AK10.77487806
63MAP3K110.77151209
64MAPK120.73230442
65TIE10.72948955
66CAMK2G0.72247281
67GSK3A0.70688573
68DYRK1B0.70647842
69PBK0.70294664
70EPHB10.69880545
71PRKAA10.69531700
72MST40.68882917
73DDR20.68062319
74EPHA30.64979777
75CSK0.63671993
76PRKACA0.60384311
77TESK10.59837081
78SGK30.59214930
79PIM20.58961174
80GRK10.58013050
81RIPK10.56751837
82TGFBR20.56712036
83PTK20.56311159
84CAMK1D0.55896438
85IKBKE0.53666894
86NEK60.53339898
87KSR20.52821786
88EIF2AK30.51726033
89PDPK10.50997595
90PRKG10.50033786
91PRKCQ0.49658141
92SRC0.49550703
93EPHA40.48707629
94MAPK70.48615279
95CSNK1G10.47694024
96FGFR30.47040705
97SGK20.45635299
98ARAF0.45061003
99ZAP700.44797908
100MAP2K10.43631003
101IGF1R0.43485675
102NUAK10.41727838
103CSF1R0.41684607
104SGK2230.41058486
105SGK4940.41058486
106PIM10.40726989
107PDK30.40471644
108PDK40.40471644
109PKN10.40005021
110EPHB20.39546023
111PDGFRA0.39087770
112MUSK0.38975719
113MAP3K50.38564439
114CDK40.37661541
115TAOK20.37493744
116PRKCB0.36930430
117MAP3K130.36600762
118MAP3K60.36277718
119TAOK10.34869044
120PRKCG0.34846591
121PRKCD0.34710150
122WNK30.34406579
123WNK40.33484139
124RET0.32238240
125EGFR0.31041492
126PDK10.30594670
127MATK0.30539219
128MAP2K20.30487431
129NTRK30.30075297
130PRKCA0.29778184
131MTOR0.27187382
132CAMK40.26873272
133OXSR10.25762055
134CSNK1G20.23813440
135PIK3CA0.23392241
136MAP3K20.22974234
137PAK30.22803855
138ABL10.22296096

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.45592343
2Nitrogen metabolism_Homo sapiens_hsa009103.55938842
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.37738971
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.31673965
5Arginine biosynthesis_Homo sapiens_hsa002203.01663090
6Tryptophan metabolism_Homo sapiens_hsa003802.70109055
7Complement and coagulation cascades_Homo sapiens_hsa046102.69418009
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.66535954
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.65745867
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.51761252
11Fatty acid degradation_Homo sapiens_hsa000712.51324451
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42633801
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.27201938
14Butanoate metabolism_Homo sapiens_hsa006502.20100320
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14072199
16Peroxisome_Homo sapiens_hsa041462.11622205
17Propanoate metabolism_Homo sapiens_hsa006401.99363833
18Chemical carcinogenesis_Homo sapiens_hsa052041.93722706
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.92091206
20Histidine metabolism_Homo sapiens_hsa003401.91187216
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.89907914
22PPAR signaling pathway_Homo sapiens_hsa033201.84719362
23Fatty acid metabolism_Homo sapiens_hsa012121.82747573
24beta-Alanine metabolism_Homo sapiens_hsa004101.72435158
25Caffeine metabolism_Homo sapiens_hsa002321.72269407
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.71674033
27Retinol metabolism_Homo sapiens_hsa008301.71294753
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.69345369
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68128390
30Staphylococcus aureus infection_Homo sapiens_hsa051501.66821650
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65098534
32Selenocompound metabolism_Homo sapiens_hsa004501.56781295
33Phenylalanine metabolism_Homo sapiens_hsa003601.55283513
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53405804
35Bile secretion_Homo sapiens_hsa049761.48945800
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45582780
37Pyruvate metabolism_Homo sapiens_hsa006201.41294591
38Tyrosine metabolism_Homo sapiens_hsa003501.41068261
39Fatty acid elongation_Homo sapiens_hsa000621.39794431
40Sulfur metabolism_Homo sapiens_hsa009201.38274518
41Starch and sucrose metabolism_Homo sapiens_hsa005001.30329830
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.27987221
43Folate biosynthesis_Homo sapiens_hsa007901.24469719
44Steroid biosynthesis_Homo sapiens_hsa001001.24049790
45Fat digestion and absorption_Homo sapiens_hsa049751.20070842
46Biosynthesis of amino acids_Homo sapiens_hsa012301.18857355
47ABC transporters_Homo sapiens_hsa020101.16194325
48Carbon metabolism_Homo sapiens_hsa012001.15912111
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.13584488
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10879143
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.03276651
52Arginine and proline metabolism_Homo sapiens_hsa003300.99152785
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98296492
54Vitamin B6 metabolism_Homo sapiens_hsa007500.95920689
55Vitamin digestion and absorption_Homo sapiens_hsa049770.95141932
56Sulfur relay system_Homo sapiens_hsa041220.92956157
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89945339
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88123216
59Lysine degradation_Homo sapiens_hsa003100.82123519
60Glutathione metabolism_Homo sapiens_hsa004800.74869817
61One carbon pool by folate_Homo sapiens_hsa006700.73070754
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72918786
63Glycerolipid metabolism_Homo sapiens_hsa005610.68595269
64Pentose phosphate pathway_Homo sapiens_hsa000300.59553881
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54983963
66Fatty acid biosynthesis_Homo sapiens_hsa000610.52552510
67Pancreatic secretion_Homo sapiens_hsa049720.51339780
68Metabolic pathways_Homo sapiens_hsa011000.47982451
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40982591
70Prion diseases_Homo sapiens_hsa050200.33064676
71Galactose metabolism_Homo sapiens_hsa000520.28318018
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28004160
73Fructose and mannose metabolism_Homo sapiens_hsa000510.27807362
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23415370
75Linoleic acid metabolism_Homo sapiens_hsa005910.22920142
76Pertussis_Homo sapiens_hsa051330.19805824
77Insulin resistance_Homo sapiens_hsa049310.19466521
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.18051298
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.14835822
80Sphingolipid metabolism_Homo sapiens_hsa006000.13746298
81Other glycan degradation_Homo sapiens_hsa005110.11277268
82Glucagon signaling pathway_Homo sapiens_hsa049220.06650199
83Serotonergic synapse_Homo sapiens_hsa047260.00508767
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2462832
85Bladder cancer_Homo sapiens_hsa05219-0.2380421
86Protein digestion and absorption_Homo sapiens_hsa04974-0.2334353
87Ether lipid metabolism_Homo sapiens_hsa00565-0.2325596
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2203463
89Mineral absorption_Homo sapiens_hsa04978-0.2006466
90Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1827806
91Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1809373
92Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1756789
93Hepatitis C_Homo sapiens_hsa05160-0.1692717
94African trypanosomiasis_Homo sapiens_hsa05143-0.1664140
95Regulation of autophagy_Homo sapiens_hsa04140-0.1647355
96Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1573830
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1556148
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1474324
99Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1335037
100N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1324282
101Insulin signaling pathway_Homo sapiens_hsa04910-0.1322254
102Renin-angiotensin system_Homo sapiens_hsa04614-0.1195264
103Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1194652
104Amoebiasis_Homo sapiens_hsa05146-0.1073298
105Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0731626
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0434445
107AMPK signaling pathway_Homo sapiens_hsa04152-0.0017451
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0012290

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