AADACL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of other organism (GO:0098543)9.69869206
2sphingoid metabolic process (GO:0046519)9.08326863
3fatty acid elongation (GO:0030497)8.55954140
4keratinization (GO:0031424)8.04582370
5sphingosine metabolic process (GO:0006670)7.54182138
6multicellular organismal water homeostasis (GO:0050891)7.23010897
7regulation of phospholipase A2 activity (GO:0032429)7.01257943
8gap junction assembly (GO:0016264)6.98837686
9diol metabolic process (GO:0034311)6.72170336
10keratinocyte differentiation (GO:0030216)6.61465876
11regulation of natural killer cell differentiation (GO:0032823)6.31984000
12endothelium development (GO:0003158)6.17080574
13keratinocyte proliferation (GO:0043616)6.09280272
14water homeostasis (GO:0030104)6.01587551
15lateral sprouting from an epithelium (GO:0060601)5.77678943
16polarized epithelial cell differentiation (GO:0030859)5.61275719
17regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)5.59191286
18negative regulation of heart growth (GO:0061117)5.56758411
19negative regulation of cardiac muscle tissue growth (GO:0055022)5.56758411
20negative regulation of interferon-gamma production (GO:0032689)5.48839768
21regulation of glomerular filtration (GO:0003093)5.40009592
22purine ribonucleotide transport (GO:0015868)5.37295946
23epidermal cell differentiation (GO:0009913)5.36792510
24long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.36765715
25atrial cardiac muscle cell action potential (GO:0086014)5.35224326
26skeletal muscle tissue regeneration (GO:0043403)5.27398485
27adenine nucleotide transport (GO:0051503)5.22829883
28intestinal epithelial cell development (GO:0060576)5.21686947
29regulation of ruffle assembly (GO:1900027)5.18434364
30epithelial cell maturation (GO:0002070)5.15894782
31regulation of chemokine secretion (GO:0090196)5.08716124
32viral transcription (GO:0019083)5.06316875
33regulation of hypersensitivity (GO:0002883)5.06011068
34imidazole-containing compound metabolic process (GO:0052803)4.92731418
35translational termination (GO:0006415)4.78615098
36regulation of tight junction assembly (GO:2000810)4.77405371
37detection of external biotic stimulus (GO:0098581)4.71747513
38phosphatidylinositol acyl-chain remodeling (GO:0036149)4.67473299
39fatty-acyl-CoA metabolic process (GO:0035337)4.63403674
40long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.61208053
41positive regulation of chemokine secretion (GO:0090197)4.60877732
42phosphatidylserine acyl-chain remodeling (GO:0036150)4.54738335
43bundle of His cell to Purkinje myocyte communication (GO:0086069)4.49328997
44epithelial cell differentiation involved in prostate gland development (GO:0060742)4.41473914
45epidermis development (GO:0008544)4.37110155
46negative regulation of acute inflammatory response (GO:0002674)4.36099349
47long-chain fatty acid biosynthetic process (GO:0042759)4.29697787
48positive regulation of interleukin-8 secretion (GO:2000484)4.29620448
49fatty-acyl-CoA biosynthetic process (GO:0046949)4.26673670
50peptide cross-linking (GO:0018149)4.24807059
51atrioventricular valve morphogenesis (GO:0003181)4.23180440
52keratinocyte development (GO:0003334)4.19604210
53purine nucleotide transport (GO:0015865)4.06912046
54interferon-gamma secretion (GO:0072643)4.06102963
55regulation of cell proliferation involved in kidney development (GO:1901722)3.97844856
56very long-chain fatty acid metabolic process (GO:0000038)3.95946602
57phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.93342384
58ribosomal small subunit biogenesis (GO:0042274)3.91963241
59renal system process involved in regulation of blood volume (GO:0001977)3.91229513
60detection of biotic stimulus (GO:0009595)3.89940281
61retinal metabolic process (GO:0042574)3.88771836
62SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.87221831
63protein targeting to ER (GO:0045047)3.85613069
64regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.83254781
65cotranslational protein targeting to membrane (GO:0006613)3.82644340
66regulation of keratinocyte differentiation (GO:0045616)3.78325125
67establishment of protein localization to endoplasmic reticulum (GO:0072599)3.77040133
68phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.76644142
69viral life cycle (GO:0019058)3.73938508
70regulation of neuron projection regeneration (GO:0070570)3.69493590
71regulation of axon regeneration (GO:0048679)3.69493590
72translational elongation (GO:0006414)3.66233943
73negative regulation of cardiac muscle tissue development (GO:0055026)3.63726816
74regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.63443371
75protein localization to endoplasmic reticulum (GO:0070972)3.63056447
76cellular protein complex disassembly (GO:0043624)3.62410072
77positive regulation of interleukin-4 production (GO:0032753)3.60940107
78regulation of interleukin-8 secretion (GO:2000482)3.59916837
79regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.53440057
80regulation of cholesterol homeostasis (GO:2000188)3.52572127
81negative regulation of T cell mediated immunity (GO:0002710)3.50672865
82skin morphogenesis (GO:0043589)3.50311561
83phosphatidylcholine acyl-chain remodeling (GO:0036151)3.49293446
84chronic inflammatory response (GO:0002544)3.48382506
85regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.46578158
86intermediate filament organization (GO:0045109)3.41475460
87negative regulation of interleukin-2 production (GO:0032703)3.39825909
88positive regulation of p38MAPK cascade (GO:1900745)3.37463550
89hair follicle morphogenesis (GO:0031069)3.37258260
90polyol transport (GO:0015791)3.36851203
91ceramide catabolic process (GO:0046514)3.36758577
92lipoxygenase pathway (GO:0019372)3.36559061
93molting cycle (GO:0042303)3.36549204
94hair cycle (GO:0042633)3.36549204
95positive regulation of vesicle fusion (GO:0031340)3.36369558
96magnesium ion transport (GO:0015693)3.32872145
97hemidesmosome assembly (GO:0031581)3.32797318
98cellular response to arsenic-containing substance (GO:0071243)3.31295838
99nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.29958907
100phospholipid scrambling (GO:0017121)3.27290185
101one-carbon compound transport (GO:0019755)3.25665455
102gland morphogenesis (GO:0022612)3.19687128
103ectoderm development (GO:0007398)3.16405389
104nucleoside transport (GO:0015858)3.16270035
105negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.14747805
106natural killer cell mediated immunity (GO:0002228)3.12972478
107natural killer cell mediated cytotoxicity (GO:0042267)3.12972478
108eyelid development in camera-type eye (GO:0061029)3.11509500
109negative regulation of lipase activity (GO:0060192)3.11350613
110maturation of SSU-rRNA (GO:0030490)3.11103251
111primary alcohol catabolic process (GO:0034310)3.11024513
112cell-cell junction assembly (GO:0007043)3.10561060
113linoleic acid metabolic process (GO:0043651)3.10111806
114thioester biosynthetic process (GO:0035384)3.09726199
115acyl-CoA biosynthetic process (GO:0071616)3.09726199
116phospholipid efflux (GO:0033700)3.09397390
117pyrimidine-containing compound transmembrane transport (GO:0072531)3.08608639
118genitalia morphogenesis (GO:0035112)3.04070024
119glucosamine-containing compound catabolic process (GO:1901072)3.00824415
120positive regulation of cellular amide metabolic process (GO:0034250)3.00366710
121negative regulation of stress fiber assembly (GO:0051497)2.99992373
122cardiolipin metabolic process (GO:0032048)2.99526598
123glutathione biosynthetic process (GO:0006750)2.98717398
124cyclooxygenase pathway (GO:0019371)2.98106308
125protein complex disassembly (GO:0043241)2.97484384
126chemical homeostasis within a tissue (GO:0048875)2.97426784
127negative regulation of adenylate cyclase activity (GO:0007194)2.97014148
128response to phenylpropanoid (GO:0080184)2.96486138
129negative regulation of cell aging (GO:0090344)2.96457221
130early endosome to late endosome transport (GO:0045022)2.95074212
131molting cycle process (GO:0022404)2.93548856
132hair cycle process (GO:0022405)2.93548856
133renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.92454377
134intermediate filament cytoskeleton organization (GO:0045104)2.92238830
135positive regulation of glomerulus development (GO:0090193)2.91632509
136negative regulation of epidermal cell differentiation (GO:0045605)2.90779963
137hair cell differentiation (GO:0035315)2.90636565
138positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.89953422
139inflammatory response to antigenic stimulus (GO:0002437)2.87536355
140sympathetic nervous system development (GO:0048485)2.87330191
141regulation of transforming growth factor beta1 production (GO:0032908)2.86062771
142establishment of tissue polarity (GO:0007164)2.85774814
143establishment of planar polarity (GO:0001736)2.85774814
144smooth muscle tissue development (GO:0048745)2.84266440
145epithelium development (GO:0060429)2.84220378
146regulation of keratinocyte proliferation (GO:0010837)2.83444268
147phospholipid catabolic process (GO:0009395)2.83097227
148regulation of apoptotic process involved in morphogenesis (GO:1902337)2.83001585
149germ cell migration (GO:0008354)2.82791208
150trophectodermal cell differentiation (GO:0001829)2.82277491
151negative regulation of cyclase activity (GO:0031280)2.81788718
152intermediate filament-based process (GO:0045103)2.81664281
153ribosomal small subunit assembly (GO:0000028)2.78563646
154protein targeting to membrane (GO:0006612)2.77744699
155positive regulation of odontogenesis (GO:0042482)2.77509798
156defense response to fungus (GO:0050832)2.77438036
157lung lobe morphogenesis (GO:0060463)2.76940144
158surfactant homeostasis (GO:0043129)2.76591411
159translational initiation (GO:0006413)2.73761429
160T-helper cell differentiation (GO:0042093)2.71229366
161CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.71229366
162regulation of glomerulus development (GO:0090192)2.67801406
163regulation of epidermis development (GO:0045682)2.67342686
164hair follicle development (GO:0001942)2.67062133
165adult heart development (GO:0007512)2.63987967
166regulation of germinal center formation (GO:0002634)2.63220514
167cardiac muscle cell action potential involved in contraction (GO:0086002)2.62866927
168cardiac muscle cell action potential (GO:0086001)2.62220375
169reflex (GO:0060004)2.61666275
170desmosome organization (GO:0002934)12.3267460
171establishment of skin barrier (GO:0061436)11.2990231
172detection of bacterium (GO:0016045)11.2610422
173regulation of water loss via skin (GO:0033561)10.5673557

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse7.08609295
2SOX9_24532713_ChIP-Seq_HFSC_Mouse2.83342632
3P63_26484246_Chip-Seq_KERATINOCYTES_Human2.75999643
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.57970062
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.28623231
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.23690657
7FUS_26573619_Chip-Seq_HEK293_Human2.12148686
8NRF2_20460467_ChIP-Seq_MEFs_Mouse2.01747037
9NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.01747037
10TP63_17297297_ChIP-ChIP_HaCaT_Human14.3414720
11ESR2_21235772_ChIP-Seq_MCF-7_Human1.93541952
12ZNF263_19887448_ChIP-Seq_K562_Human1.91696720
13PIAS1_25552417_ChIP-Seq_VCAP_Human1.87946474
14GATA1_22025678_ChIP-Seq_K562_Human1.79535951
15FOXO3_23340844_ChIP-Seq_DLD1_Human1.78856131
16ESR1_21235772_ChIP-Seq_MCF-7_Human1.75213759
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74606756
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72416489
19* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69541022
20TAF15_26573619_Chip-Seq_HEK293_Human1.69297729
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67446253
22SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.66125929
23SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.66125929
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.64382097
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62237399
26SOX2_20726797_ChIP-Seq_SW620_Human1.58122525
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.53576314
28TCF4_18268006_ChIP-ChIP_LS174T_Human1.49291787
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.48839022
30EGR1_19032775_ChIP-ChIP_M12_Human1.48134734
31TP63_23658742_ChIP-Seq_EP156T_Human1.41428144
32BCAT_22108803_ChIP-Seq_LS180_Human1.38067995
33P53_22127205_ChIP-Seq_FIBROBLAST_Human1.36489886
34TP53_18474530_ChIP-ChIP_U2OS_Human1.33634752
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33225977
36ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33216429
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30659071
38ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29705080
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29544793
40P300_19829295_ChIP-Seq_ESCs_Human1.29357162
41RXR_22108803_ChIP-Seq_LS180_Human1.29078938
42NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28776724
43CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27738841
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27490712
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27431838
46TP53_16413492_ChIP-PET_HCT116_Human1.27228141
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26635452
48BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.26261902
49CDX2_22108803_ChIP-Seq_LS180_Human1.24147929
50VDR_22108803_ChIP-Seq_LS180_Human1.23187771
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.22369390
52EWS_26573619_Chip-Seq_HEK293_Human1.20814438
53TP63_22573176_ChIP-Seq_HFKS_Human1.20636649
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.20371488
55AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.19820544
56SMAD4_21799915_ChIP-Seq_A2780_Human1.19045920
57CJUN_26792858_Chip-Seq_BT549_Human1.18486870
58EED_16625203_ChIP-ChIP_MESCs_Mouse1.16845010
59AR_21572438_ChIP-Seq_LNCaP_Human1.14523597
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13513983
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11819299
62AR_25329375_ChIP-Seq_VCAP_Human1.11717555
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11537989
64FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10795488
65RUNX1_27514584_Chip-Seq_MCF-7_Human1.10581263
66SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09804994
67JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09575692
68JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08795078
69SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07375460
70HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06254120
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05433104
72* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04730461
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03670997
74TP53_20018659_ChIP-ChIP_R1E_Mouse1.03657694
75IGF1R_20145208_ChIP-Seq_DFB_Human1.01750773
76PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01377516
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.00413617
78PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98617583
79KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98612903
80SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98611090
81STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98590218
82TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98568057
83EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98165366
84RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98165366
85TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97747231
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96062616
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95980770
88CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94987967
89CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94877061
90TCF4_22108803_ChIP-Seq_LS180_Human0.94853060
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94591220
92KLF5_25053715_ChIP-Seq_YYC3_Human0.94255186
93GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93295199
94KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.93193389
95KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.93193389
96KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.93193389
97GATA4_25053715_ChIP-Seq_YYC3_Human0.92000563
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91906295
99FOXA1_25552417_ChIP-Seq_VCAP_Human0.91678354
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91034424
101ESR1_20079471_ChIP-ChIP_T-47D_Human0.90884360
102SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90685665
103NANOG_18555785_Chip-Seq_ESCs_Mouse0.89783320
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89694781
105EZH2_27294783_Chip-Seq_ESCs_Mouse0.89369202
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88770075
107RNF2_27304074_Chip-Seq_ESCs_Mouse0.88701742
108Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88191346
109CDX2_20551321_ChIP-Seq_CACO-2_Human0.87557294
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87351808
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87351808
112SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.86766087
113TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86363644
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85953121
115FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.84693125
116PRDM14_20953172_ChIP-Seq_ESCs_Human0.84386938
117SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.84375900
118MTF2_20144788_ChIP-Seq_MESCs_Mouse0.84028463
119PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83681693
120ER_23166858_ChIP-Seq_MCF-7_Human0.83633120
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.83491386
122SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83193528
123STAT3_23295773_ChIP-Seq_U87_Human0.83176164
124TAL1_26923725_Chip-Seq_HPCs_Mouse0.82920194
125KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81647228
126AHR_22903824_ChIP-Seq_MCF-7_Human0.79867620
127FOXM1_26456572_ChIP-Seq_MCF-7_Human0.79697191
128TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.78929776
129SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.78810525
130SMAD3_21741376_ChIP-Seq_HESCs_Human0.77371183
131* SOX2_19829295_ChIP-Seq_ESCs_Human0.77356950
132* NANOG_19829295_ChIP-Seq_ESCs_Human0.77356950
133SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.77194969
134CBX2_27304074_Chip-Seq_ESCs_Mouse0.75675125
135CEBPB_22108803_ChIP-Seq_LS180_Human0.74236723
136GATA3_24758297_ChIP-Seq_MCF-7_Human0.73910103
137HTT_18923047_ChIP-ChIP_STHdh_Human0.73797375
138PPARA_22158963_ChIP-Seq_LIVER_Mouse0.71724511
139FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.70844141
140ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.70379287
141SOX2_27498859_Chip-Seq_STOMACH_Mouse0.69884762
142SA1_27219007_Chip-Seq_Bcells_Human0.69103038
143ARNT_22903824_ChIP-Seq_MCF-7_Human0.69100207
144BMI1_23680149_ChIP-Seq_NPCS_Mouse0.68973938
145ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.68340701
146ETV2_25802403_ChIP-Seq_MESCs_Mouse0.67750546
147FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67506606
148CTCF_27219007_Chip-Seq_Bcells_Human0.67354223
149ERG_21242973_ChIP-ChIP_JURKAT_Human0.66657153
150ATF3_27146783_Chip-Seq_COLON_Human0.66274903
151GATA6_21074721_ChIP-Seq_CACO-2_Human0.66163642
152DNAJC2_21179169_ChIP-ChIP_NT2_Human0.66120441
153ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.65243016
154GATA6_25053715_ChIP-Seq_YYC3_Human0.64535882
155RACK7_27058665_Chip-Seq_MCF-7_Human0.63639110
156GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.62830713
157AUTS2_25519132_ChIP-Seq_293T-REX_Human0.61022926
158CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.60295392
159RNF2_27304074_Chip-Seq_NSC_Mouse0.60158132
160SA1_27219007_Chip-Seq_ERYTHROID_Human0.58269329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier9.21648186
2MP0010234_abnormal_vibrissa_follicle5.80194752
3MP0005275_abnormal_skin_tensile5.30477978
4MP0005501_abnormal_skin_physiology5.09606420
5MP0003941_abnormal_skin_development4.58235185
6MP0002254_reproductive_system_inflammat4.27060544
7MP0004381_abnormal_hair_follicle4.05446800
8MP0001216_abnormal_epidermal_layer3.33352119
9MP0001346_abnormal_lacrimal_gland3.25651827
10MP0001188_hyperpigmentation3.20598381
11MP0002060_abnormal_skin_morphology3.15438607
12MP0010771_integument_phenotype3.08851847
13MP0010678_abnormal_skin_adnexa2.98817986
14MP0005451_abnormal_body_composition2.95396075
15MP0002098_abnormal_vibrissa_morphology2.90953513
16MP0009379_abnormal_foot_pigmentation2.76176906
17MP0000579_abnormal_nail_morphology2.68950831
18MP0000383_abnormal_hair_follicle2.59808004
19MP0000467_abnormal_esophagus_morphology2.50218129
20MP0004947_skin_inflammation2.36787139
21MP0003453_abnormal_keratinocyte_physiol2.33012185
22MP0000647_abnormal_sebaceous_gland2.06309717
23MP0005174_abnormal_tail_pigmentation1.95578553
24MP0000377_abnormal_hair_follicle1.93811619
25MP0000015_abnormal_ear_pigmentation1.89157983
26MP0004185_abnormal_adipocyte_glucose1.85253608
27MP0003566_abnormal_cell_adhesion1.70595525
28MP0001191_abnormal_skin_condition1.69820680
29MP0009931_abnormal_skin_appearance1.55096275
30MP0000427_abnormal_hair_cycle1.52703218
31MP0003136_yellow_coat_color1.48306394
32MP0001853_heart_inflammation1.47807211
33MP0001542_abnormal_bone_strength1.45332214
34MP0003279_aneurysm1.40203591
35MP0005171_absent_coat_pigmentation1.38357439
36MP0005503_abnormal_tendon_morphology1.35978433
37MP0003191_abnormal_cellular_cholesterol1.33234341
38MP0005623_abnormal_meninges_morphology1.30470996
39MP0000569_abnormal_digit_pigmentation1.28930363
40MP0000516_abnormal_urinary_system1.26882825
41MP0005367_renal/urinary_system_phenotyp1.26882825
42MP0003436_decreased_susceptibility_to1.24574551
43MP0003705_abnormal_hypodermis_morpholog1.22215041
44MP0000762_abnormal_tongue_morphology1.19205536
45MP0002009_preneoplasia1.17486307
46MP0004782_abnormal_surfactant_physiolog1.14794843
47MP0001340_abnormal_eyelid_morphology1.13696222
48MP0000428_abnormal_craniofacial_morphol1.08849401
49MP0000367_abnormal_coat/_hair1.06626776
50MP0002090_abnormal_vision1.03623426
51MP0001243_abnormal_dermal_layer1.00099158
52MP0002249_abnormal_larynx_morphology0.98166967
53MP0002877_abnormal_melanocyte_morpholog0.98108361
54MP0000465_gastrointestinal_hemorrhage0.90096773
55MP0010352_gastrointestinal_tract_polyps0.81309666
56MP0003718_maternal_effect0.80484607
57MP0000462_abnormal_digestive_system0.80093927
58MP0005023_abnormal_wound_healing0.79559137
59MP0001851_eye_inflammation0.79475303
60MP0005076_abnormal_cell_differentiation0.77427122
61MP0000750_abnormal_muscle_regeneration0.76631839
62MP0004215_abnormal_myocardial_fiber0.75104004
63MP0005197_abnormal_uvea_morphology0.73077272
64MP0000613_abnormal_salivary_gland0.71372794
65MP0008057_abnormal_DNA_replication0.70173470
66MP0009053_abnormal_anal_canal0.68911956
67MP0001784_abnormal_fluid_regulation0.67928925
68MP0004885_abnormal_endolymph0.67507409
69MP0003690_abnormal_glial_cell0.67023007
70MP0002282_abnormal_trachea_morphology0.65955663
71MP0008789_abnormal_olfactory_epithelium0.64978246
72MP0000566_synostosis0.64142359
73MP0005248_abnormal_Harderian_gland0.63400431
74MP0003638_abnormal_response/metabolism_0.63390955
75MP0003011_delayed_dark_adaptation0.62506450
76MP0003385_abnormal_body_wall0.62147213
77MP0010030_abnormal_orbit_morphology0.61127622
78MP0000538_abnormal_urinary_bladder0.60223750
79MP0000372_irregular_coat_pigmentation0.58518828
80MP0000627_abnormal_mammary_gland0.58158527
81MP0002638_abnormal_pupillary_reflex0.57157642
82MP0004484_altered_response_of0.56297062
83MP0000049_abnormal_middle_ear0.55983598
84MP0003828_pulmonary_edema0.55300589
85MP0002148_abnormal_hypersensitivity_rea0.55057453
86MP0008438_abnormal_cutaneous_collagen0.53085096
87MP0001440_abnormal_grooming_behavior0.51927267
88MP0009250_abnormal_appendicular_skeleto0.51475820
89MP0005595_abnormal_vascular_smooth0.50383346
90MP0005377_hearing/vestibular/ear_phenot0.49794368
91MP0003878_abnormal_ear_physiology0.49794368
92MP0001177_atelectasis0.48928935
93MP0005666_abnormal_adipose_tissue0.48259074
94MP0004272_abnormal_basement_membrane0.47432776
95MP0002095_abnormal_skin_pigmentation0.47380081
96MP0000432_abnormal_head_morphology0.44998623
97MP0009780_abnormal_chondrocyte_physiolo0.44853213
98MP0001984_abnormal_olfaction0.44078499
99MP0005085_abnormal_gallbladder_physiolo0.43358040
100MP0004019_abnormal_vitamin_homeostasis0.43142263
101MP0002092_abnormal_eye_morphology0.42153427
102MP0002998_abnormal_bone_remodeling0.39901908
103MP0001299_abnormal_eye_distance/0.39776048
104MP0003567_abnormal_fetal_cardiomyocyte0.39459421
105MP0004883_abnormal_blood_vessel0.37576663
106MP0002006_tumorigenesis0.37395712
107MP0005394_taste/olfaction_phenotype0.36874186
108MP0005499_abnormal_olfactory_system0.36874186
109MP0001533_abnormal_skeleton_physiology0.36693955
110MP0004510_myositis0.36314532
111MP0002177_abnormal_outer_ear0.36209155
112MP0005647_abnormal_sex_gland0.36081159
113MP0004858_abnormal_nervous_system0.35701926
114MP0000371_diluted_coat_color0.33992350
115MP0004264_abnormal_extraembryonic_tissu0.33303455
116MP0005390_skeleton_phenotype0.33111689
117MP0001881_abnormal_mammary_gland0.32364887
118MP0003137_abnormal_impulse_conducting0.32042318
119MP0008961_abnormal_basal_metabolism0.31612607
120MP0000470_abnormal_stomach_morphology0.31310526
121MP0003763_abnormal_thymus_physiology0.31109215
122MP0002166_altered_tumor_susceptibility0.31080997
123MP0003329_amyloid_beta_deposits0.30103831
124MP0005508_abnormal_skeleton_morphology0.30015698
125MP0008004_abnormal_stomach_pH0.29532458
126MP0002233_abnormal_nose_morphology0.29207232
127MP0001666_abnormal_nutrient_absorption0.27857431
128MP0009672_abnormal_birth_weight0.27597806
129MP0005075_abnormal_melanosome_morpholog0.26254682
130MP0003950_abnormal_plasma_membrane0.25987191
131MP0002277_abnormal_respiratory_mucosa0.25757619
132MP0002132_abnormal_respiratory_system0.25227907
133MP0000013_abnormal_adipose_tissue0.24368567
134MP0005375_adipose_tissue_phenotype0.23850944
135MP0005083_abnormal_biliary_tract0.23071694
136MP0002111_abnormal_tail_morphology0.22767150
137MP0009384_cardiac_valve_regurgitation0.22669004
138MP0005408_hypopigmentation0.21527854
139MP0003755_abnormal_palate_morphology0.21370801
140MP0001324_abnormal_eye_pigmentation0.21182988

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)8.85564259
2Congenital ichthyosiform erythroderma (HP:0007431)7.66564010
3Congenital nonbullous ichthyosiform erythroderma (HP:0007479)7.64760789
4Increased IgE level (HP:0003212)6.52774444
5Hypotrichosis (HP:0001006)6.31453819
6Erythema (HP:0010783)5.84133778
7Aplasia involving bones of the extremities (HP:0009825)5.57588405
8Aplasia involving bones of the upper limbs (HP:0009823)5.57588405
9Aplasia of the phalanges of the hand (HP:0009802)5.57588405
10Right ventricular cardiomyopathy (HP:0011663)5.42712579
11Woolly hair (HP:0002224)5.29109715
12Erythroderma (HP:0001019)5.15488919
13Abnormality of nail color (HP:0100643)5.13925898
14Lip pit (HP:0100267)5.08362202
15Plantar hyperkeratosis (HP:0007556)4.98985322
16Selective tooth agenesis (HP:0001592)4.98395225
17Onycholysis (HP:0001806)4.95160451
18Palmoplantar hyperkeratosis (HP:0000972)4.93887188
19Short middle phalanx of the 5th finger (HP:0004220)4.73677663
20Hypohidrosis (HP:0000966)4.64635015
21Palmar hyperkeratosis (HP:0010765)4.61556670
22Dry hair (HP:0011359)4.35083089
23Long nose (HP:0003189)4.21405943
24Severe Myopia (HP:0011003)4.18107309
25Abnormality of the axillary hair (HP:0100134)4.04635827
26Abnormality of secondary sexual hair (HP:0009888)4.04635827
27Sparse scalp hair (HP:0002209)3.95974547
28Abnormality of the dental root (HP:0006486)3.78589190
29Taurodontia (HP:0000679)3.78589190
30Abnormality of permanent molar morphology (HP:0011071)3.78589190
31Curly hair (HP:0002212)3.73695859
32Tetraparesis (HP:0002273)3.61784014
33Corneal erosion (HP:0200020)3.59150252
34Acanthosis nigricans (HP:0000956)3.57144004
35Abnormality of molar (HP:0011077)3.55440623
36Abnormality of molar morphology (HP:0011070)3.55440623
37Hyporeflexia of lower limbs (HP:0002600)3.52161736
38Popliteal pterygium (HP:0009756)3.48465021
39Fragile nails (HP:0001808)3.46051642
40Pruritus (HP:0000989)3.41320435
41Abnormality of the dental pulp (HP:0006479)3.40873669
42Gangrene (HP:0100758)3.29094620
43Conjunctival hamartoma (HP:0100780)3.25763581
44Ventricular tachycardia (HP:0004756)3.22491647
45Absent eyelashes (HP:0000561)3.09088894
46Nasolacrimal duct obstruction (HP:0000579)3.07003797
47Eczematoid dermatitis (HP:0000976)3.06527954
48Abnormality of the columella (HP:0009929)3.05020581
49Hamartoma of the eye (HP:0010568)3.02662970
50Abnormal hemoglobin (HP:0011902)3.02534958
51Duplicated collecting system (HP:0000081)3.02100272
52Abnormality of the 2nd finger (HP:0004100)3.01669585
53Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.00370289
54Abnormal blistering of the skin (HP:0008066)2.98482650
55Abnormality of hair growth rate (HP:0011363)2.96157265
56Slow-growing hair (HP:0002217)2.96157265
57Palmoplantar keratoderma (HP:0000982)2.94480637
58Sparse eyelashes (HP:0000653)2.92814400
59Abnormality of cells of the erythroid lineage (HP:0012130)2.92053523
60Ectropion (HP:0000656)2.89417177
61Urticaria (HP:0001025)2.79605598
62Split foot (HP:0001839)2.78621468
63Broad alveolar ridges (HP:0000187)2.71376274
64Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.68403202
65Abnormality of the renal collecting system (HP:0004742)2.67304234
66Concave nail (HP:0001598)2.63663254
67Nail dystrophy (HP:0008404)2.62725685
68Dry skin (HP:0000958)2.61487277
69Pili torti (HP:0003777)2.58049983
70Mixed hearing impairment (HP:0000410)2.57899237
71Anhidrosis (HP:0000970)2.57435805
72Natal tooth (HP:0000695)2.57061335
73Abnormality of the lacrimal duct (HP:0011481)2.55549424
74Brittle hair (HP:0002299)2.55527663
75Abnormality of the phalanges of the 2nd finger (HP:0009541)2.54661181
76Intention tremor (HP:0002080)2.54090827
77Hypoplastic labia majora (HP:0000059)2.52622229
78Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.48118754
79Conical tooth (HP:0000698)2.46821264
80Atrioventricular block (HP:0001678)2.46763319
81Depressed nasal tip (HP:0000437)2.46740995
82Abnormality of the nasolacrimal system (HP:0000614)2.45232695
83Absent hair (HP:0002298)2.41830559
84Advanced eruption of teeth (HP:0006288)2.41775446
85Narrow nasal bridge (HP:0000446)2.41615878
86Hypergammaglobulinemia (HP:0010702)2.41134980
87Areflexia of lower limbs (HP:0002522)2.37334719
88Thick nail (HP:0001805)2.35495872
89Abnormality of the salivary glands (HP:0010286)2.35275518
90Xerostomia (HP:0000217)2.31715029
91Short hallux (HP:0010109)2.30695533
92Stenosis of the external auditory canal (HP:0000402)2.30430927
93Abnormality of the labia majora (HP:0012881)2.29197121
94Distal lower limb muscle weakness (HP:0009053)2.28489499
95Dehydration (HP:0001944)2.24131839
96Macrocytic anemia (HP:0001972)2.23208773
97Abnormal number of erythroid precursors (HP:0012131)2.22921171
98Dysdiadochokinesis (HP:0002075)2.21787889
99Down-sloping shoulders (HP:0200021)2.19369022
100Abnormality of the gastric mucosa (HP:0004295)2.15743760
101Hypoparathyroidism (HP:0000829)2.15208769
102Melanocytic nevus (HP:0000995)2.15167142
103Hamartoma (HP:0010566)2.13950907
104Non-midline cleft lip (HP:0100335)2.12104327
105Milia (HP:0001056)2.12027768
106Aplasia/Hypoplasia of the hallux (HP:0008362)2.09066915
107Median cleft lip (HP:0000161)2.08384627
108Ventricular fibrillation (HP:0001663)2.06941197
109Hypoplastic left heart (HP:0004383)2.05632285
110Cutaneous syndactyly (HP:0012725)2.03793050
111Reticulocytopenia (HP:0001896)2.03779526
112Oral leukoplakia (HP:0002745)2.03758323
113Absent eyebrow (HP:0002223)2.03629544
114Lack of skin elasticity (HP:0100679)2.02201164
115Short 5th finger (HP:0009237)2.01300906
116Malignant hyperthermia (HP:0002047)1.99582762
117Humeroradial synostosis (HP:0003041)1.97366521
118Synostosis involving the elbow (HP:0003938)1.97366521
119Ridged nail (HP:0001807)1.96108156
120Hypoplasia of dental enamel (HP:0006297)1.92951655
121Sudden death (HP:0001699)1.91914432
122Sensory axonal neuropathy (HP:0003390)1.91679798
123Oligodontia (HP:0000677)1.89981529
124Hypoplasia of the iris (HP:0007676)1.89292798
125Abnormality of incisor morphology (HP:0011063)1.88077491
126Abnormality of the alveolar ridges (HP:0006477)1.88029456
127Pustule (HP:0200039)1.87248582
128Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.87113040
129Flared metaphyses (HP:0003015)1.85919739
130Fasciculations (HP:0002380)1.84708347
131Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.83384711
132Alopecia of scalp (HP:0002293)1.82287093
133Labial hypoplasia (HP:0000066)1.81038722
134Pallor (HP:0000980)1.80100968
135Short middle phalanx of finger (HP:0005819)1.80004920
136Blepharitis (HP:0000498)1.79323905
137Premature loss of primary teeth (HP:0006323)1.78665629
138Maternal diabetes (HP:0009800)1.78417434
139Intellectual disability, profound (HP:0002187)1.77252635
140Asthma (HP:0002099)1.75931654
141Corneal dystrophy (HP:0001131)1.75825452
142Achilles tendon contracture (HP:0001771)1.75629046
143Craniofacial hyperostosis (HP:0004493)1.73190020
144Septate vagina (HP:0001153)1.73077685
145Hypodontia (HP:0000668)1.72762236
146Cubitus valgus (HP:0002967)1.72279087
147Abnormality of the phalanges of the 5th finger (HP:0004213)1.71576498
148Pterygium (HP:0001059)1.68754662
149Villous atrophy (HP:0011473)1.68527925
150Abnormality of small intestinal villus morphology (HP:0011472)1.68527925
151Abnormality of the Achilles tendon (HP:0005109)1.68061840
152Increased connective tissue (HP:0009025)1.65051581
153Abnormal hair laboratory examination (HP:0003328)1.64059903
154Abnormality of the middle phalanges of the toes (HP:0010183)1.62531511
155Type I diabetes mellitus (HP:0100651)1.60341407

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R7.85286467
2MST44.16408060
3LATS14.06355075
4MAP3K33.68206123
5MAPKAPK33.52262655
6MAPK73.30013108
7MAPK122.91240075
8MET2.78384271
9STK32.73826413
10MAP3K22.56981974
11FER2.55422351
12TRPM72.36455064
13FGFR12.32375076
14EPHA22.31379767
15PIM22.22648478
16BRSK22.18530619
17ERBB32.15614268
18NME21.98349911
19BCR1.93755657
20FGFR21.91332153
21LRRK21.84547375
22PIK3CG1.83844274
23RPS6KB21.78672100
24GRK11.58112983
25KIT1.57647744
26MAP3K141.54319292
27MKNK21.50788748
28FGFR31.50325742
29GRK51.45445834
30MAP3K61.44487349
31EPHA41.37991452
32MAPKAPK51.33481440
33STK241.32027449
34AKT31.26953753
35TAF11.25614281
36STK101.25573905
37LATS21.18482071
38ERN11.14141640
39NLK1.11815476
40PTK61.09050204
41MAP3K71.08569590
42TAOK31.07447001
43CASK1.07445597
44STK38L1.05831445
45IRAK31.03805905
46RPS6KB11.03456794
47PKN11.00187518
48EEF2K0.99612558
49MAP2K60.96405540
50ACVR1B0.96229309
51DYRK1B0.95723549
52CDK60.91415964
53EPHB20.89578360
54SGK20.88718808
55PRKCG0.88576806
56RIPK40.88317468
57DYRK30.86061061
58CAMKK20.85826688
59MAP3K120.84539130
60NTRK20.83299891
61MKNK10.83203018
62BMPR1B0.79635909
63DDR20.78374240
64BRD40.74987420
65GRK70.74687215
66MUSK0.73946489
67IRAK10.73016278
68CDK30.68040305
69MAP3K110.67184103
70PAK30.66874127
71RIPK10.66544718
72ZAK0.64782074
73SGK4940.63186809
74SGK2230.63186809
75TGFBR20.62612444
76NUAK10.61892465
77MAP3K10.58111429
78MAPK150.54935191
79ILK0.54473275
80TTN0.53956105
81EPHA30.53747147
82ERBB40.52950090
83RPS6KA40.52886180
84IRAK20.52878328
85STK390.52566686
86NEK90.52390721
87BMPR20.51611500
88BLK0.50444954
89MAPKAPK20.49272944
90SIK10.46450456
91EIF2AK20.45834169
92PRKD10.45484122
93IGF1R0.45227289
94ROCK20.44349862
95OXSR10.44207945
96ICK0.43495152
97HIPK20.43328662
98ADRBK10.43122631
99PRKCQ0.41671410
100PRKAA20.41294171
101PRKCE0.40710040
102DMPK0.38495576
103SGK30.37975538
104IKBKB0.37794843
105PBK0.37550607
106CSNK1D0.37450625
107RPS6KA20.37097393
108TESK10.36978364
109ITK0.35494157
110ERBB20.35216847
111SGK10.35072057
112IKBKE0.34773408
113FRK0.30953670
114GSK3A0.30927684
115ABL10.29889514
116PTK20.29594652
117MAPK110.29537044
118CHUK0.29506213
119SRC0.29287874
120IRAK40.29134403
121ROCK10.29091460
122MOS0.28681601
123DYRK1A0.28605520
124MAP3K100.28549655
125MINK10.28403609
126MAP3K50.28403027
127TYK20.27682061
128PRKCH0.26773125
129OBSCN0.25906082
130MTOR0.25765414
131CDK190.25672056
132PLK20.24996316
133MAPK40.24750174
134PDGFRB0.24265473
135HCK0.24030672
136AURKA0.23946063
137PRKCA0.23238480
138MAP3K40.23040245
139MAPK90.22639155
140FGFR40.22292019
141WNK10.21721725
142MATK0.21317896
143PRKACA0.21143091
144MARK20.20639347
145MAP2K10.20172201
146TGFBR10.20028437
147CSNK1E0.20012267
148MAP2K40.18814642
149STK110.18607733
150MAPK100.17006659
151ABL20.16983856
152MARK30.16216929
153JAK10.13820762
154INSR0.12868242

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004606.01426484
2Fatty acid elongation_Homo sapiens_hsa000625.09364090
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.27146609
4Sphingolipid metabolism_Homo sapiens_hsa006004.14330463
5Ribosome_Homo sapiens_hsa030104.03043879
6Circadian rhythm_Homo sapiens_hsa047102.98848637
7Retinol metabolism_Homo sapiens_hsa008302.46151873
8Fatty acid biosynthesis_Homo sapiens_hsa000612.27576979
9Phenylalanine metabolism_Homo sapiens_hsa003602.10629033
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.07652546
11Histidine metabolism_Homo sapiens_hsa003401.72175571
12Linoleic acid metabolism_Homo sapiens_hsa005911.60995944
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.51569829
14Steroid biosynthesis_Homo sapiens_hsa001001.50292754
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49880846
16Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.39009923
17Sphingolipid signaling pathway_Homo sapiens_hsa040711.37542132
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.37020455
19Choline metabolism in cancer_Homo sapiens_hsa052311.35402015
20Arachidonic acid metabolism_Homo sapiens_hsa005901.34263240
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.33533001
22Basal cell carcinoma_Homo sapiens_hsa052171.31404211
23Fatty acid metabolism_Homo sapiens_hsa012121.30171998
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.29878677
25Tight junction_Homo sapiens_hsa045301.23622785
26Chemical carcinogenesis_Homo sapiens_hsa052041.20018659
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18690550
28Tyrosine metabolism_Homo sapiens_hsa003501.16183244
29Fatty acid degradation_Homo sapiens_hsa000711.15161121
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11045593
31Axon guidance_Homo sapiens_hsa043601.08268911
32p53 signaling pathway_Homo sapiens_hsa041151.06166168
33Nitrogen metabolism_Homo sapiens_hsa009101.01735814
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01543130
35Staphylococcus aureus infection_Homo sapiens_hsa051500.97672855
36Ether lipid metabolism_Homo sapiens_hsa005650.97269864
37ABC transporters_Homo sapiens_hsa020100.95909862
38beta-Alanine metabolism_Homo sapiens_hsa004100.95596167
39Glutamatergic synapse_Homo sapiens_hsa047240.92761723
40Hippo signaling pathway_Homo sapiens_hsa043900.90350251
41Glutathione metabolism_Homo sapiens_hsa004800.87867557
42Inositol phosphate metabolism_Homo sapiens_hsa005620.85146567
43Phospholipase D signaling pathway_Homo sapiens_hsa040720.84173688
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83713668
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78412982
46Adherens junction_Homo sapiens_hsa045200.78073754
47Collecting duct acid secretion_Homo sapiens_hsa049660.76611018
48Melanogenesis_Homo sapiens_hsa049160.75886535
49Vitamin digestion and absorption_Homo sapiens_hsa049770.73536295
50Pancreatic secretion_Homo sapiens_hsa049720.73484540
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72837931
52Renin secretion_Homo sapiens_hsa049240.72761644
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.71564193
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69789336
55PPAR signaling pathway_Homo sapiens_hsa033200.69370279
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68308464
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68079050
58Serotonergic synapse_Homo sapiens_hsa047260.67110823
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59966212
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59899682
61Phototransduction_Homo sapiens_hsa047440.59825969
62GnRH signaling pathway_Homo sapiens_hsa049120.59469611
63Wnt signaling pathway_Homo sapiens_hsa043100.59306424
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58633183
65Tryptophan metabolism_Homo sapiens_hsa003800.58376401
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57626309
67MAPK signaling pathway_Homo sapiens_hsa040100.56759002
68Long-term depression_Homo sapiens_hsa047300.56441703
69Salivary secretion_Homo sapiens_hsa049700.55885689
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.55437357
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54712194
72Calcium signaling pathway_Homo sapiens_hsa040200.54078459
73Dorso-ventral axis formation_Homo sapiens_hsa043200.53932616
74TGF-beta signaling pathway_Homo sapiens_hsa043500.53665835
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53533411
76Butanoate metabolism_Homo sapiens_hsa006500.52923607
77Ovarian steroidogenesis_Homo sapiens_hsa049130.52410494
78Bladder cancer_Homo sapiens_hsa052190.52035268
79VEGF signaling pathway_Homo sapiens_hsa043700.51990875
80Hedgehog signaling pathway_Homo sapiens_hsa043400.51697302
81ECM-receptor interaction_Homo sapiens_hsa045120.51405218
82FoxO signaling pathway_Homo sapiens_hsa040680.50619281
83Fat digestion and absorption_Homo sapiens_hsa049750.50110304
84Renin-angiotensin system_Homo sapiens_hsa046140.48218242
85Circadian entrainment_Homo sapiens_hsa047130.47722716
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47604945
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46687619
88Ras signaling pathway_Homo sapiens_hsa040140.45873210
89Proteoglycans in cancer_Homo sapiens_hsa052050.45518268
90Pancreatic cancer_Homo sapiens_hsa052120.45243105
91Gastric acid secretion_Homo sapiens_hsa049710.44794435
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.44628429
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44314578
94MicroRNAs in cancer_Homo sapiens_hsa052060.43029832
95Oxidative phosphorylation_Homo sapiens_hsa001900.42758187
96Hepatitis C_Homo sapiens_hsa051600.42382863
97Long-term potentiation_Homo sapiens_hsa047200.41614891
98Rap1 signaling pathway_Homo sapiens_hsa040150.41490577
99Pertussis_Homo sapiens_hsa051330.41436084
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40491532
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39994899
102Folate biosynthesis_Homo sapiens_hsa007900.38552242
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37922198
104Platelet activation_Homo sapiens_hsa046110.37501134
105Olfactory transduction_Homo sapiens_hsa047400.36884311
106Mineral absorption_Homo sapiens_hsa049780.36876443
107Pathways in cancer_Homo sapiens_hsa052000.35709762
108Regulation of autophagy_Homo sapiens_hsa041400.35634474
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34768872
110Toxoplasmosis_Homo sapiens_hsa051450.34542665
111Salmonella infection_Homo sapiens_hsa051320.33805236
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.33505193
113Complement and coagulation cascades_Homo sapiens_hsa046100.32560826
114Hematopoietic cell lineage_Homo sapiens_hsa046400.31369690
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31245249
116Legionellosis_Homo sapiens_hsa051340.30848041
117ErbB signaling pathway_Homo sapiens_hsa040120.30796897
118African trypanosomiasis_Homo sapiens_hsa051430.30794689
119Glioma_Homo sapiens_hsa052140.30449444
120Gap junction_Homo sapiens_hsa045400.30430801
121Thyroid cancer_Homo sapiens_hsa052160.30209628
122Alzheimers disease_Homo sapiens_hsa050100.29848926
123Amoebiasis_Homo sapiens_hsa051460.29834413
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.28088047
125Peroxisome_Homo sapiens_hsa041460.27923606
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27460205
127Tuberculosis_Homo sapiens_hsa051520.26544774
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26435626
129Cardiac muscle contraction_Homo sapiens_hsa042600.25962011
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25548246
131AMPK signaling pathway_Homo sapiens_hsa041520.24797667
132Vibrio cholerae infection_Homo sapiens_hsa051100.24563823
133Oxytocin signaling pathway_Homo sapiens_hsa049210.23857378
134Endocytosis_Homo sapiens_hsa041440.21358579
135Malaria_Homo sapiens_hsa051440.20699598
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.20153181
137Protein digestion and absorption_Homo sapiens_hsa049740.20027671
138Dopaminergic synapse_Homo sapiens_hsa047280.19976538

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