AADAT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cysteine metabolic process (GO:0006534)7.22314821
2L-phenylalanine catabolic process (GO:0006559)7.18181294
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.18181294
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.04318872
5L-phenylalanine metabolic process (GO:0006558)7.04318872
6urate metabolic process (GO:0046415)6.71135204
7glyoxylate metabolic process (GO:0046487)6.70333470
8drug transmembrane transport (GO:0006855)6.55989142
9* aromatic amino acid family catabolic process (GO:0009074)6.51311922
10* lysine metabolic process (GO:0006553)6.30988223
11* lysine catabolic process (GO:0006554)6.30988223
12* indole-containing compound catabolic process (GO:0042436)5.77995395
13* indolalkylamine catabolic process (GO:0046218)5.77995395
14* tryptophan catabolic process (GO:0006569)5.77995395
15homocysteine metabolic process (GO:0050667)5.76377411
16drug transport (GO:0015893)5.75143228
17serine family amino acid catabolic process (GO:0009071)5.51771757
18* tryptophan metabolic process (GO:0006568)5.49314811
19amino-acid betaine metabolic process (GO:0006577)5.36171067
20cellular ketone body metabolic process (GO:0046950)5.33120108
21* kynurenine metabolic process (GO:0070189)5.31059956
22bile acid biosynthetic process (GO:0006699)5.29618660
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.28455451
24response to mercury ion (GO:0046689)5.24705632
25sulfur amino acid catabolic process (GO:0000098)5.23054172
26organic cation transport (GO:0015695)5.22612270
27short-chain fatty acid metabolic process (GO:0046459)5.12170338
28serine family amino acid metabolic process (GO:0009069)4.91412397
29cellular modified amino acid catabolic process (GO:0042219)4.90588115
30valine metabolic process (GO:0006573)4.81459883
31* aromatic amino acid family metabolic process (GO:0009072)4.72519650
32* alpha-amino acid catabolic process (GO:1901606)4.70458378
33phosphate ion transport (GO:0006817)4.61491757
34ketone body metabolic process (GO:1902224)4.60740745
35alpha-linolenic acid metabolic process (GO:0036109)4.55689690
36* cellular amino acid catabolic process (GO:0009063)4.52762865
37* glutamate metabolic process (GO:0006536)4.50329881
38phosphate ion transmembrane transport (GO:0035435)4.42647902
39bile acid metabolic process (GO:0008206)4.41189094
40carnitine metabolic process (GO:0009437)4.40660084
41serine family amino acid biosynthetic process (GO:0009070)4.37501168
42fatty acid beta-oxidation (GO:0006635)4.37090286
43urea metabolic process (GO:0019627)4.35381893
44urea cycle (GO:0000050)4.35381893
45fatty acid oxidation (GO:0019395)4.34988273
46branched-chain amino acid metabolic process (GO:0009081)4.33555255
47* aspartate family amino acid catabolic process (GO:0009068)4.33219833
48tyrosine metabolic process (GO:0006570)4.29641526
49response to phenylpropanoid (GO:0080184)4.28371409
50* 2-oxoglutarate metabolic process (GO:0006103)4.27342133
51lipid oxidation (GO:0034440)4.26787945
52drug catabolic process (GO:0042737)4.09446142
53nitrogen cycle metabolic process (GO:0071941)4.09361315
54* carboxylic acid catabolic process (GO:0046395)4.05586557
55* organic acid catabolic process (GO:0016054)4.05586557
56quaternary ammonium group transport (GO:0015697)4.03738137
57* indolalkylamine metabolic process (GO:0006586)4.03258370
58tricarboxylic acid metabolic process (GO:0072350)4.03179771
59branched-chain amino acid catabolic process (GO:0009083)4.02737390
60fructose metabolic process (GO:0006000)3.98557783
61dicarboxylic acid biosynthetic process (GO:0043650)3.97519265
62aldehyde catabolic process (GO:0046185)3.95765239
63pyrimidine nucleobase catabolic process (GO:0006208)3.95172413
64triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.95069317
65fatty acid catabolic process (GO:0009062)3.93735031
66excretion (GO:0007588)3.93580826
67* acetyl-CoA metabolic process (GO:0006084)3.92746314
68monocarboxylic acid catabolic process (GO:0072329)3.90947802
69ethanol oxidation (GO:0006069)3.84957414
70coenzyme catabolic process (GO:0009109)3.83005938
71negative regulation of cholesterol transport (GO:0032375)3.81747077
72negative regulation of sterol transport (GO:0032372)3.81747077
73glycine metabolic process (GO:0006544)3.81202854
74* cellular biogenic amine catabolic process (GO:0042402)3.74638559
75* amine catabolic process (GO:0009310)3.74638559
76complement activation, alternative pathway (GO:0006957)3.74507496
77nonribosomal peptide biosynthetic process (GO:0019184)3.73804315
78peptidyl-glutamic acid carboxylation (GO:0017187)3.73494333
79protein carboxylation (GO:0018214)3.73494333
80cellular glucuronidation (GO:0052695)3.70737103
81* benzene-containing compound metabolic process (GO:0042537)3.70193997
82vitamin D metabolic process (GO:0042359)3.60473583
83biotin metabolic process (GO:0006768)3.57967060
84negative regulation of fibrinolysis (GO:0051918)3.57746027
85regulation of protein activation cascade (GO:2000257)3.57247382
86aminoglycoside antibiotic metabolic process (GO:0030647)3.56661852
87regulation of cholesterol homeostasis (GO:2000188)3.56311341
88glutathione biosynthetic process (GO:0006750)3.55993793
89uronic acid metabolic process (GO:0006063)3.51424119
90glucuronate metabolic process (GO:0019585)3.51424119
91renal absorption (GO:0070293)3.50211829
92amino-acid betaine transport (GO:0015838)3.48968136
93carnitine transport (GO:0015879)3.48968136
94* small molecule catabolic process (GO:0044282)3.47770747
95bile acid and bile salt transport (GO:0015721)3.45848800
96L-ascorbic acid metabolic process (GO:0019852)3.45741287
97* dicarboxylic acid metabolic process (GO:0043648)3.45080356
98response to nitrosative stress (GO:0051409)3.43703347
99high-density lipoprotein particle remodeling (GO:0034375)3.41729473
100regulation of fibrinolysis (GO:0051917)3.39273644
101exogenous drug catabolic process (GO:0042738)3.37946463
102nucleobase catabolic process (GO:0046113)3.14596876
103presynaptic membrane assembly (GO:0097105)3.05176250
104chromatin remodeling at centromere (GO:0031055)3.01944093
105L-serine metabolic process (GO:0006563)2.93988103
106postsynaptic membrane organization (GO:0001941)2.86840121
107intraciliary transport (GO:0042073)2.77160819
108CENP-A containing nucleosome assembly (GO:0034080)2.73371099
109limb bud formation (GO:0060174)2.70721327
110presynaptic membrane organization (GO:0097090)2.53446912
111DNA damage response, detection of DNA damage (GO:0042769)2.51185866
112protein localization to synapse (GO:0035418)2.49747807
113negative regulation of DNA recombination (GO:0045910)2.48840430
114histone exchange (GO:0043486)2.48264543
115neuron cell-cell adhesion (GO:0007158)2.47468628
116water-soluble vitamin biosynthetic process (GO:0042364)2.46525910
117DNA strand elongation involved in DNA replication (GO:0006271)2.44191186
118DNA double-strand break processing (GO:0000729)2.41963121
119epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.40755300
120short-term memory (GO:0007614)2.40606919
121translesion synthesis (GO:0019985)2.37406254
122establishment of integrated proviral latency (GO:0075713)2.36113450
123mitotic metaphase plate congression (GO:0007080)2.31968559
124DNA strand elongation (GO:0022616)2.30627975
125regulation of cilium movement (GO:0003352)2.30216381
126mitotic sister chromatid cohesion (GO:0007064)2.29943283
127resolution of meiotic recombination intermediates (GO:0000712)2.29150918
128DNA unwinding involved in DNA replication (GO:0006268)2.26407049
129L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.26299864
130amino acid salvage (GO:0043102)2.25747789
131L-methionine salvage (GO:0071267)2.25747789
132L-methionine biosynthetic process (GO:0071265)2.25747789
133metaphase plate congression (GO:0051310)2.22636925
134nucleotide-excision repair, DNA gap filling (GO:0006297)2.21944514
135DNA replication checkpoint (GO:0000076)2.21406800
136DNA replication-independent nucleosome organization (GO:0034724)2.20573835
137DNA replication-independent nucleosome assembly (GO:0006336)2.20573835
138postreplication repair (GO:0006301)2.20381264
139replication fork processing (GO:0031297)2.19278061
140positive regulation of dendritic spine morphogenesis (GO:0061003)2.19240300
141regulation of DNA endoreduplication (GO:0032875)2.18330693
142regulation of mitochondrial translation (GO:0070129)2.17296182
143axonal fasciculation (GO:0007413)2.16919522
144nonmotile primary cilium assembly (GO:0035058)2.16550045
145DNA ligation (GO:0006266)2.15994633
146retinal ganglion cell axon guidance (GO:0031290)2.15803475
147epithelial cilium movement (GO:0003351)2.14079427
148histone H2A acetylation (GO:0043968)2.13579704
149maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.13563285
150neuron recognition (GO:0008038)2.12910168
151C4-dicarboxylate transport (GO:0015740)2.12860309
152synapsis (GO:0007129)2.10437431
153protein polyglutamylation (GO:0018095)2.09621965
154oxidative demethylation (GO:0070989)2.09579141
155cilium morphogenesis (GO:0060271)2.09226388
156regulation of helicase activity (GO:0051095)2.07531013
157regulation of development, heterochronic (GO:0040034)2.06517977
158behavioral response to ethanol (GO:0048149)2.05337868
159cerebral cortex radially oriented cell migration (GO:0021799)2.05302436
160double-strand break repair via nonhomologous end joining (GO:0006303)2.04537689
161non-recombinational repair (GO:0000726)2.04537689
162somite development (GO:0061053)2.01853933
163DNA replication-dependent nucleosome assembly (GO:0006335)2.00773276
164DNA replication-dependent nucleosome organization (GO:0034723)2.00773276
165regulation of timing of cell differentiation (GO:0048505)2.00118810
166intra-S DNA damage checkpoint (GO:0031573)1.99307104
167regulation of double-strand break repair via homologous recombination (GO:0010569)1.99267805
168kinetochore organization (GO:0051383)1.98254520
169cilium organization (GO:0044782)1.98214955
170establishment of protein localization to mitochondrial membrane (GO:0090151)1.96896685
171kidney morphogenesis (GO:0060993)1.95731279
172protein complex biogenesis (GO:0070271)1.95651287
173centriole replication (GO:0007099)1.94927849
174cholesterol biosynthetic process (GO:0006695)1.94389569
175regulation of inhibitory postsynaptic membrane potential (GO:0060080)1.93890916
176regulation of centriole replication (GO:0046599)1.93229313
177cullin deneddylation (GO:0010388)1.93034918
178cilium assembly (GO:0042384)1.92936289
179ubiquinone metabolic process (GO:0006743)1.92309838
180microtubule polymerization or depolymerization (GO:0031109)1.92118226
181vocalization behavior (GO:0071625)1.91789818
182cilium movement (GO:0003341)1.91574025
183female gonad development (GO:0008585)1.91070265
184retinal cone cell development (GO:0046549)1.91052595
185regulation of penile erection (GO:0060405)1.90950795
186establishment of mitochondrion localization (GO:0051654)1.89932793
187auditory behavior (GO:0031223)1.89532017
188retinal rod cell development (GO:0046548)1.89394351
189microtubule depolymerization (GO:0007019)1.89312102
190regulation of mesoderm development (GO:2000380)1.88998697
191telomere maintenance via semi-conservative replication (GO:0032201)1.88962072

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.77562418
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.58423220
3LXR_22158963_ChIP-Seq_LIVER_Mouse6.03148348
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.53351430
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.24708843
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.41345373
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.89324465
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.73688388
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.63358726
10E2F7_22180533_ChIP-Seq_HELA_Human3.53739064
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.41119439
12RBPJ_22232070_ChIP-Seq_NCS_Mouse3.12748037
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.60864301
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.51531488
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.50374063
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.42568420
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.42122453
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.37893529
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.36648792
20FUS_26573619_Chip-Seq_HEK293_Human2.34204951
21GBX2_23144817_ChIP-Seq_PC3_Human2.31640633
22IGF1R_20145208_ChIP-Seq_DFB_Human2.28142531
23ZNF274_21170338_ChIP-Seq_K562_Hela2.24477346
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.14114001
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10072791
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.09946725
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.04162465
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.6468171
29* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99457070
30EWS_26573619_Chip-Seq_HEK293_Human1.96365528
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.92878572
32CLOCK_20551151_ChIP-Seq_293T_Human1.90069417
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88666318
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81376257
35TAF15_26573619_Chip-Seq_HEK293_Human1.75468707
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.75126374
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.72818656
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69202244
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68984687
40ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.66167137
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64593887
42P300_19829295_ChIP-Seq_ESCs_Human1.64345508
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.62481362
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58462579
45* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57186562
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.56841187
47HNF4A_19822575_ChIP-Seq_HepG2_Human1.55462778
48* PIAS1_25552417_ChIP-Seq_VCAP_Human1.54451470
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51017628
50* RNF2_27304074_Chip-Seq_NSC_Mouse1.50868467
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46896104
52EST1_17652178_ChIP-ChIP_JURKAT_Human1.46475529
53* VDR_22108803_ChIP-Seq_LS180_Human1.44977203
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.41139900
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40785989
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40086956
57IRF1_19129219_ChIP-ChIP_H3396_Human1.39322908
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37292657
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31936940
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30466058
61EZH2_22144423_ChIP-Seq_EOC_Human1.29915258
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29478380
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28987992
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28436806
65ELK1_19687146_ChIP-ChIP_HELA_Human1.27664624
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26059560
67MYC_18940864_ChIP-ChIP_HL60_Human1.25422680
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.24887369
69CBP_20019798_ChIP-Seq_JUKART_Human1.24725631
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24725631
71SOX2_27498859_Chip-Seq_STOMACH_Mouse1.24345122
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24157610
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.22965323
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22962110
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21837006
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.21025345
77CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20757319
78SMAD4_21799915_ChIP-Seq_A2780_Human1.19836890
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19391810
80MYC_18555785_ChIP-Seq_MESCs_Mouse1.18971873
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17833011
82* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17619013
83FLI1_27457419_Chip-Seq_LIVER_Mouse1.17141591
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16278723
85* GATA4_25053715_ChIP-Seq_YYC3_Human1.16099346
86* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15115421
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14088934
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12846070
89* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12413548
90SOX2_16153702_ChIP-ChIP_HESCs_Human1.11752840
91EZH2_27304074_Chip-Seq_ESCs_Mouse1.10855634
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09426765
93NANOG_16153702_ChIP-ChIP_HESCs_Human1.07481315
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06728084
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06060774
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05321952
97SOX9_26525672_Chip-Seq_HEART_Mouse1.05305564
98PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04083236
99CDX2_20551321_ChIP-Seq_CACO-2_Human1.03863868
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02219000
101JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01163926
102PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00936629
103* AR_25329375_ChIP-Seq_VCAP_Human1.00891455
104FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00438688
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99715504
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99715504
107BCAT_22108803_ChIP-Seq_LS180_Human0.98778980
108RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98488699
109TRIM28_21343339_ChIP-Seq_HEK293_Human0.98342813
110* RUNX2_22187159_ChIP-Seq_PCA_Human0.97367779
111NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96750881
112FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.96711704
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96213284
114EED_16625203_ChIP-ChIP_MESCs_Mouse0.95193141
115IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95065183
116STAT3_23295773_ChIP-Seq_U87_Human0.94844770
117LXR_22292898_ChIP-Seq_THP-1_Human0.94241474
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94144000
119EGR1_19032775_ChIP-ChIP_M12_Human0.93911533
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93524071
121REST_21632747_ChIP-Seq_MESCs_Mouse0.93473588
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93159968
123ER_23166858_ChIP-Seq_MCF-7_Human0.92247261
124TCF4_23295773_ChIP-Seq_U87_Human0.92151086
125CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92043469
126KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92032532
127FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91760862
128* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.90720130
129* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.89971583
130ETS1_20019798_ChIP-Seq_JURKAT_Human0.89949970
131GATA1_26923725_Chip-Seq_HPCs_Mouse0.88870696
132PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88840193
133TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87074418
134AR_21572438_ChIP-Seq_LNCaP_Human0.86433646
135MYCN_18555785_ChIP-Seq_MESCs_Mouse0.86150055
136TP53_22573176_ChIP-Seq_HFKS_Human0.86005391
137BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85819493
138BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.85501410
139* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85415768
140AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82348962
141SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81146387
142FOXO3_23340844_ChIP-Seq_DLD1_Human0.80875333
143HTT_18923047_ChIP-ChIP_STHdh_Human0.80671831
144STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79884151
145THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78889086
146Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75689938
147NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75178234
148NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75178234
149ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71192240
150* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70943122
151MYC_19915707_ChIP-ChIP_AK7_Human0.69113574
152* GATA6_25053715_ChIP-Seq_YYC3_Human0.69009069
153ERG_21242973_ChIP-ChIP_JURKAT_Human0.67505500
154FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67416328
155NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.66902797
156RACK7_27058665_Chip-Seq_MCF-7_Human0.66037787
157CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.64922345
158SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.64228336
159ZNF263_19887448_ChIP-Seq_K562_Human0.63901645
160SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.63716276
161* AR_21909140_ChIP-Seq_LNCAP_Human0.61436134
162AR_20517297_ChIP-Seq_VCAP_Human0.60345009
163PPAR_26484153_Chip-Seq_NCI-H1993_Human0.60127472
164* SOX2_20726797_ChIP-Seq_SW620_Human0.59966619
165ESET_19884257_ChIP-Seq_ESCs_Mouse0.59359035
166KAP1_22055183_ChIP-Seq_ESCs_Mouse0.58872940
167ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.58678208
168TAF2_19829295_ChIP-Seq_ESCs_Human0.58567221
169FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.58298043
170ESR1_20079471_ChIP-ChIP_T-47D_Human0.58035121
171SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.56900641
172CEBPB_22108803_ChIP-Seq_LS180_Human0.56500804
173* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.56278927
174GATA2_19941826_ChIP-Seq_K562_Human0.56209276
175GATA1_22025678_ChIP-Seq_K562_Human0.55769244
176SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.55011643
177* STAT1_17558387_ChIP-Seq_HELA_Human0.53399839
178GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.53168493
179* TBX20_22080862_ChIP-Seq_HEART_Mouse0.53050353
180* TBX20_22328084_ChIP-Seq_HEART_Mouse0.53050353
181CDX2_22108803_ChIP-Seq_LS180_Human0.52755127
182FOXA1_25552417_ChIP-Seq_VCAP_Human0.52547310
183PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52533871
184GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.51373231
185EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.50692073
186SOX11_22085726_ChIP-Seq_ESNs_Mouse0.50500973
187RARA_24833708_ChIP-Seq_LIVER_Mouse0.50413477
188GATA1_19941826_ChIP-Seq_K562_Human0.50389243
189FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.50369066
190EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.49655346
191ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.49060228
192TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.48287967
193RAC3_21632823_ChIP-Seq_H3396_Human0.47739932
194SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.46700729
195CREB1_26743006_Chip-Seq_LNCaP_Human0.46689825
196CBP_21632823_ChIP-Seq_H3396_Human0.46441308
197SOX2_22085726_ChIP-Seq_NPCs_Mouse0.46147361
198GATA3_24758297_ChIP-Seq_MCF-7_Human0.45011758

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.02781806
2MP0002139_abnormal_hepatobiliary_system6.99001035
3MP0005365_abnormal_bile_salt4.96271679
4MP0005085_abnormal_gallbladder_physiolo4.85896912
5MP0008875_abnormal_xenobiotic_pharmacok4.41424737
6MP0003195_calcinosis4.38973308
7MP0005332_abnormal_amino_acid4.25810068
8MP0004019_abnormal_vitamin_homeostasis3.66105183
9MP0004043_abnormal_pH_regulation3.46701566
10MP0003252_abnormal_bile_duct3.46145447
11MP0003806_abnormal_nucleotide_metabolis3.13807705
12MP0002138_abnormal_hepatobiliary_system2.87123208
13MP0009643_abnormal_urine_homeostasis2.75223753
14MP0010329_abnormal_lipoprotein_level2.53825030
15MP0003890_abnormal_embryonic-extraembry2.27033044
16MP0001666_abnormal_nutrient_absorption2.25034875
17MP0001756_abnormal_urination2.21749357
18MP0003191_abnormal_cellular_cholesterol2.16159851
19MP0006292_abnormal_olfactory_placode2.14047947
20MP0005636_abnormal_mineral_homeostasis2.08181390
21MP0001529_abnormal_vocalization2.07097801
22MP0003880_abnormal_central_pattern2.05802152
23MP0008058_abnormal_DNA_repair2.00941802
24MP0010030_abnormal_orbit_morphology2.00505789
25MP0003122_maternal_imprinting1.94780412
26MP0001765_abnormal_ion_homeostasis1.93493369
27MP0004133_heterotaxia1.90289732
28MP0002822_catalepsy1.82237475
29MP0009840_abnormal_foam_cell1.79792863
30MP0002102_abnormal_ear_morphology1.78285704
31MP0005083_abnormal_biliary_tract1.77623989
32MP0003937_abnormal_limbs/digits/tail_de1.76107897
33MP0002136_abnormal_kidney_physiology1.76047452
34MP0010094_abnormal_chromosome_stability1.74575104
35MP0003121_genomic_imprinting1.74022990
36MP0005319_abnormal_enzyme/_coenzyme1.72622976
37MP0008789_abnormal_olfactory_epithelium1.72497400
38MP0005584_abnormal_enzyme/coenzyme_acti1.70822854
39MP0002118_abnormal_lipid_homeostasis1.69766950
40MP0003119_abnormal_digestive_system1.69101152
41MP0000778_abnormal_nervous_system1.67543250
42MP0002233_abnormal_nose_morphology1.66136597
43MP0002938_white_spotting1.63510464
44MP0001293_anophthalmia1.62157842
45MP0002234_abnormal_pharynx_morphology1.58243603
46MP0000609_abnormal_liver_physiology1.57470919
47MP0001764_abnormal_homeostasis1.56653462
48MP0008877_abnormal_DNA_methylation1.54594650
49MP0005451_abnormal_body_composition1.53983741
50MP0005499_abnormal_olfactory_system1.52825929
51MP0005394_taste/olfaction_phenotype1.52825929
52MP0000566_synostosis1.51140199
53MP0003186_abnormal_redox_activity1.48849837
54MP0000631_abnormal_neuroendocrine_gland1.43947124
55MP0002736_abnormal_nociception_after1.43021706
56MP0006276_abnormal_autonomic_nervous1.39546601
57MP0002876_abnormal_thyroid_physiology1.39143352
58MP0003868_abnormal_feces_composition1.36985746
59MP0000049_abnormal_middle_ear1.29902060
60MP0003123_paternal_imprinting1.28238574
61MP0008932_abnormal_embryonic_tissue1.27059499
62MP0006072_abnormal_retinal_apoptosis1.25379570
63MP0001286_abnormal_eye_development1.23455114
64MP0000537_abnormal_urethra_morphology1.23103376
65MP0003136_yellow_coat_color1.20387379
66MP0003861_abnormal_nervous_system1.17251286
67MP0004270_analgesia1.17156385
68MP0002751_abnormal_autonomic_nervous1.16558066
69MP0003878_abnormal_ear_physiology1.16541363
70MP0005377_hearing/vestibular/ear_phenot1.16541363
71MP0001984_abnormal_olfaction1.16331551
72MP0000538_abnormal_urinary_bladder1.15148182
73MP0001299_abnormal_eye_distance/1.14355990
74MP0003755_abnormal_palate_morphology1.13951164
75MP0008961_abnormal_basal_metabolism1.13426466
76MP0000955_abnormal_spinal_cord1.13130888
77MP0002697_abnormal_eye_size1.12947658
78MP0003942_abnormal_urinary_system1.12943431
79MP0005187_abnormal_penis_morphology1.12770753
80MP0005423_abnormal_somatic_nervous1.10584758
81MP0003693_abnormal_embryo_hatching1.09156237
82MP0005646_abnormal_pituitary_gland1.08259789
83MP0003567_abnormal_fetal_cardiomyocyte1.08091087
84MP0005551_abnormal_eye_electrophysiolog1.07936061
85MP0006036_abnormal_mitochondrial_physio1.07560899
86MP0002734_abnormal_mechanical_nocicepti1.07362997
87MP0002282_abnormal_trachea_morphology1.06480207
88MP0002084_abnormal_developmental_patter1.05382941
89MP0004859_abnormal_synaptic_plasticity1.04932039
90MP0002184_abnormal_innervation1.04700879
91MP0003111_abnormal_nucleus_morphology1.04506276
92MP0003385_abnormal_body_wall1.02017951
93MP0002735_abnormal_chemical_nociception1.01537557
94MP0005535_abnormal_body_temperature1.01319756
95MP0009046_muscle_twitch1.00365189
96MP0005253_abnormal_eye_physiology0.99958129
97MP0001486_abnormal_startle_reflex0.99637779
98MP0003938_abnormal_ear_development0.99518428
99MP0005670_abnormal_white_adipose0.99051822
100MP0005391_vision/eye_phenotype0.98417125
101MP0002653_abnormal_ependyma_morphology0.98104920
102MP0002557_abnormal_social/conspecific_i0.97667986
103MP0005084_abnormal_gallbladder_morpholo0.96889405
104MP0009250_abnormal_appendicular_skeleto0.95598612
105MP0002160_abnormal_reproductive_system0.95595158
106MP0005058_abnormal_lysosome_morphology0.94636422
107MP0004957_abnormal_blastocyst_morpholog0.94073592
108MP0001661_extended_life_span0.93275191
109MP0002210_abnormal_sex_determination0.93167572
110MP0002752_abnormal_somatic_nervous0.92504093
111MP0000516_abnormal_urinary_system0.92503768
112MP0005367_renal/urinary_system_phenotyp0.92503768
113MP0002152_abnormal_brain_morphology0.90835386
114MP0003077_abnormal_cell_cycle0.90492029
115MP0003935_abnormal_craniofacial_develop0.90476170
116MP0000598_abnormal_liver_morphology0.90295439
117MP0009764_decreased_sensitivity_to0.89767415
118MP0003635_abnormal_synaptic_transmissio0.89580452
119MP0002085_abnormal_embryonic_tissue0.89209431
120MP0001958_emphysema0.88330398
121MP0009642_abnormal_blood_homeostasis0.87888784
122MP0001968_abnormal_touch/_nociception0.87553527
123MP0000230_abnormal_systemic_arterial0.87208779
124MP0002092_abnormal_eye_morphology0.86642422
125MP0005195_abnormal_posterior_eye0.86591138
126MP0008995_early_reproductive_senescence0.86579024
127MP0003315_abnormal_perineum_morphology0.85571765
128MP0005386_behavior/neurological_phenoty0.85489099
129MP0004924_abnormal_behavior0.85489099
130MP0002572_abnormal_emotion/affect_behav0.85017068
131MP0002928_abnormal_bile_duct0.84832652
132MP0001485_abnormal_pinna_reflex0.83377099
133MP0002249_abnormal_larynx_morphology0.82747538
134MP0001177_atelectasis0.82704912
135MP0002063_abnormal_learning/memory/cond0.82247049
136MP0002168_other_aberrant_phenotype0.82145744
137* MP0002882_abnormal_neuron_morphology0.81979167
138MP0002272_abnormal_nervous_system0.81134629
139MP0009745_abnormal_behavioral_response0.78949917
140MP0002116_abnormal_craniofacial_bone0.78900768
141MP0004215_abnormal_myocardial_fiber0.77589826
142MP0000604_amyloidosis0.77422931
143MP0008469_abnormal_protein_level0.76974515
144MP0003638_abnormal_response/metabolism_0.76066950
145MP0005220_abnormal_exocrine_pancreas0.74543750
146MP0002135_abnormal_kidney_morphology0.72248054
147MP0005647_abnormal_sex_gland0.71772786
148MP0003300_gastrointestinal_ulcer0.71654091
149MP0002078_abnormal_glucose_homeostasis0.69850116
150MP0005395_other_phenotype0.69676301
151MP0003705_abnormal_hypodermis_morpholog0.68701617
152MP0005408_hypopigmentation0.66228264
153MP0003656_abnormal_erythrocyte_physiolo0.65220182
154MP0004885_abnormal_endolymph0.63763357
155MP0003329_amyloid_beta_deposits0.62393115
156MP0005666_abnormal_adipose_tissue0.61503046
157MP0005376_homeostasis/metabolism_phenot0.60026583
158MP0006035_abnormal_mitochondrial_morpho0.59966384
159MP0003959_abnormal_lean_body0.59780402
160MP0004264_abnormal_extraembryonic_tissu0.58099823
161MP0009763_increased_sensitivity_to0.55391179
162MP0002796_impaired_skin_barrier0.54718116
163MP0010234_abnormal_vibrissa_follicle0.53578636
164MP0009765_abnormal_xenobiotic_induced0.52965728
165MP0003011_delayed_dark_adaptation0.47803858
166MP0002971_abnormal_brown_adipose0.47101112
167MP0003953_abnormal_hormone_level0.43211019
168MP0003690_abnormal_glial_cell0.43031981
169MP0004147_increased_porphyrin_level0.42400692
170MP0005334_abnormal_fat_pad0.42026600
171MP0009697_abnormal_copulation0.40292562
172MP0003724_increased_susceptibility_to0.40236207
173MP0003283_abnormal_digestive_organ0.40092847
174MP0002896_abnormal_bone_mineralization0.38385761
175MP0004130_abnormal_muscle_cell0.38081333
176MP0005266_abnormal_metabolism0.37885116
177MP0003075_altered_response_to0.34972929
178MP0005166_decreased_susceptibility_to0.34888340
179MP0003718_maternal_effect0.34882024
180MP0009053_abnormal_anal_canal0.34206789
181MP0010368_abnormal_lymphatic_system0.33426830
182MP0002254_reproductive_system_inflammat0.33249659
183MP0008874_decreased_physiological_sensi0.31166287
184MP0002069_abnormal_eating/drinking_beha0.30875227
185MP0009672_abnormal_birth_weight0.29636820
186MP0005167_abnormal_blood-brain_barrier0.29052118
187MP0001845_abnormal_inflammatory_respons0.28004941
188MP0003646_muscle_fatigue0.27514297
189MP0002089_abnormal_postnatal_growth/wei0.26286159
190MP0002837_dystrophic_cardiac_calcinosis0.25243876
191MP0008873_increased_physiological_sensi0.23299952
192MP0005165_increased_susceptibility_to0.23225650
193MP0008872_abnormal_physiological_respon0.22639076

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)5.95909006
2Hyperglycinuria (HP:0003108)5.59368544
3Abnormality of glutamine family amino acid metabolism (HP:0010902)5.45832748
4Metabolic alkalosis (HP:0200114)5.33849279
5Increased circulating renin level (HP:0000848)5.30939335
6Hypokalemic alkalosis (HP:0001949)5.21947088
7Abnormality of aromatic amino acid family metabolism (HP:0004338)5.20224688
8Hypomagnesemia (HP:0002917)5.19595262
9Hyperactive renin-angiotensin system (HP:0000841)5.09121412
10Abnormality of serine family amino acid metabolism (HP:0010894)4.93426692
11Abnormality of glycine metabolism (HP:0010895)4.93426692
12Hyperuricemia (HP:0002149)4.65721755
13Increased purine levels (HP:0004368)4.65721755
14Polyuria (HP:0000103)4.57602990
15Ketosis (HP:0001946)4.57044306
16Abnormal urine output (HP:0012590)4.55611446
17Ketoacidosis (HP:0001993)4.46380183
18Abnormality of chloride homeostasis (HP:0011422)4.37812603
19Abnormality of magnesium homeostasis (HP:0004921)4.36385250
20Abnormality of purine metabolism (HP:0004352)4.31635194
21Intrahepatic cholestasis (HP:0001406)4.31345386
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.28918463
23Alkalosis (HP:0001948)4.21525330
24Hyperglycinemia (HP:0002154)4.20882019
25Proximal tubulopathy (HP:0000114)4.20063910
26Abnormality of fatty-acid metabolism (HP:0004359)4.11581598
27Abnormality of renal excretion (HP:0011036)4.08317984
28Abnormality of monocarboxylic acid metabolism (HP:0010996)4.04210380
29Xanthomatosis (HP:0000991)4.02553534
30Hyperammonemia (HP:0001987)3.98152586
31Abnormality of sulfur amino acid metabolism (HP:0004339)3.97535034
32Deep venous thrombosis (HP:0002625)3.91192578
33Delayed CNS myelination (HP:0002188)3.81461855
34Tetany (HP:0001281)3.77957963
35Polydipsia (HP:0001959)3.66683860
36Abnormal drinking behavior (HP:0030082)3.66683860
37Abnormality of nucleobase metabolism (HP:0010932)3.66555131
38Renal salt wasting (HP:0000127)3.48963200
39Hyperaldosteronism (HP:0000859)3.38789664
40Abnormality of the labia minora (HP:0012880)3.22958298
41Abnormality of renin-angiotensin system (HP:0000847)3.19473981
42Generalized aminoaciduria (HP:0002909)3.12701936
43Hypobetalipoproteinemia (HP:0003563)3.12475460
44Prolonged partial thromboplastin time (HP:0003645)3.10100066
45Metabolic acidosis (HP:0001942)3.07002052
46Joint hemorrhage (HP:0005261)2.94588290
47Complement deficiency (HP:0004431)2.94431362
48Hypoglycemic coma (HP:0001325)2.94203774
49Renal tubular acidosis (HP:0001947)2.93088263
50Dicarboxylic aciduria (HP:0003215)2.92489049
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.92489049
52Hyperlipoproteinemia (HP:0010980)2.86844615
53Glycosuria (HP:0003076)2.78609780
54Abnormality of urine glucose concentration (HP:0011016)2.78609780
55Hydroxyprolinuria (HP:0003080)2.77113630
56Abnormality of proline metabolism (HP:0010907)2.77113630
57Lethargy (HP:0001254)2.69569850
58Vomiting (HP:0002013)2.66634201
59Vascular calcification (HP:0004934)2.66537630
60Fat malabsorption (HP:0002630)2.65434865
61Abnormality of serum amino acid levels (HP:0003112)2.63076555
62Abnormality of methionine metabolism (HP:0010901)2.57304858
63Septo-optic dysplasia (HP:0100842)2.56649886
64Abnormality of midbrain morphology (HP:0002418)2.56227498
65Molar tooth sign on MRI (HP:0002419)2.56227498
66Malnutrition (HP:0004395)2.55498007
67Pancreatic fibrosis (HP:0100732)2.52377663
68Enlarged kidneys (HP:0000105)2.50903017
69Nephrolithiasis (HP:0000787)2.48376739
70Nephronophthisis (HP:0000090)2.45882636
71Hypercalciuria (HP:0002150)2.41693591
72Hypokalemia (HP:0002900)2.40433151
73Optic nerve hypoplasia (HP:0000609)2.38672581
74Cardiovascular calcification (HP:0011915)2.36598531
75Abnormality of pyrimidine metabolism (HP:0004353)2.36395004
76Neonatal onset (HP:0003623)2.36138128
77Hypolipoproteinemia (HP:0010981)2.35930186
78Supernumerary spleens (HP:0009799)2.34987057
79Rickets (HP:0002748)2.34933917
80Intestinal atresia (HP:0011100)2.34899247
81Hepatocellular carcinoma (HP:0001402)2.34591815
82Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.33783295
83Epidermoid cyst (HP:0200040)2.33697065
84Bifid tongue (HP:0010297)2.33222564
85Irritability (HP:0000737)2.32785837
86Medial flaring of the eyebrow (HP:0010747)2.32198275
87Hyperphosphaturia (HP:0003109)2.31057944
88Oligodactyly (hands) (HP:0001180)2.30302108
89Abnormality of the common coagulation pathway (HP:0010990)2.29086396
90Gait imbalance (HP:0002141)2.27754361
91True hermaphroditism (HP:0010459)2.27417296
92Tubulointerstitial nephritis (HP:0001970)2.26129038
93Confusion (HP:0001289)2.25372410
94Pancreatic cysts (HP:0001737)2.24244153
95Colon cancer (HP:0003003)2.19835988
96Cerebral edema (HP:0002181)2.17061536
97Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.15911282
98Hyperbilirubinemia (HP:0002904)2.15586650
99Aplasia/Hypoplasia of the uvula (HP:0010293)2.14442916
100Genital tract atresia (HP:0001827)2.13789296
101Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.13719197
102Nephrocalcinosis (HP:0000121)2.12839545
103Congenital primary aphakia (HP:0007707)2.12648692
104Chronic hepatic failure (HP:0100626)2.12187161
105Steatorrhea (HP:0002570)2.11533819
106Spastic diplegia (HP:0001264)2.11110848
107Vaginal atresia (HP:0000148)2.10939290
108Absent septum pellucidum (HP:0001331)2.10164616
109Hypoalphalipoproteinemia (HP:0003233)2.09685485
110Meckel diverticulum (HP:0002245)2.08933801
111Anophthalmia (HP:0000528)2.07773975
112Abnormal urine phosphate concentration (HP:0012599)2.06554665
113Drooling (HP:0002307)2.05131091
114Conjugated hyperbilirubinemia (HP:0002908)2.03917235
115Abnormality of complement system (HP:0005339)2.02760868
116Facial shape deformation (HP:0011334)2.01342831
117Potter facies (HP:0002009)2.01342831
118Cortical dysplasia (HP:0002539)2.00373590
119Abnormality of potassium homeostasis (HP:0011042)1.99997902
120Hypophosphatemia (HP:0002148)1.99452839
121Abnormal enzyme/coenzyme activity (HP:0012379)1.98093727
122Abnormality of the ileum (HP:0001549)1.97127796
123Facial cleft (HP:0002006)1.97104632
124Chromsome breakage (HP:0040012)1.96845357
125Dehydration (HP:0001944)1.96276625
126Nausea (HP:0002018)1.94538758
127Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94534687
128Nephrogenic diabetes insipidus (HP:0009806)1.94365976
129Postaxial hand polydactyly (HP:0001162)1.93680355
130Abnormality of the intrinsic pathway (HP:0010989)1.92541090
131Abnormality of the renal medulla (HP:0100957)1.91439411
132Late onset (HP:0003584)1.89352422
133Sensorimotor neuropathy (HP:0007141)1.88754494
134Aplasia/Hypoplasia of the sternum (HP:0006714)1.88669906
135Retinal dysplasia (HP:0007973)1.88180344
136Postaxial foot polydactyly (HP:0001830)1.87749012
137Methylmalonic aciduria (HP:0012120)1.85280241
138Chondrocalcinosis (HP:0000934)1.84172804
139Preaxial hand polydactyly (HP:0001177)1.83992663
140Abnormality of the septum pellucidum (HP:0007375)1.82112688
141Abnormality of chromosome stability (HP:0003220)1.80952638
142Type II lissencephaly (HP:0007260)1.80205228
143Lissencephaly (HP:0001339)1.79953623
144Oligodactyly (HP:0012165)1.78971845
145Narrow forehead (HP:0000341)1.78891439
146Aplasia/Hypoplasia of the tibia (HP:0005772)1.77885459
147Abnormal biliary tract physiology (HP:0012439)1.77801513
148Bile duct proliferation (HP:0001408)1.77801513
149Volvulus (HP:0002580)1.77509444
150Short tibia (HP:0005736)1.75536181
151Absent radius (HP:0003974)1.74221219
152Anencephaly (HP:0002323)1.73122463
153Aplasia/Hypoplasia of the tongue (HP:0010295)1.71486617
154Abnormal lung lobation (HP:0002101)1.71148850
155Excessive salivation (HP:0003781)1.70749840
156Aplasia involving forearm bones (HP:0009822)1.69027157
157Absent forearm bone (HP:0003953)1.69027157
158Dandy-Walker malformation (HP:0001305)1.67420418
159Triphalangeal thumb (HP:0001199)1.67356637
160Sclerocornea (HP:0000647)1.66995758
161Broad-based gait (HP:0002136)1.66535654
162Abnormality of the parathyroid morphology (HP:0011766)1.66275386
163Patellar aplasia (HP:0006443)1.65957051
164Poor coordination (HP:0002370)1.64986642
165Micropenis (HP:0000054)1.63734880
166Aqueductal stenosis (HP:0002410)1.63147643
167Scrotal hypoplasia (HP:0000046)1.61647437
168Abnormality of the fetal cardiovascular system (HP:0010948)1.60716544
169Abnormal umbilical cord blood vessels (HP:0011403)1.60716544
170Single umbilical artery (HP:0001195)1.60716544
171Gonadotropin excess (HP:0000837)1.59800316
172Cutaneous finger syndactyly (HP:0010554)1.59294315
173Renal hypoplasia (HP:0000089)1.58897183
174Labial hypoplasia (HP:0000066)1.57770083
175Methylmalonic acidemia (HP:0002912)1.57632789
176Adrenal hypoplasia (HP:0000835)1.57261513
177Abnormality of the duodenum (HP:0002246)1.57185561
178Median cleft lip (HP:0000161)1.56200212
179Acute encephalopathy (HP:0006846)1.55976745
180Hepatoblastoma (HP:0002884)1.54822199
181Aganglionic megacolon (HP:0002251)1.53588930
182Occipital encephalocele (HP:0002085)1.53569933
183Bifid scrotum (HP:0000048)1.52570590
184Gastrointestinal atresia (HP:0002589)1.52469947
185Broad foot (HP:0001769)1.52099437
186Anal atresia (HP:0002023)1.51693027
187Hypoplastic female external genitalia (HP:0012815)1.51649344
188Poor suck (HP:0002033)1.50195193
189Abnormality of the carotid arteries (HP:0005344)1.47736613
190Small hand (HP:0200055)1.47399755
191Shawl scrotum (HP:0000049)1.46852041
192Abnormality of the preputium (HP:0100587)1.46685681
193Hyperventilation (HP:0002883)1.46403882
194Hypoplastic pelvis (HP:0008839)1.46312630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK39.37418171
2OXSR16.45434186
3WNK45.63039858
4BCKDK4.86752933
5CASK3.21765401
6PNCK2.85688035
7MARK12.59517038
8CDC72.58420555
9FGFR42.50134182
10MAP3K42.27882083
11MAP2K72.24682052
12STK392.20834451
13TNIK2.19430428
14STK38L2.19215748
15ERN12.16930251
16TRIM282.14121197
17SRPK11.97272502
18BCR1.88303803
19MKNK21.88002898
20STK161.84003834
21DYRK21.74888487
22SIK11.72064115
23SGK4941.68414914
24SGK2231.68414914
25NUAK11.68149828
26MKNK11.67485902
27PDK31.63035295
28PDK41.63035295
29PLK41.62552152
30MAPK131.61616812
31WEE11.58787893
32MST1R1.56598830
33BMPR1B1.54784178
34BRSK21.53225736
35NEK11.50329354
36TSSK61.47621585
37INSRR1.40730155
38MAP4K21.39950109
39PLK31.32989339
40ERBB41.31413633
41TTK1.31168801
42PBK1.30893227
43PDK21.29562725
44AKT31.27252604
45PLK11.23474614
46SGK21.21461277
47PINK11.21182682
48BUB11.21167747
49CSNK1G21.19252940
50SGK31.18397818
51DYRK31.14144475
52CSNK1A1L1.12737354
53PLK21.08974203
54CSNK1G31.07894084
55MAPK111.07695587
56BRD41.07033455
57GRK11.05285758
58CAMK1G1.04722648
59ERBB31.02566651
60TRIB30.96940882
61MAP3K70.96813234
62GRK60.96154836
63WNK10.95338575
64BRSK10.94544689
65MAP2K40.93319583
66NTRK20.92349969
67TIE10.91000372
68STK380.90659993
69PRKD30.90286629
70ABL20.89836443
71ACVR1B0.88669824
72PTK60.86234216
73ATR0.85823032
74TAOK30.84309078
75PKN20.84053318
76MINK10.84042696
77PHKG20.83032423
78PHKG10.83032423
79CHEK20.80454892
80EPHB10.76726806
81LATS10.76695504
82NEK20.75381373
83PRKAA10.75347968
84GSK3A0.74739894
85VRK10.71759463
86CDK190.71459583
87PRKAA20.70799495
88JAK20.69984440
89LRRK20.69869162
90EIF2AK10.67999332
91ZAK0.66097568
92ATM0.66017438
93PIK3CG0.65653624
94DAPK20.64863106
95CSNK1E0.64586270
96MAP3K30.63482798
97PTK20.61129991
98EIF2AK30.61022550
99TAF10.60340898
100DYRK1B0.59777522
101EPHB20.59572723
102PRKCZ0.59493343
103MAP3K140.58495626
104MAP3K120.57334565
105DYRK1A0.57069055
106PRKCE0.56579307
107PDPK10.56044564
108PIK3CA0.54189244
109TGFBR20.54140084
110FRK0.54039412
111AURKB0.53878377
112NME10.53074199
113CCNB10.52647367
114MET0.52322690
115TYK20.51270643
116MAP2K30.50840137
117NEK90.49323630
118PRKACG0.47451034
119AURKA0.47260987
120CDK10.47139067
121STK30.46938824
122FGFR10.44952985
123ADRBK20.44944720
124CDK180.44098756
125RIPK10.44079692
126FLT30.43995642
127MAPK150.43447839
128CHEK10.43292458
129NTRK30.43214489
130CSNK1D0.43114042
131LIMK10.43059003
132CSNK1A10.42389589
133MAP3K110.42128752
134SGK10.41641774
135VRK20.41453883
136PRKDC0.39599384
137MAPK120.39545621
138CDK140.39169510
139KDR0.39106567
140ERBB20.38933800
141CDK150.38906567
142FGFR20.38605639
143TGFBR10.36929527
144CDK30.36568471
145PDK10.36533325
146PAK30.36276774
147CSNK2A10.35924773
148EPHA40.35497735
149MAPK40.31855788
150MAP3K130.29947479
151FER0.28863333
152TBK10.24511306
153CSK0.24052410
154MST40.24045417
155CAMK2G0.23568897
156PRKCD0.23239250
157JAK10.23148694
158MAP3K100.22582957
159PRKCH0.22456233
160PRKCQ0.22199384
161IGF1R0.21130484
162IRAK20.21088811
163PRKCA0.20581453
164CDK60.20469240
165MAP2K60.19914311
166MAP3K20.18245881
167BMX0.15111026
168CAMK40.14916186
169PTK2B0.14767888
170NTRK10.14564435
171PRKACA0.14309123
172MAP2K10.14271286
173MTOR0.13774111
174AKT20.13673674
175PRKCG0.13622057
176MYLK0.11321920
177EGFR0.10884088
178CSNK1G10.09161361
179IRAK10.08881866
180PKN10.08864593
181IRAK30.08345518

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.40651042
2Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.28882770
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.26289079
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.07004275
5Butanoate metabolism_Homo sapiens_hsa006502.95327904
6Nitrogen metabolism_Homo sapiens_hsa009102.92810117
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.87540966
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.78323869
9Propanoate metabolism_Homo sapiens_hsa006402.70196626
10Arginine biosynthesis_Homo sapiens_hsa002202.69808399
11Fatty acid degradation_Homo sapiens_hsa000712.65126978
12Peroxisome_Homo sapiens_hsa041462.51093428
13* Tryptophan metabolism_Homo sapiens_hsa003802.48984587
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.46198003
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.39658649
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.36397450
17Mismatch repair_Homo sapiens_hsa034302.29398429
18Cyanoamino acid metabolism_Homo sapiens_hsa004602.21406440
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.11152329
20* 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09341681
21Protein export_Homo sapiens_hsa030602.06255039
22DNA replication_Homo sapiens_hsa030302.02410653
23beta-Alanine metabolism_Homo sapiens_hsa004101.95145884
24Fatty acid metabolism_Homo sapiens_hsa012121.93482445
25Bile secretion_Homo sapiens_hsa049761.86700055
26PPAR signaling pathway_Homo sapiens_hsa033201.84566152
27Pyruvate metabolism_Homo sapiens_hsa006201.79038357
28Fanconi anemia pathway_Homo sapiens_hsa034601.74474656
29Non-homologous end-joining_Homo sapiens_hsa034501.74332803
30Complement and coagulation cascades_Homo sapiens_hsa046101.69304695
31Vitamin digestion and absorption_Homo sapiens_hsa049771.67669549
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.65971495
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64901270
34Base excision repair_Homo sapiens_hsa034101.61052423
35Sulfur metabolism_Homo sapiens_hsa009201.59787088
36Selenocompound metabolism_Homo sapiens_hsa004501.55770091
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55761564
38Proteasome_Homo sapiens_hsa030501.54868879
39Basal transcription factors_Homo sapiens_hsa030221.53231272
40Carbon metabolism_Homo sapiens_hsa012001.53056451
41Chemical carcinogenesis_Homo sapiens_hsa052041.50550549
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50272644
43Histidine metabolism_Homo sapiens_hsa003401.48291412
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.45389631
45Homologous recombination_Homo sapiens_hsa034401.44292623
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40220492
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.37675053
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34571950
49Nucleotide excision repair_Homo sapiens_hsa034201.30700753
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.30474057
51Fatty acid elongation_Homo sapiens_hsa000621.26603096
52RNA polymerase_Homo sapiens_hsa030201.26015560
53Phenylalanine metabolism_Homo sapiens_hsa003601.25159307
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.25095214
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23823678
56RNA transport_Homo sapiens_hsa030131.21619210
57Retinol metabolism_Homo sapiens_hsa008301.21068056
58Glutathione metabolism_Homo sapiens_hsa004801.18622741
59Hedgehog signaling pathway_Homo sapiens_hsa043401.18518275
60* Biosynthesis of amino acids_Homo sapiens_hsa012301.17840918
61Starch and sucrose metabolism_Homo sapiens_hsa005001.15478127
62RNA degradation_Homo sapiens_hsa030181.13877104
63Arginine and proline metabolism_Homo sapiens_hsa003301.13050500
64Folate biosynthesis_Homo sapiens_hsa007901.12815299
65Cell cycle_Homo sapiens_hsa041101.12363102
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11804136
67Tyrosine metabolism_Homo sapiens_hsa003501.07524502
68Basal cell carcinoma_Homo sapiens_hsa052171.04301683
69Phototransduction_Homo sapiens_hsa047441.01756910
70Nicotine addiction_Homo sapiens_hsa050331.01448408
71Spliceosome_Homo sapiens_hsa030400.95432380
72Hippo signaling pathway_Homo sapiens_hsa043900.92566723
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91894629
74Caffeine metabolism_Homo sapiens_hsa002320.91307769
75Huntingtons disease_Homo sapiens_hsa050160.91301856
76Pyrimidine metabolism_Homo sapiens_hsa002400.88638650
77* Lysine degradation_Homo sapiens_hsa003100.88452914
78Staphylococcus aureus infection_Homo sapiens_hsa051500.87111809
79Oocyte meiosis_Homo sapiens_hsa041140.84134827
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83181431
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81881035
82ABC transporters_Homo sapiens_hsa020100.81462469
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.80414791
84Sulfur relay system_Homo sapiens_hsa041220.79992258
85Glycerolipid metabolism_Homo sapiens_hsa005610.75739419
86Wnt signaling pathway_Homo sapiens_hsa043100.71245419
87Purine metabolism_Homo sapiens_hsa002300.71182317
88mRNA surveillance pathway_Homo sapiens_hsa030150.67431262
89Steroid biosynthesis_Homo sapiens_hsa001000.66998255
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65368420
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64186493
92Pentose phosphate pathway_Homo sapiens_hsa000300.59960454
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59313995
94Fat digestion and absorption_Homo sapiens_hsa049750.57786499
95Fructose and mannose metabolism_Homo sapiens_hsa000510.57731108
96Dopaminergic synapse_Homo sapiens_hsa047280.56756443
97Axon guidance_Homo sapiens_hsa043600.56050428
98TGF-beta signaling pathway_Homo sapiens_hsa043500.55997859
99Cocaine addiction_Homo sapiens_hsa050300.55216754
100Circadian rhythm_Homo sapiens_hsa047100.53744651
101GABAergic synapse_Homo sapiens_hsa047270.53034702
102* Metabolic pathways_Homo sapiens_hsa011000.52779843
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50840542
104Vitamin B6 metabolism_Homo sapiens_hsa007500.48257289
105Collecting duct acid secretion_Homo sapiens_hsa049660.46067619
106Cardiac muscle contraction_Homo sapiens_hsa042600.46036915
107Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45606979
108Taste transduction_Homo sapiens_hsa047420.44976119
109Protein digestion and absorption_Homo sapiens_hsa049740.44931233
110Glutamatergic synapse_Homo sapiens_hsa047240.44146277
111One carbon pool by folate_Homo sapiens_hsa006700.41908142
112Mineral absorption_Homo sapiens_hsa049780.30435270
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29404245
114Other glycan degradation_Homo sapiens_hsa005110.27635175
115Renin-angiotensin system_Homo sapiens_hsa046140.27289246
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24030112
117Insulin resistance_Homo sapiens_hsa049310.18970840
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.17096534
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16818335
120Galactose metabolism_Homo sapiens_hsa000520.16440818
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.16383710
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.14210056
123Lysosome_Homo sapiens_hsa041420.13224202
124Fatty acid biosynthesis_Homo sapiens_hsa000610.12930828
125Thyroid hormone synthesis_Homo sapiens_hsa049180.12616648
126Oxidative phosphorylation_Homo sapiens_hsa001900.12464694
127Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.07329892
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.06336228
129Prion diseases_Homo sapiens_hsa050200.05031450
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.03905490
131Glucagon signaling pathway_Homo sapiens_hsa049220.03379062
132AMPK signaling pathway_Homo sapiens_hsa041520.00553626
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.1670840
134Linoleic acid metabolism_Homo sapiens_hsa00591-0.1621427
135Alzheimers disease_Homo sapiens_hsa05010-0.1431797
136Bladder cancer_Homo sapiens_hsa05219-0.1205472
137Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.1010563
138Hepatitis C_Homo sapiens_hsa05160-0.0867641
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0844215
140Parkinsons disease_Homo sapiens_hsa05012-0.0417795
141Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0399985
142Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0064337

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