ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	9.05895937
2	daunorubicin metabolic process (GO:0044597)	8.40406914
3	polyketide metabolic process (GO:0030638)	8.40406914
4	doxorubicin metabolic process (GO:0044598)	8.40406914
5	aminoglycoside antibiotic metabolic process (GO:0030647)	7.42111572
6	primary alcohol catabolic process (GO:0034310)	7.20687404
7	cilium or flagellum-dependent cell motility (GO:0001539)	7.10612185
8	cilium movement (GO:0003341)	6.88412668
9	epithelial cilium movement (GO:0003351)	6.28522533
10	motile cilium assembly (GO:0044458)	5.85048875
11	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.42375990
12	cellular glucuronidation (GO:0052695)	5.27735548
13	glycoside metabolic process (GO:0016137)	5.21154971
14	glucuronate metabolic process (GO:0019585)	5.11613491
15	uronic acid metabolic process (GO:0006063)	5.11613491
16	ethanol oxidation (GO:0006069)	4.71922521
17	ethanol metabolic process (GO:0006067)	4.66445767
18	intestinal cholesterol absorption (GO:0030299)	4.50247849
19	L-ascorbic acid metabolic process (GO:0019852)	4.43500574
20	progesterone metabolic process (GO:0042448)	4.37467662
21	fibrinolysis (GO:0042730)	4.23284755
22	regulation of bile acid biosynthetic process (GO:0070857)	4.22511517
23	regulation of triglyceride catabolic process (GO:0010896)	4.21943740
24	exogenous drug catabolic process (GO:0042738)	4.19950215
25	drug catabolic process (GO:0042737)	4.15299723
26	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.11910597
27	L-phenylalanine metabolic process (GO:0006558)	4.11910597
28	negative regulation of fibrinolysis (GO:0051918)	4.07396474
29	diterpenoid biosynthetic process (GO:0016102)	4.05892422
30	retinal metabolic process (GO:0042574)	3.99778840
31	epoxygenase P450 pathway (GO:0019373)	3.98332452
32	digestion (GO:0007586)	3.88698057
33	primary alcohol metabolic process (GO:0034308)	3.82050690
34	bile acid metabolic process (GO:0008206)	3.81392743
35	bile acid and bile salt transport (GO:0015721)	3.80600084
36	hormone catabolic process (GO:0042447)	3.78324044
37	urea metabolic process (GO:0019627)	3.74717735
38	vitamin transmembrane transport (GO:0035461)	3.71303491
39	regulation of fibrinolysis (GO:0051917)	3.67765413
40	intestinal absorption (GO:0050892)	3.66947991
41	negative regulation of coagulation (GO:0050819)	3.60355918
42	regulation of protein activation cascade (GO:2000257)	3.58312110
43	regulation of metalloenzyme activity (GO:0048552)	3.54829235
44	negative regulation of blood coagulation (GO:0030195)	3.53635648
45	negative regulation of hemostasis (GO:1900047)	3.53635648
46	quinone metabolic process (GO:1901661)	3.53599369
47	flavonoid metabolic process (GO:0009812)	3.50690024
48	positive regulation of lipoprotein lipase activity (GO:0051006)	3.50508267
49	positive regulation of triglyceride lipase activity (GO:0061365)	3.50508267
50	cobalamin metabolic process (GO:0009235)	3.50206771
51	urea cycle (GO:0000050)	3.47326750
52	regulation of complement activation (GO:0030449)	3.44382086
53	drug metabolic process (GO:0017144)	3.37744423
54	androgen biosynthetic process (GO:0006702)	3.37177293
55	negative regulation of wound healing (GO:0061045)	3.34664730
56	nitrogen cycle metabolic process (GO:0071941)	3.32682917
57	left/right pattern formation (GO:0060972)	3.32535217
58	cell adhesion mediated by integrin (GO:0033627)	3.31701906
59	artery smooth muscle contraction (GO:0014824)	3.29947098
60	drug transmembrane transport (GO:0006855)	3.29803521
61	glutathione derivative metabolic process (GO:1901685)	3.28852669
62	glutathione derivative biosynthetic process (GO:1901687)	3.28852669
63	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.18048985
64	L-phenylalanine catabolic process (GO:0006559)	3.18048985
65	bile acid biosynthetic process (GO:0006699)	3.15021342
66	transcytosis (GO:0045056)	3.14561916
67	cellular aldehyde metabolic process (GO:0006081)	3.13590319
68	peptidyl-glutamic acid carboxylation (GO:0017187)	3.12152535
69	protein carboxylation (GO:0018214)	3.12152535
70	androgen metabolic process (GO:0008209)	3.08433352
71	renal absorption (GO:0070293)	3.07076014
72	nucleotide-sugar biosynthetic process (GO:0009226)	3.04066277
73	regulation of plasminogen activation (GO:0010755)	3.02796527
74	C21-steroid hormone metabolic process (GO:0008207)	3.01726590
75	cyclooxygenase pathway (GO:0019371)	3.00016922
76	negative regulation of humoral immune response (GO:0002921)	2.99509597
77	phenylpropanoid metabolic process (GO:0009698)	2.98862602
78	xenobiotic metabolic process (GO:0006805)	2.98318259
79	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.89936341
80	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.88924731
81	axoneme assembly (GO:0035082)	2.88856602
82	omega-hydroxylase P450 pathway (GO:0097267)	2.88300507
83	gap junction assembly (GO:0016264)	2.86058274
84	negative regulation of protein activation cascade (GO:2000258)	2.85334072
85	tonic smooth muscle contraction (GO:0014820)	2.79271996
86	hepatocyte differentiation (GO:0070365)	2.77909075
87	desmosome organization (GO:0002934)	2.77751094
88	very-low-density lipoprotein particle assembly (GO:0034379)	2.77366607
89	terpenoid biosynthetic process (GO:0016114)	2.76905878
90	endothelial cell morphogenesis (GO:0001886)	2.75297338
91	glutamine family amino acid biosynthetic process (GO:0009084)	2.74352387
92	retinol metabolic process (GO:0042572)	2.74133921
93	glycolipid catabolic process (GO:0019377)	2.73223680
94	negative regulation of complement activation (GO:0045916)	2.70684950
95	ventricular system development (GO:0021591)	2.69183426
96	prostaglandin metabolic process (GO:0006693)	2.69005199
97	prostanoid metabolic process (GO:0006692)	2.69005199
98	intraciliary transport (GO:0042073)	2.67774393
99	negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)	2.64678943
100	fat-soluble vitamin biosynthetic process (GO:0042362)	2.62870911

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	4.88091609
2	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	4.70709582
3	TP63_17297297_ChIP-ChIP_HaCaT_Human	4.18218038
4	TRIM28_21343339_ChIP-Seq_HEK293_Human	4.13978977
5	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	3.75315864
6	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.97260529
7	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.96097124
8	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.93326983
9	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.87754086
10	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.78191887
11	ZNF263_19887448_ChIP-Seq_K562_Human	2.70995930
12	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.62643643
13	PPAR_26484153_Chip-Seq_NCI-H1993_Human	2.61430436
14	SOX2_20726797_ChIP-Seq_SW620_Human	2.56707395
15	SOX2_27498859_Chip-Seq_STOMACH_Mouse	2.53203777
16	GATA2_21666600_ChIP-Seq_HMVEC_Human	2.46582177
17	GATA4_25053715_ChIP-Seq_YYC3_Human	2.43885251
18	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.41282028
19	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.36306082
20	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.36262803
21	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.34698296
22	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.21823899
23	FOXO3_23340844_ChIP-Seq_DLD1_Human	2.10182621
24	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.09905955
25	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.08917671
26	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.00706661
27	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.92827563
28	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.92827563
29	CJUN_26792858_Chip-Seq_BT549_Human	1.92328051
30	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.92247269
31	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.85663402
32	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.81464932
33	GATA6_25053715_ChIP-Seq_YYC3_Human	1.77892744
34	VDR_22108803_ChIP-Seq_LS180_Human	1.73024483
35	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.72253911
36	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.69547980
37	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.63617981
38	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.62314414
39	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.60114935
40	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.58760313
41	TP63_23658742_ChIP-Seq_EP156T_Human	1.57920690
42	TP53_18474530_ChIP-ChIP_U2OS_Human	1.57643110
43	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.54600059
44	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.52910307
45	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.52007679
46	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.49574012
47	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.49190693
48	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.46761232
49	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.45436293
50	CLOCK_20551151_ChIP-Seq_293T_Human	1.45143444
51	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.45132364
52	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.44679908
53	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.40484933
54	CDX2_22108803_ChIP-Seq_LS180_Human	1.40332054
55	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.39022373
56	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.37161152
57	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.34283148
58	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.28512990
59	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.27703828
60	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.27703828
61	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.26895924
62	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.23958108
63	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.22185255
64	KLF5_25053715_ChIP-Seq_YYC3_Human	1.20618416
65	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.19822045
66	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.15825905
67	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.14765581
68	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.14397329
69	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.13697529
70	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.13452847
71	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.13334163
72	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.10797099
73	ATF3_27146783_Chip-Seq_COLON_Human	1.10429488
74	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.08954749
75	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.06577457
76	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.06503552
77	AR_21909140_ChIP-Seq_LNCAP_Human	1.05384056
78	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.05111854
79	AHR_22903824_ChIP-Seq_MCF-7_Human	1.03396957
80	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.02536813
81	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.99688208
82	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.98863391
83	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.96993151
84	CBP_21632823_ChIP-Seq_H3396_Human	0.93673268
85	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.92149622
86	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.91094414
87	TCF4_22108803_ChIP-Seq_LS180_Human	0.89347806
88	CEBPB_22108803_ChIP-Seq_LS180_Human	0.88965151
89	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.88914563
90	BCAT_22108803_ChIP-Seq_LS180_Human	0.85717789
91	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.83306732
92	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.82726118
93	BRD4_25478319_ChIP-Seq_HGPS_Human	0.82690383
94	TP53_22127205_ChIP-Seq_IMR90_Human	0.82532820
95	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.78648547
96	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.77882616
97	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.73981454
98	AR_20517297_ChIP-Seq_VCAP_Human	0.73544293
99	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.70338284
100	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.68587952

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	6.61397062
2	MP0005360_urolithiasis	5.33816861
3	MP0005365_abnormal_bile_salt	5.16185201
4	MP0005085_abnormal_gallbladder_physiolo	4.71799480
5	MP0008875_abnormal_xenobiotic_pharmacok	4.48339798
6	MP0001666_abnormal_nutrient_absorption	4.46352643
7	MP0003806_abnormal_nucleotide_metabolis	3.98683087
8	MP0003868_abnormal_feces_composition	3.26725307
9	MP0010368_abnormal_lymphatic_system	3.09094242
10	MP0004019_abnormal_vitamin_homeostasis	3.01021632
11	MP0003252_abnormal_bile_duct	2.83625428
12	MP0002138_abnormal_hepatobiliary_system	2.74940380
13	MP0005408_hypopigmentation	2.10229869
14	MP0004272_abnormal_basement_membrane	2.08932803
15	MP0001879_abnormal_lymphatic_vessel	2.02723487
16	MP0009697_abnormal_copulation	1.99720470
17	MP0010329_abnormal_lipoprotein_level	1.84940421
18	MP0005409_darkened_coat_color	1.75071686
19	MP0003191_abnormal_cellular_cholesterol	1.71559232
20	MP0000537_abnormal_urethra_morphology	1.53786403
21	MP0005164_abnormal_response_to	1.52171122
22	MP0010234_abnormal_vibrissa_follicle	1.48365952
23	MP0005623_abnormal_meninges_morphology	1.46759817
24	MP0003566_abnormal_cell_adhesion	1.43745624
25	MP0004264_abnormal_extraembryonic_tissu	1.40766018
26	MP0005332_abnormal_amino_acid	1.39306239
27	MP0009643_abnormal_urine_homeostasis	1.38955240
28	MP0009780_abnormal_chondrocyte_physiolo	1.38061163
29	MP0009840_abnormal_foam_cell	1.36795453
30	MP0000609_abnormal_liver_physiology	1.29079843
31	MP0003950_abnormal_plasma_membrane	1.26482383
32	MP0003195_calcinosis	1.22240838
33	MP0010352_gastrointestinal_tract_polyps	1.19717257
34	MP0002118_abnormal_lipid_homeostasis	1.14911500
35	MP0005636_abnormal_mineral_homeostasis	1.14454172
36	MP0005165_increased_susceptibility_to	1.13710436
37	MP0000465_gastrointestinal_hemorrhage	1.11875590
38	MP0001764_abnormal_homeostasis	1.10748773
39	MP0002132_abnormal_respiratory_system	1.08453418
40	MP0003718_maternal_effect	1.06296126
41	MP0004883_abnormal_blood_vessel	1.03989049
42	MP0010386_abnormal_urinary_bladder	0.98624016
43	MP0000249_abnormal_blood_vessel	0.96626143
44	MP0005376_homeostasis/metabolism_phenot	0.96385141
45	MP0009053_abnormal_anal_canal	0.94989768
46	MP0002877_abnormal_melanocyte_morpholog	0.93532397
47	MP0000566_synostosis	0.91906080
48	MP0005023_abnormal_wound_healing	0.91105116
49	MP0003828_pulmonary_edema	0.89569055
50	MP0005395_other_phenotype	0.89067324
51	MP0010155_abnormal_intestine_physiology	0.88159791
52	MP0002796_impaired_skin_barrier	0.87859987
53	MP0003943_abnormal_hepatobiliary_system	0.86634588
54	MP0006054_spinal_hemorrhage	0.86391106
55	MP0002136_abnormal_kidney_physiology	0.85964493
56	MP0005167_abnormal_blood-brain_barrier	0.84323699
57	MP0006138_congestive_heart_failure	0.83263248
58	MP0001765_abnormal_ion_homeostasis	0.79516033
59	MP0010678_abnormal_skin_adnexa	0.79447986
60	MP0004043_abnormal_pH_regulation	0.79123926
61	MP0005501_abnormal_skin_physiology	0.78122661
62	MP0005319_abnormal_enzyme/_coenzyme	0.77676141
63	MP0000858_altered_metastatic_potential	0.77244057
64	MP0003453_abnormal_keratinocyte_physiol	0.74408749
65	MP0000762_abnormal_tongue_morphology	0.73322944
66	MP0001915_intracranial_hemorrhage	0.73310707
67	MP0005187_abnormal_penis_morphology	0.72583867
68	MP0002282_abnormal_trachea_morphology	0.72498604
69	MP0004782_abnormal_surfactant_physiolog	0.71504922
70	MP0000467_abnormal_esophagus_morphology	0.71303317
71	MP0010030_abnormal_orbit_morphology	0.70749772
72	MP0003186_abnormal_redox_activity	0.69849438
73	MP0000598_abnormal_liver_morphology	0.69148421
74	MP0002876_abnormal_thyroid_physiology	0.68909273
75	MP0003705_abnormal_hypodermis_morpholog	0.68161964
76	MP0005330_cardiomyopathy	0.66257590
77	MP0005083_abnormal_biliary_tract	0.65673608
78	MP0003091_abnormal_cell_migration	0.65004047
79	MP0008873_increased_physiological_sensi	0.64706206
80	MP0008260_abnormal_autophagy	0.63633672
81	MP0009765_abnormal_xenobiotic_induced	0.61768738
82	MP0002168_other_aberrant_phenotype	0.61089523
83	MP0000013_abnormal_adipose_tissue	0.60644123
84	MP0000383_abnormal_hair_follicle	0.60542750
85	MP0005166_decreased_susceptibility_to	0.58798773
86	MP0003656_abnormal_erythrocyte_physiolo	0.58676426
87	MP0002896_abnormal_bone_mineralization	0.57305480
88	MP0005584_abnormal_enzyme/coenzyme_acti	0.55258598
89	MP0000490_abnormal_crypts_of	0.54490975
90	MP0009763_increased_sensitivity_to	0.53452477
91	MP0001756_abnormal_urination	0.53101105
92	MP0009642_abnormal_blood_homeostasis	0.53086112
93	MP0003959_abnormal_lean_body	0.52994762
94	MP0005670_abnormal_white_adipose	0.48693735
95	MP0001664_abnormal_digestion	0.47875420
96	MP0000477_abnormal_intestine_morphology	0.46352670
97	MP0002098_abnormal_vibrissa_morphology	0.46189462
98	MP0000767_abnormal_smooth_muscle	0.45973598
99	MP0006036_abnormal_mitochondrial_physio	0.45410039
100	MP0008004_abnormal_stomach_pH	0.45273299

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	9.17125949
2	Abnormal respiratory motile cilium physiology (HP:0012261)	8.37670288
3	Abnormal ciliary motility (HP:0012262)	7.96470199
4	Absent/shortened dynein arms (HP:0200106)	7.62014580
5	Dynein arm defect of respiratory motile cilia (HP:0012255)	7.62014580
6	Abnormal respiratory motile cilium morphology (HP:0005938)	7.60361780
7	Abnormal respiratory epithelium morphology (HP:0012253)	7.60361780
8	Rhinitis (HP:0012384)	7.51786437
9	Chronic bronchitis (HP:0004469)	6.09629694
10	Bronchiectasis (HP:0002110)	5.05949590
11	Abnormality of the nasal mucosa (HP:0000433)	4.54962691
12	Nasal polyposis (HP:0100582)	4.40799551
13	Abnormality of monocarboxylic acid metabolism (HP:0010996)	4.33874007
14	Deep venous thrombosis (HP:0002625)	4.26464850
15	Hypobetalipoproteinemia (HP:0003563)	4.16480976
16	Fat malabsorption (HP:0002630)	4.14399660
17	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.97693638
18	Steatorrhea (HP:0002570)	3.91913625
19	Conjugated hyperbilirubinemia (HP:0002908)	3.69108041
20	Vascular calcification (HP:0004934)	3.51585006
21	Abnormality of proline metabolism (HP:0010907)	3.16984970
22	Hydroxyprolinuria (HP:0003080)	3.16984970
23	Cardiovascular calcification (HP:0011915)	3.08779943
24	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.08477739
25	Bronchitis (HP:0012387)	3.05205445
26	Infertility (HP:0000789)	3.04925386
27	Prolonged partial thromboplastin time (HP:0003645)	3.04255727
28	Chronic sinusitis (HP:0011109)	3.03056786
29	Short nail (HP:0001799)	2.83675603
30	Male infertility (HP:0003251)	2.81677839
31	Tetraparesis (HP:0002273)	2.79952674
32	Occipital encephalocele (HP:0002085)	2.72080716
33	Hyperactive renin-angiotensin system (HP:0000841)	2.55143290
34	Recurrent otitis media (HP:0000403)	2.53376126
35	Flat acetabular roof (HP:0003180)	2.40712132
36	Complement deficiency (HP:0004431)	2.33157980
37	Confusion (HP:0001289)	2.24852050
38	Hypolipoproteinemia (HP:0010981)	2.18789336
39	Abnormality of the common coagulation pathway (HP:0010990)	2.13706364
40	Recurrent sinusitis (HP:0011108)	2.11388968
41	Intrahepatic cholestasis (HP:0001406)	2.08372179
42	Abnormality of the hepatic vasculature (HP:0006707)	2.07645440
43	Arterial tortuosity (HP:0005116)	2.05670376
44	True hermaphroditism (HP:0010459)	2.05502091
45	Atelectasis (HP:0100750)	2.05298067
46	Joint hemorrhage (HP:0005261)	2.03898495
47	Vascular tortuosity (HP:0004948)	2.02367632
48	Focal segmental glomerulosclerosis (HP:0000097)	1.98832254
49	Malnutrition (HP:0004395)	1.97642709
50	Abnormality of complement system (HP:0005339)	1.96685049
51	Abnormality of the intrinsic pathway (HP:0010989)	1.94206865
52	Glucose intolerance (HP:0000833)	1.93277876
53	Hemorrhage of the eye (HP:0011885)	1.91509726
54	Abnormality of carpal bone ossification (HP:0006257)	1.88048799
55	Xanthomatosis (HP:0000991)	1.86803777
56	Tubulointerstitial nephritis (HP:0001970)	1.85398571
57	Esophageal varix (HP:0002040)	1.84750853
58	Portal hypertension (HP:0001409)	1.84118016
59	Hyperammonemia (HP:0001987)	1.80159072
60	Reduced antithrombin III activity (HP:0001976)	1.77808021
61	Abnormality of vitamin metabolism (HP:0100508)	1.76434258
62	Mitral stenosis (HP:0001718)	1.73950167
63	Glomerulosclerosis (HP:0000096)	1.71662112
64	Tubular atrophy (HP:0000092)	1.71407548
65	Pancreatic fibrosis (HP:0100732)	1.69625760
66	Cystic liver disease (HP:0006706)	1.66771721
67	Menorrhagia (HP:0000132)	1.65934361
68	Ankyloglossia (HP:0010296)	1.64073895
69	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.63716030
70	Glomerulonephritis (HP:0000099)	1.61103965
71	Pigmentary retinal degeneration (HP:0001146)	1.60327475
72	Abnormal glucose tolerance (HP:0001952)	1.60022936
73	Hypercholesterolemia (HP:0003124)	1.58464155
74	Rickets (HP:0002748)	1.57287909
75	Glycosuria (HP:0003076)	1.56020163
76	Abnormality of urine glucose concentration (HP:0011016)	1.56020163
77	Acanthocytosis (HP:0001927)	1.54991049
78	Cone-rod dystrophy (HP:0000548)	1.54732021
79	Abnormality of dentin (HP:0010299)	1.53006251
80	Abnormality of the dental root (HP:0006486)	1.52297306
81	Taurodontia (HP:0000679)	1.52297306
82	Abnormality of permanent molar morphology (HP:0011071)	1.52297306
83	Generalized aminoaciduria (HP:0002909)	1.51573681
84	Male pseudohermaphroditism (HP:0000037)	1.50754723
85	Hepatocellular carcinoma (HP:0001402)	1.50673512
86	Exocrine pancreatic insufficiency (HP:0001738)	1.50572965
87	Congenital hepatic fibrosis (HP:0002612)	1.50354087
88	Abnormality of oral frenula (HP:0000190)	1.48927245
89	Systemic lupus erythematosus (HP:0002725)	1.48608104
90	Proximal tubulopathy (HP:0000114)	1.45053361
91	Chronic hepatic failure (HP:0100626)	1.43876195
92	Nephritis (HP:0000123)	1.43073309
93	Hypotension (HP:0002615)	1.42184044
94	Chronic otitis media (HP:0000389)	1.41412977
95	Abnormality of pyrimidine metabolism (HP:0004353)	1.40707872
96	Hyponatremia (HP:0002902)	1.39290731
97	Abnormality of the Achilles tendon (HP:0005109)	1.38335544
98	Osteolytic defects of the phalanges of the hand (HP:0009771)	1.37789643
99	Osteolytic defects of the hand bones (HP:0009699)	1.37789643
100	Abnormality of nucleobase metabolism (HP:0010932)	1.36390487

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST1R	6.77555231
2	EPHA2	5.12886622
3	MST4	4.33769560
4	EPHB2	3.88003156
5	MAPK15	3.85669430
6	MET	3.42115114
7	EIF2AK1	2.67229162
8	TIE1	2.49360140
9	SCYL2	2.40399978
10	STK39	2.37877200
11	IRAK3	2.26695476
12	MAP3K12	2.12450331
13	PDK2	1.98616018
14	ACVR1B	1.69711264
15	ERBB3	1.66817327
16	TESK1	1.63998429
17	MAPKAPK3	1.61685611
18	EIF2AK3	1.51766408
19	NME1	1.51042220
20	TRPM7	1.50161281
21	CCNB1	1.45139074
22	NME2	1.42073106
23	MAP3K2	1.41294667
24	ERBB4	1.41163863
25	PTK2B	1.38608120
26	ERN1	1.31879605
27	PTK2	1.28165350
28	NEK9	1.23642772
29	OXSR1	1.20540838
30	CDK8	1.13485474
31	TGFBR2	1.12514089
32	MAP3K3	1.12342543
33	PAK4	1.11213031
34	LIMK1	1.05623258
35	LMTK2	1.01029330
36	PNCK	1.00463128
37	BMX	0.92355311
38	BCR	0.86121256
39	STK10	0.85305628
40	FER	0.85285230
41	PBK	0.84487082
42	LRRK2	0.82692730
43	PRKG2	0.82413818
44	NEK6	0.81587423
45	TSSK6	0.78313891
46	TBK1	0.77168465
47	RPS6KB2	0.74799919
48	FRK	0.73429481
49	WNK4	0.73294053
50	RIPK1	0.71841058
51	EPHB1	0.71427812
52	STK16	0.70646562
53	MYLK	0.68346003
54	FGFR4	0.64063168
55	ICK	0.59477158
56	STK38	0.59283521
57	PIK3CA	0.59110843
58	STK24	0.58834775
59	TTN	0.57214510
60	EPHA3	0.54847980
61	TEC	0.54785401
62	MELK	0.51445435
63	STK38L	0.49882423
64	LATS1	0.49497331
65	BMPR1B	0.48559375
66	NEK1	0.48439153
67	CAMK2G	0.47284998
68	IGF1R	0.46085423
69	GRK1	0.44081641
70	MAPKAPK5	0.43467816
71	KDR	0.42676960
72	FGFR1	0.42358569
73	MAP3K7	0.39753111
74	ABL2	0.38481458
75	PRKD3	0.37757492
76	PTK6	0.37483498
77	PRKCI	0.36483817
78	PRKAA2	0.35552252
79	SIK1	0.34083604
80	BMPR2	0.33892378
81	PDPK1	0.30872936
82	FGFR3	0.30011683
83	MAP4K2	0.29962504
84	PIM2	0.29866439
85	PDGFRA	0.29169079
86	IRAK1	0.27984124
87	LATS2	0.27710872
88	EEF2K	0.27520041
89	PRKCE	0.27016235
90	STK3	0.25462676
91	AKT2	0.22282375
92	ITK	0.22138384
93	SRC	0.22117202
94	TGFBR1	0.22007627
95	SIK3	0.21991488
96	CAMK2D	0.21554206
97	BRSK2	0.20938730
98	NTRK1	0.20258087
99	CDK19	0.18533082
100	ILK	0.16866684

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.87460968
2	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	3.70574611
3	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.52544482
4	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	3.51529697
5	Chemical carcinogenesis_Homo sapiens_hsa05204	3.41614956
6	Steroid hormone biosynthesis_Homo sapiens_hsa00140	3.11756915
7	Retinol metabolism_Homo sapiens_hsa00830	2.92692373
8	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.71942444
9	Caffeine metabolism_Homo sapiens_hsa00232	2.67900610
10	Phenylalanine metabolism_Homo sapiens_hsa00360	2.60503631
11	Fat digestion and absorption_Homo sapiens_hsa04975	2.53461313
12	Starch and sucrose metabolism_Homo sapiens_hsa00500	2.49378732
13	Complement and coagulation cascades_Homo sapiens_hsa04610	2.48855722
14	Histidine metabolism_Homo sapiens_hsa00340	2.48470090
15	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.45470220
16	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.36290707
17	Arginine biosynthesis_Homo sapiens_hsa00220	2.08697416
18	Tyrosine metabolism_Homo sapiens_hsa00350	1.96810137
19	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.95782768
20	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.93906023
21	Bile secretion_Homo sapiens_hsa04976	1.90534614
22	Glutathione metabolism_Homo sapiens_hsa00480	1.85867171
23	Protein digestion and absorption_Homo sapiens_hsa04974	1.85852605
24	Pancreatic secretion_Homo sapiens_hsa04972	1.76264734
25	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.60885550
26	Fatty acid degradation_Homo sapiens_hsa00071	1.59587260
27	Sulfur metabolism_Homo sapiens_hsa00920	1.49889679
28	Glycerolipid metabolism_Homo sapiens_hsa00561	1.42195967
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.37364187
30	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.33216130
31	PPAR signaling pathway_Homo sapiens_hsa03320	1.32493049
32	beta-Alanine metabolism_Homo sapiens_hsa00410	1.25130164
33	Renin-angiotensin system_Homo sapiens_hsa04614	1.21995500
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.21848246
35	Galactose metabolism_Homo sapiens_hsa00052	1.13948144
36	Peroxisome_Homo sapiens_hsa04146	1.11243776
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.09315414
38	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.04844747
39	Arginine and proline metabolism_Homo sapiens_hsa00330	1.02525705
40	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.99591090
41	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.97865937
42	Butanoate metabolism_Homo sapiens_hsa00650	0.89754743
43	Proteasome_Homo sapiens_hsa03050	0.89564934
44	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.88185835
45	Sphingolipid metabolism_Homo sapiens_hsa00600	0.87111877
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.81516072
47	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.75777666
48	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.74429521
49	ABC transporters_Homo sapiens_hsa02010	0.72583050
50	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.71387322
51	Pentose phosphate pathway_Homo sapiens_hsa00030	0.70957635
52	Pyruvate metabolism_Homo sapiens_hsa00620	0.69253906
53	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.69067729
54	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.68972522
55	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.68680873
56	Mineral absorption_Homo sapiens_hsa04978	0.66541798
57	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.65115004
58	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.63948458
59	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.57227563
60	Metabolic pathways_Homo sapiens_hsa01100	0.55619380
61	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.54640250
62	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.53508916
63	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.52894220
64	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.50893912
65	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.49778116
66	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.48810275
67	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.48354063
68	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.42686980
69	Fatty acid metabolism_Homo sapiens_hsa01212	0.42473373
70	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.42406583
71	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.42283785
72	Tight junction_Homo sapiens_hsa04530	0.40712779
73	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.36266107
74	Carbon metabolism_Homo sapiens_hsa01200	0.35104473
75	Adherens junction_Homo sapiens_hsa04520	0.33924192
76	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.33325886
77	ECM-receptor interaction_Homo sapiens_hsa04512	0.30666450
78	Huntingtons disease_Homo sapiens_hsa05016	0.29587360
79	Propanoate metabolism_Homo sapiens_hsa00640	0.28449626
80	Sulfur relay system_Homo sapiens_hsa04122	0.26782902
81	Folate biosynthesis_Homo sapiens_hsa00790	0.26056081
82	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.22172396
83	Proteoglycans in cancer_Homo sapiens_hsa05205	0.20085000
84	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.18873102
85	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.18597203
86	Insulin resistance_Homo sapiens_hsa04931	0.15767937
87	Ether lipid metabolism_Homo sapiens_hsa00565	0.12039601
88	Pyrimidine metabolism_Homo sapiens_hsa00240	0.11923257
89	Selenocompound metabolism_Homo sapiens_hsa00450	0.10567341
90	African trypanosomiasis_Homo sapiens_hsa05143	0.09669251
91	Focal adhesion_Homo sapiens_hsa04510	0.09439216
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.06318134
93	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.06081773
94	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.04302019
95	Amoebiasis_Homo sapiens_hsa05146	0.02799971
96	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.01688555
97	Hepatitis C_Homo sapiens_hsa05160	0.01133648
98	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.00359494
99	Prion diseases_Homo sapiens_hsa05020	0.00214627
100	Other glycan degradation_Homo sapiens_hsa00511	-0.0062892

AADACP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »